Lecture 1 Dr.fatima Principles in the management of poisoned
... inhibitor) that lead to increase acetylcholine level because it compete with atropine at receptor site. 3- Dispositional antagonism: involve alteration of absorption, metabolism, distribution or excretion of toxic agents to reduce the amount available to tissues. Example in acetaminophen overdose a ...
... inhibitor) that lead to increase acetylcholine level because it compete with atropine at receptor site. 3- Dispositional antagonism: involve alteration of absorption, metabolism, distribution or excretion of toxic agents to reduce the amount available to tissues. Example in acetaminophen overdose a ...
single page dosing summary
... For small volume doses of medication, be aware that most delivery devices have a “dead space” in the applicator tip where some of the medication will remain. Be sure to take that dead space into account when calculating the volume of medication to be administered. ...
... For small volume doses of medication, be aware that most delivery devices have a “dead space” in the applicator tip where some of the medication will remain. Be sure to take that dead space into account when calculating the volume of medication to be administered. ...
Ahmed Fazary_Click Chemistry
... Click Chemistry is a general term that identifies a class of chemical transformations with a number of attaractive features including excellent functional-group tolerance, high yields and good selectivity under mild experimental conditions. As defined by K. B. Sharpless – “‘Click’ chemistry…a set of ...
... Click Chemistry is a general term that identifies a class of chemical transformations with a number of attaractive features including excellent functional-group tolerance, high yields and good selectivity under mild experimental conditions. As defined by K. B. Sharpless – “‘Click’ chemistry…a set of ...
Ars Pharmaceutica - Facultad de Farmacia
... Spectra are shown in the figure 1. Powder flow properties: The average values of Angle of Repose, Bulk Density, Tapped Density, Porosity and Compressibility of all the formulations were 28.39±0.31, 0.401±0.002, 0.473±0.004, 16.42±0.23 and 16.56±0.17 respectively. The flowability of the polymers was ...
... Spectra are shown in the figure 1. Powder flow properties: The average values of Angle of Repose, Bulk Density, Tapped Density, Porosity and Compressibility of all the formulations were 28.39±0.31, 0.401±0.002, 0.473±0.004, 16.42±0.23 and 16.56±0.17 respectively. The flowability of the polymers was ...
Phase-in substances Phase-in substances are substances
... Commercial Chemical Substances (EINECS), or that have been manufactured in the EU or countries that have acceded to the EU before 2004 but not (yet) placed on the EU market, at least once after 1 June 1992, or are so-called ‘no-longer polymers’ and are commonly referred to as ‘existing substances’. ...
... Commercial Chemical Substances (EINECS), or that have been manufactured in the EU or countries that have acceded to the EU before 2004 but not (yet) placed on the EU market, at least once after 1 June 1992, or are so-called ‘no-longer polymers’ and are commonly referred to as ‘existing substances’. ...
Hallucinogens: LSD, Peyote, Psilocybin, and PCP - ncadd-sfv
... Psilocybin, and PCP Hallucinogenic compounds in the form of, or extracted from, plants and mushrooms have been used for centuries, mostly in religious rituals. Almost all hallucinogens contain nitrogen and are classified as alkaloids. Many hallucinogens have chemical structures similar to those of n ...
... Psilocybin, and PCP Hallucinogenic compounds in the form of, or extracted from, plants and mushrooms have been used for centuries, mostly in religious rituals. Almost all hallucinogens contain nitrogen and are classified as alkaloids. Many hallucinogens have chemical structures similar to those of n ...
Greetings
... Trials Involving Human Subjects — with the legislative authority for the regulations stemming from the Food and Drugs Act. You can find all applicable laws and regulations regarding Clinical Trials at www.hc-sc.gc.ca/gcp. The Inspectorate is committed to providing the health products industry with i ...
... Trials Involving Human Subjects — with the legislative authority for the regulations stemming from the Food and Drugs Act. You can find all applicable laws and regulations regarding Clinical Trials at www.hc-sc.gc.ca/gcp. The Inspectorate is committed to providing the health products industry with i ...
