United States Anti-Doping Agency - United States Apnea Association
... safe and beneficial may be far from the truth. For example, cashew nuts may be considered all natural; however, the tree (Anacardium occidentale) producing the cashew nut belongs to the same plant family as poison ivy, poison oak and poison sumac and coats the nut with a toxic oily substance. The to ...
... safe and beneficial may be far from the truth. For example, cashew nuts may be considered all natural; however, the tree (Anacardium occidentale) producing the cashew nut belongs to the same plant family as poison ivy, poison oak and poison sumac and coats the nut with a toxic oily substance. The to ...
Sinemet® CR Product Monograph
... carbidopa) and other dopaminergic agents have reported suddenly falling asleep while engaged in activities of daily living, including the driving of a car, which has sometimes resulted in accidents. Although some of the patients reported somnolence while on SINEMET® CR, others perceived that they ha ...
... carbidopa) and other dopaminergic agents have reported suddenly falling asleep while engaged in activities of daily living, including the driving of a car, which has sometimes resulted in accidents. Although some of the patients reported somnolence while on SINEMET® CR, others perceived that they ha ...
CIPROXIN Tablets PI
... Dilution or infusion techniques-either quantitative (MIC) or breakpoint, should be used following a regularly, updated recognised and standardised method (e.g. NCCLS). Standardised susceptibility test procedures require the use of laboratory control microorganisms to control the technical aspects of ...
... Dilution or infusion techniques-either quantitative (MIC) or breakpoint, should be used following a regularly, updated recognised and standardised method (e.g. NCCLS). Standardised susceptibility test procedures require the use of laboratory control microorganisms to control the technical aspects of ...
HYDROPHILIC POLYMERS FOR DISSOLUTION ENHANCEMENT OF CELECOXIB Research Article PROF.M.V.NAGABHUSHANAM
... The dissolution data of celecoxib and their solid dispersions were also analyzed as per Hixson-Crowell’s (8) cube root equation. HixsonCrowell introduced the concept of changing surface area during dissolution and derived the “cube-root law” to nullify the effect of changing surface area and to line ...
... The dissolution data of celecoxib and their solid dispersions were also analyzed as per Hixson-Crowell’s (8) cube root equation. HixsonCrowell introduced the concept of changing surface area during dissolution and derived the “cube-root law” to nullify the effect of changing surface area and to line ...
Reyataz label - HIV Drug Resistance Database
... REYATAZ (atazanavir sulfate) is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. This indication is based on analyses of plasma HIV-1 RNA levels and CD4+ cell counts from controlled studies of 96 weeks duration in antiretroviral-naive and 48 weeks durat ...
... REYATAZ (atazanavir sulfate) is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. This indication is based on analyses of plasma HIV-1 RNA levels and CD4+ cell counts from controlled studies of 96 weeks duration in antiretroviral-naive and 48 weeks durat ...
November 2015 PBAC Meeting Agenda
... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
development, characterisation and evaluation of sildenafil aspirin co
... ED is associated with chronic disease including cardiovascular disease, high blood pressure and diabetes (Diabetes Mellitus). Furthermore, ED may be an early warning sign of these chronic diseases. It can result from physical, medical or psychological factors, or a combination of factors. Long term ...
... ED is associated with chronic disease including cardiovascular disease, high blood pressure and diabetes (Diabetes Mellitus). Furthermore, ED may be an early warning sign of these chronic diseases. It can result from physical, medical or psychological factors, or a combination of factors. Long term ...
Pharmacognosy of Coccinia grandis: a review
... bacteria as compared with hexane and water extracts. Leaf hexane extract is more effective than water extract against gram positive and gram negative bacteria. Ethanol extract of stem is more effective against Pseudomonas aeruginosa (9 mm zone of inhibition) whereas ethyl acetate extract and hexane ...
... bacteria as compared with hexane and water extracts. Leaf hexane extract is more effective than water extract against gram positive and gram negative bacteria. Ethanol extract of stem is more effective against Pseudomonas aeruginosa (9 mm zone of inhibition) whereas ethyl acetate extract and hexane ...
