Medicinal Chemistry (MDCH) 5220
... (6) What are agonists, antagonists and inverse agonists of the benzodiazepine receptor? Parkinsons (1) What is Parkinsons disease and how can we treat it? (2) Why is dopamine a poor drug for treating Parkinsons? (3) What are various hypotheses as to the cause of Parkinsons? (4) Learn about the major ...
... (6) What are agonists, antagonists and inverse agonists of the benzodiazepine receptor? Parkinsons (1) What is Parkinsons disease and how can we treat it? (2) Why is dopamine a poor drug for treating Parkinsons? (3) What are various hypotheses as to the cause of Parkinsons? (4) Learn about the major ...
Medicinal Chemistry-1 - Al
... Course outlines First Semester 2012-2013 Lecturer: Dr. Izzeddin M. Alsalahat E-mail: [email protected] Topics: ...
... Course outlines First Semester 2012-2013 Lecturer: Dr. Izzeddin M. Alsalahat E-mail: [email protected] Topics: ...
- Acute Medicine @ BHH
... • other effects: increased tone, hyperreflexia, seizures, metabolic acidosis, hypothermia, rhabdomyolysis, ARDS ...
... • other effects: increased tone, hyperreflexia, seizures, metabolic acidosis, hypothermia, rhabdomyolysis, ARDS ...
EFFECTS OF D-AMPHETAMINE SULFATE AN D DIAZEPAM ON
... the gross structure of the web, there is evidence of motor coordination disturbance fo r amphetamine in the fine structure of thread connections, but at low doses not fo r diazepam . However, in the case of diazepam, the small sample size should be considered . We would like to know precisely what c ...
... the gross structure of the web, there is evidence of motor coordination disturbance fo r amphetamine in the fine structure of thread connections, but at low doses not fo r diazepam . However, in the case of diazepam, the small sample size should be considered . We would like to know precisely what c ...
Driving under the influence of drugs
... A number of studies have shown that cannabis affects memory, psychomotor abilities, reaction times and these effects remain long after the ‘high’ has passed. The perception that drugs do not significantly impair driving capability would appear to be common among drug users. In fact they often percei ...
... A number of studies have shown that cannabis affects memory, psychomotor abilities, reaction times and these effects remain long after the ‘high’ has passed. The perception that drugs do not significantly impair driving capability would appear to be common among drug users. In fact they often percei ...
Driving Under the Influence of Drugs
... A number of studies have shown that cannabis affects memory, psychomotor abilities, reaction times and these effects remain long after the ‘high’ has passed. The perception that drugs do not significantly impair driving capability would appear to be common among drug users. In fact they often percei ...
... A number of studies have shown that cannabis affects memory, psychomotor abilities, reaction times and these effects remain long after the ‘high’ has passed. The perception that drugs do not significantly impair driving capability would appear to be common among drug users. In fact they often percei ...
Link - thejabberwock
... “The most important finding of this review is that signs and symptoms of psychosis or mania, particularly hallucinations, can occur in some patients with no identifiable risk factors at usual doses of any of the drugs currently used to treat ADHD.” FDA ADHD Review 2006 ADHD drugs: “helping” kids “gr ...
... “The most important finding of this review is that signs and symptoms of psychosis or mania, particularly hallucinations, can occur in some patients with no identifiable risk factors at usual doses of any of the drugs currently used to treat ADHD.” FDA ADHD Review 2006 ADHD drugs: “helping” kids “gr ...
ANESTHESIOLOGY Paulo Vilanova Jr., MD Medstudents
... some degree of cardiovascular depression when these drugs are used, mediated by direct effects on hemodinamics plus indirect effect by blocking the “adrenergic drive”. BNZs are avaliable for enteral and parenteral administration. Being lipophilic their clinical effect is observed at short period of ...
... some degree of cardiovascular depression when these drugs are used, mediated by direct effects on hemodinamics plus indirect effect by blocking the “adrenergic drive”. BNZs are avaliable for enteral and parenteral administration. Being lipophilic their clinical effect is observed at short period of ...
sheet_4
... Drugs Used to Treat Variceal Hemorrhage Portal hypertension most commonly occurs as a consequence of chronic liver disease. ...
... Drugs Used to Treat Variceal Hemorrhage Portal hypertension most commonly occurs as a consequence of chronic liver disease. ...
