Lema et al., 2009
... duplicate. Each run included duplicate samples lacking cDNA template to further check for DNA contamination during RNA preparation. As an internal reaction control for each gene of interest, we quantified transcript levels of 18s (QuantumRNA Universal 18s, ABI). Within each tissue, transcript levels ...
... duplicate. Each run included duplicate samples lacking cDNA template to further check for DNA contamination during RNA preparation. As an internal reaction control for each gene of interest, we quantified transcript levels of 18s (QuantumRNA Universal 18s, ABI). Within each tissue, transcript levels ...
A Study of Serum Thyroid Stimulating Hormone and Prolactin Levels
... Diagnostic and research unit at Khartoum teaching hospital for hormonal evaluation from March, 2014 to august, 2015. Thirty (30) healthy fertile females with similar age range were selected as controls group. The association between thyroid dysfunction and levels of serum Prolactin was reviewed. Res ...
... Diagnostic and research unit at Khartoum teaching hospital for hormonal evaluation from March, 2014 to august, 2015. Thirty (30) healthy fertile females with similar age range were selected as controls group. The association between thyroid dysfunction and levels of serum Prolactin was reviewed. Res ...
Psychological well-being on thyroid hormone replacement
... evidence of deiodinase gene polymorphisms affecting circulating thyroid hormone levels and their possible role in psychological wellbeing in normal population. Thus, my work in the area, “Psychological wellbeing in patients of thyroid hormone replacement therapy” has provided several landmark findin ...
... evidence of deiodinase gene polymorphisms affecting circulating thyroid hormone levels and their possible role in psychological wellbeing in normal population. Thus, my work in the area, “Psychological wellbeing in patients of thyroid hormone replacement therapy” has provided several landmark findin ...
Standard PDF - Wiley Online Library
... of the illness.4 It has been reported that low-T3 syndrome was also observed in patients with heart failure, and that impairment of thyroxine (T4) to T3 conversion was found to be proportional to the clinical severity of heart failure.5,6 Furthermore, it has been reported that the impaired concentra ...
... of the illness.4 It has been reported that low-T3 syndrome was also observed in patients with heart failure, and that impairment of thyroxine (T4) to T3 conversion was found to be proportional to the clinical severity of heart failure.5,6 Furthermore, it has been reported that the impaired concentra ...
Serum thyroxine (T4) and triiodothyronine (T3,) concentrations were
... on Day - 4 in the morning and one in the afternoon were calculated and the number of degrees of freedom for error adjusted accordingly. Two-factor split-plot analysis of variance for the complete set of data (Table 1) indicated a significant influence of sampling day but not consistent diurnal effec ...
... on Day - 4 in the morning and one in the afternoon were calculated and the number of degrees of freedom for error adjusted accordingly. Two-factor split-plot analysis of variance for the complete set of data (Table 1) indicated a significant influence of sampling day but not consistent diurnal effec ...
Screening and Treatment of Thyroid Dysfunction: An Evidence
... evaluated effects of treatment of subclinical hypothyroidism on cognitive function (35, 37). One trial that also included patients who were euthyroid (37) found no effect, and the second trial found a statistically significant but clinically small improvement in memory using a composite outcome in pe ...
... evaluated effects of treatment of subclinical hypothyroidism on cognitive function (35, 37). One trial that also included patients who were euthyroid (37) found no effect, and the second trial found a statistically significant but clinically small improvement in memory using a composite outcome in pe ...
Elective central compartment neck dissection in patients with
... recurrent papillary thyroid carcinoma in the jugular chain lymph nodes. Study Design: Retrospective medical record review and analysis of survival outcomes. Methods: The study was conducted at Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University. Fifty-one patients who h ...
... recurrent papillary thyroid carcinoma in the jugular chain lymph nodes. Study Design: Retrospective medical record review and analysis of survival outcomes. Methods: The study was conducted at Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University. Fifty-one patients who h ...
Use of LT4 and LT3 in the treatment of hypothyroidism
... higher prevalence of depression and anxiety in L-T4treated hypothyroid women of 40 years and older. The few other studies on this topic are limited by their small sample size. In a population-based study of middleaged women in Sweden, 29 women were identified who were treated with L-T4. Twelve years ...
