STRESS DEGRADATION STUDIES AND DEVELOPMENT AND VALIDATION OF RP-HPLC
... filter. The composition of the mobile phase on the retention time of Asenapine was thoroughly investigated. The concentrations of the methanol:n-butanol:glacial acetic acid (60:20:20) were optimized to give symmetric peak with short runtime. The eluent were monitored at 270 nm, flow rate was 1.0 mL/ ...
... filter. The composition of the mobile phase on the retention time of Asenapine was thoroughly investigated. The concentrations of the methanol:n-butanol:glacial acetic acid (60:20:20) were optimized to give symmetric peak with short runtime. The eluent were monitored at 270 nm, flow rate was 1.0 mL/ ...
Facts and Treatment of Diabetes Mellitus
... Metformin is well absorbed from small intestine, stable, does not bind to plasma proteins, excreted unchanged in urine. Half life of Metformin is 1.5 4.5 hours, taken in three doses with meals ...
... Metformin is well absorbed from small intestine, stable, does not bind to plasma proteins, excreted unchanged in urine. Half life of Metformin is 1.5 4.5 hours, taken in three doses with meals ...
Antilipemic Agents
... 3. Inhibits FFA release from adipose tissues by inhibiting the intracellular lipase system 4. Reduces circulating fibrinogen (contributes to clot formation) and ↑ tissue plasminogen activator (clot ...
... 3. Inhibits FFA release from adipose tissues by inhibiting the intracellular lipase system 4. Reduces circulating fibrinogen (contributes to clot formation) and ↑ tissue plasminogen activator (clot ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... uses radiant heat or immersion in hot water. Mechanical methods involve the application of pressure to a digit, ear or tail and the response is noted. HPLC coupled to a mass spectrometer (LC-MS) is very important in analysing complex sample matrices where compounds may be present in very low concent ...
... uses radiant heat or immersion in hot water. Mechanical methods involve the application of pressure to a digit, ear or tail and the response is noted. HPLC coupled to a mass spectrometer (LC-MS) is very important in analysing complex sample matrices where compounds may be present in very low concent ...
In vitro metabolism and drug-drug interaction potential of irosustat, a
... use of a drug, including dosing adjustments or warnings about drug-drug interactions. The most common fate of metabolism is the formation of inactive products (metabolites having no physiological effect). If the drug is converted to inactive metabolites pre-systemically or too quickly for the desire ...
... use of a drug, including dosing adjustments or warnings about drug-drug interactions. The most common fate of metabolism is the formation of inactive products (metabolites having no physiological effect). If the drug is converted to inactive metabolites pre-systemically or too quickly for the desire ...
Intranasal midazolam delivery procedure
... Newer data discussed above suggests that IN dexmedetomidine may be the best option for sedation if more than just mild sedation is needed and prolonged affect is required (also slower onset of action). Reasonable IN starting dose: o Midazolam 0.4 to 0.5 mg/kg Use the lower dose for minor, non- ...
... Newer data discussed above suggests that IN dexmedetomidine may be the best option for sedation if more than just mild sedation is needed and prolonged affect is required (also slower onset of action). Reasonable IN starting dose: o Midazolam 0.4 to 0.5 mg/kg Use the lower dose for minor, non- ...
presentation source
... Special prescribing in diabetes • A carefully designed insulin (+ glucose, +K+) regime is usually used in diabetics who: – are acutely ill, have had myocardial infarction – are fasting e.g. for an operation – are pregnant ...
... Special prescribing in diabetes • A carefully designed insulin (+ glucose, +K+) regime is usually used in diabetics who: – are acutely ill, have had myocardial infarction – are fasting e.g. for an operation – are pregnant ...
Slide 1
... — Based on specific factors in each phase of clinical development and benchmarked against historical parameters — Absolute probability of approval as well as comparison to similar agents ...
... — Based on specific factors in each phase of clinical development and benchmarked against historical parameters — Absolute probability of approval as well as comparison to similar agents ...
