DETERMINATION OF LEVOCETIRIZINE CONFIGURATIONAL STABILITY IN TABLETS USING CHIRAL HPLC METHOD Research Article
... concern with conditions required to keep the drugs configurationally stable during manufacturing processes and for the whole shelf life. While pharmacological time scale is concerned with the stability under physiological condition (37 ْ C, pH 7.4) and for the drug residence time in the ...
... concern with conditions required to keep the drugs configurationally stable during manufacturing processes and for the whole shelf life. While pharmacological time scale is concerned with the stability under physiological condition (37 ْ C, pH 7.4) and for the drug residence time in the ...
Cocaine and opioid overdose : Awareness - BTEC
... In fact, the alcohol/cocaine combination is far from benign.7 This mixture produces an active metabolite—cocaethylene—which increases the euphoric effects of cocaine. This metabolite is more toxic than cocaine taken on its own.5,25 For example, cocaethylene has a half-life that is three times greate ...
... In fact, the alcohol/cocaine combination is far from benign.7 This mixture produces an active metabolite—cocaethylene—which increases the euphoric effects of cocaine. This metabolite is more toxic than cocaine taken on its own.5,25 For example, cocaethylene has a half-life that is three times greate ...
Pathway-Dependent Inhibition of Paclitaxel Hydroxylation by Kinase
... neurotoxicity. Recent reports suggest that while CYP2C8*3 is associated with a higher rate of clinical responses, it is also correlated with an increased risk for neurotoxicity (Leskelä et al., 2011; Hertz et al., 2012, 2013). In addition, the CYP3A4*22 genotype has been shown to affect paclitaxel-i ...
... neurotoxicity. Recent reports suggest that while CYP2C8*3 is associated with a higher rate of clinical responses, it is also correlated with an increased risk for neurotoxicity (Leskelä et al., 2011; Hertz et al., 2012, 2013). In addition, the CYP3A4*22 genotype has been shown to affect paclitaxel-i ...
Fabrication and Evaluation of Curcumin-loaded
... Although curcumin has shown a wide range of pharmacological activities, there were also some potential limitations. Photodegradation, short half-life and low bioavailability were major hurdles for the therapeutic use of curcumin. curcumin, with phenolic group and conjugated double bounds, which is u ...
... Although curcumin has shown a wide range of pharmacological activities, there were also some potential limitations. Photodegradation, short half-life and low bioavailability were major hurdles for the therapeutic use of curcumin. curcumin, with phenolic group and conjugated double bounds, which is u ...
413 - The AIDS InfoNet
... Didanosine can interact with other drugs or supplements you are taking. These interactions can change the amount of each drug in your bloodstream and cause an underor overdose. New interactions are constantly being identified. Make sure that your health care provider knows about ALL drugs and supple ...
... Didanosine can interact with other drugs or supplements you are taking. These interactions can change the amount of each drug in your bloodstream and cause an underor overdose. New interactions are constantly being identified. Make sure that your health care provider knows about ALL drugs and supple ...
(HMG-CoA) REDUCTASE INHIBITORS ON THE CYP3A4
... inhibition of mexazolam metabolism in male and female human liver microsomes by HMG-CoA reductase inhibitors were determined by a Dixon plot (Fig. 5, a and b; Table 3). The formation of M-1 from mexazolam in human liver microsomes was not inhibited by pravastatin (acid form), but it was inhibited co ...
... inhibition of mexazolam metabolism in male and female human liver microsomes by HMG-CoA reductase inhibitors were determined by a Dixon plot (Fig. 5, a and b; Table 3). The formation of M-1 from mexazolam in human liver microsomes was not inhibited by pravastatin (acid form), but it was inhibited co ...
Archives of Medical Research
... lipid peroxidation (26). The fact that orally administered SOD decreases the serum concentrations of malondialdehyde suggests that SOD is absorbed by the gastrointestinal tract. The reason for this absorption may be due to the nelaton tube, which allowed delivery of the drug directly into the small ...
