(1) - PhUSE Wiki
... the recommendations made here are mainly based on the authors experience with these trials and submission to regulatory bodies (and ICH-E14 guidelines and Q&A at the time this White Paper was written). The content of this document can be used when developing the analysis plan for individual clinical ...
... the recommendations made here are mainly based on the authors experience with these trials and submission to regulatory bodies (and ICH-E14 guidelines and Q&A at the time this White Paper was written). The content of this document can be used when developing the analysis plan for individual clinical ...
Nimodipine - 25% ME Group
... Doctors’ PROTOCOLS for use of calcium channel blockers IN M.E A few different CCBs have been used clinically or in controlled studies of M.E. patients. There have been successes with verapamil-SR, nifedipine and isradipine but it is generally thought that nimodipine's action on the brain will give t ...
... Doctors’ PROTOCOLS for use of calcium channel blockers IN M.E A few different CCBs have been used clinically or in controlled studies of M.E. patients. There have been successes with verapamil-SR, nifedipine and isradipine but it is generally thought that nimodipine's action on the brain will give t ...
.-4 L
... “characterizes the documented mechanism by which a nutrient or dietary ingredient acts to maintain such structure or function. ” 21 U.S.C. $ 343(r). The nutritional support statements made for Cholestin fall well within these statutory parameters, and extensive foreign clinical trials and one recent ...
... “characterizes the documented mechanism by which a nutrient or dietary ingredient acts to maintain such structure or function. ” 21 U.S.C. $ 343(r). The nutritional support statements made for Cholestin fall well within these statutory parameters, and extensive foreign clinical trials and one recent ...
product monograph
... Resistant tachyarrhythmias due to excessive catecholamine action during anesthesia: Tachyarrhythmias due to excessive catecholamine action during anesthesia may sometimes arise because of release of endogenous catecholamines or administration of catecholamines. When usual measures fail in such arrhy ...
... Resistant tachyarrhythmias due to excessive catecholamine action during anesthesia: Tachyarrhythmias due to excessive catecholamine action during anesthesia may sometimes arise because of release of endogenous catecholamines or administration of catecholamines. When usual measures fail in such arrhy ...
4. post-exposure prophylaxis for hiv
... drugs for preventing and treating HIV have changed. Some of the drugs listed as alternative drugs for post-exposure prophylaxis in 2007 (stavudine and saquinavir) are now no longer recommended for ART. The latest WHO guidelines for ART, issued in 2013 (3), give preference to tenofovir disoproxil fum ...
... drugs for preventing and treating HIV have changed. Some of the drugs listed as alternative drugs for post-exposure prophylaxis in 2007 (stavudine and saquinavir) are now no longer recommended for ART. The latest WHO guidelines for ART, issued in 2013 (3), give preference to tenofovir disoproxil fum ...
Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs
... and selectivity of ICSS to detect abuse potential of many classes of abused drugs is similar to the sensitivity and selectivity of drug self-administration procedures. Moreover, similar to progressive-ratio drug selfadministration procedures, ICSS data can be used to rank the relative abuse potentia ...
... and selectivity of ICSS to detect abuse potential of many classes of abused drugs is similar to the sensitivity and selectivity of drug self-administration procedures. Moreover, similar to progressive-ratio drug selfadministration procedures, ICSS data can be used to rank the relative abuse potentia ...
Introduction
... shown in table 1. Plasma concentration data were fit to a two compartment (biexponential) model, after applications of residual methods. Calculated pharmacokinetic parameters are reported in table 2. In table 3, the median, minimum, and maximum values of plasma concentration of ranitidine of the new ...
... shown in table 1. Plasma concentration data were fit to a two compartment (biexponential) model, after applications of residual methods. Calculated pharmacokinetic parameters are reported in table 2. In table 3, the median, minimum, and maximum values of plasma concentration of ranitidine of the new ...
