Central Nervous System Depressant, Analgesic and Antidiarrheal
... (DOAJ), African Journal Online, Bioline International, Open-J-Gate and Pharmacy Abstracts ...
... (DOAJ), African Journal Online, Bioline International, Open-J-Gate and Pharmacy Abstracts ...
ABSTRACT Title of Document:
... during our MR imaging sessions. I would also like to thank the staff at the animal MRI facility at the NIH, as I have greatly appreciated their eager willingness always to help. I thank Dr. Ginger Tansey and the veterinary technicians: Denise Parker, Mark Lawson, Carrie Silver, Beth Case, Mark Szar ...
... during our MR imaging sessions. I would also like to thank the staff at the animal MRI facility at the NIH, as I have greatly appreciated their eager willingness always to help. I thank Dr. Ginger Tansey and the veterinary technicians: Denise Parker, Mark Lawson, Carrie Silver, Beth Case, Mark Szar ...
STATISTICAL OPTIMIZATION OF FIXED DOSE COMBINATION OF GLIMEPIRIDE AND ATORVASTATIN CALCIUM IN IMMEDIATE RELEASE TABLET FORMULATION
... Long term administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet with insulin. For this complication atorvastatin calcium can be used to reduce the cardiovascular mortility. The objective ...
... Long term administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet with insulin. For this complication atorvastatin calcium can be used to reduce the cardiovascular mortility. The objective ...
Pharmacotherapy of Angina Pectoris
... – aspirin exerts an antithrombotic effect by inhibiting cyclooxygenase and synthesis of platelet TXA2 – in patients with stable angina, aspirin reduces the risk of adverse cardiovascular events by 33% – in patients with unstable angina, aspirin decreases the short and long-term risk of fatal and non ...
... – aspirin exerts an antithrombotic effect by inhibiting cyclooxygenase and synthesis of platelet TXA2 – in patients with stable angina, aspirin reduces the risk of adverse cardiovascular events by 33% – in patients with unstable angina, aspirin decreases the short and long-term risk of fatal and non ...
Impact of amiodarone and cisapride on simulated human ventricular
... Both drugs show similar prolongation of the QT interval, although they present different electrophysiological properties in the single-cell as well as in tissue simulations of cardiac excitation propagation. These computer simulations help to better understand the underlying mechanisms responsible f ...
... Both drugs show similar prolongation of the QT interval, although they present different electrophysiological properties in the single-cell as well as in tissue simulations of cardiac excitation propagation. These computer simulations help to better understand the underlying mechanisms responsible f ...
Folie 1 - Leibniz Institute for Age Research
... ACD-SC: Database from Molecular Design Ltd. Agonists: Known active compounds Docking of ligands to the estrogen receptor (nuclear hormone receptor) ...
... ACD-SC: Database from Molecular Design Ltd. Agonists: Known active compounds Docking of ligands to the estrogen receptor (nuclear hormone receptor) ...
7 Antifungal therapy c h a P t e r
... a several human cases of blastomycosis in 1957 illustrate the speed with which the search for effective and safe antifungal agents was progressing.12,13 The introduction of oral griseofulvin and topical chlormidazole in 1958 and the subsequent introduction of IV AmB in 1960 heralded the beginning of ...
... a several human cases of blastomycosis in 1957 illustrate the speed with which the search for effective and safe antifungal agents was progressing.12,13 The introduction of oral griseofulvin and topical chlormidazole in 1958 and the subsequent introduction of IV AmB in 1960 heralded the beginning of ...
Safety Evaluation of a Combination, Defined Extract of
... A specific ratio of S. baicalensis and A. catechu metabolically balances the inhibition of COX-1 and COX-2 enzymes and provides a comparable amount of 5-lipoxygenase (5-LOX) enzyme inhibition in the conversion of arachidonic acid (AA) to inflammatory metabolites (unpublished). This mechanism of acti ...
