bioequivalence guideline
... is required. Level A IVIVC is rarely established for immediate release oral dosage forms. Clarification on requirements for low solubility drug substance is sought ...
... is required. Level A IVIVC is rarely established for immediate release oral dosage forms. Clarification on requirements for low solubility drug substance is sought ...
Artemisia annua (Asteraceae) Description of the plant Plant parts
... The definite mode of action is not yet known. Tests about uptake of radio-labeled substances like hypoxanthin in infected cells suggest that artemisinin diminishes the nucleic acid synthesis and that protein synthesis is one of its prime targets. In concentrations equivalent to therapeutic levels ar ...
... The definite mode of action is not yet known. Tests about uptake of radio-labeled substances like hypoxanthin in infected cells suggest that artemisinin diminishes the nucleic acid synthesis and that protein synthesis is one of its prime targets. In concentrations equivalent to therapeutic levels ar ...
... phagocytosis and burst activity of neutrophils (Paape, M. J. et al., 1990). Other studies suggests that CAP directly induce apoptosis in haematopoietic stem cells, directly leading to AA (Kong C. T., et al., 2000). In a study, Chloramphenicol was administered at dose levels of 150 mg/kg in rats for ...
Document
... This drug is not approved by FDA for use in neither adult nor pediatric hyperbilirubinemia patients, due to possibility of significant systemic side-effects. Exact pathway is not known, but it is believed to act as an inducing agent on UDPglucuronosyltransferase, thereby improving conjugation of ...
... This drug is not approved by FDA for use in neither adult nor pediatric hyperbilirubinemia patients, due to possibility of significant systemic side-effects. Exact pathway is not known, but it is believed to act as an inducing agent on UDPglucuronosyltransferase, thereby improving conjugation of ...
The Pharmacology of Psychedelic Drugs
... Finally, the alterations in consciousness brought about by carbon dioxide in various concentrations will not be discussed here, since they have recently been extensively described in a monograph edited by Meduna (1958). A general caution may be necessary at this point. As is now becoming more and mo ...
... Finally, the alterations in consciousness brought about by carbon dioxide in various concentrations will not be discussed here, since they have recently been extensively described in a monograph edited by Meduna (1958). A general caution may be necessary at this point. As is now becoming more and mo ...
EMERGENCY DEPARTMENT VISITS INVOLVING NARCOTIC PAIN RELIEVERS AUTHORS INTRODUCTION
... Narcotic pain relievers are prescription pain medications that act on the brain to provide relief from pain. Chemically similar to heroin, they also have the potential to produce a feeling of euphoria. Although narcotic pain relievers offer important medical benefits when used appropriately, these d ...
... Narcotic pain relievers are prescription pain medications that act on the brain to provide relief from pain. Chemically similar to heroin, they also have the potential to produce a feeling of euphoria. Although narcotic pain relievers offer important medical benefits when used appropriately, these d ...
EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME
... of Bio-resources, Division of Biotechnology, Frontier Science Research Center, Miyazaki University, were used throughout the study. The rats were housed in stainless steel cages with three animals per cage in a temperaturecontrolled (22–24°C) room with a 12-h light/dark cycle. The rats were allowed ...
... of Bio-resources, Division of Biotechnology, Frontier Science Research Center, Miyazaki University, were used throughout the study. The rats were housed in stainless steel cages with three animals per cage in a temperaturecontrolled (22–24°C) room with a 12-h light/dark cycle. The rats were allowed ...
Antiparasitic Chemotherapy for Human and Veterinary Use 3rd
... 9:20 Descoteaux A., INRS- Institut Armand-Frappier, Laval, Canada (COST invited ...
... 9:20 Descoteaux A., INRS- Institut Armand-Frappier, Laval, Canada (COST invited ...
Involvement of к/Dynorphin System in WIN 55212-2 Self
... (0.1 mg/kg i.p.) in the home-cage 24 h before the first self-administration session. Similarly, the effects of a KOR antagonist on the acquisition of WIN (12.5 mg/kg/injection) self-administration were evaluated by injecting nor-binaltorphimine (5 mg/kg s.c.) 4 h before the first self-administration ...
