Dosage Adjustment for Cytotoxics in Hepatic Impairment
... Pharmion – In the 3 NCI studies involving azacitadine there was no significant increase in adverse reactions in patients with hepatic impairment compared with those with normal hepatic function. However the drug should be used with caution as it is metabolised by hepatic enzymes. In addition there i ...
... Pharmion – In the 3 NCI studies involving azacitadine there was no significant increase in adverse reactions in patients with hepatic impairment compared with those with normal hepatic function. However the drug should be used with caution as it is metabolised by hepatic enzymes. In addition there i ...
SOLID-STATE NMR - National Institute of Chemistry
... Parts of the drug have an average position in or on its binding site, rather than a highly rigid location for the whole molecule. Deuterium substitutions give rise to either motionally broadened or a motionally narrowed spectrum. The method is sensitive enough to differentiate unbound ligand as a na ...
... Parts of the drug have an average position in or on its binding site, rather than a highly rigid location for the whole molecule. Deuterium substitutions give rise to either motionally broadened or a motionally narrowed spectrum. The method is sensitive enough to differentiate unbound ligand as a na ...
Filters and Filtration: A Review of Mechanisms That Impact Cost
... we do not completely understand the nature of such filters and random or un-informed usage could introduce unwanted alterations in the quality or quantity of the product. Thus, one needs to be aware that filters could alter the stability, quality and safety of the product if the right choices are no ...
... we do not completely understand the nature of such filters and random or un-informed usage could introduce unwanted alterations in the quality or quantity of the product. Thus, one needs to be aware that filters could alter the stability, quality and safety of the product if the right choices are no ...
Medicinal properties of Ginger ( Zingiber officinale Article
... possesses anti-skin tumourpromoting effects, and that the mechanism of such effects may involve inhibition of tumour promoter-caused cellular, biochemical, and molecular changes in mouse skin. Anti-viral Rhinoviruses are among those viruses which cause the common cold therefore, the dried rhizomes o ...
... possesses anti-skin tumourpromoting effects, and that the mechanism of such effects may involve inhibition of tumour promoter-caused cellular, biochemical, and molecular changes in mouse skin. Anti-viral Rhinoviruses are among those viruses which cause the common cold therefore, the dried rhizomes o ...
Dextromethorphan abuse: Clinical effects
... (>12 years of age) of DM range from 60 to 120 mg/day in divided doses.19 In children older than 2 years, doses range from 2.5 to 10 mg administered up to four times daily. DM is currently not recommended for use in children younger than 2 years.20 The drug is rapidly absorbed from the gastrointestin ...
... (>12 years of age) of DM range from 60 to 120 mg/day in divided doses.19 In children older than 2 years, doses range from 2.5 to 10 mg administered up to four times daily. DM is currently not recommended for use in children younger than 2 years.20 The drug is rapidly absorbed from the gastrointestin ...
An Update on Artemisinin- A Multifaceted Drug
... disease reemerged due to chloroquine resistant Plasmodium falciparum strains and resistance of mosquito, the malarial vector to the insecticides. Under this circumstances, in 1967 Chinese government set up a secret military project during Vietnam war, known as 'Project 523’ lead by the Pharmaceutica ...
... disease reemerged due to chloroquine resistant Plasmodium falciparum strains and resistance of mosquito, the malarial vector to the insecticides. Under this circumstances, in 1967 Chinese government set up a secret military project during Vietnam war, known as 'Project 523’ lead by the Pharmaceutica ...
MCS Sense and Non-Se..
... better recaptures the mean parameter values and, in general, the starting dispersion (except Kpc) However, for AUC distribution generation, it is clear that Log-normal is preferred because it performs better for the parameter of interest (SCL) for both mean value and dispersion We have seen exam ...
... better recaptures the mean parameter values and, in general, the starting dispersion (except Kpc) However, for AUC distribution generation, it is clear that Log-normal is preferred because it performs better for the parameter of interest (SCL) for both mean value and dispersion We have seen exam ...
11146002
... or granules. In certain cases tablets may be obtained by molding or extrusion techniques. They are uncoated or coated.Tabletscontain one or more active ingredients. They may contain excipients such as diluents, binders, disintegrating agents, glidants, lubricants, substances capable of modifying the ...
... or granules. In certain cases tablets may be obtained by molding or extrusion techniques. They are uncoated or coated.Tabletscontain one or more active ingredients. They may contain excipients such as diluents, binders, disintegrating agents, glidants, lubricants, substances capable of modifying the ...
Monte Carlo Simulation: Sense and Non-sense
... better recaptures the mean parameter values and, in general, the starting dispersion (except Kpc) However, for AUC distribution generation, it is clear that Log-normal is preferred because it performs better for the parameter of interest (SCL) for both mean value and dispersion We have seen exam ...
... better recaptures the mean parameter values and, in general, the starting dispersion (except Kpc) However, for AUC distribution generation, it is clear that Log-normal is preferred because it performs better for the parameter of interest (SCL) for both mean value and dispersion We have seen exam ...
NATURAL AND PARTIALLY SYNTETIc ANALGESIcS
... compound is only a weak agonist of µ-opioid receptors, which is the case with codeine. The morphine is further metabolised in the liver and also in the small intestine to normorphine and codeine. With morphine, the active metabolite morphine-6-glucuronide exerts important clinical opioid effects, wh ...
... compound is only a weak agonist of µ-opioid receptors, which is the case with codeine. The morphine is further metabolised in the liver and also in the small intestine to normorphine and codeine. With morphine, the active metabolite morphine-6-glucuronide exerts important clinical opioid effects, wh ...
