Effects of Acute and Repeated Administration of Oxycodone and
... been used for almost 100 years in medicine, mostly for the treatment of various forms of pain (Kalso, 2005; Wightman et al., 2012). Although oxycodone has excellent efficacy as an analgesic, it also produces tolerance and dependence, similar to other opioid compounds (Mars et al., 2014). Patients tr ...
... been used for almost 100 years in medicine, mostly for the treatment of various forms of pain (Kalso, 2005; Wightman et al., 2012). Although oxycodone has excellent efficacy as an analgesic, it also produces tolerance and dependence, similar to other opioid compounds (Mars et al., 2014). Patients tr ...
BIAXIN® Filmtab® (clarithromycin tablets, USP) BIAXIN
... administered with clarithromycin (a theophylline sustained-release formulation was dosed at either 6.5 mg/kg or 12 mg/kg together with 250 or 500 mg q12h clarithromycin), the steady-state levels of Cmax, Cmin, and the area under the serum concentration time curve (AUC) of theophylline increased abou ...
... administered with clarithromycin (a theophylline sustained-release formulation was dosed at either 6.5 mg/kg or 12 mg/kg together with 250 or 500 mg q12h clarithromycin), the steady-state levels of Cmax, Cmin, and the area under the serum concentration time curve (AUC) of theophylline increased abou ...
DRUG NAME: Tamoxifen
... Tamoxifen may also have cytotoxic activity; tamoxifen may induce apoptosis independent of estrogen receptor ...
... Tamoxifen may also have cytotoxic activity; tamoxifen may induce apoptosis independent of estrogen receptor ...
“All flesh is coupled by the wave of circular rotational similarity” 1
... science consists of several special directions. A fruitful professional dialog does not necessarily occur between experimenters and clinicians. We would like this book to be available not only for representatives of theoretical medicine (pharmacologists, physiologists, and immunologists), but also f ...
... science consists of several special directions. A fruitful professional dialog does not necessarily occur between experimenters and clinicians. We would like this book to be available not only for representatives of theoretical medicine (pharmacologists, physiologists, and immunologists), but also f ...
NIH Public Access - The Scripps Research Institute
... Indeed, as noted above, h/rFAAH exhibited an inhibitor sensitivity profile that matched closely with that of hFAAH regardless of inhibition mechanism (reversible or irreversible) or species specificity (higher potency for hFAAH or rFAAH). This strategy finally led to the 2nd crystal structure of FAA ...
... Indeed, as noted above, h/rFAAH exhibited an inhibitor sensitivity profile that matched closely with that of hFAAH regardless of inhibition mechanism (reversible or irreversible) or species specificity (higher potency for hFAAH or rFAAH). This strategy finally led to the 2nd crystal structure of FAA ...
IDENTIFICATION OF NATURAL PRODUCTS AS ANTIDIABETIC AGENTS Laura Guasch Pàmies
... agents are medications that work to lower blood glucose concentrations (i.e., the amount of sugar in the blood). There are different classes of antidiabetic drugs, and their selection depends on the nature of the diabetes and the age and situation of the person, as well as other factors. Antidiabeti ...
... agents are medications that work to lower blood glucose concentrations (i.e., the amount of sugar in the blood). There are different classes of antidiabetic drugs, and their selection depends on the nature of the diabetes and the age and situation of the person, as well as other factors. Antidiabeti ...
HIGHLIGHTS OF PRESCRIBING INFORMATION FULL
... The breast milk of 12 lactating women following administration of ella was collected in 24-hour increments to measure the concentrations of ulipristal acetate and monodemethyl-ulipristal acetate in breast milk. The mean daily concentrations of ulipristal acetate in breast milk were 22.7 ng/mL [0-24 ...
... The breast milk of 12 lactating women following administration of ella was collected in 24-hour increments to measure the concentrations of ulipristal acetate and monodemethyl-ulipristal acetate in breast milk. The mean daily concentrations of ulipristal acetate in breast milk were 22.7 ng/mL [0-24 ...
Journal home page: http://www.iajpr.com/index.php/en/ INDO
... Diabetes mellitus is metabolic disorder which independent risk factor for coronary artery disease, hypertension, myocardial infaraction & hyperlipidemia. Diabetes & its related complication are closely related with free radical induced oxidative stress. Any antidiabetic drug can acts via multidirect ...
