Prodrugs for Amines
... membrane penetration by passive diffusion. The impact of this is amplified for the large number of amino drugs that are required to penetrate the blood brain barrier in order to reach their pharmacological targets. A second issue that can affect the development of amino drugs is instability. An exam ...
... membrane penetration by passive diffusion. The impact of this is amplified for the large number of amino drugs that are required to penetrate the blood brain barrier in order to reach their pharmacological targets. A second issue that can affect the development of amino drugs is instability. An exam ...
P otective effects of inhaled ipratropium ... on bronchoconstriction induced by adenosine
... In the second phase of the study, patients attended the laboratory on four occasions, not less than 72 h apart, to undertake dose-response studies with inhaled methacholine and AMP after ipratropium bromide or matched placebo, administered double-blind and in random order. On each occasion three bas ...
... In the second phase of the study, patients attended the laboratory on four occasions, not less than 72 h apart, to undertake dose-response studies with inhaled methacholine and AMP after ipratropium bromide or matched placebo, administered double-blind and in random order. On each occasion three bas ...
ALLEGRA-D - hebust.edu.cn
... Care should be taken in the administration of ALLEGRA-D concomitantly with other sympathomimetic amines because combined effects on the cardiovascular system may be harmful to the patient (see WARNINGS). Carcinogenesis, Mutagenesis, Impairment of Fertility There are no animal or in vitro studies on ...
... Care should be taken in the administration of ALLEGRA-D concomitantly with other sympathomimetic amines because combined effects on the cardiovascular system may be harmful to the patient (see WARNINGS). Carcinogenesis, Mutagenesis, Impairment of Fertility There are no animal or in vitro studies on ...
Abstract Ethnopharmacological relevance Achillea millefolium L
... (Lister, 1987 and Borsini et al., 2002). However, debatable is whether the elevated plus maze can detect the anxiolytic-like effects of antidepressants, such as selective serotonin reuptake inhibitors (Rodgers and Cole, 1994 and Borsini et al., 2002). Marble-burying behavior in mice and rats is base ...
... (Lister, 1987 and Borsini et al., 2002). However, debatable is whether the elevated plus maze can detect the anxiolytic-like effects of antidepressants, such as selective serotonin reuptake inhibitors (Rodgers and Cole, 1994 and Borsini et al., 2002). Marble-burying behavior in mice and rats is base ...
KHAT (CATHA EDULIS) A CONTROVERSIAL PLANT: BLESSING
... is mainly a recreational drug in the countries where it grows, though it may also be used by farmers and agricultural and other laborers for reducing physical fatigue and by lorry drivers and high-school students for improving attention. Children very often start chewing khat around the age of 10. A ...
... is mainly a recreational drug in the countries where it grows, though it may also be used by farmers and agricultural and other laborers for reducing physical fatigue and by lorry drivers and high-school students for improving attention. Children very often start chewing khat around the age of 10. A ...
Gastrointestinal Disorders: Nausea in Adults
... Nausea and vomiting of pregnancy (NVP) is common and can often be controlled effectively. Up to 85% of all pregnant women experience varying degrees of nausea and vomiting, usually in the first 16 weeks of pregnancy. NVP can occur throughout the day despite the common expression “morning sickness.” ...
... Nausea and vomiting of pregnancy (NVP) is common and can often be controlled effectively. Up to 85% of all pregnant women experience varying degrees of nausea and vomiting, usually in the first 16 weeks of pregnancy. NVP can occur throughout the day despite the common expression “morning sickness.” ...
- EurekaMag.com
... sense you possess is heightened and somehow in tune with the jungle, as though the 'sapo' put the rhythm of the jungle into your blood." The violent visceral effects of sapo have been confirmed by GoRMAN (personal com munication) in about ten self-applications of the drug, and correspond exactly to ...
... sense you possess is heightened and somehow in tune with the jungle, as though the 'sapo' put the rhythm of the jungle into your blood." The violent visceral effects of sapo have been confirmed by GoRMAN (personal com munication) in about ten self-applications of the drug, and correspond exactly to ...
Evaluation of the Anti Platelet Aggregation Effects of Diltiazem
... and Aspirin are used to reduce the platelet aggregation for the prevention and treatment of cardiovascular diseases. Resistance to these traditional drugs is observed as recurrent attacks of MI and stroke are being observed despite the use of these medicines. The reported incidence of resistance to ...
... and Aspirin are used to reduce the platelet aggregation for the prevention and treatment of cardiovascular diseases. Resistance to these traditional drugs is observed as recurrent attacks of MI and stroke are being observed despite the use of these medicines. The reported incidence of resistance to ...
prescribing information xylocaine® ointment 5%
... The lowest dosage that results in effective anesthesia should be used to avoid high plasma levels and serious adverse effects. Tolerance to elevated blood levels varies with the status of the patient. Lidocaine should be used with caution in patients with sepsis and/or traumatized mucosa at the area ...
