Bolesť a jej liečba - Comenius University
... Derivate of pyrazolone Synonyms Noramidopyrín, Dipyrón has spasmolytic properties. ...
... Derivate of pyrazolone Synonyms Noramidopyrín, Dipyrón has spasmolytic properties. ...
PHARMACOKINETICS OF FELODIPINE AFTER SINGLE ORAL
... Felodipine is a dihydropyridine calcium antagonist, widely used as a potent antihypertensive drug [1, 2]. The currently available pharmaceutical formulations with felodipine are mostly slow release coated tablets, containing 2.5, 5 or 10 mg felodipine. It is well known that in case of slowrelease fo ...
... Felodipine is a dihydropyridine calcium antagonist, widely used as a potent antihypertensive drug [1, 2]. The currently available pharmaceutical formulations with felodipine are mostly slow release coated tablets, containing 2.5, 5 or 10 mg felodipine. It is well known that in case of slowrelease fo ...
ASEC 2014 Understanding the Unwanted Side Effects of the
... Propofol is a short acting hypnotic that is unrelated to other general anesthetic drugs. Propofol’s onset of action is within seconds and the duration of effect of a single bolus is 2 to 5 minutes. Induction is usually smooth; however muscle twitching can occur. The incidence of muscle twitching can ...
... Propofol is a short acting hypnotic that is unrelated to other general anesthetic drugs. Propofol’s onset of action is within seconds and the duration of effect of a single bolus is 2 to 5 minutes. Induction is usually smooth; however muscle twitching can occur. The incidence of muscle twitching can ...
Continued Use of Illicit Substances: A Retention
... Elavil, Placidyl) or alcohol. Many drug users overdose after coming out of jail because their tolerance has fallen. Users should do a tester shot if it is from a new source or they have not used in a while. ...
... Elavil, Placidyl) or alcohol. Many drug users overdose after coming out of jail because their tolerance has fallen. Users should do a tester shot if it is from a new source or they have not used in a while. ...
APPLICATIONS FOR INVESTIGATIONAL NEW DRUGS (INDs
... causing photosensitivity or the nature of action suggests such a potential) 12.5.6 Rectal tolerance test (For all preparations meant for rectal administration) 12.6 Genotoxicity 12.7 Allergenicity/Hypersensitivity ...
... causing photosensitivity or the nature of action suggests such a potential) 12.5.6 Rectal tolerance test (For all preparations meant for rectal administration) 12.6 Genotoxicity 12.7 Allergenicity/Hypersensitivity ...
Pharmacological and Pharmaceutical Profile of Gliclazide: A Review
... secretion and consequently are effective only when some residual pancreatic beta-cell activity is present; during long-term administration they also have an extrapancreatic action. All may cause hypoglycaemia but this is uncommon and usually indicates excessive dosage. Sulphonylurea-induced hypoglyc ...
... secretion and consequently are effective only when some residual pancreatic beta-cell activity is present; during long-term administration they also have an extrapancreatic action. All may cause hypoglycaemia but this is uncommon and usually indicates excessive dosage. Sulphonylurea-induced hypoglyc ...
Dermatologic Pharmacology
... • Lindane (Hexachlorocyclohexane): – (Very toxic drug due its accumulation of in fatty tissues and we don’t use it unless the first drug applied is ineffective) – 10% absorbed and concentrated in fatty tissues. – Can cause neurotoxicity and hematoxicity ...
... • Lindane (Hexachlorocyclohexane): – (Very toxic drug due its accumulation of in fatty tissues and we don’t use it unless the first drug applied is ineffective) – 10% absorbed and concentrated in fatty tissues. – Can cause neurotoxicity and hematoxicity ...
SINAREST-LP TABLETS
... anticholinergic and antiserotonin effects and therefore is preferred in patients with nasal congestion because it does not over dry nasal secretions. Phenylephrine acts on alpha-receptors causing vasoconstriction of blood vessels in the lining of the nasal passages and sinuses. This leads to shrinka ...
... anticholinergic and antiserotonin effects and therefore is preferred in patients with nasal congestion because it does not over dry nasal secretions. Phenylephrine acts on alpha-receptors causing vasoconstriction of blood vessels in the lining of the nasal passages and sinuses. This leads to shrinka ...
Enhancement of dissolution rate of poorly water
... In the following study several factors were varied including the ratios of drug, PG (ranging from 40% to 50% w/w), and the carrier coat ratios (i.e., different R-values, ranging from 5 to 15). In order to address the flowability and ...
... In the following study several factors were varied including the ratios of drug, PG (ranging from 40% to 50% w/w), and the carrier coat ratios (i.e., different R-values, ranging from 5 to 15). In order to address the flowability and ...
Beta blocker equivalency table nebivolol
... Jan 15, 2008 beta-blockers with additional vasodilating effects, the latter showing no adverse and propranolol inhibits the conversion of thyroxine to triiodothyronine. fact that there are actually “three generations of beta-blockers” (Table 1), to vasodilator betablockers, such as carvedilol and n ...
