• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Chapter 9
Chapter 9

... cell layer and bipolar cell layer before reaching the rods and cones. In response to light, the rods and cones generate electrical signals that are sent to bipolar cells and then to ganglion cells. These cells begin the processing of visual information. ...
May 30, 04copy.doc
May 30, 04copy.doc

... Furthermore, electrolytic lesion of thalamus in the newborn decreases α1 in layers III-IV, but increases α2, α3, and α5 in the same SI layers (Paysan, 1997). When whiskers are trimmed during a critical period of early postnatal development, stimulation of the regrown whiskers causes a degraded tunin ...
Cells of the Nervous System
Cells of the Nervous System

... 4.Describe the measurement of the action potential and explain how the balance between the forces of diffusion and electrostatic pressure is responsible for the membrane potential. 5.Describe the role of ion channels in action potentials and explain the all-ornone law and the rate law. 6.Describe th ...
Does the Conventional Leaky Integrate-and
Does the Conventional Leaky Integrate-and

... 2- Variation of the delay between pre-synaptic spike arrival and post-synaptic channel opening, in different synapses. (Synaptic noise) 3- The noise due to spontaneous firings of the neurons, which is often treated as a Poisson process. (Spontaneous noise) Thus, if the cortical neural groups are ass ...
Untitled
Untitled

... found that the depletion of intracellular calcium stores, or what has been called "ER stress", produced an increase in Ih. ...
Document
Document

...  Receptor – site of stimulus  Sensory neuron – transmits the afferent impulse to the CNS  Integration center – either monosynaptic or polysynaptic region within the CNS  Motor neuron – conducts efferent impulses from the integration center to an effector  Effector – muscle fiber or gland that r ...
FREE Sample Here
FREE Sample Here

... Rationale: Astrocytes form scar tissue in brain that acts to impede the regrowth of nerve cells. 2.1-37. Myelination of brain nerve axon membranes is accomplished by a. oligodendrocytes. b. microglia. c. astrocytes. d. neurocytes. e. Schwann cells. Difficulty: 1 Question ID: 2.1-37 Page Ref: 37 Topi ...
extrasynaptic glutamate does not reach the postsynaptic density
extrasynaptic glutamate does not reach the postsynaptic density

... et al. [20], ACPD, selective agonist of certain subtypes of these receptors, inhibited population spike in CA1 (but not in CA3) neurons leaving the EPSC unaffected. The age of the animals is critical for this phenomenology. In the rats younger than P20, ACPD inhibits EPSCs as well. This action is me ...
Is Embryonic Limulus Heart Really Myogenic? Experimental
Is Embryonic Limulus Heart Really Myogenic? Experimental

... concomitant with lumen formation in the rear heart segments. All lumen-containing heart sections that we have examined, from the earliest on, have revealed neural elements in a bundle at the dorsal midline of the heart. Axons 1/i.m or less in diameter are prevalent: vesicle-filled terminal-like area ...
Inferring spike-timing-dependent plasticity from spike train data
Inferring spike-timing-dependent plasticity from spike train data

... In the past few years model-based methods have been developed that allow the estimation of coupling between pairs of neurons from spike train data [6, 7, 8, 9, 10, 11]. These methods have been successfully applied to data from a variety of brain areas including retina [10], hippocampus [8], as well ...
Contacts among non-sister dendritic branches at
Contacts among non-sister dendritic branches at

... for contact. Yet, it is not clear whether such non-self recognition-based contact occurs spontaneously, or they are allocated and stabilized by a dedicated mechanism. We found that non-sister dendritic branches make stable contacts preferably at sites of bifurcations. Formation of such contacts is c ...
Discussion and future directions
Discussion and future directions

... Put generally, it demonstrates that a self–organizing map can learn to distinctively represent and command 12 directions of movement, by extracting the similarity relationships from the input space. The success of the self–organization process is dependent on two factors: the input patterns and the ...
Spike-Timing Theory of Working Memory
Spike-Timing Theory of Working Memory

... Figure 2. Associative short-term plasticity implemented in a form of short-term-STDP or via simulated NMDA receptors resulting in NMDA spikes. (A) The synaptic change is triggered by the classical STDP protocol at time ‘‘stimulation’’ (marked by arrows) but the change decays to 0 (baseline) within a ...
Chapter 5 - Rooprai Spinal Trust
Chapter 5 - Rooprai Spinal Trust

... until one was identified that provided dominant contribution to wrist and finger flexion of digits 1-3.[Video 3] When identifying the function of individual nerve fascicles, it is important to use the lowest current that can effectively activate the muscle groups to avoid current spread to adjacent ...
The Integrated Nature of Motor Cortical Function
The Integrated Nature of Motor Cortical Function

Central nervous System Lesions Leading to Disability
Central nervous System Lesions Leading to Disability

... of motor cortex controlling the arm receive input from premotor arm areas and influence corresponding armcontrol areas of the descending brainstem pathways). A hierarchical level receives information from the periphery, so that sensory input can modify the action of descending commands. Finally, a f ...
- TestbankU
- TestbankU

Betz et al
Betz et al

Ch 12
Ch 12

... • Neurons are electrically excitable due to the voltage difference across their membrane • Communicate with 2 types of electric signals – action potentials that can travel long distances – graded potentials that are local membrane changes only • In living cells, a flow of ions occurs through ion cha ...
Chapter 3
Chapter 3

... • Neurons are electrically excitable due to the voltage difference across their membrane • Communicate with 2 types of electric signals – action potentials that can travel long distances – graded potentials that are local membrane changes only • In living cells, a flow of ions occurs through ion cha ...
studies on the myoneural physiology of echinodermata
studies on the myoneural physiology of echinodermata

... animals were dissected under a dim light known to be below the threshold intensity of light stimulation for the preparation; this was, however, discontinued because it was found that, after the first 2 hr., the behaviour of such preparations was no different from those dissected under normal illumin ...
The Rat Ventromedial Thalamic Nucleus and Motor Control: Role of
The Rat Ventromedial Thalamic Nucleus and Motor Control: Role of

... substantia nigra. In addition, the superior colliculus, the mesencephalic reticular formation, and the reticular thalamic nucleus contribute to the afferent input to the VM (Beckstead et al., 1979; Carter and Fibiger, 1978; Haroian et al., 198 1; Herkenham, 1979; Jones, 1975). In contrast to the pri ...
Simulation of signal flow in 3D reconstructions of an anatomically
Simulation of signal flow in 3D reconstructions of an anatomically

Nothing can be coincidence: synaptic inhibition and plasticity in the
Nothing can be coincidence: synaptic inhibition and plasticity in the

... circuits with intrinsically active neurons have rules for information transfer and storage that distinguish them from other brain regions. Introduction Neurons and synapses throughout the vertebrate brain share many common properties, which have given rise to the useful generalizations taught in int ...
Biomechanics Models Motor Cortex Using Spinal Cord and Limb
Biomechanics Models Motor Cortex Using Spinal Cord and Limb

... Our model is aimed at predicting the neural activity of a subset of M1 neurons, which contribute linearly and additively to the input of the motorneuron pools (whether such a contribution is achieved through direct or indirect connections to motorneurons). We refer to such neurons as muscle related ...
< 1 ... 20 21 22 23 24 25 26 27 28 ... 209 >

Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report