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Peripheral Neuropathy
Peripheral Neuropathy

... • In the most common forms of polyneuropathy, the nerve fibers most distant from the brain and the spinal cord malfunction first. • Pain and other symptoms often appear symmetrically, for example, in both feet followed by a gradual progression up both legs. ...
18. Cranial Nerves
18. Cranial Nerves

... Cranial nerve III Function:  eye movements, opening of eyelid, constriction of pupil, focusing, proprioception Clinical tests for injury:  differences in pupil size; pupillary response to light; eye tracking Effects of damage  dropping eyelid, dilated pupil, double vision ...
Study materials CNS
Study materials CNS

... Prof. Š. Kujaník, MD, PhD: Comments to Central Nervous System ...
Nervous System - Neurons
Nervous System - Neurons

...  Cell body – contains the nucleus, main body of cell  Dendrites – projections from the cell body that carry messages to the cell body  Axons – one large projection that carry messages away from the cell body ...
Nervous System - Neurons
Nervous System - Neurons

...  Cell body – contains the nucleus, main body of cell  Dendrites – projections from the cell body that carry messages to the cell body  Axons – one large projection that carry messages away from the cell body ...
Spinal Nerves and Nerve Plexus
Spinal Nerves and Nerve Plexus

... • Ventral rami of spinal nerves T2 –T12 – pass anteriorly to supply the muscles of intercostal spaces, and the skin and muscles of the anterior and lateral trunk ...
The role of T helper cells in neuroprotection and - Direct-MS
The role of T helper cells in neuroprotection and - Direct-MS

... for a number of reasons. The mouse lines display profound differences in their immune systems, the lesion is either in the CNS or in the peripheral nervous system (PNS), the parameters evaluated are different, and either activated CD4+ T cells or mixed splenocytes have been administered without furt ...
Spinal Cord and Spinal Nerves
Spinal Cord and Spinal Nerves

... • Ventral rami of spinal nerves T2 –T12 – pass anteriorly to supply the muscles of intercostal spaces, and the skin and muscles of the anterior and lateral trunk ...
Chapter 3
Chapter 3

... A neuronal network may contain thousands or even millions of neurons. Neuronal circuits are involved in many ...
Author`s personal copy - Vanderbilt University
Author`s personal copy - Vanderbilt University

... pressure. Though the precise mechanisms that mediate or transduce this sensitivity are not clear, the axon of the retinal ganglion cell appears to be vulnerable to disease-relevant stressors early in progression. One reason may be because the axon is generally thin for both its unmyelinated and myel ...
Lecture 2: Structure and function of the NS
Lecture 2: Structure and function of the NS

... Figure 3–4 Brains of a series of representative mammals, all reproduced at the same scale. Brain size is partly related to body size (e.g., cat versus lion, human versus elephant) and partly related to mental abilities (e.g., lion versus human). Not all parts of the brain change size in proportion t ...
TABLE OF CONTENTS
TABLE OF CONTENTS

... a. Neurons vary enormously in size, shape, and function. b. A neuron’s function is closely related to its shape. c. A neuron’s shape is plastic (changeable) as new experiences can modify the shape of a neuron. Glia (neuroglia): a. Glia are the other major component of the nervous system. Glia have m ...
Jeopardy
Jeopardy

... a. they are always excitatory b. they respond to acetylcholine ...
Hsiang-Tung Chang
Hsiang-Tung Chang

... The experiments consisted of sectioning the ventral root of the spinal cord at the level of the lumbar segments. After 3 months of survival to produce the atrophy and a complete degeneration of the muscles, the 28 muscle nerves from the hindlimbs were carefully dissected and fixed in vinegar to be p ...
the giant serotonergic neuron of aplysia: a multi
the giant serotonergic neuron of aplysia: a multi

... Ambron et al., 1980; Shkolnik and Schwartz, 1980). For appear faceted to conform to adjacent axons of other light microscopic radioautography, 2-pm sections were neurons (Fig. 2B). Another variation in the shape of the mounted on glass slides, which then were coated by varicosity also was observed i ...
Post-Polio Motor Neurons and Units: What We Know
Post-Polio Motor Neurons and Units: What We Know

