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Regulation of Neurosteroid Biosynthesis by Neurotransmitters and
Regulation of Neurosteroid Biosynthesis by Neurotransmitters and

... is evidence that sulfated neurosteroids and NPY are involved in the regulation of similar behavioral activities. For instance, ∆5PS and DHEAS, like NPY, are implicated in the control of food intake in rodents (Reddy and Kulkarni 1998; Schwartz et al. 2000). Similarly, ∆5PS and NPY are known to regul ...
The NEURON Simulation Environment
The NEURON Simulation Environment

... time step, and when it crosses threshold an event is generated for each of the targets. Fan−out from artificial neurons is also very efficient, since their discrete event mechanisms do not have to be checked at each time step. However, the greatest computational savings are offered by synaptic conve ...
Timing of Impulses From the Central Amygdala and Bed Nucleus of
Timing of Impulses From the Central Amygdala and Bed Nucleus of

... test, P ⬍ 0.02). However, the likelihood of observing BLevoked orthodromic responses was similar for CE neurons with short versus long conduction times to the brain stem (Fisher exact test, P ⬎ 0.15). As shown in the representative examples of Fig. 4, A1 and A2, CE cells generally responded with a p ...
On the Significance of Neuronal Giantism in Gastropods
On the Significance of Neuronal Giantism in Gastropods

... need is met largely by an increase in brain size and neuron number; even in the opisthobranch/pulmonate line, the number of neurons (and the number of peripheral axons) increases with body size, in parallel with the striking increase in size of identified neurons (Coggeshall, 1967). But if, as has b ...
Learning: On the Multiple Facets of a Colloquial Concept
Learning: On the Multiple Facets of a Colloquial Concept

... and compare to see if it is the same or different. The internal thinking or musical audiation (Gordon 1993) relies on the capacity of the working memory. The bigger it is and the faster one can retrieve information from it, the more one will succeed in making connections and developing new associati ...
Cognitive Ability is Associated with Altered
Cognitive Ability is Associated with Altered

... parallel correlations of volume reduction and altered connectivity in comparable cortical regions with diminished executive function in 22q11DS patients. Apparently, 22q11 deletion alters behaviorally relevant circuits in a distinct cortical region that are essential for cognitive function. Keywords ...
Smell and Taste
Smell and Taste

... of the olf. bulb. Their primary apical dendrite extends into spherical glomerulus (about 25 mitral cells converge to one glomerulus), which accepts axons primary olfactory neurons. Axons of mitral cells make tzv. lateral olfactory tract. These axons give collaterals involved in pos. and neg. feedbac ...
Omega 3 fatty acids and the brain - Asia Pacific Journal of Clinical
Omega 3 fatty acids and the brain - Asia Pacific Journal of Clinical

... signaling,18 [b] stimulation of neurite growth in hippocampal cells,19 [c] selective accumulation of DHA by synaptic growth cones during neuronal development,20 [d] regulation of neuron size,21 [e] regulation of nerve growth factor,22 and [f] stimulation of cell membrane expansion by action on synta ...
Consolidation of motor memory
Consolidation of motor memory

... session were eliminated if subjects received rTMS for the 15 min between the two practice sessions. The rTMS was applied over an area of right M1 selected for its capacity to elicit motor evoked potentials in the left flexor pollicis brevis, and known to be associated with practice-induced changes i ...
The Nervous System  - Home
The Nervous System - Home

... cells in the body because: 1. Neurons have specialized extensions called dendrites and axons. Dendrites bring information to the cell body and axons take information away from the cell body. 2. Neurons communicate with each other through an electrochemical process. 3. Neurons contain some specialize ...
Dopamine is one of major neurotransmitters in the brain
Dopamine is one of major neurotransmitters in the brain

... molecular mechanisms that give rise to the segregation of neurons from two of these pathways, the nigrostriatal and the mesolimbic pathways. This experiment further substantiates the role of Ephrin-B1/EphB2 in the determination of those two pathways by verifying that segregation and expression of th ...
unexpected - Revista Pesquisa Fapesp
unexpected - Revista Pesquisa Fapesp

... learning and, in pathological situations, the development of epilepsy) and the frontal cortex (associated with more advanced cognitive processes, such as decision-making). They observed a complex pattern of response in the analyzed genes. ...
as a PDF
as a PDF

... facilitates glutamate actions at NMDA receptors [26,27,69,70]. D2 receptor activity attenuates glutamate actions at non-NMDA receptors [26,70]. Since the nonNMDA glutamate activity is necessary before the NMDA receptor can become activated, this selective amplification of the NMDA response should se ...
accepted manuscript - Radboud Repository
accepted manuscript - Radboud Repository

