Drug-like properties and the causes of poor solubility
... the small number of known drug-like compounds and the vastness of chemistry space, there are only several possibilities on the distribution of drugs in chemistry space. At the extremes, either drugs are found in small, infrequently distributed clusters in the vastness of chemistry space (the authors ...
... the small number of known drug-like compounds and the vastness of chemistry space, there are only several possibilities on the distribution of drugs in chemistry space. At the extremes, either drugs are found in small, infrequently distributed clusters in the vastness of chemistry space (the authors ...
Data Sheet
... inhibition of CYP2D6 would result in the change of phenotype into poor metabolizer (phenocopying, see Clinical pharmacology pharmacokinetic). Caution should therefore be exercised when co-administering potent CYP2D6 inhibitors with metoprolol. Known clinically significant potent inhibitors of CYP2D6 ...
... inhibition of CYP2D6 would result in the change of phenotype into poor metabolizer (phenocopying, see Clinical pharmacology pharmacokinetic). Caution should therefore be exercised when co-administering potent CYP2D6 inhibitors with metoprolol. Known clinically significant potent inhibitors of CYP2D6 ...
Prescribing Information
... reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The safety assessment is based on all data from 1203 subjects in the Phase 3 placebo-controlled trials, TMC125-C206 ...
... reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The safety assessment is based on all data from 1203 subjects in the Phase 3 placebo-controlled trials, TMC125-C206 ...
PDF file - Via Medica Journals
... Class III drugs prolong the QT interval by blocking mainly the delayed rectifier rapid potassium outward current (IKr), with little effect on depolarization. This K+ channel in encoded by the human ether-a-go-go-related gene (hERG). Inhibition of hERG potassium currents by class III antiarrhythmic d ...
... Class III drugs prolong the QT interval by blocking mainly the delayed rectifier rapid potassium outward current (IKr), with little effect on depolarization. This K+ channel in encoded by the human ether-a-go-go-related gene (hERG). Inhibition of hERG potassium currents by class III antiarrhythmic d ...
Speaker`s Notes
... A. FALSE - Extra-label use of feed medication used in feed to treat disease. The is illegal. A veterinarian cannot provide extraFDA determines which drugs are label directions for medicated feed. VFD drugs. These drugs must be ordered by your veterinarian. You may not buy Veterinary Feed Directive ( ...
... A. FALSE - Extra-label use of feed medication used in feed to treat disease. The is illegal. A veterinarian cannot provide extraFDA determines which drugs are label directions for medicated feed. VFD drugs. These drugs must be ordered by your veterinarian. You may not buy Veterinary Feed Directive ( ...
2014 EASO Position Statement on the Use of Anti
... With this unsatisfactory situation in mind, in 2012 the US Food and Drug Administration (FDA) registered two new drugs (lorcaserine and an extended-release topiramate/phentermine combination) [20] and, recently (September 2014), a third one, namely a combination of naltrexone and bupropion. Lorcaser ...
... With this unsatisfactory situation in mind, in 2012 the US Food and Drug Administration (FDA) registered two new drugs (lorcaserine and an extended-release topiramate/phentermine combination) [20] and, recently (September 2014), a third one, namely a combination of naltrexone and bupropion. Lorcaser ...
The Insults of Illicit Drug Use on Male Fertility
... alcohol use, height, weight, and body mass index. However, a more recent study suggests that different narcotics may have different impacts on male fertility, because men using buprenorphine, a partial-opioid agonist for opioid dependence, reported significantly higher testosterone levels and lower ...
... alcohol use, height, weight, and body mass index. However, a more recent study suggests that different narcotics may have different impacts on male fertility, because men using buprenorphine, a partial-opioid agonist for opioid dependence, reported significantly higher testosterone levels and lower ...
Konuray, A. O., 2008, Development of Tolerance and Dependence
... whose target of action is the brain. Although its use has decreased over the years, phenobarbital is still being prescribed to many patients. As a side effect, phenobarbital enhances the synthesis of its own metabolic enzymes in the liver. This enzyme induction problem causes increased tolerance to ...
... whose target of action is the brain. Although its use has decreased over the years, phenobarbital is still being prescribed to many patients. As a side effect, phenobarbital enhances the synthesis of its own metabolic enzymes in the liver. This enzyme induction problem causes increased tolerance to ...
