Alan Goldhammer, PhD
... …determination of the seriousness of a condition: ... is a matter of judgment, but generally is based on its impact on such factors as survival, day-to-day functioning, or the likelihood that the disease, if left untreated, will progress from a less severe condition to a more serious one. Thus, acqu ...
... …determination of the seriousness of a condition: ... is a matter of judgment, but generally is based on its impact on such factors as survival, day-to-day functioning, or the likelihood that the disease, if left untreated, will progress from a less severe condition to a more serious one. Thus, acqu ...
OxyContin®: Oxycodone Hydrochloride
... with or without physician direction can develop a tolerance or resistance to its effects and can become either physically dependent or addicted. Oxycodone-based products have been used illicitly for the past 30 years. Like other opioids, oxycodone can be highly addictive when used in non-medical cir ...
... with or without physician direction can develop a tolerance or resistance to its effects and can become either physically dependent or addicted. Oxycodone-based products have been used illicitly for the past 30 years. Like other opioids, oxycodone can be highly addictive when used in non-medical cir ...
Lecture on Air Pollution Prevention and Control
... Title III of the CAAA lists 189 hazardous air pollutants (Table 1) and directs EPA to establish and enforce Maximum Achievable Control Technology (MACT) standards for industrial sources emitting these pollutants. MACTs may be achieved through process changes, installation of pollution controls, mate ...
... Title III of the CAAA lists 189 hazardous air pollutants (Table 1) and directs EPA to establish and enforce Maximum Achievable Control Technology (MACT) standards for industrial sources emitting these pollutants. MACTs may be achieved through process changes, installation of pollution controls, mate ...
Inhalant Abuse - American Psychological Association
... • Ethical concerns prevent studies in people, especially juveniles • There are 100’s of chemicals to study • The strong odors of most solvents will make them easily distinguishable from other drugs and difficult to study ...
... • Ethical concerns prevent studies in people, especially juveniles • There are 100’s of chemicals to study • The strong odors of most solvents will make them easily distinguishable from other drugs and difficult to study ...
S2 GYNO-PEVARYL® 50, 150 Ovule
... The active substance of GYNO-PEVARYL DEPOT spreads over the vaginal epithelium where it forms a gel layer serving as an econazole depot. The antimycotic effect is thus ensured for several days. A broad spectrum of antimycotic activity has been demonstrated against dermatophytes, yeasts and moulds. E ...
... The active substance of GYNO-PEVARYL DEPOT spreads over the vaginal epithelium where it forms a gel layer serving as an econazole depot. The antimycotic effect is thus ensured for several days. A broad spectrum of antimycotic activity has been demonstrated against dermatophytes, yeasts and moulds. E ...
Chemical and physical changes
... In physical changes, molecules do not change because substances continue being the same ones. The molecular kinetic theory explains the physical changes supposing that molecules move more or less quickly and they come close together or move away. In chemical reactions, molecules change because some ...
... In physical changes, molecules do not change because substances continue being the same ones. The molecular kinetic theory explains the physical changes supposing that molecules move more or less quickly and they come close together or move away. In chemical reactions, molecules change because some ...
Amber star information sheet - March 2015 - Surrey PAD
... hypothyroidism; sinus bradycardia and sino-atrial heart block, combined use with drugs that may induce torsades de pointes (see Drug Interactions below), pregnancy (except in exceptional circumstances) and breast feeding. In patients with severe conduction disturbances or sinus node disease, amiodar ...
... hypothyroidism; sinus bradycardia and sino-atrial heart block, combined use with drugs that may induce torsades de pointes (see Drug Interactions below), pregnancy (except in exceptional circumstances) and breast feeding. In patients with severe conduction disturbances or sinus node disease, amiodar ...
ARCI-011-020 Medications and Prohibited Substances
... (d) Drugs with prominent CNS depressant action; (e) Antidepressant and antipsychotic drugs, with or without prominent CNS stimulatory or depressant effects; (f) Muscle blocking drugs which have a direct neuromuscular blocking action; (g) Local anesthetics which have a reasonable potential for use as ...
... (d) Drugs with prominent CNS depressant action; (e) Antidepressant and antipsychotic drugs, with or without prominent CNS stimulatory or depressant effects; (f) Muscle blocking drugs which have a direct neuromuscular blocking action; (g) Local anesthetics which have a reasonable potential for use as ...
and transdermal drug delivery: a review
... Drugs are rarely administered as pure chemical substances; mostly they are given as formulated preparations. These can vary from relatively simple solutions to complex drug delivery systems. The side effects of some drugs cannot always be eliminated; however, their undesirable behavior can also be s ...