... lipid peroxidation (26). The fact that orally administered SOD decreases the serum concentrations of malondialdehyde suggests that SOD is absorbed by the gastrointestinal tract. The reason for this absorption may be due to the nelaton tube, which allowed delivery of the drug directly into the small ...
combined hormonal contraception
... Is cost effective A monophasic COC containing 20 - 35 micrograms of ethinylestradiol with a low dose of either norethisterone or levonorgestrel is a suitable first line option. Examples are Rigevidon, Ovranette, Microgynon 30, Ovysmen, Brevinor, Loestrin 30. Tailored regimes may improve bleeding p ...
... Is cost effective A monophasic COC containing 20 - 35 micrograms of ethinylestradiol with a low dose of either norethisterone or levonorgestrel is a suitable first line option. Examples are Rigevidon, Ovranette, Microgynon 30, Ovysmen, Brevinor, Loestrin 30. Tailored regimes may improve bleeding p ...
Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery
... examples of nanotechnology application.1-3 Nanoparticles can improve drug efficacy in cancer and other diseases, while simultaneously diminishing side effects, due to features such as more targeted localization in tumors and active cellular uptake.4-6 The reason why nanomaterials are excellent candi ...
... examples of nanotechnology application.1-3 Nanoparticles can improve drug efficacy in cancer and other diseases, while simultaneously diminishing side effects, due to features such as more targeted localization in tumors and active cellular uptake.4-6 The reason why nanomaterials are excellent candi ...
mind altering… synthetic (designer) and naturally occuring
... who can use it to alleviate neuropathic pain, spasticity, overactive bladder, and other symptoms. Sativex is also being prescribed to alleviate pain due to cancer and has been researched in various models of peripheral and central neuropathic pain. Sativex is distinct from all other pharmaceutically ...
... who can use it to alleviate neuropathic pain, spasticity, overactive bladder, and other symptoms. Sativex is also being prescribed to alleviate pain due to cancer and has been researched in various models of peripheral and central neuropathic pain. Sativex is distinct from all other pharmaceutically ...
Interactions between the cytochrome P450 system and
... is to measure the clearance rate of caffeine, a substrate of this enzyme. Bertilsson and associates43 observed that individuals who rapidly cleared caffeine had lower serum levels of clozapine after receiving a single dose of this medication. Bender and Eap44 observed that in 2 individuals who were ...
... is to measure the clearance rate of caffeine, a substrate of this enzyme. Bertilsson and associates43 observed that individuals who rapidly cleared caffeine had lower serum levels of clozapine after receiving a single dose of this medication. Bender and Eap44 observed that in 2 individuals who were ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
... Headache, dyspepsia, nausea, dizziness, insomnia, liver dysfunction Zafirlukast Headache, nausea, diarrhea, liver dysfunction Montelukast has fewer adverse effects ...
... Headache, dyspepsia, nausea, dizziness, insomnia, liver dysfunction Zafirlukast Headache, nausea, diarrhea, liver dysfunction Montelukast has fewer adverse effects ...
Antiplatelet drugs compared - Consumer Reports Best Buy Drugs
... Six Groups Who Might Need an Antiplatelet Drug It’s useful to divide the population of people who need aspirin or another antiplatelet drug into six groups: ■ People who have risk factors that make them ...
... Six Groups Who Might Need an Antiplatelet Drug It’s useful to divide the population of people who need aspirin or another antiplatelet drug into six groups: ■ People who have risk factors that make them ...
Microtubule-active drugs: mechanism of action and resistance
... Cytoskeleton has been shown to participate in almost every aspect in the life of a cell and the list of its functions by far extends the original designation of cytoskeleton as a static "scaffold". Three essential classes of cytoskeletal structures exist, one of them being microtubules, the other tw ...
... Cytoskeleton has been shown to participate in almost every aspect in the life of a cell and the list of its functions by far extends the original designation of cytoskeleton as a static "scaffold". Three essential classes of cytoskeletal structures exist, one of them being microtubules, the other tw ...
Young Innovators 2009
... We have queried the cmap to identify drugs that might be connected to AD. Hits with statistically significant negative connectivity scores can be considered as potential treatments. Although the two gene signatures used to query the cmap shared no common genes, both queries resulted in common list o ...