... Macaque brain used in Caret is called F99, it is based on an individual macaque monkey MRI, from which a cortical surface mesh has been extracted (Van Essen, 2004). Registration of brain maps is done by drawing its regions as two-dimensional shapes on the cortical surface. Caret comes with eight dif ...
Event-Driven Simulation Scheme for Spiking Neural Networks Using
Event-Driven Simulation Scheme for Spiking Neural Networks Using

... matrix) for storing synaptic delays. This is suited only for handling a fixed number of latencies. In contrast, our simulation needed to support arbitrary synaptic delays. This required that each spike transmitted between two cells is represented internally by two events. The first one (the firing e ...
The Octopus: A Model for a Comparative Analysis of the Evolution of
The Octopus: A Model for a Comparative Analysis of the Evolution of

... The first known record of the behavioral capabilities of octopuses and their close relatives dates back to Aristotle, who defined octopuses as “stupid” animals, since their strong exploratory drive made it easy for people to catch them by simply waving their hands underwater (Aristotle, 1910). Moder ...
Molecular Mechanisms of Appetite Regulation
Molecular Mechanisms of Appetite Regulation

... 3-kinase (PI3K)-Akt-FoxO1 signaling pathway [31]. Through these effects, insulin relays an anorexigenic signal to the brain. The role of insulin in the regulation of energy balance was supported by finding that deletion of the neuron-specific insulin receptor and IRS-2 causes an obesity phenotype in ...
Learning nonlinear functions on vectors: examples and predictions
Learning nonlinear functions on vectors: examples and predictions

... signal makes network construction much easier. While it is possible to solve any of these problems with multiple scalar error signals operating on separate connection weight matrices (or separate post populations), we predict that using a multidimensional error signal increases the amount of informa ...
PAPER Glucosensing neurons do more than just sense glucose
PAPER Glucosensing neurons do more than just sense glucose

... brain areas such as the hypothalamus, glucosensing neurons also contain receptors for insulin, leptin, monoamines and other transmitters and peptides involved in energy homeostasis.8 – 12 Thus, many or all glucosensing neurons respond to both short- and long-term signals relating to both the physica ...
Repetition and the brain: neural models of stimulus
Repetition and the brain: neural models of stimulus

... of neural models that have been proposed to account for repetition suppression (RS). We focus primarily on studies using visually presented objects and their effects on the ventral object processing stream, to maximize overlap between monkey and human studies. We evaluate the neural models in terms ...
Memory Extinction, Learning Anew, and Learning the New
Memory Extinction, Learning Anew, and Learning the New

... Neurotrophins such as brain-derived neurotrophic factor (BDNF) are thought to be transferred from post- to presynaptic neurons and to be involved in the formation and plasticity of neural circuits. However, direct evidence for a transneuronal transfer of BDNF and its relation to neuronal activity re ...
Mike Webster the king of the NFL comes in with all his brute force
Mike Webster the king of the NFL comes in with all his brute force

... CTE is life threatening by disintegrating every micrometer of your brain. It works by a  series of acids and fluids, some are very strong such as sarin acid but others are weaker but  deadly too. CTE first starts out by a series of hard hits. This causes the protective fluid in your  brain to damage ...
Repetition and the brain: neural models of stimulus
Repetition and the brain: neural models of stimulus

... of neural models that have been proposed to account for repetition suppression (RS). We focus primarily on studies using visually presented objects and their effects on the ventral object processing stream, to maximize overlap between monkey and human studies. We evaluate the neural models in terms ...
The Stress-Induced Atf3-Gelsolin Cascade Underlies
The Stress-Induced Atf3-Gelsolin Cascade Underlies

... Arc, have been implicated in the synaptic deficits associated with autism (Auerbach et al., 2011; Gkogkas et al., 2013; EbrahimiFakhari and Sahin, 2015); however, systematic translational profiling in these mTOR pathology disease models is lacking. TSC is an autosomal dominant multisystem disorder c ...
Chapter 2
Chapter 2

... Organs or tissues that create chemicals that control bodily functions ...
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Activity-dependent plasticity

A defining feature of the brain is its capacity to undergo changes based on activity-dependent functions, also called activity-dependent plasticity. Its ability to remodel itself forms the basis of the brain’s capacity to retain memories, improve motor function, and enhance comprehension and speech amongst other things. It is this trait to retain and form memories that is functionally linked to plasticity and therefore many of the functions individuals perform on a daily basis. This plasticity is the result of changed gene expression that occurs because of organized cellular mechanisms.The brain’s ability to adapt toward active functions has allowed humans to specialize in specific processes based on relative use and activity. For example, a right-handed person may perform any movement poorly with his/her left hand but continuous practice with the less dominant hand can make both hands just as able. Another example is if someone was born with a neurological disorder such as autism or had a stroke that resulted in a disorder, then they are capable of retrieving much of their lost function by practicing and “rewiring” the brain in order to incorporate these lost manners. Thanks to the pioneers within this field, many of these advances have become available to most people and many more will continue to arrive as new features of plasticity are discovered.
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