Marine Origin Polysaccharides in Drug Delivery Systems
... have M/G ratios of 1.16 and 1.82, respectively [30]. Alginate is biocompatible, has low toxicity and high bioavailability as well. These are the main advantages that make alginate one of the biopolymers with the widest biomedical applicability. One of the most common applications of alginate is thei ...
... have M/G ratios of 1.16 and 1.82, respectively [30]. Alginate is biocompatible, has low toxicity and high bioavailability as well. These are the main advantages that make alginate one of the biopolymers with the widest biomedical applicability. One of the most common applications of alginate is thei ...
Updated US Public Health Service Guidelines for the Management
... Occupational Exposures to HIV and Recommendations for Postexposure Prophylaxis.6 The PHS working group was comprised of members from the CDC, the FDA, the Health Resources and Services Administration, and the National Institutes of Health. Names, credentials, and affiliations of the PHS working grou ...
... Occupational Exposures to HIV and Recommendations for Postexposure Prophylaxis.6 The PHS working group was comprised of members from the CDC, the FDA, the Health Resources and Services Administration, and the National Institutes of Health. Names, credentials, and affiliations of the PHS working grou ...
Propranolol blocks cardiac and neuronal voltage
... efficacy in treating cardiovascular disorders and in the prevention of migraine headaches. At plasma concentrations exceeding those required for β-adrenergic receptor inhibition, propranolol also exhibits anti-arrhythmic (“membrane stabilizing”) effects that are not fully explained by β-blockade. Pr ...
... efficacy in treating cardiovascular disorders and in the prevention of migraine headaches. At plasma concentrations exceeding those required for β-adrenergic receptor inhibition, propranolol also exhibits anti-arrhythmic (“membrane stabilizing”) effects that are not fully explained by β-blockade. Pr ...
APPLICATION CHECKLIST (ICH CTD)
... Product name to be entered in capital letters Strength of the active ingredient should generally be included as part of the product name to allow differentiation between different ...
... Product name to be entered in capital letters Strength of the active ingredient should generally be included as part of the product name to allow differentiation between different ...
![[Salvia divinorum - a potential drug for abuse]](http://s1.studyres.com/store/data/007845527_1-baa04152dad6511298825048970e3c2d-300x300.png)
[Salvia divinorum - a potential drug for abuse]
... Selective kappa receptoragonists have been shown to produce analgesic effects with potential for reduced tolerance and dependence. However, psychotomimesis (hallucinogenic and/or psychotic effects), dysphoria and diuresis have been observed with their therapeutic use (Tidgewell et aI., 2004). In add ...
... Selective kappa receptoragonists have been shown to produce analgesic effects with potential for reduced tolerance and dependence. However, psychotomimesis (hallucinogenic and/or psychotic effects), dysphoria and diuresis have been observed with their therapeutic use (Tidgewell et aI., 2004). In add ...
DOBUTamine
... Signs and Symptoms: Toxicity from dobutamine hydrochloride is usually due to excessive cardiac β-receptor stimulation. The duration of action of dobutamine hydrochloride is generally short (T½ = 2 minutes) because it is rapidly metabolized by catechol-O-methyltransferase. The symptoms of toxicity ma ...
... Signs and Symptoms: Toxicity from dobutamine hydrochloride is usually due to excessive cardiac β-receptor stimulation. The duration of action of dobutamine hydrochloride is generally short (T½ = 2 minutes) because it is rapidly metabolized by catechol-O-methyltransferase. The symptoms of toxicity ma ...
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces
... ABSTRACT Serious clinical liabilities associated with the prescription of opiates for pain control include constipation, respiratory depression, pruritus, tolerance, abuse, and addiction. A recognized strategy to circumvent these side effects is to combine opioids with other antinociceptive agents. ...
... ABSTRACT Serious clinical liabilities associated with the prescription of opiates for pain control include constipation, respiratory depression, pruritus, tolerance, abuse, and addiction. A recognized strategy to circumvent these side effects is to combine opioids with other antinociceptive agents. ...
Kinetics of Respiratory Depression in Rats Induced
... performed using sham-operated rats. The same doses of NBN and physiological saline were administered through the femoral cannula and the ventricular cannula, respectively. The respiratory rate of the rats was measured before, and until 280 min after, drug administration. In another experiment, after ...
