Antiepilepsy Drugs: pharmacodynamics and
... are essentially equally efficacious, but some statistically significant differences can be found in tolerability and side effects.4–7 The great majority of industry-sponsored clinical trials are designed as placebo-controlled, add-on therapy, prospective trials in subjects whose seizures are not wel ...
... are essentially equally efficacious, but some statistically significant differences can be found in tolerability and side effects.4–7 The great majority of industry-sponsored clinical trials are designed as placebo-controlled, add-on therapy, prospective trials in subjects whose seizures are not wel ...
Psychotropics in Psychiatric Patient – Bipolar disorders
... does not undergo autoinduction and does not have polymorphisms Caution should be exercised in patients who sensitive to carbamazepine (30% crosssensitivity with oxcarbazepine) ...
... does not undergo autoinduction and does not have polymorphisms Caution should be exercised in patients who sensitive to carbamazepine (30% crosssensitivity with oxcarbazepine) ...
Health 9 Teaching Guides
... divided into four parts: What to Know, What to Process, What to Understand and What to Transfer. The activities are designed for diverse learners, acknowledging their individual capacities, interests, and learning styles. Therefore, the learners will definitely realize their potentials of becoming r ...
... divided into four parts: What to Know, What to Process, What to Understand and What to Transfer. The activities are designed for diverse learners, acknowledging their individual capacities, interests, and learning styles. Therefore, the learners will definitely realize their potentials of becoming r ...
Quantum of Effectiveness Evidence in FDA`s Approval of
... enactment of the Orphan Drug Act through June 30, 2010. The current study was designed to determine, over the 4 years since the original study, how frequently FDA has required marketing applications of drugs for rare diseases to provide the conventional level of proof of effectiveness that is ordina ...
... enactment of the Orphan Drug Act through June 30, 2010. The current study was designed to determine, over the 4 years since the original study, how frequently FDA has required marketing applications of drugs for rare diseases to provide the conventional level of proof of effectiveness that is ordina ...
Analysis of the Acquisition of Drug Discrimination Reveals
... acquisition criterion. Taken together these results suggest that a higher training-dose of MDMA produced a more robust discriminative stimulus effect than the 1.5 mg/kg dose which is typically used. It must be acknowledged that the present training period was only 63 days in duration. While this was ...
... acquisition criterion. Taken together these results suggest that a higher training-dose of MDMA produced a more robust discriminative stimulus effect than the 1.5 mg/kg dose which is typically used. It must be acknowledged that the present training period was only 63 days in duration. While this was ...
Doctoral theses MÁRIA TÓTH MD. Semmelweis University
... drugs are added to the others. The exact identifications of mechanism of interactions need to clarify the pharmacokinetic and clinical pharmacology properties of the drugs are involved into the interaction. The knowing of the potential interaction of tacrolimus as narrow therapic range immunosuppres ...
... drugs are added to the others. The exact identifications of mechanism of interactions need to clarify the pharmacokinetic and clinical pharmacology properties of the drugs are involved into the interaction. The knowing of the potential interaction of tacrolimus as narrow therapic range immunosuppres ...
gemcitabine - Cancer Care Ontario
... May dilute reconstituted drug in normal saline for IV infusion, resulting in a minimum final concentration of at least 0.1 mg/mL. Infuse over 30 minutes through free-flowing IV. Infusion time beyond 60 minutes has been shown to increase toxicity. ...
... May dilute reconstituted drug in normal saline for IV infusion, resulting in a minimum final concentration of at least 0.1 mg/mL. Infuse over 30 minutes through free-flowing IV. Infusion time beyond 60 minutes has been shown to increase toxicity. ...
Study Guide for Veterinary Drug Dispenser Licence
... (vaccines and bacterins) should be handled, stored and used. Pharmaceuticals have brought enormous benefits to mankind. Some of the most deadly diseases such as Small Pox have been eradicated while others have been effectively controlled through vaccines. The same benefits have been achieved through ...
... (vaccines and bacterins) should be handled, stored and used. Pharmaceuticals have brought enormous benefits to mankind. Some of the most deadly diseases such as Small Pox have been eradicated while others have been effectively controlled through vaccines. The same benefits have been achieved through ...
