results - Pakistan Journal of Pharmaceutical Sciences
... significant at (P<0.05). This was supported by Al-Rekabi et al., 2009 who found significantly increased levels of ALP after inducing a 3 fold higher dose (0.6mg/kg) of meloxicam in rats. Similar observations were also reported by Mahaprabhu et al., 2011 who described significantly increased levels o ...
... significant at (P<0.05). This was supported by Al-Rekabi et al., 2009 who found significantly increased levels of ALP after inducing a 3 fold higher dose (0.6mg/kg) of meloxicam in rats. Similar observations were also reported by Mahaprabhu et al., 2011 who described significantly increased levels o ...
Document
... function. A number of SCr-based equations, including variables such as age, sex, race, and body size have been developed to provide a relatively accurate and simple calculation of creatinine clearance as an index of estimated GFR (eGFR) over the use of SCr alone.1,2 However, eGFR overestimates actua ...
... function. A number of SCr-based equations, including variables such as age, sex, race, and body size have been developed to provide a relatively accurate and simple calculation of creatinine clearance as an index of estimated GFR (eGFR) over the use of SCr alone.1,2 However, eGFR overestimates actua ...
The Glycine Transporter-1 Inhibitor SSR103800 Displays a
... Schizophrenia has been initially associated with dysfunction in dopamine neurotransmission. However, the observation that antagonists of the glutamate N-methyl-D-aspartate (NMDA) receptor produce schizophrenic-like symptoms in humans has led to the idea of a dysfunctioning of the glutamatergic syste ...
... Schizophrenia has been initially associated with dysfunction in dopamine neurotransmission. However, the observation that antagonists of the glutamate N-methyl-D-aspartate (NMDA) receptor produce schizophrenic-like symptoms in humans has led to the idea of a dysfunctioning of the glutamatergic syste ...
Drugs of abuse modulate dopaminergic neurotransmission : effects
... The term “drugs of abuse” refers to substances that are not taken for medical reasons, but usually for mind-altering effects including feelings of emotional warmth, empathy toward others, enhanced sensory perception, a general sense of well being and decreased anxiety. Many of these drugs are only t ...
... The term “drugs of abuse” refers to substances that are not taken for medical reasons, but usually for mind-altering effects including feelings of emotional warmth, empathy toward others, enhanced sensory perception, a general sense of well being and decreased anxiety. Many of these drugs are only t ...
PHARMACOLOGICAL SCREENING AND EVALUATION OF ANTI-PEPTIC ULCER PROPERTY OF Research Article
... Plants constitute a major remedy in the traditional medical system. The practice continues today due to their biomedical benefits, non toxic nature, their easy access and a place in cultural benefits. In the present scenario, medicinal plants have been used as a source of drugs and as a potential so ...
... Plants constitute a major remedy in the traditional medical system. The practice continues today due to their biomedical benefits, non toxic nature, their easy access and a place in cultural benefits. In the present scenario, medicinal plants have been used as a source of drugs and as a potential so ...
Substance Abuse: Cocaine This course expires on June 26, 2016.
... and physical assessment. Kim graduated with a nursing diploma from Foothills Hospital School of Nursing in Calgary, Alberta in 1989. She achieved her Bachelor in Nursing through Athabasca University, Alberta in 2000, and her Master of Science in Nursing through University of Phoenix in 2005. Kim is ...
... and physical assessment. Kim graduated with a nursing diploma from Foothills Hospital School of Nursing in Calgary, Alberta in 1989. She achieved her Bachelor in Nursing through Athabasca University, Alberta in 2000, and her Master of Science in Nursing through University of Phoenix in 2005. Kim is ...
Chapter 1 Introduction and thesis outline
... found with craving in other substances, are associated with benzodiazepine craving. The length to which these results support and challenge existing craving theories and other empirical findings is discussed. Chapter 4 addresses the course of benzodiazepine craving, over a 21-month follow-up period b ...