... Drugs are rarely administered as pure chemical substances; mostly they are given as formulated preparations. These can vary from relatively simple solutions to complex drug delivery systems. The side effects of some drugs cannot always be eliminated; however, their undesirable behavior can also be s ...
antibacterial agents - NC State Veterinary Medicine
... Modification of the antibiotic or its target may involve various methodologies, such as production of antibiotic-inactivating or altering enzymes, chemical alterations (such as acetylation or phosphorylation) to the antibiotic or its binding site, or chromosomal or DNA changes that induce protein st ...
... Modification of the antibiotic or its target may involve various methodologies, such as production of antibiotic-inactivating or altering enzymes, chemical alterations (such as acetylation or phosphorylation) to the antibiotic or its binding site, or chromosomal or DNA changes that induce protein st ...
Omalizumab in ABPA - Stanford University
... to another etiology 2. Total serum IgE >500 IU/mL 3. Positive immediate skin test or in vitro demonstration of IgE antibody to A. fumigatus 4. One or both of the following: a. Serum precipitins or IgG antibodies to A. fumigatus. b. New or recent abnormalities on chest x-ray (e.g., infiltrates) or ch ...
... to another etiology 2. Total serum IgE >500 IU/mL 3. Positive immediate skin test or in vitro demonstration of IgE antibody to A. fumigatus 4. One or both of the following: a. Serum precipitins or IgG antibodies to A. fumigatus. b. New or recent abnormalities on chest x-ray (e.g., infiltrates) or ch ...
New Steps Aimed at Cutting Risks from Acetaminophen
... “Overdoses from prescription products containing acetaminophen account for nearly half of all cases of acetaminophen-related liver failure in the U.S., many of which result in liver transplant or death,” says Kweder. Most of the cases of severe liver injury occurred in patients who • took more than ...
... “Overdoses from prescription products containing acetaminophen account for nearly half of all cases of acetaminophen-related liver failure in the U.S., many of which result in liver transplant or death,” says Kweder. Most of the cases of severe liver injury occurred in patients who • took more than ...
Medical Marijuana in the Workplace
... Recognize that cannabis is not a prescribed drug; it is legally accessible as an alternative therapeutic application.[6,13,14] The fact that employers have a duty to accommodate the underlying disability is true[4,33]; however, this cannot be done at the expense of workplace safety.[9] The evidence ...
... Recognize that cannabis is not a prescribed drug; it is legally accessible as an alternative therapeutic application.[6,13,14] The fact that employers have a duty to accommodate the underlying disability is true[4,33]; however, this cannot be done at the expense of workplace safety.[9] The evidence ...
New Hope for the Treatment and Prevention of Age
... Insulin sensitizers were discovered more than 25 years ago. After more than 12 years of clinical use, they have been shown to provide durable therapeutic effects in the treatment of diabetes. More than a decade after the first insulin sensitizers were discovered, a hypothesis was developed that acti ...
... Insulin sensitizers were discovered more than 25 years ago. After more than 12 years of clinical use, they have been shown to provide durable therapeutic effects in the treatment of diabetes. More than a decade after the first insulin sensitizers were discovered, a hypothesis was developed that acti ...
167-987-1-SP - Journal of Ayurveda and Holistic Medicine
... Upper respiratory infections are very common due their high incidence in paediatric age group and recurrence also is more because of low immunity. Currently available options of treatment for the management of Upper respiratory tract infections are Decongestants, analgesics and Anti-biotics. However ...
... Upper respiratory infections are very common due their high incidence in paediatric age group and recurrence also is more because of low immunity. Currently available options of treatment for the management of Upper respiratory tract infections are Decongestants, analgesics and Anti-biotics. However ...
FORCED OXIDATIVE DEGRADATION STUDY OF DORIPENEM BY UV SPECTROPHOTOMETRIC METHOD Research Article
... available guidelines and main references. Stability indicating RP- HPLC method has been reported for analysis of doripenem injectable formulation in Brazil. To evaluate the stability of drug substance and formulation, a stress testing of drug substance and formulation by exposing to various stress c ...
... available guidelines and main references. Stability indicating RP- HPLC method has been reported for analysis of doripenem injectable formulation in Brazil. To evaluate the stability of drug substance and formulation, a stress testing of drug substance and formulation by exposing to various stress c ...
Duration of action
... • A- Potency and reliability : the first requirement of such a substance is that when administered correctly and in an adequate dosage it consistently produces effective local anesthesia . earlier agent (e.g. cocaine ) were obtained from natural sources and there was considerable variation in their ...