Bacterial Growth Kinetics of "M. lufu" in the Presence and Absence
... on drug uptake, metabolism, and excretion and therefore on the effective drug concentration for therapy. Besides this, these pharmacokinetic influences in mice are, in general, different from the influence of the human organism on the drug molecules. This limits the conclusions which can be drawn fo ...
... on drug uptake, metabolism, and excretion and therefore on the effective drug concentration for therapy. Besides this, these pharmacokinetic influences in mice are, in general, different from the influence of the human organism on the drug molecules. This limits the conclusions which can be drawn fo ...
Extrapyramidal motor side-effects of first
... such an analysis, we framed our results in the context of clinically important effects, defined as an odds ratio of 2.0 or 0.5, a double or half risk of EPS between the two study groups. Statistical power was limited but this approach allows us to conclude that there were few clinically relevant dif ...
... such an analysis, we framed our results in the context of clinically important effects, defined as an odds ratio of 2.0 or 0.5, a double or half risk of EPS between the two study groups. Statistical power was limited but this approach allows us to conclude that there were few clinically relevant dif ...
Enrocare 10% Injection
... The safety of the product has not been established in pigs or calves when administered by the intravenous route and use of this route of administration is not recommended in these animal groups. Degenerative changes of articular cartilage were observed in calves treated orally with 30 mg enrofloxaci ...
... The safety of the product has not been established in pigs or calves when administered by the intravenous route and use of this route of administration is not recommended in these animal groups. Degenerative changes of articular cartilage were observed in calves treated orally with 30 mg enrofloxaci ...
Population Pharmacokinetics
... relationship describing these changes can be directly used in drug dosing algorithms. ...
... relationship describing these changes can be directly used in drug dosing algorithms. ...
Amendments to the PM(NOC) Regulations
... A second person is not required to send a NOA in respect of a patent added to the Register in respect of the innovator’s drug on or after the date of filing of the second person’s submission [similar timing as a result of the AstraZeneca Supreme Court decision for existing proceedings] The deeme ...
... A second person is not required to send a NOA in respect of a patent added to the Register in respect of the innovator’s drug on or after the date of filing of the second person’s submission [similar timing as a result of the AstraZeneca Supreme Court decision for existing proceedings] The deeme ...
Methamphetamine Use Spreading Across US, New Federal Studies
... 4. Marijuana dependent persons, like other drug dependent people, should be offered treatment rather than punishment for their illness. Treatment of marijuana dependence should be part of the plan for rehabilitation of any person convicted of a drug-related offense, including driving under the influ ...
... 4. Marijuana dependent persons, like other drug dependent people, should be offered treatment rather than punishment for their illness. Treatment of marijuana dependence should be part of the plan for rehabilitation of any person convicted of a drug-related offense, including driving under the influ ...
Organic and Bio-Molecular Chemistry
... which are made by carbon atoms, and includes also all the synthetic compounds the skeletons of which contain carbon atoms. Living organisms are “built up and organized” exploiting compounds the skeleton of which is mainly made up of carbon atoms. The study of these compounds, defined Natural Compoun ...
... which are made by carbon atoms, and includes also all the synthetic compounds the skeletons of which contain carbon atoms. Living organisms are “built up and organized” exploiting compounds the skeleton of which is mainly made up of carbon atoms. The study of these compounds, defined Natural Compoun ...
Macrolids
... The major metabolite is 14-hydroxyclarithromycin, which also has antibacterial activity. A portion of active drug and this major metabolite is eliminated in the urine, and dosage reduction (eg, a 500-mg loading dose, then 250 mg once or twice daily) is recommended for patients with creatinine cleara ...
... The major metabolite is 14-hydroxyclarithromycin, which also has antibacterial activity. A portion of active drug and this major metabolite is eliminated in the urine, and dosage reduction (eg, a 500-mg loading dose, then 250 mg once or twice daily) is recommended for patients with creatinine cleara ...
National Conference on “Recent Advances in Herbal Drug Technology”
... Abstract: Tectona grandis Linn. (Verbenaceae) is an important medicinal plant commonly known as sagwan. The bark of this plant is acrid and useful in the treatment of bronchitis. Aim of the present study is to validate traditional asthmatic action of the bark. Dried powdered bark was extracted using ...