... The lowest dosage that results in effective anesthesia should be used to avoid high plasma levels and serious adverse effects. Tolerance to elevated blood levels varies with the status of the patient. Lidocaine should be used with caution in patients with sepsis and/or traumatized mucosa at the area ...
Glycine receptors in the central nervous system
... in such quantities that the beneficial health effects are lost. What separates these individuals from those able to enjoy alcohol without developing a destructive behavioural pattern? No common factor for all addicted individuals has been found, probably because no such factor exists. That there is ...
... in such quantities that the beneficial health effects are lost. What separates these individuals from those able to enjoy alcohol without developing a destructive behavioural pattern? No common factor for all addicted individuals has been found, probably because no such factor exists. That there is ...
Grapefruit Interactions
... Does fresh grapefruit have the same effect as grapefruit juice? Yes. The substance in grapefruit that produces this interaction is found in the fresh fruit as well as in the juice. How long does the grapefruit effect last? Can I have my grapefruit in the morning and take my pills safely later in the ...
... Does fresh grapefruit have the same effect as grapefruit juice? Yes. The substance in grapefruit that produces this interaction is found in the fresh fruit as well as in the juice. How long does the grapefruit effect last? Can I have my grapefruit in the morning and take my pills safely later in the ...
Does Oral Trenbolone Really Have the Best Steroid
... Oral Trenbolone PCT The drugs you will take during PCT include aromatase inhibitors and Selective Estrogen Receptor Modulators (SERM). Aromatase inhibitors stop androgens from binding with estrogen receptors and SERMs are supposed to prevent their effects. However, with oral Trenbolone, users are sp ...
... Oral Trenbolone PCT The drugs you will take during PCT include aromatase inhibitors and Selective Estrogen Receptor Modulators (SERM). Aromatase inhibitors stop androgens from binding with estrogen receptors and SERMs are supposed to prevent their effects. However, with oral Trenbolone, users are sp ...
Teratogenicity as a Consequence of Drug-Induced
... functional during a restricted period in rodent embryonic life (gestational days 10-14 in rats), but not thereafter. Single doses during this period caused stage-specific external, visceral and skeletal defects in rats. The later the treatment was during this period, the more caudal the site of the ...
... functional during a restricted period in rodent embryonic life (gestational days 10-14 in rats), but not thereafter. Single doses during this period caused stage-specific external, visceral and skeletal defects in rats. The later the treatment was during this period, the more caudal the site of the ...
Motivational views of reinforcement: implications - Research
... across several different investigators offering a multitude of theoretical approaches, motivation is seen by many as being fundamental to the process of reinforcement. The reinforcer has been described as a goal, a commodity, an incentive, or a stimulus that is being approached, self-administered, a ...
... across several different investigators offering a multitude of theoretical approaches, motivation is seen by many as being fundamental to the process of reinforcement. The reinforcer has been described as a goal, a commodity, an incentive, or a stimulus that is being approached, self-administered, a ...
Opioid Handout - Oral Surgery Albuquerque NM
... held responsible for the willful and deceptive behavior of patients who successfully obtain opioids for non-dental purposes. 6. Appropriate education in addictive disease and pain management should be provided as part of the core curriculum at all dental schools. ...
... held responsible for the willful and deceptive behavior of patients who successfully obtain opioids for non-dental purposes. 6. Appropriate education in addictive disease and pain management should be provided as part of the core curriculum at all dental schools. ...
министерство здравоохранения республики беларусь
... Neuroleptic malignant syndrome is a life threatening disorder that occurs in patients who are extremely sensitive to the extrapyramidal effects of antipsychotics. This syndrome is believed to result from an excessively rapid blockage of post synaptic dopaminergic receptors. A severe form of extrapyr ...
... Neuroleptic malignant syndrome is a life threatening disorder that occurs in patients who are extremely sensitive to the extrapyramidal effects of antipsychotics. This syndrome is believed to result from an excessively rapid blockage of post synaptic dopaminergic receptors. A severe form of extrapyr ...
Hallucinogens - Multidisciplinary Association for Psychedelic Studies
... not cause life-threatening changes in cardiovascular, renal, or hepatic function because they have little or no affinity for the biological receptors and targets that mediate vital vegetative functions. In contrast to many other abused drugs, hallucinogens do not engender drug dependence or addictio ...