... higher prevalence of depression and anxiety in L-T4treated hypothyroid women of 40 years and older. The few other studies on this topic are limited by their small sample size. In a population-based study of middleaged women in Sweden, 29 women were identified who were treated with L-T4. Twelve years ...
central hypothyroidism: a diagnosis overlooked?
... response to TRH stimulated TSH have been observed to increase by 29-37% (mean 32%) at 120 minutes after stimulation while FT4 levels increased by 14%. In CH this response is blunted. Distinguishing between hypothalamic CH and pituitary CH by TRH test can be difficult. Also normal TRH tests do not ex ...
... response to TRH stimulated TSH have been observed to increase by 29-37% (mean 32%) at 120 minutes after stimulation while FT4 levels increased by 14%. In CH this response is blunted. Distinguishing between hypothalamic CH and pituitary CH by TRH test can be difficult. Also normal TRH tests do not ex ...
Ultrasensitive Thyroid Stimulating Hormone (U
... hormone (TSH or thyrotropin) is recognized as a sensitive method in the diagnosis of primary and secondary hypothyroidism. (1) TSH is secreted by the anterior lobe of the pituitary gland and induces the production and release of thyroxine and triiodothyronine from the thyroid gland. (2) It is a glyc ...
... hormone (TSH or thyrotropin) is recognized as a sensitive method in the diagnosis of primary and secondary hypothyroidism. (1) TSH is secreted by the anterior lobe of the pituitary gland and induces the production and release of thyroxine and triiodothyronine from the thyroid gland. (2) It is a glyc ...
2015 American Thyroid Association Management Guidelines for
... These patients have structural or functional (RAI scan, 18FDG-PET) evidence of locoregional or distant metastases . This category includes both patients with biopsy proven disease and also patients in whom structural or functional disease is identified which is highly likely to be metastatic disease ...
... These patients have structural or functional (RAI scan, 18FDG-PET) evidence of locoregional or distant metastases . This category includes both patients with biopsy proven disease and also patients in whom structural or functional disease is identified which is highly likely to be metastatic disease ...
Rapid Thyroid Stimulating Hormone (Rapid TSH) Test
... without gel barrier. Allow the blood to clot. Centrifuge the specimen to separate the serum from the cells. Samples may be refrigerated at 2-8°C for a maximum period of five (5) days. If the specimen(s) cannot be assayed within this time, the sample(s) may be stored at temperatures of -20°C for up t ...
... without gel barrier. Allow the blood to clot. Centrifuge the specimen to separate the serum from the cells. Samples may be refrigerated at 2-8°C for a maximum period of five (5) days. If the specimen(s) cannot be assayed within this time, the sample(s) may be stored at temperatures of -20°C for up t ...
Management of primary hypothyroidism
... There has been a growing controversy about the upper limit of the reference range for serum TSH.11,12 Reference ranges are derived from a reference population that comprises a large group of subjects who do not have thyroid disease and are otherwise well. By convention, a reference range usually onl ...
... There has been a growing controversy about the upper limit of the reference range for serum TSH.11,12 Reference ranges are derived from a reference population that comprises a large group of subjects who do not have thyroid disease and are otherwise well. By convention, a reference range usually onl ...
THYROID-STIMULATING HORMONE AND FOLLICLE
... correlation between these variables.2 We found a positive correlation of FSH with age. This correlation has been frequently observed and is considered the norm in women approaching menopause and during menopause. Our data show, however, that the general tendency for FSH to increase with age differs ...
... correlation between these variables.2 We found a positive correlation of FSH with age. This correlation has been frequently observed and is considered the norm in women approaching menopause and during menopause. Our data show, however, that the general tendency for FSH to increase with age differs ...
Slide - Texas Tech University Departments
... specific increase in type 3 deiodinase (Dio3) activity8, as observed in consumptive hypothyroidism, combined with decreased activity of type 1 deiodinase (Dio1)9,10 results in inactivation of T4 into rT3 and reduced synthesis and increased degradation of T3. NTIS is associated with decreased express ...
... specific increase in type 3 deiodinase (Dio3) activity8, as observed in consumptive hypothyroidism, combined with decreased activity of type 1 deiodinase (Dio1)9,10 results in inactivation of T4 into rT3 and reduced synthesis and increased degradation of T3. NTIS is associated with decreased express ...