... Abstract: Tectona grandis Linn. (Verbenaceae) is an important medicinal plant commonly known as sagwan. The bark of this plant is acrid and useful in the treatment of bronchitis. Aim of the present study is to validate traditional asthmatic action of the bark. Dried powdered bark was extracted using ...
references - Rajiv Gandhi University of Health Sciences
... Natural products are playing a vital role in health care for decades. Often different sources of natural products, plants have been a source of chemical substance, which serves as drugs in their own right or key ingredients in formulation containing synthetic drugs. The selection of the plant specie ...
... Natural products are playing a vital role in health care for decades. Often different sources of natural products, plants have been a source of chemical substance, which serves as drugs in their own right or key ingredients in formulation containing synthetic drugs. The selection of the plant specie ...
LOCAL DRUG DELIVERY IN PERIODONTICS: A STRATEGIC INTERVENTION Review Article
... results due to the fact that the active product could not achieve an adequate concentration at the site of action and/or due to the inability of the active product to be retained locally for a sufficient period of time. These drawbacks would be markedly reduced if antimicrobial agents applied locall ...
... results due to the fact that the active product could not achieve an adequate concentration at the site of action and/or due to the inability of the active product to be retained locally for a sufficient period of time. These drawbacks would be markedly reduced if antimicrobial agents applied locall ...
National Conference on Nanoscience and Nanotechnology (NCNN
... potentially potential for drug delivery, discovery and theranostics. They have a high adsorptive surface and can be employed exhaustively for absorbing drugs on the surface. Cancer nanotheranostics is a rapidly developing field which aims at combining both imaging and therapy of tumor involving nano ...
... potentially potential for drug delivery, discovery and theranostics. They have a high adsorptive surface and can be employed exhaustively for absorbing drugs on the surface. Cancer nanotheranostics is a rapidly developing field which aims at combining both imaging and therapy of tumor involving nano ...
etd-tamu-2003A-2003032721-Vaug-1 - OAKTrust Home
... response. Drug distribution can also be non-selective, resulting in drug residue appearing in tissues (e.g. liver and kidney) other than the targeted site of action. Not only can drug non-selectivity be wasteful, but it can also contribute to toxicity.2 As a result, the full therapeutic potential of ...
... response. Drug distribution can also be non-selective, resulting in drug residue appearing in tissues (e.g. liver and kidney) other than the targeted site of action. Not only can drug non-selectivity be wasteful, but it can also contribute to toxicity.2 As a result, the full therapeutic potential of ...
19 Improving the Oral Absorption of S-SEDDS Formulations
... the generation of a microemulsion with a particle size from 150 nm to as low as 10–20 nm, when properly optimized. SEDDS/S-SEDDS formulations are useful in improving the animal or human oral bioavailability of poorly soluble drugs. S-SEDDS formulations contain less surfactant (and lipid) than the r ...
... the generation of a microemulsion with a particle size from 150 nm to as low as 10–20 nm, when properly optimized. SEDDS/S-SEDDS formulations are useful in improving the animal or human oral bioavailability of poorly soluble drugs. S-SEDDS formulations contain less surfactant (and lipid) than the r ...
Full Text
... the existing Food, Drug and Cosmetic Act (FD&C Act) and FDA regulations could be applied in this area. The initial focus will be on the paradigm suicide machines, namely those developed by Dr. Kevorkian, which will serve as the starting point for a discussion of how the FDA could regulate not only d ...
... the existing Food, Drug and Cosmetic Act (FD&C Act) and FDA regulations could be applied in this area. The initial focus will be on the paradigm suicide machines, namely those developed by Dr. Kevorkian, which will serve as the starting point for a discussion of how the FDA could regulate not only d ...
STD/1573
... concrete containing < 0.007% notified chemical within a mixing drum. The concrete will be pumped or gravity fed to the construction area, where workers will shovel and rake fresh concrete and finish the surface with vibrators, trowels and possibly a "helicopter" finishing tool. ...
... concrete containing < 0.007% notified chemical within a mixing drum. The concrete will be pumped or gravity fed to the construction area, where workers will shovel and rake fresh concrete and finish the surface with vibrators, trowels and possibly a "helicopter" finishing tool. ...
Drug List - The North Carolina Office of EMS
... renal insufficiency. Not to be used in patients with allergies to aspirin or other NSAID drugs Avoid in patients currently taking anticoagulants, such as coumadin. ...
... renal insufficiency. Not to be used in patients with allergies to aspirin or other NSAID drugs Avoid in patients currently taking anticoagulants, such as coumadin. ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.