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(Figure 4B) in 12 month old Cln5-/- mice. To survey effects on glial
(Figure 4B) in 12 month old Cln5-/- mice. To survey effects on glial

... reactive phenotype that is more pronounced compared to results from a study in younger Cln5-/- mice. These data emphasize the progressive nature of the NCLs. Consistent with a mouse model of JNCL (Cln3 null mutant), Cln5-/- mice display a profound loss of sensory relay thalamic neurons, yet no loss ...
The Spinal Cord
The Spinal Cord

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Lecture 14 (Chapter 13) Last Quiz The Adult Spinal Cord Gross
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Chapter 2: The Biological Basis of Behavior
Chapter 2: The Biological Basis of Behavior

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Mechanisms of Plasticity of Inhibition in Chronic Pain Conditions
Mechanisms of Plasticity of Inhibition in Chronic Pain Conditions

... Abstract  The balance between inhibition and excitation in the dorsal spinal cord plays a critical role in ensuring that sensory information is relayed accurately to the brain. In particular, a loss of inhibitory control, and the ensuing increase in excitability in spinal dorsal horn neuronal circui ...
Lab #6: Neurophysiology Simulation
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Molecular Underpinnings of Motor Pattern Generation: Differential

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Evidence of sympathetic ®bers in the male rat pelvic nerve
Evidence of sympathetic ®bers in the male rat pelvic nerve

... neurons in the sacral parasympathetic nucleus and in the LSC was comparable. Extended lesion of the LSC or ventral rhizotomy (T12-S2) decreased by 25% the number of ®bers in the rat pelvic nerve31 . To our knowledge there is no clear demonstration of a loss of neural ®bers in the pelvic nerve follow ...
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... reflex depression of cord function below the level of injury, with associated loss of all sensorimotor functions – (+) Increase in blood pressure (initially) due to the release of catecholamines, followed by hypotension – (+) Flaccid paralysis, including of the bowel and bladder – Symptoms last seve ...
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... Physiologic anatomy of the synapse • Anterior motor neuron in the anterior horn of the spinal cord – the soma, which is the main body of the neuron; – a single axon, which extends from the soma into a peripheral nerve that leaves the spinal cord; – the dendrites, which are great numbers of branchin ...
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... Phenytoin (Dilantin) (Epamin) Dilantin is known to most doctors and many other people as a treatment for epilepsy. However, it has a wide range of pharmacologic effects other than its anticonvulsant activity. There have been more than 8,000 papers published on Dilantin and there have been clinical r ...
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...  “Information” travels within the nervous system as propagated electrical signals (action potentials)  The most important information (vision, balance, motor commands) is carried by large-diameter, ...
nervous system
nervous system

... b. Consists of nerves that originate (but have left) from brain and spinal cord i. Cranial nerves ii. Spinal nerves c. Peripheral nerves link all regions of the body to the CNS 3. Autonomic Nervous System (ANS): has parts of the CNS and PNS. Controls autonomic function (blood pressure, digestion, et ...
innervation of the ventral diaphragm of the locust
innervation of the ventral diaphragm of the locust

... Neighbouring fibres were also hyperpolarized, to a degree that was progressively smaller with increasing distance from the stimulation site. Hyperpolarizations could not be recorded when the suction electrode was released or when the recording electrode was withdrawn from the fibre. It is therefore ...
Chapter 15
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... Preganglionic neuron ascends or descends to another ganglion along sympathetic chain before synapsing with postganglionic neuron. An axon may project through a ganglion and synapse with a postglanglionic neuron in one of the prevertebral ganglia. Preganglionic sympathetic fibers synapse on the adren ...
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Chapter 8 - Faculty Web Sites

... Disorders of the Nervous System  Spinal cord injury  Results in loss of function below site of injury  Depending on which nerve tracts are damaged, injury may result in paralysis, loss of sensation, or both  If the cord is completely severed, then there is complete loss of sensation and volunta ...
exercise - Anatomy and Physiology
exercise - Anatomy and Physiology

... The flow of aqueous humor from the ciliary processes of the ciliary body to the scleral venous sinus. 7. The iris is composed primarily of two smooth muscle layers, one arranged radially and the other circularly. Which of these dilates the pupil? The radial layer 8. You would expect the pupil to be ...
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Spinal cord- 2 - Weebly

... pyramidal decussation, where they continue to descend in the lateral funiculus of the spinal cord as the lateral corticospinal tract (LCST). The tract descends all the way of spinal cord with fibers continually leaving it in order to synapse on interneurons in the anterior gray horn. ( Some even sy ...
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Neuroregeneration

Neuroregeneration refers to the regrowth or repair of nervous tissues, cells or cell products. Such mechanisms may include generation of new neurons, glia, axons, myelin, or synapses. Neuroregeneration differs between the peripheral nervous system (PNS) and the central nervous system (CNS) by the functional mechanisms and especially the extent and speed. When an axon is damaged, the distal segment undergoes Wallerian degeneration, losing its myelin sheath. The proximal segment can either die by apoptosis or undergo the chromatolytic reaction, which is an attempt at repair. In the CNS, synaptic stripping occurs as glial foot processes invade the dead synapse.Nervous system injuries affect over 90,000 people every year. It is estimated that spinal cord injuries alone affect 10,000 each year. As a result of this high incidence of neurological injuries, nerve regeneration and repair, a subfield of neural tissue engineering, is becoming a rapidly growing field dedicated to the discovery of new ways to recover nerve functionality after injury. The nervous system is divided into two parts: the central nervous system, which consists of the brain and spinal cord, and the peripheral nervous system, which consists of cranial and spinal nerves along with their associated ganglia. While the peripheral nervous system has an intrinsic ability for repair and regeneration, the central nervous system is, for the most part, incapable of self-repair and regeneration. There is currently no treatment for recovering human nerve function after injury to the central nervous system. In addition, multiple attempts at nerve re-growth across the PNS-CNS transition have not been successful. There is simply not enough knowledge about regeneration in the central nervous system. In addition, although the peripheral nervous system has the capability for regeneration, much research still needs to be done to optimize the environment for maximum regrowth potential. Neuroregeneration is important clinically, as it is part of the pathogenesis of many diseases, including multiple sclerosis.
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