Intravenous Agents - RAH
... the rapidly acting agents are relatively unionised at plasma pH and are absorbed according to their lipid solubility thiopentone, being highly lipid soluble, equilibrates with the brain rapidly phenobarbital, with relatively low lipid solubility, may take over 15 mins to achieve unconsciousness when ...
... the rapidly acting agents are relatively unionised at plasma pH and are absorbed according to their lipid solubility thiopentone, being highly lipid soluble, equilibrates with the brain rapidly phenobarbital, with relatively low lipid solubility, may take over 15 mins to achieve unconsciousness when ...
Indole alkaloids
... • is the dried whole plant of catharanthus roseus. F. Apocynaceae. • Folklore uses as an oral hypoglycemic agent. • It contain 150 alkaloids, the most important are the anticancer agents vincristine and vinblastine. • These are complex bisindole (dimeric indole) natural products present in small qua ...
... • is the dried whole plant of catharanthus roseus. F. Apocynaceae. • Folklore uses as an oral hypoglycemic agent. • It contain 150 alkaloids, the most important are the anticancer agents vincristine and vinblastine. • These are complex bisindole (dimeric indole) natural products present in small qua ...
Depressants and inhalants
... Meprobamate (Miltown) was the first in 1955 for this purpose, although its effects resulted more from its sedative properties than from its ability to relieve anxiety. ...
... Meprobamate (Miltown) was the first in 1955 for this purpose, although its effects resulted more from its sedative properties than from its ability to relieve anxiety. ...
Tutorial - 3: Diuretics
... 19. Compound ____________ is an example of hydrothiazide and its name is _____________. 20. The name of the compound J is ____________________ and it is an example of _________________________ diuretics and it acts at site _________ in the __________________________________________ and _____________ ...
... 19. Compound ____________ is an example of hydrothiazide and its name is _____________. 20. The name of the compound J is ____________________ and it is an example of _________________________ diuretics and it acts at site _________ in the __________________________________________ and _____________ ...
New Functions of Old Drugs: Aureolic Acid Group of Anti
... preferential COX-1 inhibitors or older NSAIDs may be much more effective because their side effects are well studied and can be managed by using combination drug treatment. Despite the above problems it may not be wise to discard the COX-2 selective NSAIDs because they have immense potential against ...
... preferential COX-1 inhibitors or older NSAIDs may be much more effective because their side effects are well studied and can be managed by using combination drug treatment. Despite the above problems it may not be wise to discard the COX-2 selective NSAIDs because they have immense potential against ...
Antihistamines - Consumer Health Choices
... But severe allergic reactions do occur and can be lifethreatening. They are mostly reactions to insect stings, drugs, or foods—not to mold, pollen, or other hay-fever triggers. You might have heard the term “anaphylactic shock.” This is a type of allergic reaction in which a large amount of histamin ...
... But severe allergic reactions do occur and can be lifethreatening. They are mostly reactions to insect stings, drugs, or foods—not to mold, pollen, or other hay-fever triggers. You might have heard the term “anaphylactic shock.” This is a type of allergic reaction in which a large amount of histamin ...
PRODUCT CIRCULAR Tablets HYZAAR (losartan potassium and
... reported to reduce levels of active metabolite. The clinical consequences of these interactions have not been evaluated. As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, ...
... reported to reduce levels of active metabolite. The clinical consequences of these interactions have not been evaluated. As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, ...
Spring Newsletter April 2016
... Step therapy requirements – Some drugs on the Plan’s formulary are available on a step therapy basis. This means that certain other drugs must be tried before the step therapy drug will be allowed. If there is evidence in the member’s drug history that he/she has had the lower step drug or drugs, no ...
... Step therapy requirements – Some drugs on the Plan’s formulary are available on a step therapy basis. This means that certain other drugs must be tried before the step therapy drug will be allowed. If there is evidence in the member’s drug history that he/she has had the lower step drug or drugs, no ...
GOUT LEARNING OBJECTIVES • At the end of lecture students
... It suppresses inflammatory process only in gout. Although it is not analgesic but it relieves pain in acute attack of gout as it suppresses inflammatory process. Colchicine binds with tubulin and inhibits the migration of macrophages and neutrophils at the site of inflammation. It also inhibits the ...