LEVODOPA
... An alternative but complementary approach has been to restore the normal balance of cholinergic and dopaminergic influences on the basal ganglia with antimuscarinic drugs. The pathophysiologic basis for this therapy is that in idiopathic parkinsonism, dopaminergic neurons in the substantia nigra tha ...
... An alternative but complementary approach has been to restore the normal balance of cholinergic and dopaminergic influences on the basal ganglia with antimuscarinic drugs. The pathophysiologic basis for this therapy is that in idiopathic parkinsonism, dopaminergic neurons in the substantia nigra tha ...
Promega`s P450-GloTM Luminescent Cytochrome
... A large group of enzymes known as cytochromes P450 (CYP or P450) are responsible for the oxidative metabolism of many xenobiotic, hydrophobic chemicals, which include most therapeutic drugs1. P450 metabolism can influence the clearance rate of drugs, their toxicity, and their interactions with other ...
... A large group of enzymes known as cytochromes P450 (CYP or P450) are responsible for the oxidative metabolism of many xenobiotic, hydrophobic chemicals, which include most therapeutic drugs1. P450 metabolism can influence the clearance rate of drugs, their toxicity, and their interactions with other ...
Synthesis and Physicochemical Characterization of Folate
... targeting drug delivery systems. In particular, it was demonstrated that the glutamate γ-carboxyl group activation does not provoke significant loss of folic acid affinity for the receptor. Among the folate-based carriers described in the literature are radionuclide deferoxamine-folate complexes for ...
... targeting drug delivery systems. In particular, it was demonstrated that the glutamate γ-carboxyl group activation does not provoke significant loss of folic acid affinity for the receptor. Among the folate-based carriers described in the literature are radionuclide deferoxamine-folate complexes for ...
Bossong et al 2005 proefprint AB-2
... Meta-chlorophenylpiperazine: mCPP In September 2004, another ecstasy-like drug appeared on the Dutch drug market: meta-chlorophenylpiperazine (mCPP). mCPP is a pharmacologically active metabolite of the antidepressant drugs trazodone, nefazodone and etoperidone and of the minor tranquillizer mepipra ...
... Meta-chlorophenylpiperazine: mCPP In September 2004, another ecstasy-like drug appeared on the Dutch drug market: meta-chlorophenylpiperazine (mCPP). mCPP is a pharmacologically active metabolite of the antidepressant drugs trazodone, nefazodone and etoperidone and of the minor tranquillizer mepipra ...
To Pill or Not to Pill – That is the question… (But what
... etc – SSRIs (Lexapro, Celexa, Zoloft are preferred) For acute behavioral problems when resident is violent and a danger to themselves and others – may consider short term use of antipsychotic medications and rule out possible causes ...
... etc – SSRIs (Lexapro, Celexa, Zoloft are preferred) For acute behavioral problems when resident is violent and a danger to themselves and others – may consider short term use of antipsychotic medications and rule out possible causes ...
ELAEOCARPUS SPHAERICUS EXTRACT Research Article
... (p<0.05) increase in tail flick response. Therefore, it can be inferred that the inhibitory effect of methanolic and aqueous extract at dose 200 mg/kg of Elaeocarpus sphaericus leaves on carrageenan induced inflammation may be due to inhibition of the enzyme cyclooxygenase leading to inhibition of p ...
... (p<0.05) increase in tail flick response. Therefore, it can be inferred that the inhibitory effect of methanolic and aqueous extract at dose 200 mg/kg of Elaeocarpus sphaericus leaves on carrageenan induced inflammation may be due to inhibition of the enzyme cyclooxygenase leading to inhibition of p ...
CRIXIVAN - cri.or.th
... used in combination therapy with other antiretroviral drugs to pospone the occurrence resistance. Indinavir should be administered at optimal therapeutic doses as subobtimal doses of drugs can promote the development of high-level protease resistance. When it is used with others drugs in drugs inter ...
... used in combination therapy with other antiretroviral drugs to pospone the occurrence resistance. Indinavir should be administered at optimal therapeutic doses as subobtimal doses of drugs can promote the development of high-level protease resistance. When it is used with others drugs in drugs inter ...