... performed using sham-operated rats. The same doses of NBN and physiological saline were administered through the femoral cannula and the ventricular cannula, respectively. The respiratory rate of the rats was measured before, and until 280 min after, drug administration. In another experiment, after ...
PRESCRIBING INFORMATION AND CONSUMER
... Geriatric patients are especially susceptible to the anticholinergic side effects of constipation, dryness of mouth and urinary retention (especially in males). If these side effects continue or are severe, discontinuation of medication should be considered. Due care is necessary when anticholinergi ...
... Geriatric patients are especially susceptible to the anticholinergic side effects of constipation, dryness of mouth and urinary retention (especially in males). If these side effects continue or are severe, discontinuation of medication should be considered. Due care is necessary when anticholinergi ...
IVM
... • Resistance is now common. • In nematodes of ruminants and horses, Fasciola • Resistance to all drug classes but with gaps in the matrix • Why it is so serious in sheep? ...
... • Resistance is now common. • In nematodes of ruminants and horses, Fasciola • Resistance to all drug classes but with gaps in the matrix • Why it is so serious in sheep? ...
Pharmacogenetic Determinants of Codeine Induction by Rifampin
... al., 1994; Steiner et al., 1985). The influence of various factors such as liver disease, age, gender and diet on the in vivo indexes of CYP2D6 is generally of minor magnitude compared with the major genetic effect (Bock et al., 1994; Steiner et al., 1985; Larrey et al., 1989). On the other hand, su ...
... al., 1994; Steiner et al., 1985). The influence of various factors such as liver disease, age, gender and diet on the in vivo indexes of CYP2D6 is generally of minor magnitude compared with the major genetic effect (Bock et al., 1994; Steiner et al., 1985; Larrey et al., 1989). On the other hand, su ...
Ketoconazole and Itraconazole Pharmacokinetic
... KTC is known to be a potent inhibitor of the metabolism of variety of drugs such as cyclosporine, phenytoin and warfarin. It is therefore, possible that the increases in AUC0-∞, Cmax, tl/2 and MRT, seen in this study, when CIP was given together with KTC may be due to the inhibition of cytochromes ...
... KTC is known to be a potent inhibitor of the metabolism of variety of drugs such as cyclosporine, phenytoin and warfarin. It is therefore, possible that the increases in AUC0-∞, Cmax, tl/2 and MRT, seen in this study, when CIP was given together with KTC may be due to the inhibition of cytochromes ...
PDF - Austin Publishing Group
... Many people in the world suffer from peptic ulcers. Of the two main types of peptic ulcers (gastric and duodenal) that develop in humans, gastric ulcers are the most commonly found. Although many medications are currently available for the management of gastric ulcers, prolonged use of these drugs m ...
... Many people in the world suffer from peptic ulcers. Of the two main types of peptic ulcers (gastric and duodenal) that develop in humans, gastric ulcers are the most commonly found. Although many medications are currently available for the management of gastric ulcers, prolonged use of these drugs m ...
NIH Public Access
... To ensure acquisition of conditioned responses, an initial training session was included in the screening visit (approximately 4 weeks before the experimental phase) comprising six CS+ (all reinforced) and six CS− presentations. The sessions on experimental days 1, 2 and 4, started with a brief star ...
... To ensure acquisition of conditioned responses, an initial training session was included in the screening visit (approximately 4 weeks before the experimental phase) comprising six CS+ (all reinforced) and six CS− presentations. The sessions on experimental days 1, 2 and 4, started with a brief star ...
Drug-resistant TB: surveillance and response: supplement to global
... Data on levels of TB drug resistance available for countries with 95% of world’s population AND TB CASES By 2014, data on drug resistance were available for 144 countries, which collectively have 95% of the world’s population and TB cases. This shows impressive progress: in the period 1994−1999, dat ...
... Data on levels of TB drug resistance available for countries with 95% of world’s population AND TB CASES By 2014, data on drug resistance were available for 144 countries, which collectively have 95% of the world’s population and TB cases. This shows impressive progress: in the period 1994−1999, dat ...
Submission May 2013 notice of Delegate's interim decisions Purpose
... Re. Proposal to reschedule alprazolam from Schedule 4 to Schedule 8 We write in support of the Therapeutic Goods Administration’s interim decision to reschedule alprazolam from Schedule 4 to Schedule 8. As public health researchers with expertise in the epidemiology of illicit drug use in Australia, ...