GI Drugs
... o Prochlorperazine MOA: Antagonist at D2, M, H1, 5-HT, and alpha-1 receptors Uses: antiemetic (reserved for vomiting resistant to other drugs) and antipsychotic Side effects: extrapyramidal effects and hyperprolactinemia o Metoclopramide MOA: D2 antagonist (anti-emesis at CTZ) and 5-HT4 agon ...
... o Prochlorperazine MOA: Antagonist at D2, M, H1, 5-HT, and alpha-1 receptors Uses: antiemetic (reserved for vomiting resistant to other drugs) and antipsychotic Side effects: extrapyramidal effects and hyperprolactinemia o Metoclopramide MOA: D2 antagonist (anti-emesis at CTZ) and 5-HT4 agon ...
Legal Drugs
... breathing, dry mouth, ataxia, urinary retention, drowsiness, memory problems, inability to concentrate, hallucinations, psychosis, and a marked increased sensitivity to external stimuli. ...
... breathing, dry mouth, ataxia, urinary retention, drowsiness, memory problems, inability to concentrate, hallucinations, psychosis, and a marked increased sensitivity to external stimuli. ...
pharmacokinetic
... completely removed per unit time. The amount eliminated is proportional to the concentration of the drug in the blood. The elimination constant (K): is the fraction of the drug in the body eliminated per unit time. Cl = K x Vd ...
... completely removed per unit time. The amount eliminated is proportional to the concentration of the drug in the blood. The elimination constant (K): is the fraction of the drug in the body eliminated per unit time. Cl = K x Vd ...
STRUCTURAL ACTIVITY RELATIONSHIP AMONG THE
... salivation, loss of binocular accommodation, miosis ...
... salivation, loss of binocular accommodation, miosis ...
MDMA powder
... MDMA. Pills may include a variety of non-psychoactive substances as well, such as paracetamol, ibuprofen, talcum powder, etc.[88] A number of deaths have been attributed to para-methoxyamphetamine (PMA), a hallucinogenic amphetamine, being sold as ecstasy.[89][90] PMA is unique in its ability to qui ...
... MDMA. Pills may include a variety of non-psychoactive substances as well, such as paracetamol, ibuprofen, talcum powder, etc.[88] A number of deaths have been attributed to para-methoxyamphetamine (PMA), a hallucinogenic amphetamine, being sold as ecstasy.[89][90] PMA is unique in its ability to qui ...
PATIENT HISTORY Patient Name Date Date of Birth _____
... Opioids should be kept in a secure place out of reach of children and protected from theft or misuse. Accidental consumption especially in children may result in overdose or death. Respiratory Depression Respiratory depression is the chief hazard from all opioid agonists, which can result in death. ...
... Opioids should be kept in a secure place out of reach of children and protected from theft or misuse. Accidental consumption especially in children may result in overdose or death. Respiratory Depression Respiratory depression is the chief hazard from all opioid agonists, which can result in death. ...
ROUTES OF DRUG ADMINISTRATION
... membranes and the liver, for the first time, during the absorption process after oral administration. This is also known PreSystemic elimination. h) Drugs interaction may occur if two drugs are given cocurrently. ...
... membranes and the liver, for the first time, during the absorption process after oral administration. This is also known PreSystemic elimination. h) Drugs interaction may occur if two drugs are given cocurrently. ...
Bruyere/Primrose Units - R. Halil, August 2015
... Lack of flexibility Not always logical (anti-tussive + expectorant?) Herbals/Natural Products: (Lozenges) Little evidence to support use Stimulate saliva secretion – throat soothing Echinacea: requires large doses, avoid in autoimmune diseases Vitamin C (>1g/day) decreases cold sx dura ...
... Lack of flexibility Not always logical (anti-tussive + expectorant?) Herbals/Natural Products: (Lozenges) Little evidence to support use Stimulate saliva secretion – throat soothing Echinacea: requires large doses, avoid in autoimmune diseases Vitamin C (>1g/day) decreases cold sx dura ...
• The smallest effective dose of a laxative should be used, and this
... Neurological conditions (e.g. spinal or pelvic nerve injury, Parkinson's disease, MS, autonomic neuropathy - most commonly due to diabetes mellitus) Psychiatric conditions (e.g. depression) Adverse effects of drugs (e.g. opioids, anticholinergics, iron preparations) Pregnancy, due to the muscle rela ...