Vytorin - Merck.com
... are no adequate and well-controlled studies of VYTORIN use during pregnancy; however, in rare reports congenital anomalies were observed following intrauterine exposure to statins. In rat and rabbit animal reproduction studies, simvastatin revealed no evidence of teratogenicity. VYTORIN should be ad ...
... are no adequate and well-controlled studies of VYTORIN use during pregnancy; however, in rare reports congenital anomalies were observed following intrauterine exposure to statins. In rat and rabbit animal reproduction studies, simvastatin revealed no evidence of teratogenicity. VYTORIN should be ad ...
VAGINAL BLEEDING AFTER USE OF SINGLE DOSE ORAL
... analogue. It can be used in both gastroenterological and gynecological conditions. In gastroenterologic use, misoprostol therapy indicated in patients who have duodenal or gastric ulcer due to use nonsteroidal anti-inflammatory drugs (NSAIDs). It acts upon gastric parietal cells, inhibiting the secr ...
... analogue. It can be used in both gastroenterological and gynecological conditions. In gastroenterologic use, misoprostol therapy indicated in patients who have duodenal or gastric ulcer due to use nonsteroidal anti-inflammatory drugs (NSAIDs). It acts upon gastric parietal cells, inhibiting the secr ...
ROLE OF HEPATIC TRANSPORT PROTEINS IN DRUG
... excretion of drugs/metabolites. Understanding how altered hepatic transport (due to sex, genetic polymorphisms, disease states, drug interactions) influences systemic and hepatic exposure of drugs/metabolites is important from both a therapeutic and toxicologic standpoint. The objective of this diss ...
... excretion of drugs/metabolites. Understanding how altered hepatic transport (due to sex, genetic polymorphisms, disease states, drug interactions) influences systemic and hepatic exposure of drugs/metabolites is important from both a therapeutic and toxicologic standpoint. The objective of this diss ...
Yohimbine enhances the effect of sildenafil on erectile
... Combining the centrally acting drug yohimbine with the peripheral conditioner sildenafil might be an approach to erectile dysfunction cases in which sildenafil alone failed. This work aimed to investigate the effect of yohimbine on sildenafil-induced facilitation of erectile process. Erectile respon ...
... Combining the centrally acting drug yohimbine with the peripheral conditioner sildenafil might be an approach to erectile dysfunction cases in which sildenafil alone failed. This work aimed to investigate the effect of yohimbine on sildenafil-induced facilitation of erectile process. Erectile respon ...
Changes in the mitochondrial electron transport chain (ETC
... young people whereas the use of the other substances continues to fall (4). Although, LSD is not considered as an addictive drug since it does not produce compulsive drug-seeking behavior and most users of LSD voluntarily decrease or stop its use over time, LSD does produce a physiologic tolerance r ...
... young people whereas the use of the other substances continues to fall (4). Although, LSD is not considered as an addictive drug since it does not produce compulsive drug-seeking behavior and most users of LSD voluntarily decrease or stop its use over time, LSD does produce a physiologic tolerance r ...
Medication Safety in the Neonatal Intensive Care Unit
... NICU patients often have long hospital stays, which increases exposure to medications and medication errors. In premature infants, the immaturity of developing body systems affects the absorption, distribution, metabolism, and excretion of drugs, and therefore, an exponential risk for medication err ...
... NICU patients often have long hospital stays, which increases exposure to medications and medication errors. In premature infants, the immaturity of developing body systems affects the absorption, distribution, metabolism, and excretion of drugs, and therefore, an exponential risk for medication err ...
Panadol® Osteo - GSK Australia
... The sustained release layer is formulated in such a manner that it rapidly hydrates to form a gel layer at the matrix periphery; the drug is then released from the matrix by a combination of diffusion and erosion of the gel layer. PANADOL Osteo releases drug at a rate which ensures that therapeutica ...
... The sustained release layer is formulated in such a manner that it rapidly hydrates to form a gel layer at the matrix periphery; the drug is then released from the matrix by a combination of diffusion and erosion of the gel layer. PANADOL Osteo releases drug at a rate which ensures that therapeutica ...