03-19-2010 Osmunson Letter – Fluoride and the Endocrine System
... on factors such as age, sex, dietary calcium intake, dose and duration of fluoride intake, and renal efficiency in fluoride handling. In some cases, secondary hyperparathyroidism is observed with associated characteristic bone changes. He also noted the preponderance of males among fluorosis patient ...
... on factors such as age, sex, dietary calcium intake, dose and duration of fluoride intake, and renal efficiency in fluoride handling. In some cases, secondary hyperparathyroidism is observed with associated characteristic bone changes. He also noted the preponderance of males among fluorosis patient ...
Subclinical hypothyroidism
... It is a state in which we cant find clinical features of hypothyroidism and euthyroidism is reached by compensatory increasing of TSH secretion and that’s why synthesis and secretion of such level of thyroid hormone that will be enough for organism. It is an asymptomatic state in which serum T4 and ...
... It is a state in which we cant find clinical features of hypothyroidism and euthyroidism is reached by compensatory increasing of TSH secretion and that’s why synthesis and secretion of such level of thyroid hormone that will be enough for organism. It is an asymptomatic state in which serum T4 and ...
Triiodothyronine modulates the expression of aquaporin
... to as N), hypothyroid (referred to as Hypo), and T3-treated hypothyroid rats (referred to as HypoCT3). Hypothyroidism was induced by the i.p. administration of propylthiouracil (1 mg/100 g body weight) for 4 weeks together with a weekly i.p. injection of iopanoic acid (6 mg/100 g body weight; Lanni ...
... to as N), hypothyroid (referred to as Hypo), and T3-treated hypothyroid rats (referred to as HypoCT3). Hypothyroidism was induced by the i.p. administration of propylthiouracil (1 mg/100 g body weight) for 4 weeks together with a weekly i.p. injection of iopanoic acid (6 mg/100 g body weight; Lanni ...
Case Report Severe Hypoglycemia Accompanied with
... we believe that hypoglycemia may have been caused by congestive heart failure and liver dysfunction. Although lactic acid was not determined, our case resembled the second case reported by Kobayashi et al. [4]. Congestive heart failure is associated with hypoglycemia because of decreasing insulin cl ...
... we believe that hypoglycemia may have been caused by congestive heart failure and liver dysfunction. Although lactic acid was not determined, our case resembled the second case reported by Kobayashi et al. [4]. Congestive heart failure is associated with hypoglycemia because of decreasing insulin cl ...
the hypothalamus-pituitary-thyroid axis in critical illness
... adaptive and beneficial, as they may postpone anabolism and, at the same time, activate the immune response. 4 In prolonged critical illness, a so-called ‘wasting syndrome’ occurs: despite feeding, protein continues to be lost from vital organs and tissues due to both activated degradation and suppr ...
... adaptive and beneficial, as they may postpone anabolism and, at the same time, activate the immune response. 4 In prolonged critical illness, a so-called ‘wasting syndrome’ occurs: despite feeding, protein continues to be lost from vital organs and tissues due to both activated degradation and suppr ...
Management
... Atrial fibrillation in thyrotoxicosis Atrial fibrillation occurs in about 10% of patients with thyrotoxicosis. The incidence increases with age, so that almost half of all males with thyrotoxicosis over the age of 60 are affected. Moreover, subclinical thyrotoxicosis is a risk factor for atrial fib ...
... Atrial fibrillation in thyrotoxicosis Atrial fibrillation occurs in about 10% of patients with thyrotoxicosis. The incidence increases with age, so that almost half of all males with thyrotoxicosis over the age of 60 are affected. Moreover, subclinical thyrotoxicosis is a risk factor for atrial fib ...
Diagnostic Testing for Feline Thyroid Disease: Hyperthyroidism
... for measuring canine TSH (cTSH) are widely available, and it has been suggested that these assays may provide some diagnostic information in cats with suspected hyperthyroidism.19,23–25 Theoretically, as in people, it could be expected that serum TSH levels should be low in early stages of hyperthyr ...
... for measuring canine TSH (cTSH) are widely available, and it has been suggested that these assays may provide some diagnostic information in cats with suspected hyperthyroidism.19,23–25 Theoretically, as in people, it could be expected that serum TSH levels should be low in early stages of hyperthyr ...