... Neurological conditions (e.g. spinal or pelvic nerve injury, Parkinson's disease, MS, autonomic neuropathy - most commonly due to diabetes mellitus) Psychiatric conditions (e.g. depression) Adverse effects of drugs (e.g. opioids, anticholinergics, iron preparations) Pregnancy, due to the muscle rela ...
Deuterium Modification Offers Great Promise to Improve the Profiles
... doses and the ability to maintain similar systemic exposure with decreased peak levels and increased trough levels. This could result in lower side effects and enhanced efficacy, depending on the particular drug’s pharmacokinetic/ pharmacodynamic relationship. 3. Lower doses, improved tolerability R ...
... doses and the ability to maintain similar systemic exposure with decreased peak levels and increased trough levels. This could result in lower side effects and enhanced efficacy, depending on the particular drug’s pharmacokinetic/ pharmacodynamic relationship. 3. Lower doses, improved tolerability R ...
*.. l-\
... Nicotine is one of severalalkaloids present in tobacco. small doses,such as those obtained by smokers, stimulate the involuntary nervous svsrem. Large dosesare toxic and result in nicotine poisoning. Nicotine is a iabituating drug-one on which people acquire a dependence.An addicting drug is one tha ...
... Nicotine is one of severalalkaloids present in tobacco. small doses,such as those obtained by smokers, stimulate the involuntary nervous svsrem. Large dosesare toxic and result in nicotine poisoning. Nicotine is a iabituating drug-one on which people acquire a dependence.An addicting drug is one tha ...
SEDATIVE/HYPNOTICS (Antianxiety Drugs)
... develop upon long-term use. • Depression of the medullary respiratory centers is the usual cause of death of sedative/hypnotic overdose. Also loss of brainstem vasomotor control and myocardial depression. ...
... develop upon long-term use. • Depression of the medullary respiratory centers is the usual cause of death of sedative/hypnotic overdose. Also loss of brainstem vasomotor control and myocardial depression. ...
Drug Induced Dementia
... Indomethacin(Indocin) Headache, dizziness, vertigo, somnolence, depression, fatigue Disopyramide(Norpace): Strongly anticholinergic properties, which can result in confusion, delirium, and hallucinations ...
... Indomethacin(Indocin) Headache, dizziness, vertigo, somnolence, depression, fatigue Disopyramide(Norpace): Strongly anticholinergic properties, which can result in confusion, delirium, and hallucinations ...
Pharynx, larynx, trachea
... Usually oral administration as capsule Absorbed from GIT Passes from blood to parietal cells and canaliculi Increase dose: disproportional increase in plasma (improves its own bioavailability) – Half life: 1 hour, dose lasts 1-2 days – High protein binding – Drug interactions: • CYP inhibitor : – ↑ ...
... Usually oral administration as capsule Absorbed from GIT Passes from blood to parietal cells and canaliculi Increase dose: disproportional increase in plasma (improves its own bioavailability) – Half life: 1 hour, dose lasts 1-2 days – High protein binding – Drug interactions: • CYP inhibitor : – ↑ ...
ESC Study Group of Sports Cardiology Position Paper on
... hyperlipidemia, hypertension, thrombosis, arrythmogenesis, heart failure and sudden cardiac death have been noted following drug abuse. This paper reviews the literature on the adverse cardiovascular effects after abuse of prohibited substances and methods in athletes, aiming to inform physicians, t ...
... hyperlipidemia, hypertension, thrombosis, arrythmogenesis, heart failure and sudden cardiac death have been noted following drug abuse. This paper reviews the literature on the adverse cardiovascular effects after abuse of prohibited substances and methods in athletes, aiming to inform physicians, t ...
MDMA (Ecstasy/Molly)
... 3,4-methylenedioxy-methamphetamine (MDMA) is a synthetic drug that alters mood and perception (awareness of surrounding objects and conditions). It is chemically similar to both stimulants and hallucinogens, producing feelings of increased energy, pleasure, emotional warmth, and distorted sensory an ...
... 3,4-methylenedioxy-methamphetamine (MDMA) is a synthetic drug that alters mood and perception (awareness of surrounding objects and conditions). It is chemically similar to both stimulants and hallucinogens, producing feelings of increased energy, pleasure, emotional warmth, and distorted sensory an ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.