STIMULANTS: Amphetamines, Cocaine (p.1) 1. History of
... tolerance develops fairly rapidly, so increased doses frequently seen increased risk for OD toxic effects that mimic paranoid psychosis occurs at dose levels 60-300 mg/day and can last for longer duration than that seen with cocaine requires tx with high-potency antipsychotics (e.g. Haldol/haloperid ...
... tolerance develops fairly rapidly, so increased doses frequently seen increased risk for OD toxic effects that mimic paranoid psychosis occurs at dose levels 60-300 mg/day and can last for longer duration than that seen with cocaine requires tx with high-potency antipsychotics (e.g. Haldol/haloperid ...
A Look at Opioid Maintenance Therapy - ascls-nd
... • Common examples: morphine, codeine, fentanyl, hydrocodone, oxycodone ...
... • Common examples: morphine, codeine, fentanyl, hydrocodone, oxycodone ...
09107sgp04ppt
... 1990—It was released as Serevent but the product was under license from Allen & Hanburys 2005—The American FDA released a health advisory, alerting the public to findings that show the use of Long-acting β2-agonists could lead to a worsening of symptoms, and in some cases death. ...
... 1990—It was released as Serevent but the product was under license from Allen & Hanburys 2005—The American FDA released a health advisory, alerting the public to findings that show the use of Long-acting β2-agonists could lead to a worsening of symptoms, and in some cases death. ...
Cardiovascular Drug Delivery - Technologies, Markets and Companies Brochure
... technologies are also applicable to peripheral arterial diseases. Controlled release systems are based on chronopharmacology, which deals with the effects of circadian biological rhythms on drug actions.A full chapter is devoted to drug-eluting stents as treatment for restenosis following stenting o ...
... technologies are also applicable to peripheral arterial diseases. Controlled release systems are based on chronopharmacology, which deals with the effects of circadian biological rhythms on drug actions.A full chapter is devoted to drug-eluting stents as treatment for restenosis following stenting o ...
see p. Rx1 - Viktor`s Notes for the Neurosurgery Resident
... 1. Anxiety disorders – benzodiazepines are most effective anxiolytics!!! do not use to alleviate normal stress of everyday life. use only for short periods (addiction potential). longer acting agents (e.g. DIAZEPAM) at low doses are preferred. ALPRAZOLAM is most effective for panic disorders ...
... 1. Anxiety disorders – benzodiazepines are most effective anxiolytics!!! do not use to alleviate normal stress of everyday life. use only for short periods (addiction potential). longer acting agents (e.g. DIAZEPAM) at low doses are preferred. ALPRAZOLAM is most effective for panic disorders ...
Guideline on the management of bleeding in patients on
... critical bleeding was associated with arterial thrombosis in 55% vs. 32% in placebo in all patient groups and 108% vs. 41% in placebo in patients >75 years (Levi et al, 2010). Efficacy of rFVIIa as a reversal agent has been demonstrated in vitro, in animal studies and single case reports, which ...
... critical bleeding was associated with arterial thrombosis in 55% vs. 32% in placebo in all patient groups and 108% vs. 41% in placebo in patients >75 years (Levi et al, 2010). Efficacy of rFVIIa as a reversal agent has been demonstrated in vitro, in animal studies and single case reports, which ...
NOTHAPODYTES NIMMONIANA STEM Research Article
... available. Ayurveda is one of the most ancient systems of life, health and cure. Ayurveda is a highly evolved and codified system of life and health science based on its own unique and original concepts and fundamental principles1. The traditional medicinal methods, especially the use of medicinal p ...
... available. Ayurveda is one of the most ancient systems of life, health and cure. Ayurveda is a highly evolved and codified system of life and health science based on its own unique and original concepts and fundamental principles1. The traditional medicinal methods, especially the use of medicinal p ...
Non-Clinical Investigation of the Dependence Potential of Medicinal
... to which the investigational active substance belongs. However, if this is not possible, i.e. for NCE’s with a novel mode of action or with atypical actions, then the positive control chosen should be selected based on the similarity of the behavioural pharmacology of the NCE and the positive contro ...