September 2001
... anhydride method. The antisera having the relatively higher titre value among the antisera obtained were used for subsequent study. The antibodies were raised in rabbits and showed cross-reactivity with a few structurally similar steroids. Especially those steroids having a 17a-methyl group such as ...
... anhydride method. The antisera having the relatively higher titre value among the antisera obtained were used for subsequent study. The antibodies were raised in rabbits and showed cross-reactivity with a few structurally similar steroids. Especially those steroids having a 17a-methyl group such as ...
GHB: An Important Pharmacologic and Clinical Update
... that may explain the described seizure-like phenomenon in users. Studies have shown no correlation between GHB-induced absence seizures and hypothermia. They seem to occur by separate, independent mechanisms.56 Clinicians should keep in mind that serum levels may fluctuate with circadian rhythm. One ...
... that may explain the described seizure-like phenomenon in users. Studies have shown no correlation between GHB-induced absence seizures and hypothermia. They seem to occur by separate, independent mechanisms.56 Clinicians should keep in mind that serum levels may fluctuate with circadian rhythm. One ...
triumeq - GSK Source
... To reduce the risk of a life-threatening hypersensitivity reaction, regardless of HLA-B*5701 status, discontinue TRIUMEQ immediately if a hypersensitivity reaction is suspected, even when other diagnoses are possible (e.g., acute onset respiratory diseases such as pneumonia, bronchitis, pharyngitis, ...
... To reduce the risk of a life-threatening hypersensitivity reaction, regardless of HLA-B*5701 status, discontinue TRIUMEQ immediately if a hypersensitivity reaction is suspected, even when other diagnoses are possible (e.g., acute onset respiratory diseases such as pneumonia, bronchitis, pharyngitis, ...
Appendix 10: Administering drugs via feeding tubes
... In addition to the general guidance (Box A10.B), the following should be considered when giving drugs via feeding tubes: • sterility with jejunal tube, use sterile water because the acid barrier in the stomach is bypassed; 1 some centres use an aseptic technique to reduce the risk of infective diar ...
... In addition to the general guidance (Box A10.B), the following should be considered when giving drugs via feeding tubes: • sterility with jejunal tube, use sterile water because the acid barrier in the stomach is bypassed; 1 some centres use an aseptic technique to reduce the risk of infective diar ...
Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers
... double-stranded non-coding RNA molecules that play an ...
... double-stranded non-coding RNA molecules that play an ...
Carprofen Caplets Brochure (for Pet Owners)
... varying from 1-35 mg/kg of body weight. After a 100 mg single intravenous bolus dose, the mean elimination half-life was approximately 11.7 hours in the dog. Carprofen is more than 99% bound to plasma protein and exhibits a very small volume of distribution. Carprofen is eliminated in the dog primar ...
... varying from 1-35 mg/kg of body weight. After a 100 mg single intravenous bolus dose, the mean elimination half-life was approximately 11.7 hours in the dog. Carprofen is more than 99% bound to plasma protein and exhibits a very small volume of distribution. Carprofen is eliminated in the dog primar ...
... The left carotid artery was cannulated and the catheter filled with heparin–saline (10 U·mL-1) and connected to a pressure transducer (model P23XL; Viggo-Spectramed, Helsingborg, Sweden) to monitor the mean arterial blood pressure (MAP) throughout the experiments. Another polyethylene catheter was i ...
Warfarin Management - Adult - Ambulatory Clinical Practice Guideline
... 5. Initial dosing should be tailored based on patient bleed risk, potential sensitivity to warfarin, indication for anticoagulation, goal INR range and if potential drug interactions are present3 (Class I, Level C) 6. A baseline INR should be resulted prior to initiating warfarin therapy3 (Class I, ...
... 5. Initial dosing should be tailored based on patient bleed risk, potential sensitivity to warfarin, indication for anticoagulation, goal INR range and if potential drug interactions are present3 (Class I, Level C) 6. A baseline INR should be resulted prior to initiating warfarin therapy3 (Class I, ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.