... with the stimulation of the whole muscle. Single-fiber EMG demonstrates the phenomenon called jitter, and increased jitter is a measure of dysfunction of terminal axons. We can also use a stain for a ...
Chapter 8a
Chapter 8a

... Before the return to competition the following guidelines must be met: • Full Range of Motion • Strength, Power, and endurance are proportional to the athlete’s size, and sport • No pain during running, jumping, or cutting ...
Anatomy
Anatomy

... Before the return to competition the following guidelines must be met: • Full Range of Motion • Strength, Power, and endurance are proportional to the athlete’s size, and sport • No pain during running, jumping, or cutting ...
The Skin Senses
The Skin Senses

... •  Nature  of  hap;c  explora;on   •  Visually  impaired   –  Time  of  visual  loss  is  important  (late  blind)   –  Braille  alphabet   ...
Membrane potential (mV)
Membrane potential (mV)

... New adjacent returning to by local inactive area current resting into which flow; now potential; no depolarization longer active active at is spreading; because of peak of will soon reach Remainder of axon still action refractory threshold at resting potential potential period ...
Neurons - Holterman
Neurons - Holterman

... 4. The sodium-potassium pump pushes 3 Na and 2 K against their concentration gradients using 1 ATP. It restores and maintains the resting potential by pushing more Na out of neuron and pushing more K into neuron. (But overall, it pushes more positive charges out of the cell than it brings in.) 5. T ...
Operative record sheet for Decompressive Laminectomy Date of
Operative record sheet for Decompressive Laminectomy Date of

... with gel pads on knees under adequate anesthesia on radiolucent Wilson spinal frame. Made skin incision direct posterior approach to spine overlying the spinous processes of entile vertebra between paraspinal muscles. Dissected subcutaneous tissue down to fascia and use gelpi retracture. Cauterized ...
Use of a Recombinant Pseudorabies Virus to
Use of a Recombinant Pseudorabies Virus to

... plastic changes induced in the central nervous system by estrogen application (Horvath et al., 2002). In fact, utilization of Ba-DupLac allowed us to reduce the problem to an all-ornone labeling paradigm. The literature cited above leads us to suppose that n7x induces complex changes, e.g. surface m ...
the nervous system and resilience
the nervous system and resilience

... but the actual symptoms themselves (e.g., headaches, stomach aches, weak limbs, poor concentration, sadness) are almost always the same.” Studies have also found many cognitive symptoms to be associated with traumatic events. These include memory, attention, and concentration problems. Brain imaging ...
neocortex-basic neuron types
neocortex-basic neuron types

... (stellate appearance). Their axons produce a local axonal cluster of columnar extent within layer IV, before ...
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Neuroregeneration

Neuroregeneration refers to the regrowth or repair of nervous tissues, cells or cell products. Such mechanisms may include generation of new neurons, glia, axons, myelin, or synapses. Neuroregeneration differs between the peripheral nervous system (PNS) and the central nervous system (CNS) by the functional mechanisms and especially the extent and speed. When an axon is damaged, the distal segment undergoes Wallerian degeneration, losing its myelin sheath. The proximal segment can either die by apoptosis or undergo the chromatolytic reaction, which is an attempt at repair. In the CNS, synaptic stripping occurs as glial foot processes invade the dead synapse.Nervous system injuries affect over 90,000 people every year. It is estimated that spinal cord injuries alone affect 10,000 each year. As a result of this high incidence of neurological injuries, nerve regeneration and repair, a subfield of neural tissue engineering, is becoming a rapidly growing field dedicated to the discovery of new ways to recover nerve functionality after injury. The nervous system is divided into two parts: the central nervous system, which consists of the brain and spinal cord, and the peripheral nervous system, which consists of cranial and spinal nerves along with their associated ganglia. While the peripheral nervous system has an intrinsic ability for repair and regeneration, the central nervous system is, for the most part, incapable of self-repair and regeneration. There is currently no treatment for recovering human nerve function after injury to the central nervous system. In addition, multiple attempts at nerve re-growth across the PNS-CNS transition have not been successful. There is simply not enough knowledge about regeneration in the central nervous system. In addition, although the peripheral nervous system has the capability for regeneration, much research still needs to be done to optimize the environment for maximum regrowth potential. Neuroregeneration is important clinically, as it is part of the pathogenesis of many diseases, including multiple sclerosis.
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