... to which the investigational active substance belongs. However, if this is not possible, i.e. for NCE’s with a novel mode of action or with atypical actions, then the positive control chosen should be selected based on the similarity of the behavioural pharmacology of the NCE and the positive contro ...
... The K. vesicatoria extract was tested against two different drug-resistant strains of M. tuberculosis, which resulted in an MIC of 50.00 μg/mL on both strains. The combination of K. vesicatoria with INH exhibited the best synergistic antimycobacterial activity with a fractional inhibitory concentrati ...
adrenaline acid tartrate injection
... Palpitations, tachycardia (sometimes with anginal pain) and cardiac arrhythmias may also occur along with hypertension which in some instances may induce reflex bradycardia as can vasodilation with flushing and hypotension. Ventricular fibrillation may occur and severe hypertension may lead to cereb ...
... Palpitations, tachycardia (sometimes with anginal pain) and cardiac arrhythmias may also occur along with hypertension which in some instances may induce reflex bradycardia as can vasodilation with flushing and hypotension. Ventricular fibrillation may occur and severe hypertension may lead to cereb ...
Substance use disorders: treatment with genetic potential?
... 15-64 (roughly 53 million individuals) using amphetamines in 2013; crystal methamphetamine use has increased in North America and Europe in particular. Prevalence rates for psychoactive substances are difficult to estimate due to their transient and diverse use (United Nations Office on Drugs and Cr ...
... 15-64 (roughly 53 million individuals) using amphetamines in 2013; crystal methamphetamine use has increased in North America and Europe in particular. Prevalence rates for psychoactive substances are difficult to estimate due to their transient and diverse use (United Nations Office on Drugs and Cr ...
The antinociceptive activity of Polygonatum verticillatum rhizomes in
... divided into five groups (n = 6). The writhes were induced by intraperitoneal injection of 1.0% acetic acid (v/v, 0.1 ml/10 g body weight). Group I was used as control, received normal saline (10 ml/kg, i.p.); groups II, III and IV were treated with PR (50, 100 and 200 mg/kg, i.p.), respectively; gro ...
... divided into five groups (n = 6). The writhes were induced by intraperitoneal injection of 1.0% acetic acid (v/v, 0.1 ml/10 g body weight). Group I was used as control, received normal saline (10 ml/kg, i.p.); groups II, III and IV were treated with PR (50, 100 and 200 mg/kg, i.p.), respectively; gro ...
Successful cases of Traceability in the Healthcare Sector in
... GMP, among authorities of high sanitary surveillance. Moreover, in December 2009, ANMAT was named the First Authority of Reference in America following an extensive audit by the Pan American Health Organization (OPS). In this context, the implementation of the National Drug Traceability System place ...
... GMP, among authorities of high sanitary surveillance. Moreover, in December 2009, ANMAT was named the First Authority of Reference in America following an extensive audit by the Pan American Health Organization (OPS). In this context, the implementation of the National Drug Traceability System place ...
Controlled Substance Strategies at CVS Health
... medical use.2,6 Abuse of prescription drugs, also called “nonmedical use,” is defined by the National Institute on Drug Abuse as “the use of a medication without a prescription, in a way other than as prescribed, or for the experience or feelings elicited.”7 Schedule I substances have the highest po ...
... medical use.2,6 Abuse of prescription drugs, also called “nonmedical use,” is defined by the National Institute on Drug Abuse as “the use of a medication without a prescription, in a way other than as prescribed, or for the experience or feelings elicited.”7 Schedule I substances have the highest po ...
Express Scripts 2015 Drug Trend Report Workers` Compensation
... consultative tools and predictive analytics, like the morphine equivalent dose (MED) point-of-sale program, physician outreach programs and patient narcotic education. These resources allow us to flag situations that could indicate abuse or misuse, whether in the actions of physicians, pharmacies or ...