... (0.1 mg/kg i.p.) in the home-cage 24 h before the first self-administration session. Similarly, the effects of a KOR antagonist on the acquisition of WIN (12.5 mg/kg/injection) self-administration were evaluated by injecting nor-binaltorphimine (5 mg/kg s.c.) 4 h before the first self-administration ...
The effect of oral midazolam ... on respiration in normal subjects
... significant depression of the hypoxic ventilatory response (HVR) to isocapnic hypoxia. In another study (6], i.v. midazolam suppressed the HVR in eight healthy volunteers. FoRSTER et a/ [7] used equipotent doses of parenteral midazolam and diazepam in eight healthy volunteers, and found that the ven ...
... significant depression of the hypoxic ventilatory response (HVR) to isocapnic hypoxia. In another study (6], i.v. midazolam suppressed the HVR in eight healthy volunteers. FoRSTER et a/ [7] used equipotent doses of parenteral midazolam and diazepam in eight healthy volunteers, and found that the ven ...
Suggestion from clinicians
... efficacy of rosuvastatin in 19,596 participants. Rosuvastatin 10 to 40 mg/day caused LDL-cholesterol decreases of 46%to 55%, when all the trials were combined using the generic inverse variance method. The quality of evidence for these effects is high. Log dose-response data over doses of 1to 80 mg, ...
... efficacy of rosuvastatin in 19,596 participants. Rosuvastatin 10 to 40 mg/day caused LDL-cholesterol decreases of 46%to 55%, when all the trials were combined using the generic inverse variance method. The quality of evidence for these effects is high. Log dose-response data over doses of 1to 80 mg, ...
Depressants Sedative Hypnotics
... performance (especially memory) • Decreases academic performance • Reduces psychomotor functioning • Effects can occur for long periods after the drugs are discontinued • Impairments decrease over time (usually) ...
... performance (especially memory) • Decreases academic performance • Reduces psychomotor functioning • Effects can occur for long periods after the drugs are discontinued • Impairments decrease over time (usually) ...
pharmacy technical assistance - Ministère de l`Éducation et de l
... A situational competency describes the situation in which students are placed to acquire learning, and allows for actions and results to vary from one student to another. It consists of the following features: The statement of the competency is the result of the job analysis, the orientations and ge ...
... A situational competency describes the situation in which students are placed to acquire learning, and allows for actions and results to vary from one student to another. It consists of the following features: The statement of the competency is the result of the job analysis, the orientations and ge ...
Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures Zheng Zhou
... because of the positively charged amine group and the electronegative halogen atoms, points in approximately the same direction, from TM10 to TM1. Not only are the dichlorophenyl group of sertraline and the trifluoromethylphenoxy groups of both fluoxetine enantiomers roughly superimposable, but all ...
... because of the positively charged amine group and the electronegative halogen atoms, points in approximately the same direction, from TM10 to TM1. Not only are the dichlorophenyl group of sertraline and the trifluoromethylphenoxy groups of both fluoxetine enantiomers roughly superimposable, but all ...
Disintegration of Tablets and Capsules Measured by Isothermal
... 10 minutes and those disintegrating in more than 30 minutes. The IsoTMA method can identify the drug delivery process as orally occurring over 15-30 seconds, gastrically over 2- 30 minutes and intestinally over 30-90 minutes. The percent relative error for IsoTMA measured disintegration times was a ...
... 10 minutes and those disintegrating in more than 30 minutes. The IsoTMA method can identify the drug delivery process as orally occurring over 15-30 seconds, gastrically over 2- 30 minutes and intestinally over 30-90 minutes. The percent relative error for IsoTMA measured disintegration times was a ...
Secundum Artem
... ORA-SWEET AND ORA-SWEET SF - PART II INTRODUCTION The most commonly used oral dosage forms today include tablets and capsules. Many patients cannot easily swallow these products so alternate formulations must be prepared, or compounded, by the pharmacist. When a modification is made to a commercial ...
... ORA-SWEET AND ORA-SWEET SF - PART II INTRODUCTION The most commonly used oral dosage forms today include tablets and capsules. Many patients cannot easily swallow these products so alternate formulations must be prepared, or compounded, by the pharmacist. When a modification is made to a commercial ...