... A specific ratio of S. baicalensis and A. catechu metabolically balances the inhibition of COX-1 and COX-2 enzymes and provides a comparable amount of 5-lipoxygenase (5-LOX) enzyme inhibition in the conversion of arachidonic acid (AA) to inflammatory metabolites (unpublished). This mechanism of acti ...
Nate Wood - Adirondack Area Network
... As with cocaine, can have body stuffers and body packers, leading to severe overdoses. ...
... As with cocaine, can have body stuffers and body packers, leading to severe overdoses. ...
Carbon Monoxide poisoning
... – Psychiatric should follow up regularly for the suicide cases – If a child was overdosed, the case should be reported to Social Service – Substances resulted in chronic effects, should be monitored & need follow up: • acetaminophen (APAP) may cause delayed liver damage (liver enzymes must be monito ...
... – Psychiatric should follow up regularly for the suicide cases – If a child was overdosed, the case should be reported to Social Service – Substances resulted in chronic effects, should be monitored & need follow up: • acetaminophen (APAP) may cause delayed liver damage (liver enzymes must be monito ...
Ipratropium use in COPD
... - Oral inhalation aerosol should be stored at 25 °C. - Exposure to excessive humidity should be avoided - Cooling of the propellants may decrease the internal pressure of the canister and result in delivery of particles too large to provide full therapeutic effect. - Inhalation solutions for nebuliz ...
... - Oral inhalation aerosol should be stored at 25 °C. - Exposure to excessive humidity should be avoided - Cooling of the propellants may decrease the internal pressure of the canister and result in delivery of particles too large to provide full therapeutic effect. - Inhalation solutions for nebuliz ...
Domperidone
... underestimated. Riordan (1997 , p. 96) points out that "breastfeeding is disease prevention in its purest form . . . human milk lowers health care costs and reduces human suffering." Individuals who are likely to experience decreased milk production, and may benefit from pharmacological intervention ...
... underestimated. Riordan (1997 , p. 96) points out that "breastfeeding is disease prevention in its purest form . . . human milk lowers health care costs and reduces human suffering." Individuals who are likely to experience decreased milk production, and may benefit from pharmacological intervention ...
Approaches to Drug Dosing in Renal Dysfunction
... Oppenheim MI, et al. Impact of a computerized alert during physician order entry on medication dosing in patients with renal impairment. Proc AMIA Symp. ...
... Oppenheim MI, et al. Impact of a computerized alert during physician order entry on medication dosing in patients with renal impairment. Proc AMIA Symp. ...
Determination of Atorvastatin Pharmacokinetic
... Atorvastatin is a synthetic second generation3-hydroxy-3- methylglutarylcoenzyme (HMG-CoA) reductase inhibitor which lowers plasma cholesterol levels by inhibiting theHMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis ...
... Atorvastatin is a synthetic second generation3-hydroxy-3- methylglutarylcoenzyme (HMG-CoA) reductase inhibitor which lowers plasma cholesterol levels by inhibiting theHMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis ...
Management of PUD, H. pylori infection
... Endogenous prostaglandins (PGE2 & I2) contribute to GI mucosa integrity by -stimulation of mucus & bicarbonate secretion -maintenance of blood flow (allows removal of luminal H-ions) -prevention of luminal H-ions from diffusing into the mucosa (e.g. in response to C2H5OH) -↓ of gastric acid secretio ...
... Endogenous prostaglandins (PGE2 & I2) contribute to GI mucosa integrity by -stimulation of mucus & bicarbonate secretion -maintenance of blood flow (allows removal of luminal H-ions) -prevention of luminal H-ions from diffusing into the mucosa (e.g. in response to C2H5OH) -↓ of gastric acid secretio ...
hydralazine and isosorbide dinitrate
... any other heart medicines, especially those used to treat high blood pressure or irregular heartbeats. • You may require a dosage adjustment or special monitoring during your treatment if you are taking any of the ...
... any other heart medicines, especially those used to treat high blood pressure or irregular heartbeats. • You may require a dosage adjustment or special monitoring during your treatment if you are taking any of the ...