Disease modifying treatments - MS-UK
... How can it help? Studies have shown that people with rapidly evolving severe relapsing remitting MS (RES) showed a decrease of 81% in relapses when taking Tysabri. In addition, the rate of their disease progression was slowed by approximately two thirds and the accumulation of new lesions that could ...
... How can it help? Studies have shown that people with rapidly evolving severe relapsing remitting MS (RES) showed a decrease of 81% in relapses when taking Tysabri. In addition, the rate of their disease progression was slowed by approximately two thirds and the accumulation of new lesions that could ...
AP Chemistry Standards and Benchmarks
... These descriptive facts, including chemistry involved in environmental and societal issues, should not be isolated form the principles being studied but should be taught throughout the course to illustrate and illuminate the principles. The following areas should be covered: • chemical reactivity an ...
... These descriptive facts, including chemistry involved in environmental and societal issues, should not be isolated form the principles being studied but should be taught throughout the course to illustrate and illuminate the principles. The following areas should be covered: • chemical reactivity an ...
Document
... Select known 3D structures of lipase (for example). Compare the target sequence with the known lipase structure by magic fit of Swiss-pdb Viewer. Use center the molecule on one atom tool bar to focus on the region of binding site. Compare the above two structures. ...
... Select known 3D structures of lipase (for example). Compare the target sequence with the known lipase structure by magic fit of Swiss-pdb Viewer. Use center the molecule on one atom tool bar to focus on the region of binding site. Compare the above two structures. ...
Scandium and Yttrium - Mercyhurst University
... resemble sunlight. As mentioned, scandium(III) triflate (Sc(CF3SO3)3) is a useful Lewis acid in organic synthesis as it is water-stable.1 Current Research Much like transition metals ions, scandium(III) and yttrium(III) will coordinate to a variety of ligands, including crown ethers, aza-crown ether ...
... resemble sunlight. As mentioned, scandium(III) triflate (Sc(CF3SO3)3) is a useful Lewis acid in organic synthesis as it is water-stable.1 Current Research Much like transition metals ions, scandium(III) and yttrium(III) will coordinate to a variety of ligands, including crown ethers, aza-crown ether ...
Syllabus
... the structural formulas. These new compounds may have important pharmacological functions such as anti-cancer and other medications. Some try to synthesize compounds which have known structures and which are difficult or expensive to obtain from natural sources. Other organic chemists try to determi ...
... the structural formulas. These new compounds may have important pharmacological functions such as anti-cancer and other medications. Some try to synthesize compounds which have known structures and which are difficult or expensive to obtain from natural sources. Other organic chemists try to determi ...
Aim 7a-d Organic Chemistry Notes
... Aim #7b: How are carbohydrates necessary for living things? ...
... Aim #7b: How are carbohydrates necessary for living things? ...
Introduction - African Journals Online
... use, as DDDs per 100 bed-days) (WHO, 2003). Provided that there is consistency in applied methodology, the ATC/DDD system is a valuable tool to monitor drug use over time and to compare between regions (Hutchinson et al., 2004). In this study, the ATC/DDD methodology was used to evaluate the sale of ...
... use, as DDDs per 100 bed-days) (WHO, 2003). Provided that there is consistency in applied methodology, the ATC/DDD system is a valuable tool to monitor drug use over time and to compare between regions (Hutchinson et al., 2004). In this study, the ATC/DDD methodology was used to evaluate the sale of ...
Topical Therapy
... occur with prolonged use and are more likely to occur in areas of sweating, occlusion, or high penetration such as the axilla or groin In general, atrophy does not occur until the agent has been used for 3 to 4 weeks and is ...
... occur with prolonged use and are more likely to occur in areas of sweating, occlusion, or high penetration such as the axilla or groin In general, atrophy does not occur until the agent has been used for 3 to 4 weeks and is ...
MP16z - Appendix 2 - NMP approval to practice form.dot
... Competency is defined by appropriate qualifications, additional post registration courses, clinical reflection / supervision and other evidence of continuing professional development. This includes taking into account the Nursing & Midwifery Council Circular 22/2007 – Prescribing for Children & Youn ...