... It suppresses inflammatory process only in gout. Although it is not analgesic but it relieves pain in acute attack of gout as it suppresses inflammatory process. Colchicine binds with tubulin and inhibits the migration of macrophages and neutrophils at the site of inflammation. It also inhibits the ...
Beta blocker sotalol metoprolol conversion calculator
... Blockers, Vasodilators, anti. I have been experiencing palpitations for 18 months now and am exhausted from them. I have been put on beta blockers to see if they can control them. as I have. Beta-Blocker Equivalent Doses • The effect of BB in HF is not a class effect. It is recommended that patients ...
... Blockers, Vasodilators, anti. I have been experiencing palpitations for 18 months now and am exhausted from them. I have been put on beta blockers to see if they can control them. as I have. Beta-Blocker Equivalent Doses • The effect of BB in HF is not a class effect. It is recommended that patients ...
MS_Word ~ 184 KB
... ‘Medication Management Plan’ or otherwise), as part of the patient’s health care record, must be in accordance with the facility’s local protocols and procedures. Facilities must establish systems and implement local protocols for the regular review of medication orders, as appropriate in the partic ...
... ‘Medication Management Plan’ or otherwise), as part of the patient’s health care record, must be in accordance with the facility’s local protocols and procedures. Facilities must establish systems and implement local protocols for the regular review of medication orders, as appropriate in the partic ...
Sabiduría Spring 2015 Table of Contents
... refers to the relationship between drug concentration at the site of action and the resulting effect, including the time course and intensity of therapeutic and adverse events (“side effects”). The thesis of this research paper is that both pharmacokinetics and pharmacodynamics are key components of ...
... refers to the relationship between drug concentration at the site of action and the resulting effect, including the time course and intensity of therapeutic and adverse events (“side effects”). The thesis of this research paper is that both pharmacokinetics and pharmacodynamics are key components of ...
Issue 4 - Society of Forensic Toxicologists
... system depressant, but at low doses can act as a stimulant by depression of inhibitory centers. It is used primarily in social settings and rarely used for medicinal purposes (1). Ethanol is very water soluble and distributes evenly throughout the human body. This allows ethanol concentrations to be ...
... system depressant, but at low doses can act as a stimulant by depression of inhibitory centers. It is used primarily in social settings and rarely used for medicinal purposes (1). Ethanol is very water soluble and distributes evenly throughout the human body. This allows ethanol concentrations to be ...
DRUG PROFILES Structural formula of Losartan
... agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP. Clopidogrel does not inhibit phosphor diesterase activity (Chan et al., ...
... agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP. Clopidogrel does not inhibit phosphor diesterase activity (Chan et al., ...
Dabigatran
... – Elderly, pediatrics, pregnant – Heparin compromised (e.g., HIT) – Acute vs non-acute VTE – Chronically ill ...
... – Elderly, pediatrics, pregnant – Heparin compromised (e.g., HIT) – Acute vs non-acute VTE – Chronically ill ...
full prescribing information
... Plasma concentrations at any given dose are generally higher in the elderly: proceed slowly with dose escalation. The starting dose should be 5 mg/day for all elderly patients. Then titrate elderly patients according to weight, but to half the dose presented in Table 1, as tolerated. If necessary an ...
... Plasma concentrations at any given dose are generally higher in the elderly: proceed slowly with dose escalation. The starting dose should be 5 mg/day for all elderly patients. Then titrate elderly patients according to weight, but to half the dose presented in Table 1, as tolerated. If necessary an ...
Dyslipidemia - Annals of Internal Medicine
... lipid profile, discuss adherence, side effects If LDL-C goal not achieved consider intensification of therapy (reevaluate in 6 weeks) Add new/add’l drugs 1 at a time to help assess adverse effects if they occur Routine LFTs not recommended for patients on statins Behavioral lifestyle chang ...
... lipid profile, discuss adherence, side effects If LDL-C goal not achieved consider intensification of therapy (reevaluate in 6 weeks) Add new/add’l drugs 1 at a time to help assess adverse effects if they occur Routine LFTs not recommended for patients on statins Behavioral lifestyle chang ...
