Saudi Drug Bulletin
... potency and dose of statins. The increase in risk became non-significant for patients treated with rosuvastatin when dose was taken into account. These findings may be interpreted to support a true pharmacological class effect of statins on the development of diabetes. However, an alternative explan ...
... potency and dose of statins. The increase in risk became non-significant for patients treated with rosuvastatin when dose was taken into account. These findings may be interpreted to support a true pharmacological class effect of statins on the development of diabetes. However, an alternative explan ...
formulation and evaluation of floating microspheres of diclofenac
... Gastro-retentive floating microspheres are low density system that has a sufficient buoyancy to float over the gastric contents and remain in stomach for prolonged period. As the system floats over the gastric contents, the drug is released slowly at desired rate which results in increased gastric r ...
... Gastro-retentive floating microspheres are low density system that has a sufficient buoyancy to float over the gastric contents and remain in stomach for prolonged period. As the system floats over the gastric contents, the drug is released slowly at desired rate which results in increased gastric r ...
Document
... • Ulcer healing is related not only to neutralization of gastric acid but also to other actions • The following are hypothesized mechanisms for the acid-independent actions of antacids : – Aluminum hydroxide binds growth factors and enhances their binding to experimental ulcers, possibly serving to ...
... • Ulcer healing is related not only to neutralization of gastric acid but also to other actions • The following are hypothesized mechanisms for the acid-independent actions of antacids : – Aluminum hydroxide binds growth factors and enhances their binding to experimental ulcers, possibly serving to ...
New Psychoactive Substances
... Although precautionary approaches taken by some governments in creating pre-emptive legislation may remove some NPS from a widely accessible market, the reality is that as soon as one substance is made illegal, several others have appeared within days/weeks to take its place. The rapidly evolving na ...
... Although precautionary approaches taken by some governments in creating pre-emptive legislation may remove some NPS from a widely accessible market, the reality is that as soon as one substance is made illegal, several others have appeared within days/weeks to take its place. The rapidly evolving na ...
BRIEF RESUME OF THE INTENDED WORK: Need for the study
... mechanisms of antidepressants concerned with modification by voltage gated potassium channels. As there is lack of literature regarding effect of peripheral administration of potassium channel modulators on antinociceptive effect of antidepressants, the present study may shed more light on their rol ...
... mechanisms of antidepressants concerned with modification by voltage gated potassium channels. As there is lack of literature regarding effect of peripheral administration of potassium channel modulators on antinociceptive effect of antidepressants, the present study may shed more light on their rol ...
used
... c. By inhibiting MAO, these drugs increase the amount of monoamine neurotransmitters (NE, DA, and 5-HT) available for release into the synapse. The more common side effects include changes in blood pressure, sleep disturbances (including insomnia), and overeating—especially of carbohydrates—which ma ...
... c. By inhibiting MAO, these drugs increase the amount of monoamine neurotransmitters (NE, DA, and 5-HT) available for release into the synapse. The more common side effects include changes in blood pressure, sleep disturbances (including insomnia), and overeating—especially of carbohydrates—which ma ...
Main presentation heading in one or two lines
... Translational medicine A scientific discipline that bridge the gap between preclinical and clinical studies Allows us to understand the likely behavior of experimental medicines in humans Enables cost-effective determination of efficacy & safety through use of biomarkers ...
... Translational medicine A scientific discipline that bridge the gap between preclinical and clinical studies Allows us to understand the likely behavior of experimental medicines in humans Enables cost-effective determination of efficacy & safety through use of biomarkers ...
STUDIES ON DISSOLUTION ENHANCEMENT OF LOVASTATIN USING SOLUPLUS BY SOLID
... For a successful formulation, various formulation parameters that play a crucial role are aqueous solubility; stability at ambient temperature and humidity, photo-stability, compatibility with solvents etc. Among all these, Solubility is the most important property for developing formulations. The p ...
... For a successful formulation, various formulation parameters that play a crucial role are aqueous solubility; stability at ambient temperature and humidity, photo-stability, compatibility with solvents etc. Among all these, Solubility is the most important property for developing formulations. The p ...
Neurophar2016
... No formal system for the classification of receptors exists. A receptor is usually defined as a protein that binds a relatively specific molecule called the ligand. The binding of the ligand to its receptor has a functional effect. The two main types of receptors could be defined as ionotropic and m ...
... No formal system for the classification of receptors exists. A receptor is usually defined as a protein that binds a relatively specific molecule called the ligand. The binding of the ligand to its receptor has a functional effect. The two main types of receptors could be defined as ionotropic and m ...
Metacam Risks in Cats
... by refusing these tests; it’s essential to know if your cat is at greater risk. Should side effects occur, your vet is likely to order another round of tests to check the drug’s impact on your cat. Be prepared for these costs. Problems with Smaller Cats The post-surgical use of Metacam Oral in small ...
... by refusing these tests; it’s essential to know if your cat is at greater risk. Should side effects occur, your vet is likely to order another round of tests to check the drug’s impact on your cat. Be prepared for these costs. Problems with Smaller Cats The post-surgical use of Metacam Oral in small ...
lab 8
... DRUG DOSAGE BASED ON AGE • Neonate have immature renal and hepatic functions, while elderly in addition to diminished organ function, they frequently have concomitant pathologies, so age must be taken in consideration when determining the drug dosage. • In the past There were different rules used t ...
... DRUG DOSAGE BASED ON AGE • Neonate have immature renal and hepatic functions, while elderly in addition to diminished organ function, they frequently have concomitant pathologies, so age must be taken in consideration when determining the drug dosage. • In the past There were different rules used t ...