... Jan 15, 2008 beta-blockers with additional vasodilating effects, the latter showing no adverse and propranolol inhibits the conversion of thyroxine to triiodothyronine. fact that there are actually “three generations of beta-blockers” (Table 1), to vasodilator betablockers, such as carvedilol and n ...
summary of product characteristics 1. name of the medicinal
... (approximately 40-50%) with peak plasma concentrations occurring at 2-4 hours after dosing. The atenolol blood levels are consistent and subject to little variability. There is no significant hepatic metabolism of atenolol and more than 90% of that absorbed reaches the systemic circulation unaltered ...
... (approximately 40-50%) with peak plasma concentrations occurring at 2-4 hours after dosing. The atenolol blood levels are consistent and subject to little variability. There is no significant hepatic metabolism of atenolol and more than 90% of that absorbed reaches the systemic circulation unaltered ...
US FDA Drug Approval Strategies for Pharmaceutical Industry
... In Pharmaceutical Industry, Regulatory Affairs Department makes an interface between the regulatory authorities and pharmaceutical industry. The Regulatory Affairs department is an important part of the organizational structure of pharmaceutical companies. Internally it liaises at the inter phase of ...
... In Pharmaceutical Industry, Regulatory Affairs Department makes an interface between the regulatory authorities and pharmaceutical industry. The Regulatory Affairs department is an important part of the organizational structure of pharmaceutical companies. Internally it liaises at the inter phase of ...
The Apothecary`s Cabinet 16pp - UW
... jalap “a safe purgative, performing its office mildly; seldom occasioning nausea or gripes.” It came to the attention of European physicians in the early 1600s. Two hundred years later when Rush used it liberally, the exact source of the root was not yet determined. It would be Rush’s student, John ...
... jalap “a safe purgative, performing its office mildly; seldom occasioning nausea or gripes.” It came to the attention of European physicians in the early 1600s. Two hundred years later when Rush used it liberally, the exact source of the root was not yet determined. It would be Rush’s student, John ...
Blood clots
... smaller pieces, dislodge from the location where it was initially formed.) An embolus is a blood clot, piece/globule of fatty deposit, or other object that is carried through the bloodstream. An embolism refers to the obstruction of a blood vessel by a foreign substance or a blood clot that trav ...
... smaller pieces, dislodge from the location where it was initially formed.) An embolus is a blood clot, piece/globule of fatty deposit, or other object that is carried through the bloodstream. An embolism refers to the obstruction of a blood vessel by a foreign substance or a blood clot that trav ...
Drug-induced sleepiness and insomnia: an update
... September 2010) due to the high probability of myocardial infarction, heart failure, pericardial effusion, and other cardiac disorders associated with its use(16). The use of pioglitazone (ACTOS®) was not restricted by the same regulatory agency, and among its side effects there is no record of chan ...
... September 2010) due to the high probability of myocardial infarction, heart failure, pericardial effusion, and other cardiac disorders associated with its use(16). The use of pioglitazone (ACTOS®) was not restricted by the same regulatory agency, and among its side effects there is no record of chan ...
drug awareness sheets
... Made mainly from a powerful industrial solvent (GBL), GHB is a drug often associated to parties. • GHB is more and more popular, especially among young people. • Contrary to popular belief, GHB is mostly taken voluntarily for personal pleasure. • GHB also comes in a white powder form. ...
... Made mainly from a powerful industrial solvent (GBL), GHB is a drug often associated to parties. • GHB is more and more popular, especially among young people. • Contrary to popular belief, GHB is mostly taken voluntarily for personal pleasure. • GHB also comes in a white powder form. ...
Proteus, Klebsiella, E. coli
... Sudafed may decrease effect of beta blockers May increase blood pressure, dysrhythmias with MAOIs May increase restlessness, palpitations with caffeine (e.g., coffee, tea) ...
... Sudafed may decrease effect of beta blockers May increase blood pressure, dysrhythmias with MAOIs May increase restlessness, palpitations with caffeine (e.g., coffee, tea) ...
Classroom Expectations
... To learn how to distinguish between their signs if they are given as unknown drugs. ...
... To learn how to distinguish between their signs if they are given as unknown drugs. ...
1-cholinergic 3
... Clinical uses: Rarely used because of high potency and long duration of action except in the eye to cause Miosis and to decrease intraocular ...
... Clinical uses: Rarely used because of high potency and long duration of action except in the eye to cause Miosis and to decrease intraocular ...
The Pharmaceutical Industry Presented to Geoffrey Poitras Bus 417
... Pfizer dropped from 205.1B in 2004 to 182.15B as of early 2006 Roche has risen from 87.4B to 135.28B in the same amount of time European Pharmaceutical Companies are putting much more emphasis on Research and Development – not so with North American firms Source: The National Post, Financial Post, J ...
... Pfizer dropped from 205.1B in 2004 to 182.15B as of early 2006 Roche has risen from 87.4B to 135.28B in the same amount of time European Pharmaceutical Companies are putting much more emphasis on Research and Development – not so with North American firms Source: The National Post, Financial Post, J ...
Drugs of Abuse - California Society of Addiction Medicine
... More often H. flu, S. aureus, Ps. aeruginosa relative to nonIDUs IDU’s have increased risk of TB activation, unknown why ...
... More often H. flu, S. aureus, Ps. aeruginosa relative to nonIDUs IDU’s have increased risk of TB activation, unknown why ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.