About the Guide - American Chemical Society
... (endorphins and enkephalins. There are three kinds of receptors widely distributed throughout the brain—mu, delta, and kappa receptors. These receptors, through second messengers, also influence the likelihood that ion channels (primarily chloride ion) will open, which in certain cases reduces the ...
... (endorphins and enkephalins. There are three kinds of receptors widely distributed throughout the brain—mu, delta, and kappa receptors. These receptors, through second messengers, also influence the likelihood that ion channels (primarily chloride ion) will open, which in certain cases reduces the ...
Prevention of prescription opioid abuse
... self-administration of a medication for a nonmedical purpose such as altering one’s state of consciousness (for example, “getting high”) dAddiction: a primary, chronic, neurobiological disease, with genetic, psychosocial and environmental factors influencing its development and manifestations; it is ...
... self-administration of a medication for a nonmedical purpose such as altering one’s state of consciousness (for example, “getting high”) dAddiction: a primary, chronic, neurobiological disease, with genetic, psychosocial and environmental factors influencing its development and manifestations; it is ...
effects of cytochrome p450 enzyme inhibitors and inducers
... The human body eliminates foreign compounds primarily by metabolizing them to hydrophilic forms to facilitate effective excretion through the kidneys. Cytochrome P450 (CYP) enzymes in the liver and intestine contribute to the metabolism of many drugs. Pharmacokinetic drugdrug interactions occur if t ...
... The human body eliminates foreign compounds primarily by metabolizing them to hydrophilic forms to facilitate effective excretion through the kidneys. Cytochrome P450 (CYP) enzymes in the liver and intestine contribute to the metabolism of many drugs. Pharmacokinetic drugdrug interactions occur if t ...
Fluphenazine Decanoate Injection, USP Package Insert
... crises, opisthotonos, and hyperreflexia. Muscle rigidity sometimes accompanied by hyperthermia has been reported following use of fluphenazine decanoate. Most often these extrapyramidal symptoms are reversible; however, they may be persistent (see below). The frequency of such reactions is related i ...
... crises, opisthotonos, and hyperreflexia. Muscle rigidity sometimes accompanied by hyperthermia has been reported following use of fluphenazine decanoate. Most often these extrapyramidal symptoms are reversible; however, they may be persistent (see below). The frequency of such reactions is related i ...
Guideline on the Evaluation of the Pharmacokinetics of
... Pharmacokinetic studies are used to identify special subgroups of patients in whom an alternative dosing regimen may be indicated for efficacy and/or safety reasons. Since liver is an important organ with respect to drug disposition, patients with hepatic impairment constitute an important subgroup ...
... Pharmacokinetic studies are used to identify special subgroups of patients in whom an alternative dosing regimen may be indicated for efficacy and/or safety reasons. Since liver is an important organ with respect to drug disposition, patients with hepatic impairment constitute an important subgroup ...
Drug and Alcohol Abuse Policy - John Paul the Great Catholic
... Alcohol is a central nervous system depressant and it is the central nervous system which is the bodily system that is most severely affected by alcohol (see chart below). The degree to which the central nervous system function is impaired is directly proportional to the concentration of alcohol in ...
... Alcohol is a central nervous system depressant and it is the central nervous system which is the bodily system that is most severely affected by alcohol (see chart below). The degree to which the central nervous system function is impaired is directly proportional to the concentration of alcohol in ...
Prolonged dexmedetomidine infusion to facilitate drug detoxification
... and withdrawal process itself and these patients are prone to develop delirium in ICU. Unfortunately the drugs of choice such as benzodiazepine and opioid are similar to ones that are abused. Once patient’s primary condition improved, smooth withdrawal of sedative-analgesic without psychomimetic sym ...
... and withdrawal process itself and these patients are prone to develop delirium in ICU. Unfortunately the drugs of choice such as benzodiazepine and opioid are similar to ones that are abused. Once patient’s primary condition improved, smooth withdrawal of sedative-analgesic without psychomimetic sym ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.