... Re. Proposal to reschedule alprazolam from Schedule 4 to Schedule 8 We write in support of the Therapeutic Goods Administration’s interim decision to reschedule alprazolam from Schedule 4 to Schedule 8. As public health researchers with expertise in the epidemiology of illicit drug use in Australia, ...
DRUG NAME: Octreotide SYNONYM(S): COMMON TRADE NAME(S):
... Octreotide LAR pharmacokinetics is similar once the drug is released from microspheres.4 Interpatient variability no information found Absorption SC: rapidly and completely absorbed; LAR injection: steady state after 2-3 injections at 4weekly intervals,4 which is chosen to cover escape between days ...
... Octreotide LAR pharmacokinetics is similar once the drug is released from microspheres.4 Interpatient variability no information found Absorption SC: rapidly and completely absorbed; LAR injection: steady state after 2-3 injections at 4weekly intervals,4 which is chosen to cover escape between days ...
Document
... Study of how drugs may best be used in the treatment of illnesses Study of which drug would be most appropriate or least appropriate to use for a specific disease; what dose would be required; etc. ...
... Study of how drugs may best be used in the treatment of illnesses Study of which drug would be most appropriate or least appropriate to use for a specific disease; what dose would be required; etc. ...
O A
... paralysis of movement, without actual loss of consciousness [7]. Ketamine has some effects such as sedation, analgesia, and immobility. This drug has low intestinal absorption rate. It's bioavailability in human with oral administration is %20±7 [15] and with rectal administration in cat is %43.5±6/ ...
... paralysis of movement, without actual loss of consciousness [7]. Ketamine has some effects such as sedation, analgesia, and immobility. This drug has low intestinal absorption rate. It's bioavailability in human with oral administration is %20±7 [15] and with rectal administration in cat is %43.5±6/ ...
The purpose of this summary is exclusively educational, to provide
... dosing; (ii) gold standard test to confirm or rule out drug hypersensitivity (in some clinical situations, it might be more useful to look for safe drug alternatives instead of performing a DPT); (iii) especially important when skin or in vitro allergy testing results are unstandardized, unavailable ...
... dosing; (ii) gold standard test to confirm or rule out drug hypersensitivity (in some clinical situations, it might be more useful to look for safe drug alternatives instead of performing a DPT); (iii) especially important when skin or in vitro allergy testing results are unstandardized, unavailable ...
Hydrocodone Bitartrate and Acetaminophen Tablets USP 5 mg/325
... hypersensitivity and anaphylaxis associated with use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention. ...
... hypersensitivity and anaphylaxis associated with use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention. ...
A clickable analogue of ketamine retains NMDA receptor activity
... to delayed (e.g., antidepressant at low doses) behavioral changes. We first examined near-anesthetic doses of compounds to test acute psychoactive effects18. We quantified locomotor activity and rearing behavior for 60 min following a single i.p. injection. Ketamine at 100 mg/kg (n = 8) significant ...
... to delayed (e.g., antidepressant at low doses) behavioral changes. We first examined near-anesthetic doses of compounds to test acute psychoactive effects18. We quantified locomotor activity and rearing behavior for 60 min following a single i.p. injection. Ketamine at 100 mg/kg (n = 8) significant ...
Adverse events associated with dietary supplements - Direct-MS
... defined by repeated doses for more than 8 h, which is consistent with the definition in TESS.10 We assigned probable cause scores using a multitiered review process. Clinicians at the originating poison control centre, the principal investigator, and two outside experts ranked probable cause on a fi ...
... defined by repeated doses for more than 8 h, which is consistent with the definition in TESS.10 We assigned probable cause scores using a multitiered review process. Clinicians at the originating poison control centre, the principal investigator, and two outside experts ranked probable cause on a fi ...
Life Sciences, Vol. 32, pp. 971{-978 /_ Pergamo n Press
... analysis in this study (6). No claim is being made that cats given LSD are hallucinating, since it is impossible to know what a nonverbal organism is experiencing. The behavioral syndrome, especially the limb flick response, is a useful animal model for studying the actions of hallucinogenic drugs b ...
... analysis in this study (6). No claim is being made that cats given LSD are hallucinating, since it is impossible to know what a nonverbal organism is experiencing. The behavioral syndrome, especially the limb flick response, is a useful animal model for studying the actions of hallucinogenic drugs b ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.