EBOLA and FDA: reviewing the response to the 2014 outbreak, to
... symptoms are nonspecific11 and can be confused with those of diseases more common in Equatorial Africa.12 The most useful tests for confirming an Ebola diagnosis—reverse transcriptase polymerase chain reaction and antigen detection by enzyme linked immunosorbent assay—are only available in referral ...
... symptoms are nonspecific11 and can be confused with those of diseases more common in Equatorial Africa.12 The most useful tests for confirming an Ebola diagnosis—reverse transcriptase polymerase chain reaction and antigen detection by enzyme linked immunosorbent assay—are only available in referral ...
The influence of macrolide antibiotics on the uptake of organic
... OATP1B1- and OATP1B3-mediated uptake of BSP and pravastatin can be inhibited by increasing concentrations of all macrolides except azithromycin. The IC50 values for the inhibition of OATP1B3-mediated BSP uptake were 11 µM for telithromycin, 32 µM for clarithromycin, 34 µM for erythromycin, and 37 µM ...
... OATP1B1- and OATP1B3-mediated uptake of BSP and pravastatin can be inhibited by increasing concentrations of all macrolides except azithromycin. The IC50 values for the inhibition of OATP1B3-mediated BSP uptake were 11 µM for telithromycin, 32 µM for clarithromycin, 34 µM for erythromycin, and 37 µM ...
CANNABIS-INDUCED IMPAIRMENT OF LEARNING AND MEMORY
... brain was increased after vinpocetine and donepezil and was markedly elevated after Ginkgo biloba. Piracetam restored the decrease in glucose and nitric oxide by cannabis. Cannabis caused dose-dependent increases of brain serotonin, noradrenaline and dopamine. After cannabis treatment, noradrenaline ...
... brain was increased after vinpocetine and donepezil and was markedly elevated after Ginkgo biloba. Piracetam restored the decrease in glucose and nitric oxide by cannabis. Cannabis caused dose-dependent increases of brain serotonin, noradrenaline and dopamine. After cannabis treatment, noradrenaline ...
The efficacy of glucosamine sulfate in osteoarthritis
... those of independent research. The first is the study design. Pharmaceutical companies have experienced clinical pharmacologists who can design trials that are better suited to showing the efficacy of a certain drug because they avoid the influence of confounders. This sometimes has the drawback of ...
... those of independent research. The first is the study design. Pharmaceutical companies have experienced clinical pharmacologists who can design trials that are better suited to showing the efficacy of a certain drug because they avoid the influence of confounders. This sometimes has the drawback of ...
2 Long-acting agonists: a new perspective
... studies seems to be similar, whereas In isolated tissues there might be a difference In the binding characteristics to the ~ 2 -adrenoceptor. Longacting ~ 2 -agonlsts could have an inhibitory effect on Inflammatory events related to asthma, but the clinical relevance of these effects Is not clear at ...
... studies seems to be similar, whereas In isolated tissues there might be a difference In the binding characteristics to the ~ 2 -adrenoceptor. Longacting ~ 2 -agonlsts could have an inhibitory effect on Inflammatory events related to asthma, but the clinical relevance of these effects Is not clear at ...
Fentanyl - Spirit of Healing: Alberta First Nations Conquering
... respiratory depression. The respiratory depressant effect lasts longer than the pain killing effects. ◦ Respiratory cessation (in other words the user stops breathing). The risk for respiratory cessation is higher than for other opioid drugs (like morphine and ...
... respiratory depression. The respiratory depressant effect lasts longer than the pain killing effects. ◦ Respiratory cessation (in other words the user stops breathing). The risk for respiratory cessation is higher than for other opioid drugs (like morphine and ...
Evaluation of Pharmacokinetic Interaction between PA
... handled in the following manner. The lower limit of quantitation for midazolam and 1-hydroxy midazolam bioanalysis was 0.1 ng/ml. PK parameters were not calculated for subjects for whom there were insufficient data. For the calculation of the PK parameters, plasma concentrations that were BLQ prior ...
