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Sensory systems
Sensory systems

... orientation only ...
Making Memories Stick
Making Memories Stick

... of calcium ions through voltage-sensitive channels in the cell membrane. Neurons live in a virtual sea of calcium ions, but inside a neuron the concentration of calcium is kept extremely low-20,000 times lower than the concentration outside. When the voltage across the neuronal membrane reaches a cr ...
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Molecular heterogeneity of central synapses: afferent and target
Molecular heterogeneity of central synapses: afferent and target

... (Fig. 1b). On the presynaptic side, neurotransmitter synthetic enzymes and vesicular and plasma membrane transporters that determine the chemical nature of a synapse generally fall into this category. The GABA synthetic enzyme glutamic acid decarboxylase (GAD65 and GAD67), the vesicular inhibitory a ...
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Nervous_System__Ch_7__S2015

THE PERIPHERAL NERVOUS SYSTEM AND REFLEX ACTIVITY
THE PERIPHERAL NERVOUS SYSTEM AND REFLEX ACTIVITY

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Biology 201-Worksheet on Autonomic Nervous System

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A&P Ch 8 PowerPoint(Nervous System)

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Power Point CH 14

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NERVOUS SYSTEM
NERVOUS SYSTEM

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Midterm Review Answers
Midterm Review Answers

... hyperpolarize membrane potential. The repolarization of the action potential could be due to a K+ or Ca++ influx, a Cl- efflux, or an inactivation of the outward Na+ current. B. Propose an experiment to test your hypothesis regarding the falling phase of the action potential. There are many differen ...
lec#37 by Dalin Mohammad corrected by Bayan
lec#37 by Dalin Mohammad corrected by Bayan

... 300). This will not affect the action potential because in both ways it will reach the threshold, what differs is the next action potential site, in the relative refractory period or after. So the frequency if what differs. A receptor with a certain threshold, give it some pressure, you will not hav ...
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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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