... found with craving in other substances, are associated with benzodiazepine craving. The length to which these results support and challenge existing craving theories and other empirical findings is discussed. Chapter 4 addresses the course of benzodiazepine craving, over a 21-month follow-up period b ...
of Administering Medications to Elderly Patients
... medications. Most medications are absorbed by passive diffusion which is unaffected by age. However, older persons have reduced gastric acidity (achlorhydria) which reduces the bioavailability of medications that depend upon gastric acidity for absorption. Some tablets and capsules and some specific ...
... medications. Most medications are absorbed by passive diffusion which is unaffected by age. However, older persons have reduced gastric acidity (achlorhydria) which reduces the bioavailability of medications that depend upon gastric acidity for absorption. Some tablets and capsules and some specific ...
Public Policy Statement on the Use of Naloxone for the
... overdose. It acts quickly, is non-addictive, may be dispensed by injection (preferably intramuscular) or nasal application, and has mild side effects when used at the proper low dosage. Currently, paramedics and emergency room staff are authorized to administer naloxone to resuscitate drug overdose ...
... overdose. It acts quickly, is non-addictive, may be dispensed by injection (preferably intramuscular) or nasal application, and has mild side effects when used at the proper low dosage. Currently, paramedics and emergency room staff are authorized to administer naloxone to resuscitate drug overdose ...
EUGENIA SINGAMPATTIANA Research Article
... and fixed oil. Acute toxicity study revealed the non-toxic nature of the ethanol extract of E. singampattiana leaf. Table 1 shows the levels of blood glucose, plasma insulin, urea, creatinine and glycosylated haemoglobin of normal, diabetic rats and drug treated rats. The alloxan induced diabetic ra ...
... and fixed oil. Acute toxicity study revealed the non-toxic nature of the ethanol extract of E. singampattiana leaf. Table 1 shows the levels of blood glucose, plasma insulin, urea, creatinine and glycosylated haemoglobin of normal, diabetic rats and drug treated rats. The alloxan induced diabetic ra ...
Title 32: PROFESSIONS AND OCCUPATIONS
... signed agreement between one or more pharmacists with training and experience relevant to the scope of the collaborative practice and a practitioner that supervises or provides direct consultation to the pharmacist or pharmacists engaging in collaborative drug therapy management that: A. Defines the ...
... signed agreement between one or more pharmacists with training and experience relevant to the scope of the collaborative practice and a practitioner that supervises or provides direct consultation to the pharmacist or pharmacists engaging in collaborative drug therapy management that: A. Defines the ...
- EBioMedicine
... Michaelis-Menten reaction kinetic constants of maximum velocity (Vmax) and affinity (Km) in children 0– 10 years old. We measured the rates of isoniazid elimination and N-acetylisoniazid production in the blood of 30 children. Since maturation effects could be non-linear, we utilized a pharmacometric ...
... Michaelis-Menten reaction kinetic constants of maximum velocity (Vmax) and affinity (Km) in children 0– 10 years old. We measured the rates of isoniazid elimination and N-acetylisoniazid production in the blood of 30 children. Since maturation effects could be non-linear, we utilized a pharmacometric ...
Prepared By - Beckman Coulter
... “Ecstasy” is the popular street name used to refer to methylenedioxymethamphetamine (MDMA).2 Ecstasy and related drugs, methylenedioxyamphetamine (MDA) and methylenedioxyethamphetamine (MDEA), are amphetamine derivatives. The tablets, as sold illicitly in Europe and North America, may also include a ...
... “Ecstasy” is the popular street name used to refer to methylenedioxymethamphetamine (MDMA).2 Ecstasy and related drugs, methylenedioxyamphetamine (MDA) and methylenedioxyethamphetamine (MDEA), are amphetamine derivatives. The tablets, as sold illicitly in Europe and North America, may also include a ...
Clenbuterol and the Horse
... disease and obtained a decrease in the work of breathing and resistance. Sasse6 administered clenbuterol (0.8 mg/kg, IV) to horses affected with COPD and measured the change in pleural pressure three hours later. Clenbuterol significantly decreased pleural pressure change (a measure of the severity ...
... disease and obtained a decrease in the work of breathing and resistance. Sasse6 administered clenbuterol (0.8 mg/kg, IV) to horses affected with COPD and measured the change in pleural pressure three hours later. Clenbuterol significantly decreased pleural pressure change (a measure of the severity ...