How to Use the Drug Store to Treat Coughs and Colds By: Raymond
... is to get rest and plenty of fluids. Fluids will help prevent dehydration and may help thin the mucus. In addition to consuming fluid, the use of saline nasal spray and cool-mist vaporizers are critical in the management of sinus congestion. Nasal saline helps clear mucus out of the nose. Many produ ...
... is to get rest and plenty of fluids. Fluids will help prevent dehydration and may help thin the mucus. In addition to consuming fluid, the use of saline nasal spray and cool-mist vaporizers are critical in the management of sinus congestion. Nasal saline helps clear mucus out of the nose. Many produ ...
Lipid Nanoparticulate Drug Delivery Systems: A
... Heterolipids are lipids containing nitrogen (N) and phosphorus (P) atoms in addition to the usual C, H and O e.g. phospholipids, glycolipids and sulfolipids. They are also known as compound lipids. The emphasis here will be on the phospholipids only. Two main classes of phospholipids occur naturally ...
... Heterolipids are lipids containing nitrogen (N) and phosphorus (P) atoms in addition to the usual C, H and O e.g. phospholipids, glycolipids and sulfolipids. They are also known as compound lipids. The emphasis here will be on the phospholipids only. Two main classes of phospholipids occur naturally ...
(embelin)-a second solid gold of india
... arrest a substrate from entering the enzyme's active site and/or hinder the enzyme from catalyzing its reaction. Inhibitor binding is either reversible or irreversible. Most of the drugs are identified as enzyme inhibitors. Eventually, not all substances or molecules that bind to enzymes are inhibit ...
... arrest a substrate from entering the enzyme's active site and/or hinder the enzyme from catalyzing its reaction. Inhibitor binding is either reversible or irreversible. Most of the drugs are identified as enzyme inhibitors. Eventually, not all substances or molecules that bind to enzymes are inhibit ...
A PRELIMINARY ANTIHYPERGLYCEMIC AND ANTINOCICEPTIVE ACTIVITY EVALUATION OF CAMPANULATUS
... mechanism of action has been attributed to inhibition of cyclooxygenase2 activity. Lupeol (along with ursolic acid) has also been shown to be the responsible agents behind the analgesic activity shown by methanol extract of Cissus repens in mice in acetic acid-induced writhing responses and formalin ...
... mechanism of action has been attributed to inhibition of cyclooxygenase2 activity. Lupeol (along with ursolic acid) has also been shown to be the responsible agents behind the analgesic activity shown by methanol extract of Cissus repens in mice in acetic acid-induced writhing responses and formalin ...
Quality Control, Screening, Toxicity, and Regulation of Herbal Drugs 2
... of medicine (e.g. Ayurvedic, Chinese, Unani, Homeopathy, and Siddha) and modern medicine. Nowadays, plant materials are employed throughout the industrialized and developing world as home remedies, over-the-counter drugs, and ingredients for the pharmaceutical industry. As such, they represent a sub ...
... of medicine (e.g. Ayurvedic, Chinese, Unani, Homeopathy, and Siddha) and modern medicine. Nowadays, plant materials are employed throughout the industrialized and developing world as home remedies, over-the-counter drugs, and ingredients for the pharmaceutical industry. As such, they represent a sub ...
Document
... previously used acetylcysteine infusion, used to treat paracetamol poisoning.2 We now examine carboplatin, used to treat cancer. Acetylcysteine bags are made up on the ward by staff who are not used to making up infusions, whereas carboplatin is made up by trained pharmacy staff in controlled and st ...
... previously used acetylcysteine infusion, used to treat paracetamol poisoning.2 We now examine carboplatin, used to treat cancer. Acetylcysteine bags are made up on the ward by staff who are not used to making up infusions, whereas carboplatin is made up by trained pharmacy staff in controlled and st ...
drugs acting at the neuromuscular junction
... contraction. It is generally accepted that non-depolarizing agents block by acting as reversible competitive inhibitors. That is, they bind to the receptor as antagonists and that leaves fewer receptors available for ACh to bind to. As it is a ‘competitive’ block- an increase in the concentration of ...