Propoxyphene Napsylate and Acetaminophen Tablets
... of 0.1 mg/kg body weight may be administered. If an IV route of administration is not available, naloxone may be administered IM or subcutaneously in divided doses. If necessary, naloxone can be diluted with Sterile Water for Injection. Blood gases, pH, and electrolytes should be monitored in order ...
... of 0.1 mg/kg body weight may be administered. If an IV route of administration is not available, naloxone may be administered IM or subcutaneously in divided doses. If necessary, naloxone can be diluted with Sterile Water for Injection. Blood gases, pH, and electrolytes should be monitored in order ...
the-serotonergic-hallucinogen-5-meo-dmt-disrupts
... ML-0.2 to -0.4, DV-1.0 to -2.5 below brain surface; coordinates in mm). In most experiments simultaneous recordings of oscillatory activity in the primary somatosensory (S1, AP+0.5, ML+3.0), primary auditory (Au1, AP-2.8, ML+4.2) or primary visual (V1, AP-3.6, ML+2.5) cortices were also performed us ...
... ML-0.2 to -0.4, DV-1.0 to -2.5 below brain surface; coordinates in mm). In most experiments simultaneous recordings of oscillatory activity in the primary somatosensory (S1, AP+0.5, ML+3.0), primary auditory (Au1, AP-2.8, ML+4.2) or primary visual (V1, AP-3.6, ML+2.5) cortices were also performed us ...
EES Granules - Arbor Pharmaceuticals
... soon as possible. Drug Interactions Theophylline Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophylline toxicity and/or elevated serum theophylline levels ...
... soon as possible. Drug Interactions Theophylline Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophylline toxicity and/or elevated serum theophylline levels ...
Natural Treatment Alternative for Psoriasis
... There are five main types of psoriasis, namely; Plaque psoriasis, Guttate psoriasis, Inverse (Flexural) psoriasis, Pustular psoriasis and Erythrodermic psoriasis. Apart from these nail psoriasis is there, which is localized to the nails only and psoriatic arthritis is limited to joint and connective ...
... There are five main types of psoriasis, namely; Plaque psoriasis, Guttate psoriasis, Inverse (Flexural) psoriasis, Pustular psoriasis and Erythrodermic psoriasis. Apart from these nail psoriasis is there, which is localized to the nails only and psoriatic arthritis is limited to joint and connective ...
SCLEROTIUM ROLFSII AND ANTIFUNGAL ACTIVITY Research Article
... with serum albumin and show greater bio efficacy than the free drug4. Interestingly, AmB has also been shown to interact with serum albumins and Polyvinylpyrrolidone (PVP) rendering it water soluble3,17. In the present study, a lectin from Sclerotium rolfsii (SRL) has been ...
... with serum albumin and show greater bio efficacy than the free drug4. Interestingly, AmB has also been shown to interact with serum albumins and Polyvinylpyrrolidone (PVP) rendering it water soluble3,17. In the present study, a lectin from Sclerotium rolfsii (SRL) has been ...
Cannabis
... effects but is also more likely to produce an unpleasant reaction. Too high a dose may result in feelings of losing control, confusion, agitation, paranoia and panic. Pseudohallucinations (seeing things such as pattern and colour that you know are not real) or true hallucinations (where you lose tou ...
... effects but is also more likely to produce an unpleasant reaction. Too high a dose may result in feelings of losing control, confusion, agitation, paranoia and panic. Pseudohallucinations (seeing things such as pattern and colour that you know are not real) or true hallucinations (where you lose tou ...
Behavioral Profiles in Rats Distinguish Among “Ecstasy
... MDMA when compared with other psychoactive substances (Paulus & Geyer, 1991). The hyperlocomotion after administration of MA was shown later to be different, but the pattern elicited by DOI, although with considerably reduced locomotion, is similar to that observed with MDMA (Paulus & Geyer, 1992). ...
... MDMA when compared with other psychoactive substances (Paulus & Geyer, 1991). The hyperlocomotion after administration of MA was shown later to be different, but the pattern elicited by DOI, although with considerably reduced locomotion, is similar to that observed with MDMA (Paulus & Geyer, 1992). ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.