... not cause life-threatening changes in cardiovascular, renal, or hepatic function because they have little or no affinity for the biological receptors and targets that mediate vital vegetative functions. In contrast to many other abused drugs, hallucinogens do not engender drug dependence or addictio ...
Salvia Divinorum: Establish Restrictions But Don`t Criminalize It
... learned about Salvia and introduced the plant to the United States in 1962.vii Salvia is most often smoked, but can also be used sublingually or orally (chewed and swallowed), ...
... learned about Salvia and introduced the plant to the United States in 1962.vii Salvia is most often smoked, but can also be used sublingually or orally (chewed and swallowed), ...
International Narcotics Control Board
... The regular analysis of consumption data, particularly regarding narcotic drugs, convinced the Board that the level of consumption of narcotic drugs was very low in a number of countries. Therefore, in 1989, the Board, in cooperation with WHO, assessed the medical need for opiates in the world. They ...
... The regular analysis of consumption data, particularly regarding narcotic drugs, convinced the Board that the level of consumption of narcotic drugs was very low in a number of countries. Therefore, in 1989, the Board, in cooperation with WHO, assessed the medical need for opiates in the world. They ...
DRI® Amphetamines Assay - Thermo Fisher Scientific
... 1000 ng/mL. The assay provides a simple and rapid analytical screening procedure for detecting amphetamine and methamphetamine in urine on automated clinical analyzers. The assay is calibrated with methamphetamine. This assay provides only a preliminary analytical test result. A more specific altern ...
... 1000 ng/mL. The assay provides a simple and rapid analytical screening procedure for detecting amphetamine and methamphetamine in urine on automated clinical analyzers. The assay is calibrated with methamphetamine. This assay provides only a preliminary analytical test result. A more specific altern ...
Involvement of к/Dynorphin System in WIN 55212-2 Self
... THC or WIN 55,212-2 (WIN) can only be revealed in mice if they received a previous injection of the drug 24 h before the first conditioning day (Valjent and Maldonado, 2000; Castañé et al, 2004). Studies with genetically modified animals have provided further support to this hypothesis and have re ...
... THC or WIN 55,212-2 (WIN) can only be revealed in mice if they received a previous injection of the drug 24 h before the first conditioning day (Valjent and Maldonado, 2000; Castañé et al, 2004). Studies with genetically modified animals have provided further support to this hypothesis and have re ...
ACMD Advisory Council on the Misuse of Drugs ACMD consideration of tramadol
... serotonin syndrome being characterised by hyperpyrexia (very high body temperature) associated with secondary complications including rhabdomyolysis (breakdown of skeleton muscle), disseminated intravascular coagulation (formation of blood clots) and acute kidney injury. This syndrome is more likely ...
... serotonin syndrome being characterised by hyperpyrexia (very high body temperature) associated with secondary complications including rhabdomyolysis (breakdown of skeleton muscle), disseminated intravascular coagulation (formation of blood clots) and acute kidney injury. This syndrome is more likely ...
Suggestion from clinicians
... The STELLAR trial is the largest trial of its kind to date to compare dose-related effects of statins on lipid goal achievement in patients with hypercholesterolemia. Trial results indicate that rosuvastatin 10 to 40 mg has greater efficacy than atorvastatin 10 to 80 mg, simvastatin 10 to 80 mg, and ...
... The STELLAR trial is the largest trial of its kind to date to compare dose-related effects of statins on lipid goal achievement in patients with hypercholesterolemia. Trial results indicate that rosuvastatin 10 to 40 mg has greater efficacy than atorvastatin 10 to 80 mg, simvastatin 10 to 80 mg, and ...
Boletín Latinoamericano y del Caribe de Plantas Medicinales y
... • To stimulate the existing work groups interested in the medicinal and aromatic plants in Latin America, investigators, producers, governmental agencies or general public interested in the subject, by publishing a Bulletin dedicated to the dissemination of their investigations and the activities th ...
... • To stimulate the existing work groups interested in the medicinal and aromatic plants in Latin America, investigators, producers, governmental agencies or general public interested in the subject, by publishing a Bulletin dedicated to the dissemination of their investigations and the activities th ...
Methadone Maintenance A Practical Guide to Pharmacotherapy
... There may be a rapid change in tolerance when methadone ingestion is interrupted or discontinued 1–2 days missed dose: Administer usual dose as long as no other contraindication 3–4 consecutive days missed: If dose is 30 mg or less, continue; if dose is greater than 30 mg, start at 50% of ...
... There may be a rapid change in tolerance when methadone ingestion is interrupted or discontinued 1–2 days missed dose: Administer usual dose as long as no other contraindication 3–4 consecutive days missed: If dose is 30 mg or less, continue; if dose is greater than 30 mg, start at 50% of ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.