... contraction. It is generally accepted that non-depolarizing agents block by acting as reversible competitive inhibitors. That is, they bind to the receptor as antagonists and that leaves fewer receptors available for ACh to bind to. As it is a ‘competitive’ block- an increase in the concentration of ...
SUBSTÂNCIAS DE ABUSO II
... Psilocin and psilocybin are controlled substances under Schedule I of the United Nations 1971 Convention on Psychotropic Substances. However, the control of the mushrooms that contain these substances is interpreted in many different ways across Europe. Probably this reflects the extent to which the ...
... Psilocin and psilocybin are controlled substances under Schedule I of the United Nations 1971 Convention on Psychotropic Substances. However, the control of the mushrooms that contain these substances is interpreted in many different ways across Europe. Probably this reflects the extent to which the ...
drug-supplement interactions: a counter-offensive
... Chromium picolinate, 600 mcg/day, may reverse steroid-induced diabetes in humans; one study demonstrated a decrease in mean blood glucose from 250 mg/dL to 150 mg/dL and a 50% reduction in dose requirement for oral hypoglycemics14. Similar effects have been described in rats treated with dexamethaso ...
... Chromium picolinate, 600 mcg/day, may reverse steroid-induced diabetes in humans; one study demonstrated a decrease in mean blood glucose from 250 mg/dL to 150 mg/dL and a 50% reduction in dose requirement for oral hypoglycemics14. Similar effects have been described in rats treated with dexamethaso ...
Electronic Structure Based Classification of Neurotransmitters and
... alter neurotransmission or that change the affinity and number of receptors can manifest different neurological or psychiatric symptoms and result in disease. Examples for disorders associated with the defects in neurotransmission are 1) Alzheimer’s disease caused by reduced synthesis of the neurotr ...
... alter neurotransmission or that change the affinity and number of receptors can manifest different neurological or psychiatric symptoms and result in disease. Examples for disorders associated with the defects in neurotransmission are 1) Alzheimer’s disease caused by reduced synthesis of the neurotr ...
Chapter 3 - ROP Pharmacology for Health Care Professionals
... ampule indicates the area where the ampule can be safely broken in two. An alcohol swab is placed around the neck of the ampule, and the ampule is quickly snapped into two pieces. A syringe and a needle are used to withdraw the liquid drug from the body of the broken ampule. An ampule can be used on ...
... ampule indicates the area where the ampule can be safely broken in two. An alcohol swab is placed around the neck of the ampule, and the ampule is quickly snapped into two pieces. A syringe and a needle are used to withdraw the liquid drug from the body of the broken ampule. An ampule can be used on ...
ANTINOCICEPTIVE ACTIVITY OF FREEZE DRIED POWDERED MORINDA CITRIFOLIA L. FRUIT
... sensation, generally occurs by external and internal noxious stimuli [5]. In case of tissue injury, visceral distension, and in many other factors pain occurs because of the stimulation of the peripheral nociceptors. In such cases, pain sensation is supposed to be a normal physiological response med ...
... sensation, generally occurs by external and internal noxious stimuli [5]. In case of tissue injury, visceral distension, and in many other factors pain occurs because of the stimulation of the peripheral nociceptors. In such cases, pain sensation is supposed to be a normal physiological response med ...
development of polymeric drug delivery systems for biotech products
... particular interest to biotech products, such as DNA and proteins. Although difficult, their large-scale production enabled the therapeutic use of this compounds. Proteins and DNA sequences can be very interesting therapeutic molecules owing to their high selectivity/affinity for the receptor or the ...
... particular interest to biotech products, such as DNA and proteins. Although difficult, their large-scale production enabled the therapeutic use of this compounds. Proteins and DNA sequences can be very interesting therapeutic molecules owing to their high selectivity/affinity for the receptor or the ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.