... handled in the following manner. The lower limit of quantitation for midazolam and 1-hydroxy midazolam bioanalysis was 0.1 ng/ml. PK parameters were not calculated for subjects for whom there were insufficient data. For the calculation of the PK parameters, plasma concentrations that were BLQ prior ...
FDA Approved Labeling 12.19.08 3pm NovaDel Pharma Inc.
... Use in patients with depression: As with other sedative-hypnotic drugs, Zolpimist should be administered with caution to patients exhibiting signs or symptoms of depression. Suicidal tendencies may be present in such patients and protective measures may be required. Intentional over-dosage is more c ...
... Use in patients with depression: As with other sedative-hypnotic drugs, Zolpimist should be administered with caution to patients exhibiting signs or symptoms of depression. Suicidal tendencies may be present in such patients and protective measures may be required. Intentional over-dosage is more c ...
REVIEWS
... reason, fibrates and nicotinic acid (niacin) are the mainstays of therapy to raise HDL. Fibrates exert their indirect effect on HDL levels by activating the nuclear transcription factor peroxisome proliferative activated receptor-α (PPARα). They increase HDL levels and decrease triglyceride concentr ...
... reason, fibrates and nicotinic acid (niacin) are the mainstays of therapy to raise HDL. Fibrates exert their indirect effect on HDL levels by activating the nuclear transcription factor peroxisome proliferative activated receptor-α (PPARα). They increase HDL levels and decrease triglyceride concentr ...
DXM
... • Majority of respondents (79%) reported using DXM to explore their consciousness or alter their state of mind.! • While many respondents mentioned DXM’s accessibility (legal, readily available, cheap) as a reason or benefit of using DXM, the focus was on specific effects, such as dissociation and ...
... • Majority of respondents (79%) reported using DXM to explore their consciousness or alter their state of mind.! • While many respondents mentioned DXM’s accessibility (legal, readily available, cheap) as a reason or benefit of using DXM, the focus was on specific effects, such as dissociation and ...
oxycodone/naloxone controlled release
... controlled release (CR) NOT be listed on OxyContin® plus a preventative bowel any WSIB formulary as there are no trials ...
... controlled release (CR) NOT be listed on OxyContin® plus a preventative bowel any WSIB formulary as there are no trials ...
03-A922-R2 Erythromycin Tablets PI - 3-25-14
... contact their physician as soon as possible. Drug Interactions Theophylline Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophylline toxicity and/or elevated ...
... contact their physician as soon as possible. Drug Interactions Theophylline Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophylline toxicity and/or elevated ...
PDF - SAGE Journals
... glutamatergic synapses in the rat striatum and also induce extrapyramidal side effects like Parkinsonism, akathisia, muscular dystonia and TD.9,10 Furthermore, chronic administration of haloperidol may mobilize arachidonic acid, which can produce various inflammatory prostaglandins and cause neurona ...
... glutamatergic synapses in the rat striatum and also induce extrapyramidal side effects like Parkinsonism, akathisia, muscular dystonia and TD.9,10 Furthermore, chronic administration of haloperidol may mobilize arachidonic acid, which can produce various inflammatory prostaglandins and cause neurona ...
bioequivalence guideline
... is required. Level A IVIVC is rarely established for immediate release oral dosage forms. Clarification on requirements for low solubility drug substance is sought ...
... is required. Level A IVIVC is rarely established for immediate release oral dosage forms. Clarification on requirements for low solubility drug substance is sought ...
full document
... Petersen, N. West, and J. M. Ansermino (2012b). “Closed-loop anesthesia in children using a PID controller: a pilot study”. In: Proc. IFAC Conference on Advances in PID Control. Brescia, Italy. The first study with a PID controller-based automatic drug delivery system for propofol anesthesia in chil ...
... Petersen, N. West, and J. M. Ansermino (2012b). “Closed-loop anesthesia in children using a PID controller: a pilot study”. In: Proc. IFAC Conference on Advances in PID Control. Brescia, Italy. The first study with a PID controller-based automatic drug delivery system for propofol anesthesia in chil ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.