Comparative veterinary H. Hutchinson
... Results for clearance rates obtained from in vitro metabolism experiments can then be extrapolated to the in vivo situation using scaling factors (e.g. number of hepatocytes per liver; weight of microsomal protein per gram of liver, etc.). Allometric methods can also be used to scale in vitro result ...
... Results for clearance rates obtained from in vitro metabolism experiments can then be extrapolated to the in vivo situation using scaling factors (e.g. number of hepatocytes per liver; weight of microsomal protein per gram of liver, etc.). Allometric methods can also be used to scale in vitro result ...
2 review of literature 28.06.2013
... 2011). More than 70% of the Indian population still relies on these natural product derived medicines (Paul et al., 2006). Large numbers of tropical plants have not yet been exploited in detail for their pharmacological properties or chemical constituents. Use of plants had been spontaneously recogn ...
... 2011). More than 70% of the Indian population still relies on these natural product derived medicines (Paul et al., 2006). Large numbers of tropical plants have not yet been exploited in detail for their pharmacological properties or chemical constituents. Use of plants had been spontaneously recogn ...
SIMULTANEOUS DETERMINATION AND VALIDATION OF AMOLODIPINE AND METAPROLOL
... besylate. Amlodipine3 exists in "left- and right-handed" chiral forms (more accurately called the R-(+)Fig-1A and the S-(-)- enantiomers) Fig-1B. Only the (S)- form of this molecule is active against hypertension. When a mixture of (R) and (S)-forms (called a racemic mixture) is used, patients may e ...
... besylate. Amlodipine3 exists in "left- and right-handed" chiral forms (more accurately called the R-(+)Fig-1A and the S-(-)- enantiomers) Fig-1B. Only the (S)- form of this molecule is active against hypertension. When a mixture of (R) and (S)-forms (called a racemic mixture) is used, patients may e ...
Antihyperlipidemic effect of biochanin A on streptozotocin induced
... cleared from the circulation [25]. This increased LDL concentration in the plasma of diabetic rats might be due to the defect in LDL-C receptor either through failure in its production (or) function. HDL-C is protective by reversing cholesterol transport, inhibiting the oxidation of LDL-C and by neu ...
... cleared from the circulation [25]. This increased LDL concentration in the plasma of diabetic rats might be due to the defect in LDL-C receptor either through failure in its production (or) function. HDL-C is protective by reversing cholesterol transport, inhibiting the oxidation of LDL-C and by neu ...
(MDMA), Amphetamine, and LSD
... energeticness and mental confusion, in British Ecstasy users. The above studies also described marked physiological changes, with increased heart rate, sweating and dehydration. These can easily lead to medical emergencies, particularly in the hot and crowded conditions of raves and dances. The conf ...
... energeticness and mental confusion, in British Ecstasy users. The above studies also described marked physiological changes, with increased heart rate, sweating and dehydration. These can easily lead to medical emergencies, particularly in the hot and crowded conditions of raves and dances. The conf ...
Drugs: Safety and Effectiveness
... provisions and requiring that manufacturers show drugs to be effective as well.7 Congress has amended the FFDCA many times, leading to FDA’s current mission of assuring Americans that the medicines they use do no harm and actually work—that they are, in other words, safe and effective. In recent dec ...
... provisions and requiring that manufacturers show drugs to be effective as well.7 Congress has amended the FFDCA many times, leading to FDA’s current mission of assuring Americans that the medicines they use do no harm and actually work—that they are, in other words, safe and effective. In recent dec ...
Research Protocol - Newcastle University
... Legal or otherwise, NPS may cause significant acute harms; the Office for National Statistics (ONS) reported 56 deaths in England and Wales in 2012 where an NPS was mentioned on the death certificate following a drug-related death, almost double the figure for 2011.27 ONS also reported increases in ...
... Legal or otherwise, NPS may cause significant acute harms; the Office for National Statistics (ONS) reported 56 deaths in England and Wales in 2012 where an NPS was mentioned on the death certificate following a drug-related death, almost double the figure for 2011.27 ONS also reported increases in ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.