... Diabetes mellitus is metabolic disorder which independent risk factor for coronary artery disease, hypertension, myocardial infaraction & hyperlipidemia. Diabetes & its related complication are closely related with free radical induced oxidative stress. Any antidiabetic drug can acts via multidirect ...
AusPAR: Sevelamer hydrochloride
... allylamine content, epichlorohydrin content and particle size are in line or tighter than those specified in the draft USP monograph for sevelamer hydrochloride. All of the tests have been adequately described and were adequately validated. The level of total titratable amines in the drug substance ...
... allylamine content, epichlorohydrin content and particle size are in line or tighter than those specified in the draft USP monograph for sevelamer hydrochloride. All of the tests have been adequately described and were adequately validated. The level of total titratable amines in the drug substance ...
C 3 R
... Cytochrome P450 (P450s) are involved in the metabolism of approximately 80% of the drugs currently on the market (1, 2). In some cases drugs can be oxidized by P450s to electrophilic reactive intermediates, which subsequently can react with nucleophilic functional groups in biomolecules such as prot ...
... Cytochrome P450 (P450s) are involved in the metabolism of approximately 80% of the drugs currently on the market (1, 2). In some cases drugs can be oxidized by P450s to electrophilic reactive intermediates, which subsequently can react with nucleophilic functional groups in biomolecules such as prot ...
MAGNESIUM SULFATE IN 5% DEXTROSE
... abnormalities in the developing fetus. These bone abnormalities include skeletal demineralization and osteopenia. In addition, cases of neonatal fracture have been reported. The shortest duration of treatment that can lead to fetal harm is not known. Magnesium sulfate should be used during pregnancy ...
... abnormalities in the developing fetus. These bone abnormalities include skeletal demineralization and osteopenia. In addition, cases of neonatal fracture have been reported. The shortest duration of treatment that can lead to fetal harm is not known. Magnesium sulfate should be used during pregnancy ...
Research Paper Synthesis and Evaluation of Clozapine
... phosphoroxycloride and benzene are used. This present synthetic process, it avoid the use of above toxic chemicals and makes use of less toxic and safe chemicals like TiCl4 and ethyl acetate. The impurity profiling for this synthetic process by HPLC has revealed four impurities viz; starting materia ...
... phosphoroxycloride and benzene are used. This present synthetic process, it avoid the use of above toxic chemicals and makes use of less toxic and safe chemicals like TiCl4 and ethyl acetate. The impurity profiling for this synthetic process by HPLC has revealed four impurities viz; starting materia ...
Acetaminophen
... (NAPQI). This compound is under normal doses rapidly detoxified by conjugation with reduced glutathione, which are further transformed to mercapturic acid conjugates. With high doses of acetaminophen, the glutathione deposits may be depleted, and the glucuronidation and sulfation pathways become sat ...
... (NAPQI). This compound is under normal doses rapidly detoxified by conjugation with reduced glutathione, which are further transformed to mercapturic acid conjugates. With high doses of acetaminophen, the glutathione deposits may be depleted, and the glucuronidation and sulfation pathways become sat ...
Performance Enhancing Hormone Doping in Sport
... TUE 13. This exempts the athlete from the Code’s strict liability provision and permits them to compete during ongoing treatment. WADA provides medical guidelines that standardize the evaluation and management of TUE applications for a range of medical illnesses. A TUE is granted by a national anti- ...
... TUE 13. This exempts the athlete from the Code’s strict liability provision and permits them to compete during ongoing treatment. WADA provides medical guidelines that standardize the evaluation and management of TUE applications for a range of medical illnesses. A TUE is granted by a national anti- ...
psychoactive substances
... or drugs amount to €12,700 or more. In the case of individuals who are addicted to drugs and where their addiction is a substantial factor in their drug dealing, the sentence may be reviewed after five years. This Act also created the offence of money laundering which involves concealing or disguisi ...
... or drugs amount to €12,700 or more. In the case of individuals who are addicted to drugs and where their addiction is a substantial factor in their drug dealing, the sentence may be reviewed after five years. This Act also created the offence of money laundering which involves concealing or disguisi ...
Sterile Vancomycin Hydrochloride, USP
... that the result should be considered equivocal, and if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situation ...
... that the result should be considered equivocal, and if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situation ...