Sound-Alike/Look-Alike Drugs for Hospital
... Fatal errors have occurred, often due to name similarity, when patients were erroneously given Vincristine intravenously, but at the higher Vinblastine dose. Similar names and some similar strengths have contributed to medication errors. This may represent significant overdose, leading to serious ad ...
... Fatal errors have occurred, often due to name similarity, when patients were erroneously given Vincristine intravenously, but at the higher Vinblastine dose. Similar names and some similar strengths have contributed to medication errors. This may represent significant overdose, leading to serious ad ...
Studies in detail: Blatter et al. (2002)
... Key issue – How to Prevent Drug Abuse ........................................................................................... 33 Evidence in Practice – Content Analysis ............................................................................................... 35 Methodology: use of animals ...
... Key issue – How to Prevent Drug Abuse ........................................................................................... 33 Evidence in Practice – Content Analysis ............................................................................................... 35 Methodology: use of animals ...
Exelon (rivastigmine)
... • Store the medication in its originally labeled, light-resistant container, away from heat and moisture. Heat and moisture may precipitate breakdown of your medication. • Keep your medication out of reach of children. If you have any questions about your medication, consult your physician or pharma ...
... • Store the medication in its originally labeled, light-resistant container, away from heat and moisture. Heat and moisture may precipitate breakdown of your medication. • Keep your medication out of reach of children. If you have any questions about your medication, consult your physician or pharma ...
side effect
... Stepwise approach for managing infants and young children (<5 years Severity class ...
... Stepwise approach for managing infants and young children (<5 years Severity class ...
Aminoglycoside
... Monitor patient for nephrotoxicity periodically .if serum creatinine increases by more than 50% over baseline value it may be advisable to discontinue drug ttt & use less nephrotoxic agent. Monitor neuromuscular function when administering the drug IV. Too rapid administration may cause paralysis & ...
... Monitor patient for nephrotoxicity periodically .if serum creatinine increases by more than 50% over baseline value it may be advisable to discontinue drug ttt & use less nephrotoxic agent. Monitor neuromuscular function when administering the drug IV. Too rapid administration may cause paralysis & ...
... occurring compounds such as morphine and codeine and semi-synthetic drugs such as heroin. Opiates act to control pain by depressing the central nervous system. The drugs demonstrate addictive properties when used for sustained periods of time; symptoms of withdrawal may include sweating, shaking, na ...
view article pdf
... inhibition of peristalsis in the intestines, and glycogen to be broken down into glucose in the liver. Although EPINEPHrine is rapidly metabolized by monoamine oxidase and catechol-O-methyltransferase, it is used as a medication for the resuscitation from anaphylactic shock and the treatment of acut ...
... inhibition of peristalsis in the intestines, and glycogen to be broken down into glucose in the liver. Although EPINEPHrine is rapidly metabolized by monoamine oxidase and catechol-O-methyltransferase, it is used as a medication for the resuscitation from anaphylactic shock and the treatment of acut ...
Document
... Other opioids include synthesised drugs such as methadone, fentanyl and pethidine that have effects analogous to those of the naturally occurring and semi-synthetic opioids.1 Today, opioids are widely used for pain relief in medical and clinical practice but they are also used recreationally for the ...
... Other opioids include synthesised drugs such as methadone, fentanyl and pethidine that have effects analogous to those of the naturally occurring and semi-synthetic opioids.1 Today, opioids are widely used for pain relief in medical and clinical practice but they are also used recreationally for the ...
Macrolide Resistance in Adults with Bacteremic Pneumococcal Pneumonia
... steeply with advancing age (1). Although considerable controversy exists about the clinical impact of pneumococcal drug resistance (2), the prevalence of single-drug and multidrug–resistant pneumococci has increased in the last 2 decades (3,4). Drug-resistant pneumococci clearly emerge under the sel ...
... steeply with advancing age (1). Although considerable controversy exists about the clinical impact of pneumococcal drug resistance (2), the prevalence of single-drug and multidrug–resistant pneumococci has increased in the last 2 decades (3,4). Drug-resistant pneumococci clearly emerge under the sel ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.