Does High-Dose Buprenorphine Cause Respiratory Depression
... Various drugs that induce (antiepileptic drugs) or inhibit (macrolides, azole-based antimycotic drugs and HIV protease inhibitors) the CYP 3A4, may interfere with buprenorphine metabolism. However, their clinical implications remain unknown. The relationship between buprenorphine plasma concentratio ...
... Various drugs that induce (antiepileptic drugs) or inhibit (macrolides, azole-based antimycotic drugs and HIV protease inhibitors) the CYP 3A4, may interfere with buprenorphine metabolism. However, their clinical implications remain unknown. The relationship between buprenorphine plasma concentratio ...
highlights of prescribing information
... Embryofetal Toxicity (Use with Ribavirin and Peginterferon Alfa) Ribavirin may cause birth defects and/or death of the exposed fetus. Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients. Ribavirin therapy should not be started unless a report of a ...
... Embryofetal Toxicity (Use with Ribavirin and Peginterferon Alfa) Ribavirin may cause birth defects and/or death of the exposed fetus. Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients. Ribavirin therapy should not be started unless a report of a ...
Ganja and Geriatrics: The Health Benefits and Risks of Medicinal
... have been found to aid in relieving nausea and vomiting include nabilone and levonantradol. These drugs, along with dronabinol, are mostly used by patients who receive chemotherapy (Hall & Degenhardt, 2003). The most recent information on these drugs reports, that in some cases, they show more antie ...
... have been found to aid in relieving nausea and vomiting include nabilone and levonantradol. These drugs, along with dronabinol, are mostly used by patients who receive chemotherapy (Hall & Degenhardt, 2003). The most recent information on these drugs reports, that in some cases, they show more antie ...
EVALUATION OF ANTIDEPRESSANT EFFECT OF CHRONIC ADMINISTRATION OF TRAMADOL
... antidepressants produce effect on brain monoaminergic system. The clinically used analgesic Tramadol apart from having effect on µ type opioid receptors, also have monoaminergic uptake blockade effect. Hence, the present study was carried out to evaluate the antidepressant activity of Tramadol in Ta ...
... antidepressants produce effect on brain monoaminergic system. The clinically used analgesic Tramadol apart from having effect on µ type opioid receptors, also have monoaminergic uptake blockade effect. Hence, the present study was carried out to evaluate the antidepressant activity of Tramadol in Ta ...
DOPamine Hydrochloride and 5% Dextrose Injection, USP
... Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sy ...
... Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sy ...
Interchangeability and study design
... Bioavailability means the rate and extent to which the active substance or therapeutic moiety is absorbed from a pharmaceutical form and becomes available at the site of action. ...
... Bioavailability means the rate and extent to which the active substance or therapeutic moiety is absorbed from a pharmaceutical form and becomes available at the site of action. ...
Document
... mild sedative action and a feeling of well-being. • In the Middle Ages, stramonium was employed to drug victims prior to robbing • them. During this event, the victim appeared normal and was cooperative, though afterwards could usually not remember what ...
... mild sedative action and a feeling of well-being. • In the Middle Ages, stramonium was employed to drug victims prior to robbing • them. During this event, the victim appeared normal and was cooperative, though afterwards could usually not remember what ...
PART I B SUMMARY OF PRODUCT CHARACTERISTICS
... 50%. For patients with CLCR <30 mL/min the dose of clarithromycin should be decreased by 75%. Doses of clarithromycin greater than 1 gm/day should not be coadministered with ritonavir. Similar dose adjustments should be considered in patients with reduced renal function when ritonavir is used as a p ...
... 50%. For patients with CLCR <30 mL/min the dose of clarithromycin should be decreased by 75%. Doses of clarithromycin greater than 1 gm/day should not be coadministered with ritonavir. Similar dose adjustments should be considered in patients with reduced renal function when ritonavir is used as a p ...
Serotonin-mediated central fatigue underlies increased endurance
... reference to central fatigue, although the effect of dopamine receptor agonists and transport inhibitors during exercise is well established [3, 4]. The predictive factor in 5-HT-generated central fatigue may not be 5-HT concentration alone, but the ratio of 5-HT:DA in such brain regions as the stri ...
... reference to central fatigue, although the effect of dopamine receptor agonists and transport inhibitors during exercise is well established [3, 4]. The predictive factor in 5-HT-generated central fatigue may not be 5-HT concentration alone, but the ratio of 5-HT:DA in such brain regions as the stri ...
Diabetes Research and Clinical Practice 28 Suppl. (1995) S115
... Glibenclamide; Glimepiride; Insulin action; Adipocytes; Diaphragm; Glucose transport; Metabolism; ...
... Glibenclamide; Glimepiride; Insulin action; Adipocytes; Diaphragm; Glucose transport; Metabolism; ...
2011
... in slightly basic medium to obtain a pink colour; which is measured at a fixed wavelength to correlate the quantity of the drug with the optical density. Identify the drug under estimation? (A) Streptomycin sulphate B Thiamine hydrochloride (C) Dexamethasone (D) Sulphamethoxazole Answer: Q.61 In the ...
... in slightly basic medium to obtain a pink colour; which is measured at a fixed wavelength to correlate the quantity of the drug with the optical density. Identify the drug under estimation? (A) Streptomycin sulphate B Thiamine hydrochloride (C) Dexamethasone (D) Sulphamethoxazole Answer: Q.61 In the ...
(1) - PhUSE Wiki
... the recommendations made here are mainly based on the authors experience with these trials and submission to regulatory bodies (and ICH-E14 guidelines and Q&A at the time this White Paper was written). The content of this document can be used when developing the analysis plan for individual clinical ...
... the recommendations made here are mainly based on the authors experience with these trials and submission to regulatory bodies (and ICH-E14 guidelines and Q&A at the time this White Paper was written). The content of this document can be used when developing the analysis plan for individual clinical ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.