... We have queried the cmap to identify drugs that might be connected to AD. Hits with statistically significant negative connectivity scores can be considered as potential treatments. Although the two gene signatures used to query the cmap shared no common genes, both queries resulted in common list o ...
O R I G I N A L A R T I C L E
... pargyline > clorgyline > iproniazid > fluoxetine > desipramine > amitriptyline > imipramine > citalopram > venlafaxine > reboxetine > olanzapine > mirtazapine > tianeptine > moclobemide, cocaine >> lithium, valproate. MAO-B was inhibited by the following drugs: pargyline > clorgyline > iproniazid > ...
... pargyline > clorgyline > iproniazid > fluoxetine > desipramine > amitriptyline > imipramine > citalopram > venlafaxine > reboxetine > olanzapine > mirtazapine > tianeptine > moclobemide, cocaine >> lithium, valproate. MAO-B was inhibited by the following drugs: pargyline > clorgyline > iproniazid > ...
MPT Regimen - Cancer Care Ontario
... Swallow capsules whole; they should not be broken, chewed, or opened. Thalidomide should be administered at bedtime to minimize adverse effects such as dizziness and somnolence. Avoid use of alcohol since this may potentiate sedation. Do not extensively handle the capsules. Females who may become or ...
... Swallow capsules whole; they should not be broken, chewed, or opened. Thalidomide should be administered at bedtime to minimize adverse effects such as dizziness and somnolence. Avoid use of alcohol since this may potentiate sedation. Do not extensively handle the capsules. Females who may become or ...
Product Information – Australia Atenolol. Chemical Name:
... Eye and Skin Reactions Various skin rashes and conjunctival xerosis have been reported with beta-blockers. Cross-reactions may occur between beta-blockers, therefore substitutions within the group may not necessarily preclude occurrence of symptoms. During long-term treatment with the beta-blocking ...
... Eye and Skin Reactions Various skin rashes and conjunctival xerosis have been reported with beta-blockers. Cross-reactions may occur between beta-blockers, therefore substitutions within the group may not necessarily preclude occurrence of symptoms. During long-term treatment with the beta-blocking ...
Dusano-ISAP-post
... • While measuring the biomarker is straightforward, there are issues about the surrogate endpoint (discussed shortly) • Why do we do reasonably well with identifying exposure-response relationships in antiinfective trials? • The answer is that the MIC gives us a normalizing measure for docking the s ...
... • While measuring the biomarker is straightforward, there are issues about the surrogate endpoint (discussed shortly) • Why do we do reasonably well with identifying exposure-response relationships in antiinfective trials? • The answer is that the MIC gives us a normalizing measure for docking the s ...
The Commodity Management Cycle
... Use: The person living with HIV/AIDS (PLWA) is the key end-user; other users include laboratory staff who use laboratory commodities to perform lab tests needed by PLWA, clinical staff who will issue or use the medical supplies to care for the PLWA. In the next sections, we shall look at each compo ...
... Use: The person living with HIV/AIDS (PLWA) is the key end-user; other users include laboratory staff who use laboratory commodities to perform lab tests needed by PLWA, clinical staff who will issue or use the medical supplies to care for the PLWA. In the next sections, we shall look at each compo ...
Understanding FDA Regulatory Requirements for Investigational
... involves the use of a drug.8 Hence, to authorize a drug study in humans, the FDA requires sufficient information to assess the safety of the intended research study. The IND is the mechanism by which by the investigator or sponsor provides the requisite information to obtain authorization to adminis ...
... involves the use of a drug.8 Hence, to authorize a drug study in humans, the FDA requires sufficient information to assess the safety of the intended research study. The IND is the mechanism by which by the investigator or sponsor provides the requisite information to obtain authorization to adminis ...
Institutional Diversion Prevention, Detection and Response
... pharmacy and the supervisor of the employee suspected of diversion • Structured according to organizational culture and preferences • Must be able to meet on very short notice and at odd hours • Must have the authority to require a drug screen and to suspend an employee ...
... pharmacy and the supervisor of the employee suspected of diversion • Structured according to organizational culture and preferences • Must be able to meet on very short notice and at odd hours • Must have the authority to require a drug screen and to suspend an employee ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.