... • A- Potency and reliability : the first requirement of such a substance is that when administered correctly and in an adequate dosage it consistently produces effective local anesthesia . earlier agent (e.g. cocaine ) were obtained from natural sources and there was considerable variation in their ...
Eperimental studies of V.Ostwald and J.van Hoff
... generation to benefit from the extensive Dutch education reforms of the 1860s. He attended the newly formed Hoogere Burgerschool (High School) in Rotterdam. These new schools emphasized the study of mathematics and science to prepare students for a career in the growing industrial economy of the Net ...
... generation to benefit from the extensive Dutch education reforms of the 1860s. He attended the newly formed Hoogere Burgerschool (High School) in Rotterdam. These new schools emphasized the study of mathematics and science to prepare students for a career in the growing industrial economy of the Net ...
PDF
... commonly found in the atmosphere above marine areas, where it is used as a carbon source by the airborne bacteria Afipia,[2] and is found distinctively in human melanoma cells. A literature survey reveals that Nuclear magnetic resonance (NMR) studies have been demonstrated that oral doses of MSM are ...
... commonly found in the atmosphere above marine areas, where it is used as a carbon source by the airborne bacteria Afipia,[2] and is found distinctively in human melanoma cells. A literature survey reveals that Nuclear magnetic resonance (NMR) studies have been demonstrated that oral doses of MSM are ...
Alnylam`s ALN-VSP Abstract Published by American Society of
... RNAi is a natural process of gene silencing that occurs in organisms ranging from plants to mammals. By harnessing the natural biological process of RNAi occurring in our cells, the creation of a major new class of medicines, known as RNAi therapeutics, is on the horizon. Small interfering RNAs (siR ...
... RNAi is a natural process of gene silencing that occurs in organisms ranging from plants to mammals. By harnessing the natural biological process of RNAi occurring in our cells, the creation of a major new class of medicines, known as RNAi therapeutics, is on the horizon. Small interfering RNAs (siR ...
CHENOPODIUM ALBUM LINN. PARACETAMOLINDUCED HEPATIC INJURY IN RATS Research Article
... further confirmed the hepatoprotective activity of these extracts when compared with Paracetamol treated control groups. The result obtained were compared with silymarin (100mg/kg; oral), the standard drug. In conclusion Aetone and Methanol extract at (400mg/kg, or ...
... further confirmed the hepatoprotective activity of these extracts when compared with Paracetamol treated control groups. The result obtained were compared with silymarin (100mg/kg; oral), the standard drug. In conclusion Aetone and Methanol extract at (400mg/kg, or ...
A c a d
... exhibit sol - to - gel phase transition on the ocular surface due to change in a specific physicochemical parameter (ionic strength, temperature, pH, or solvent exchange). Formulations containing in situ gelling system for ocular drug delivery approaches are listed in Table 1. Polymers that may unde ...
... exhibit sol - to - gel phase transition on the ocular surface due to change in a specific physicochemical parameter (ionic strength, temperature, pH, or solvent exchange). Formulations containing in situ gelling system for ocular drug delivery approaches are listed in Table 1. Polymers that may unde ...
RoHS Statement - Thin Film Technology Corp.
... Thin Film Technology, an ISO 9001 registered company, manufactures and sells passive electronic components. This letter outlines the current RoHS/RoHS2 compliance status for the products that we manufacture and distribute. Some product lines that we manufacture are also still available in non-RoHS c ...
... Thin Film Technology, an ISO 9001 registered company, manufactures and sells passive electronic components. This letter outlines the current RoHS/RoHS2 compliance status for the products that we manufacture and distribute. Some product lines that we manufacture are also still available in non-RoHS c ...
Immune Functions of B Cells
... “ Let us […] imagine the despair of the mouse experimentalist when we suggest that he or she randomly allocate treatments to animals of different genetic backgrounds and immunized with different disease triggers.” ….[This is essentially how we treat RA in 2006] ...
... “ Let us […] imagine the despair of the mouse experimentalist when we suggest that he or she randomly allocate treatments to animals of different genetic backgrounds and immunized with different disease triggers.” ….[This is essentially how we treat RA in 2006] ...
Toward a Drug-Free University
... other drug use and to provide students and employees with appropriate information and services to back up those policies orientation sessions for new students, alcohol awareness weeks and other special events, reduced alcohol availability and consistent enforcement activities aid in the disseminatio ...
... other drug use and to provide students and employees with appropriate information and services to back up those policies orientation sessions for new students, alcohol awareness weeks and other special events, reduced alcohol availability and consistent enforcement activities aid in the disseminatio ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.