How do different analgesics prevent pain?
... • Used to treat mild pain • Mild analgesics function by intercepting the pain stimulus at the source, often by interfering with the production of substances (for example, prostaglandins). • Constricts blood vessels near the pain source reducing inflammation. • Prevent an increase in body temperature ...
... • Used to treat mild pain • Mild analgesics function by intercepting the pain stimulus at the source, often by interfering with the production of substances (for example, prostaglandins). • Constricts blood vessels near the pain source reducing inflammation. • Prevent an increase in body temperature ...
07 Rhinitis & cough
... • Many of the 1st generation drugs have effects that are not mediated by H1- receptors. • Such as antimuscarinic activity, alpha adrenoceptors blocking, serotonin receptors antagonism & local anesthetic receptor sites. • Some of these actions are of therapeutic value & some are undesirable. ...
... • Many of the 1st generation drugs have effects that are not mediated by H1- receptors. • Such as antimuscarinic activity, alpha adrenoceptors blocking, serotonin receptors antagonism & local anesthetic receptor sites. • Some of these actions are of therapeutic value & some are undesirable. ...
RATIONAL PRESCRIPTION & USE: A SNAPSHOT OF THE EVIDENCE FROM... EMERGING CONCERNS Research Article
... The average number of drugs prescribed per patient is 3 or more in Pakistan as compared to an average of 2-3 in LMICs [5] (Table 1). The use of medicine is significantly higher in private sector with an average of 4.1 medicines per prescription as compared to 2.7 in public sector (p<0.001)[7]. Simil ...
... The average number of drugs prescribed per patient is 3 or more in Pakistan as compared to an average of 2-3 in LMICs [5] (Table 1). The use of medicine is significantly higher in private sector with an average of 4.1 medicines per prescription as compared to 2.7 in public sector (p<0.001)[7]. Simil ...
2.3 Drug control under the League of Nations, 1920-1945
... exportation outweighed the economic advantages and revised its policy. It announced that it would end opium exports to any state or colony acting as a centre for the illicit traffic (such as Macao at the time), even if such a government were to produce any valid import certification. In 1926, the Go ...
... exportation outweighed the economic advantages and revised its policy. It announced that it would end opium exports to any state or colony acting as a centre for the illicit traffic (such as Macao at the time), even if such a government were to produce any valid import certification. In 1926, the Go ...
Lack of Dose Flexibility in Solid Oral Controlled
... pharmacokinetics of whole and half tablets of CR theophylline tablets indicate that half tablets dissolve faster and result in higher plasma levels. Thus, for CR medications, if titration or a change of dose is recommended in the product’s dosing instructions, dose adjustment can be somewhat more on ...
... pharmacokinetics of whole and half tablets of CR theophylline tablets indicate that half tablets dissolve faster and result in higher plasma levels. Thus, for CR medications, if titration or a change of dose is recommended in the product’s dosing instructions, dose adjustment can be somewhat more on ...
Urbanization as a risk factor for drug misuse
... population aged 16 years and over were not from metropolitan areas; i.e.: Blackpool & the Fylde (19.4); Brighton & Hove (17.8); Western Cumbria (17.3); and Newcastle-upon-Tyne (10.1). Conversely, coroners from more densely populated areas (i.e.: London, Liverpool, Birmingham and Manchester) reported ...
... population aged 16 years and over were not from metropolitan areas; i.e.: Blackpool & the Fylde (19.4); Brighton & Hove (17.8); Western Cumbria (17.3); and Newcastle-upon-Tyne (10.1). Conversely, coroners from more densely populated areas (i.e.: London, Liverpool, Birmingham and Manchester) reported ...
More Dosage calculations 2
... 5 ml solution. How many mL should patient received? ______________________ 3. Insulin is usually administered in a syringe (U-50 or U-100) that corresponds to the concentration of the insulin stock solution of 100U / mL (U-100). If an insulin syringe is not available, a tuberculin syringe may be use ...
... 5 ml solution. How many mL should patient received? ______________________ 3. Insulin is usually administered in a syringe (U-50 or U-100) that corresponds to the concentration of the insulin stock solution of 100U / mL (U-100). If an insulin syringe is not available, a tuberculin syringe may be use ...
Outline
... o Gastrointestinal: Anorexia, diarrhea, nausea, vomiting, drying of mucous membranes, abdominal pain o Genitourinary: Malodor of urine, hematuria, ...
... o Gastrointestinal: Anorexia, diarrhea, nausea, vomiting, drying of mucous membranes, abdominal pain o Genitourinary: Malodor of urine, hematuria, ...
Implications of Immunogenicity in Drug Development
... Both drug quantitation and ADA determination assays are subject to interference from matrix components. For drug quantitation assays this includes the presence of ADA; ADA assays are similarly prone to interference from free drug. Antibody drugs in particular have long half-lives, and ADA may stabil ...
... Both drug quantitation and ADA determination assays are subject to interference from matrix components. For drug quantitation assays this includes the presence of ADA; ADA assays are similarly prone to interference from free drug. Antibody drugs in particular have long half-lives, and ADA may stabil ...
tresaderm
... Caution(s): Federal law restricts this drug to use by or on the order of a licensed veterinarian. On rare occasions dogs may be sensitive to neomycin. In these animals, application of the drug will result in erythema of the treated area, which may last for 24 to 48 hours. Also, evidence of transient ...
... Caution(s): Federal law restricts this drug to use by or on the order of a licensed veterinarian. On rare occasions dogs may be sensitive to neomycin. In these animals, application of the drug will result in erythema of the treated area, which may last for 24 to 48 hours. Also, evidence of transient ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.