Third Amended Master Consolidated Class Action Complaint
... The Johnson & Johnson Group Has Been the Target of Government Investigations .................................................................................................161 ...
... The Johnson & Johnson Group Has Been the Target of Government Investigations .................................................................................................161 ...
Cannabis Report of the Swiss Federal Commission For Drug Issues
... (the Subcommission for Drug Issues attached to the Federal Narcotics Commission which was disbanded in 1996) had always assumed the view all illegal drugs were equivalent, as the basis for its discussions and reports; however, the marked changes that had taken place in the drug scene subsequently ca ...
... (the Subcommission for Drug Issues attached to the Federal Narcotics Commission which was disbanded in 1996) had always assumed the view all illegal drugs were equivalent, as the basis for its discussions and reports; however, the marked changes that had taken place in the drug scene subsequently ca ...
PEGylation of Biopharmaceuticals: A Review of Chemistry and
... A commercial product may consist of multiple positional isomers and each could have differential effects on pharmacologic, toxicologic, and immunogenic activity. The primary impurities in the final conjugate that need to be minimized are the native unPEGylated protein, unreacted or free PEG, and mult ...
... A commercial product may consist of multiple positional isomers and each could have differential effects on pharmacologic, toxicologic, and immunogenic activity. The primary impurities in the final conjugate that need to be minimized are the native unPEGylated protein, unreacted or free PEG, and mult ...
Tumescent Technique Chronicles Local Anesthesia, Liposuction
... The reality of tumescent liposuction is just the opposite of what one might expect based on common sense and experience. The dilution of a local anesthetic solution of lidocaine and epinephrine does not weaken its effect, it actually enhances the degree of anesthesia, and vasoconstriction. Although ...
... The reality of tumescent liposuction is just the opposite of what one might expect based on common sense and experience. The dilution of a local anesthetic solution of lidocaine and epinephrine does not weaken its effect, it actually enhances the degree of anesthesia, and vasoconstriction. Although ...
Development and preliminary evidence for the validity of an
... alert that does not require that a meaningful response will result in a decrease, and eventual elimination, of responding to the alert. This risk highlights the importance of reducing the rate of false alarms, as well as the importance of an alarm philosophy that minimizes alerts overall. Habituatio ...
... alert that does not require that a meaningful response will result in a decrease, and eventual elimination, of responding to the alert. This risk highlights the importance of reducing the rate of false alarms, as well as the importance of an alarm philosophy that minimizes alerts overall. Habituatio ...
TRIDURAL Product Monograph
... In general, caution should be used when selecting the dose for an elderly patient. The elimination half-life of tramadol may be prolonged in patients over 75 years, thereby increasing the potential for adverse events. Usually, dose administration should start at the low end of the dosing range, refl ...
... In general, caution should be used when selecting the dose for an elderly patient. The elimination half-life of tramadol may be prolonged in patients over 75 years, thereby increasing the potential for adverse events. Usually, dose administration should start at the low end of the dosing range, refl ...
S F R SAMHSA
... levels. It is highly bound to plasma protein and is inactivated by enzymatic transformation via N-dealkylation and conjugation (Elkader & Sproule, 2005). Buprenorphine is widely distributed, with peak plasma concentration occurring at about 90 minutes and a half-life of 4 to 5 hours. It is metaboliz ...
... levels. It is highly bound to plasma protein and is inactivated by enzymatic transformation via N-dealkylation and conjugation (Elkader & Sproule, 2005). Buprenorphine is widely distributed, with peak plasma concentration occurring at about 90 minutes and a half-life of 4 to 5 hours. It is metaboliz ...
HIGHLIGHTS OF PRESCRIBING INFORMATION
... 5.2 Increased Risk of ALT Elevations During clinical trials with VIEKIRA PAK with or without ribavirin, elevations of ALT to greater than 5 times the upper limit of normal (ULN) occurred in approximately 1% of all subjects [see Adverse Reactions (6.1)]. ALT elevations were typically asymptomatic, oc ...
... 5.2 Increased Risk of ALT Elevations During clinical trials with VIEKIRA PAK with or without ribavirin, elevations of ALT to greater than 5 times the upper limit of normal (ULN) occurred in approximately 1% of all subjects [see Adverse Reactions (6.1)]. ALT elevations were typically asymptomatic, oc ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.