... Competency is defined by appropriate qualifications, additional post registration courses, clinical reflection / supervision and other evidence of continuing professional development. This includes taking into account the Nursing & Midwifery Council Circular 22/2007 – Prescribing for Children & Youn ...
FoundationsofChemistryppt
... Do you agree or disagree? 1. The atoms in all objects are the same. 2. You cannot always tell by an object’s appearance whether it is made of more than one type of atom. 3. The weight of a material never changes, regardless of where it is. 4. Boiling is one method used to separate parts of a mixtur ...
... Do you agree or disagree? 1. The atoms in all objects are the same. 2. You cannot always tell by an object’s appearance whether it is made of more than one type of atom. 3. The weight of a material never changes, regardless of where it is. 4. Boiling is one method used to separate parts of a mixtur ...
Chapter 8: Using the Study Results to Design
... Table 8.1 contains a list of issues that you should consider when designing an intervention. For interventions that will have an educational component, the issues involve: (1) defining target groups and target behaviors; (2) selecting the best educational approach and materials; and (3) implementing ...
... Table 8.1 contains a list of issues that you should consider when designing an intervention. For interventions that will have an educational component, the issues involve: (1) defining target groups and target behaviors; (2) selecting the best educational approach and materials; and (3) implementing ...
IOSR Journal of Environmental Science, Toxicology and Food Technology (IOSR-JESTFT)
... such as cereals. The occurrence of phenolics in non-vascular plants, i.e., bryophytes is also quite common. Some phenolics like rosmarinic acid are reported from mosses (Vigeslang et al., 2005). Phenolic compounds play an important role in prevention of chronic diseases, and thus prove beneficial to ...
... such as cereals. The occurrence of phenolics in non-vascular plants, i.e., bryophytes is also quite common. Some phenolics like rosmarinic acid are reported from mosses (Vigeslang et al., 2005). Phenolic compounds play an important role in prevention of chronic diseases, and thus prove beneficial to ...
Chemical reactions alter arrangements of atoms.
... Reactants are the substances present at the beginning of a chemical reaction. In the burning of natural gas, for example, methane (CH4) and oxygen (O2) are the reactants in the chemical reaction. Products are the substances formed by a chemical reaction. In the burning of natural gas, carbon dioxide ...
... Reactants are the substances present at the beginning of a chemical reaction. In the burning of natural gas, for example, methane (CH4) and oxygen (O2) are the reactants in the chemical reaction. Products are the substances formed by a chemical reaction. In the burning of natural gas, carbon dioxide ...
MDMA produces stimulant-like conditioned locomotor activity* I
... stereotyPy; however, some qualitative differences were observed (Gold et al. 1988a). For example, the duration of the locomotor hyperactivity is quite prolonged and has a ...
... stereotyPy; however, some qualitative differences were observed (Gold et al. 1988a). For example, the duration of the locomotor hyperactivity is quite prolonged and has a ...
eTable 1. Study inclusion and exclusion criteria Inclusion criteria
... Subjects who currently meet the criteria for diagnosis of moderate or severe substance use disorder, by DSM-5 criteria,1 for any substances other than opioids, caffeine2, or nicotine Subjects with uncontrolled medical or psychiatric illness or any clinically significant finding/abnormality in pa ...
... Subjects who currently meet the criteria for diagnosis of moderate or severe substance use disorder, by DSM-5 criteria,1 for any substances other than opioids, caffeine2, or nicotine Subjects with uncontrolled medical or psychiatric illness or any clinically significant finding/abnormality in pa ...
Slide 1
... A. Characteristics I. Slowly growing organism; making them relatively resistant to antibiotics II. Mycobacterial cells can also be dormant and thus completely resistant to many drugs III. Lipid rich mycobacterial cell wall is impermeable to many agents IV. Substantial proportion of mycobacterial or ...
... A. Characteristics I. Slowly growing organism; making them relatively resistant to antibiotics II. Mycobacterial cells can also be dormant and thus completely resistant to many drugs III. Lipid rich mycobacterial cell wall is impermeable to many agents IV. Substantial proportion of mycobacterial or ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.