Amiloride - Developing Anaesthesia
... Category C drugs are those drugs which, owing to their pharmacological effects, have caused or may be suspected of causing harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Specialised texts should be consulted for further details. There is ...
... Category C drugs are those drugs which, owing to their pharmacological effects, have caused or may be suspected of causing harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Specialised texts should be consulted for further details. There is ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... of 250 mg/kg but it is considered as insignificant because there was no elevation of AST /ALT or both of the biochemical parameters supporting any evidence of liver tissue damage . From the above results it can be assured that the accuracy of purification process, ratio and combination of ingredient ...
... of 250 mg/kg but it is considered as insignificant because there was no elevation of AST /ALT or both of the biochemical parameters supporting any evidence of liver tissue damage . From the above results it can be assured that the accuracy of purification process, ratio and combination of ingredient ...
IRTRA® Combination Tablets LD/HD
... long half-life in blood and a 24-hour-lasting blood pressure-lowering effect, having high anti-hypertensive effect in mild to severe hypertension. Based on the large-scale clinical trials, IDNT and IRMA2, which are often cited in the major international guidelines, this drug is also recognized as th ...
... long half-life in blood and a 24-hour-lasting blood pressure-lowering effect, having high anti-hypertensive effect in mild to severe hypertension. Based on the large-scale clinical trials, IDNT and IRMA2, which are often cited in the major international guidelines, this drug is also recognized as th ...
Research Report Series: MDMA (Ecstasy) Abuse
... concern during periods of increased physical activity, thereby further complicating these problems. MDMA is rapidly absorbed into the human blood stream, but once in the body MDMA interferes with the body's ability to metabolize, or break down, the drug. As a result, additional doses of MDMA can pro ...
... concern during periods of increased physical activity, thereby further complicating these problems. MDMA is rapidly absorbed into the human blood stream, but once in the body MDMA interferes with the body's ability to metabolize, or break down, the drug. As a result, additional doses of MDMA can pro ...
Importance of NMDA Receptor Activation During Initial
... (a protein hormone) levels peak 5‐10 minutes after stress onset. This is because ACTH is lipophobic and will not immediately diffuse out of the secreting cell after synthesis, so it can be synthesized and stored in advance. After the conclusion of a stressor the PVN will no longer be stimulated ...
... (a protein hormone) levels peak 5‐10 minutes after stress onset. This is because ACTH is lipophobic and will not immediately diffuse out of the secreting cell after synthesis, so it can be synthesized and stored in advance. After the conclusion of a stressor the PVN will no longer be stimulated ...
GUÍA DEL MEDICAMENTO INCIVEK
... telaprevir resistance-associated substitutions emerge on treatment with INCIVEK. (12.4, 14.3) INCIVEK efficacy has not been established for patients who have previously failed therapy with a treatment regimen that includes INCIVEK or other HCV NS3/4A protease inhibitors. (12.4) --------------------- ...
... telaprevir resistance-associated substitutions emerge on treatment with INCIVEK. (12.4, 14.3) INCIVEK efficacy has not been established for patients who have previously failed therapy with a treatment regimen that includes INCIVEK or other HCV NS3/4A protease inhibitors. (12.4) --------------------- ...
Atropine
... Injections of atropine are used in the treatment of bradycardia (an extremely low heart rate), asystole and pulseless electrical activity (PEA) in cardiac arrest. This works because the main action of the vagus nerve of the parasympathetic system on the heart is to decrease heart rate. Atropine bloc ...
... Injections of atropine are used in the treatment of bradycardia (an extremely low heart rate), asystole and pulseless electrical activity (PEA) in cardiac arrest. This works because the main action of the vagus nerve of the parasympathetic system on the heart is to decrease heart rate. Atropine bloc ...
Application of Hepatocytes for In Vitro Uptake Studies
... drug will have a high rate of passive diffusion and require one or more biotransformation reactions to be eliminated ...
... drug will have a high rate of passive diffusion and require one or more biotransformation reactions to be eliminated ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.