Impairment in Cognitive and Exercise Performance during
... of 74% accuracy with the matching-to-sample task (M-t-S) (18 –21). In this task, a grid pattern of red and green squares is presented on a computer screen and, after a delay, the grid is replaced with 2 similar patterns, 1 of which is the original. This test of attention, spatial and short-term memo ...
... of 74% accuracy with the matching-to-sample task (M-t-S) (18 –21). In this task, a grid pattern of red and green squares is presented on a computer screen and, after a delay, the grid is replaced with 2 similar patterns, 1 of which is the original. This test of attention, spatial and short-term memo ...
Parathyroid Hormone Levels in Thyroid-Vein Blood of
... this investigation to temper the use of venous sampling for the support of the diagnosis of hyperparathyroidism in equivocal cases with normal peripheral parathyroid hormone levels. Case 1 shows the influence of the catheterization procedure on the magnitude of a local increase in thyroid-vein hormo ...
... this investigation to temper the use of venous sampling for the support of the diagnosis of hyperparathyroidism in equivocal cases with normal peripheral parathyroid hormone levels. Case 1 shows the influence of the catheterization procedure on the magnitude of a local increase in thyroid-vein hormo ...
Iodine-131
Iodine-131 (131I), also loosely and nonspecifically called radioiodine, is an important radioisotope of iodine discovered by Glenn Seaborg and John Livingood in 1938 at the University of California, Berkeley. It has a radioactive decay half-life of about eight days. It is associated with nuclear energy, medical diagnostic and treatment procedures, and natural gas production. It also plays a major role as a radioactive isotope present in nuclear fission products, and was a significant contributor to the health hazards from open-air atomic bomb testing in the 1950s, and from the Chernobyl disaster, as well as being a large fraction of the contamination hazard in the first weeks in the Fukushima nuclear crisis. This is because I-131 is a major uranium, plutonium fission product, comprising nearly 3% of the total products of fission (by weight). See fission product yield for a comparison with other radioactive fission products. I-131 is also a major fission product of uranium-233, produced from thorium.Due to its mode of beta decay, iodine-131 is notable for causing mutation and death in cells that it penetrates, and other cells up to several millimeters away. For this reason, high doses of the isotope are sometimes less dangerous than low doses, since they tend to kill thyroid tissues that would otherwise become cancerous as a result of the radiation. For example, children treated with moderate dose of I-131 for thyroid adenomas had a detectable increase in thyroid cancer, but children treated with a much higher dose did not. Likewise, most studies of very-high-dose I-131 for treatment of Graves disease have failed to find any increase in thyroid cancer, even though there is linear increase in thyroid cancer risk with I-131 absorption at moderate doses. Thus, iodine-131 is increasingly less employed in small doses in medical use (especially in children), but increasingly is used only in large and maximal treatment doses, as a way of killing targeted tissues. This is known as ""therapeutic use.""Iodine-131 can be ""seen"" by nuclear medicine imaging techniques (i.e., gamma cameras) whenever it is given for therapeutic use, since about 10% of its energy and radiation dose is via gamma radiation. However, since the other 90% of radiation (beta radiation) causes tissue damage without contributing to any ability to see or ""image"" the isotope, other less-damaging radioisotopes of iodine such as iodine-123 (see isotopes of iodine) are preferred in situations when only nuclear imaging is required. The isotope I-131 is still occasionally used for purely diagnostic (i.e., imaging) work, due to its low expense compared to other iodine radioisotopes. Very small medical imaging doses of I-131 have not shown any increase in thyroid cancer. The low-cost availability of I-131, in turn, is due to the relative ease of creating I-131 by neutron bombardment of natural tellurium in a nuclear reactor, then separating I-131 out by various simple methods (i.e., heating to drive off the volatile iodine). By contrast, other iodine radioisotopes are usually created by far more expensive techniques, starting with reactor radiation of expensive capsules of pressurized xenon gas.Iodine-131 is also one of the most commonly used gamma-emitting radioactive industrial tracer. Radioactive tracer isotopes are injected with hydraulic fracturing fluid to determine the injection profile and location of fractures created by hydraulic fracturing.Much smaller incidental doses of iodine-131 than those used in medical therapeutic procedures, are thought to be the major cause of increased thyroid cancers after accidental nuclear contamination. These cancers happen from residual tissue radiation damage caused by the I-131, and usually appear years after exposure, long after the I-131 has decayed.