... consultative tools and predictive analytics, like the morphine equivalent dose (MED) point-of-sale program, physician outreach programs and patient narcotic education. These resources allow us to flag situations that could indicate abuse or misuse, whether in the actions of physicians, pharmacies or ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... Maceration process involves separation of medicinally active portions of the crude drugs. It is based on the immersion of the crude drugs in the bulk of solvent or menstrum. Solid drug material was taken in a stopperd container with about 750ml of the menstrum and allowed to stand for at least three ...
... Maceration process involves separation of medicinally active portions of the crude drugs. It is based on the immersion of the crude drugs in the bulk of solvent or menstrum. Solid drug material was taken in a stopperd container with about 750ml of the menstrum and allowed to stand for at least three ...
Review Article Amla (Emblica officinalis) – Medicinal Food and
... The effect of crude amla (traditionally known as amalaki rasayana) on total serum protein and its fractions was studied in rabbits. The drug had no significant effect on the levels of serum protein fractions but it raised the total protein level and increased the body weight. The studies indicated t ...
... The effect of crude amla (traditionally known as amalaki rasayana) on total serum protein and its fractions was studied in rabbits. The drug had no significant effect on the levels of serum protein fractions but it raised the total protein level and increased the body weight. The studies indicated t ...
Cytochrome P450 and Chemical Toxicology
... Most of our understanding of bioactivation reactions is in the context of the generation of electrophilic products that become covalently bound to proteins and DNA. With drugs, there are examples in which a drug metabolite may have more intrinsic activity with a receptor than the parent compound (81 ...
... Most of our understanding of bioactivation reactions is in the context of the generation of electrophilic products that become covalently bound to proteins and DNA. With drugs, there are examples in which a drug metabolite may have more intrinsic activity with a receptor than the parent compound (81 ...
Chapter_021
... Prolongs time that levodopa is available to the brain Increases levodopa availability by inhibiting COMT, which decreases production of levodopa metabolites that compete with levodopa for transport Adverse effects: from increasing levodopa levels ...
... Prolongs time that levodopa is available to the brain Increases levodopa availability by inhibiting COMT, which decreases production of levodopa metabolites that compete with levodopa for transport Adverse effects: from increasing levodopa levels ...
Enzymatic Catalysis
... third aspect of metal ion catalysis. The other forms of enzyme-mediated metal ion catalysis are considered in later chapters in conjunction with discussions of specific enzyme mechanisms. a. Metal Ions Promote Catalysis through Charge Stabilization In many metal ion–catalyzed reactions, the metal io ...
... third aspect of metal ion catalysis. The other forms of enzyme-mediated metal ion catalysis are considered in later chapters in conjunction with discussions of specific enzyme mechanisms. a. Metal Ions Promote Catalysis through Charge Stabilization In many metal ion–catalyzed reactions, the metal io ...
Atypical Urinary Opiate Excretion Pattern*
... estimated plasma half-lifeof 10-40 rain (3,4). Morphine may be further metabolized by demethylation to normorphine, and both forms can be conjugated before excretion. Morphine and its metabolites are excreted as free and glucuronide or sulfate conjugates in bile, sweat, hair, and urine. Morphine glu ...
... estimated plasma half-lifeof 10-40 rain (3,4). Morphine may be further metabolized by demethylation to normorphine, and both forms can be conjugated before excretion. Morphine and its metabolites are excreted as free and glucuronide or sulfate conjugates in bile, sweat, hair, and urine. Morphine glu ...
Answers Small Group II
... 7G. Laboratory tests reveal that M.R. is suffering from renal impairment. Since aminoglycosides such as tobramycin are eliminated almost exclusively via the kidney, impaired renal function will act to significantly reduce the clearance of these drugs in such patients. Hence, administration of a norm ...
... 7G. Laboratory tests reveal that M.R. is suffering from renal impairment. Since aminoglycosides such as tobramycin are eliminated almost exclusively via the kidney, impaired renal function will act to significantly reduce the clearance of these drugs in such patients. Hence, administration of a norm ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.