warning: addiction, abuse, and misuse
... caregiver/family during periods of changing analgesic requirements, including initial titration. During chronic therapy, periodically reassess the continued need for the use of opioid analgesics. Patients who experience breakthrough pain may require a dosage adjustment of KADIAN, or may need rescue ...
... caregiver/family during periods of changing analgesic requirements, including initial titration. During chronic therapy, periodically reassess the continued need for the use of opioid analgesics. Patients who experience breakthrough pain may require a dosage adjustment of KADIAN, or may need rescue ...
Pharmacology_1
... A Antipsychotic effect B Antivomiting effect C Arterial pressure increase D Arterial pressure decrease E Anxiolytic effect ANSWER: E 95Benzodiazepine tranquilizers intensify the action A Psychomotor stimulants B Analeptics C Antidepressants D Nootropic preparations E General anesthetics, analgesics, ...
... A Antipsychotic effect B Antivomiting effect C Arterial pressure increase D Arterial pressure decrease E Anxiolytic effect ANSWER: E 95Benzodiazepine tranquilizers intensify the action A Psychomotor stimulants B Analeptics C Antidepressants D Nootropic preparations E General anesthetics, analgesics, ...
5 1 Prereview - World Health Organization
... modafinil were essentially similar in that all three agents enhanced extracellular concentrations of dopamine and noradrenaline in the PFC, although some differences were also observed. When PO lisdexamfetamine was administered, smaller increases in striatal dopamine efflux were observed as compared ...
... modafinil were essentially similar in that all three agents enhanced extracellular concentrations of dopamine and noradrenaline in the PFC, although some differences were also observed. When PO lisdexamfetamine was administered, smaller increases in striatal dopamine efflux were observed as compared ...
Granska/Öppna
... The aim of this study series was to study the role of placental transporters, apical P-gp and basal MRP1, using saquinavir as a probe drug, and to study transfer of quetiapine and the role of P-gp in its transfer in the dually perfused human placenta/cotyledon. Furthermore, two ABCB1 (encoding P-gp) ...
... The aim of this study series was to study the role of placental transporters, apical P-gp and basal MRP1, using saquinavir as a probe drug, and to study transfer of quetiapine and the role of P-gp in its transfer in the dually perfused human placenta/cotyledon. Furthermore, two ABCB1 (encoding P-gp) ...
PHARMACEUTICAL BENEFITS ADVISORY COMMITTEE (PBAC
... Closing date for consumer comments 11 February 2015 Submission type (new listing, change to listing) ...
... Closing date for consumer comments 11 February 2015 Submission type (new listing, change to listing) ...
Product Information: Lisdexamfetamine dimesilate
... A double-blind, randomised, placebo-controlled, parallel-group study was conducted in children aged 6 to 12 (N=290) who met DSM-IV criteria for ADHD (either the combined type or the hyperactive-impulsive type). Patients were randomised to fixed dose treatment groups receiving final doses of 30, 50, ...
... A double-blind, randomised, placebo-controlled, parallel-group study was conducted in children aged 6 to 12 (N=290) who met DSM-IV criteria for ADHD (either the combined type or the hyperactive-impulsive type). Patients were randomised to fixed dose treatment groups receiving final doses of 30, 50, ...
PDF version of March 2015 PBAC Meeting Agenda
... Closing date for consumer comments 11 February 2015 Submission type (new listing, change to listing) ...
... Closing date for consumer comments 11 February 2015 Submission type (new listing, change to listing) ...
Pharmaceutical Administration and Regulations in Japan
... same tasks. It consists of the ministry proper, ...
... same tasks. It consists of the ministry proper, ...
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view/Open[285279] - S
... chain reaction (PCR)-restriction fragment length polymorphism analysis, as previously reported.20 In brief, genomic DNA was amplified using CYP3A5 6956Fm (5′-CTT TAA AGA GCT CTT TTG TCT CTC A-3′) as the forward primer and CYP3A5 7155R (5′-CCA GGA AGC CAG ACT TTG AT-3′) as the reverse primer. After a ...
... chain reaction (PCR)-restriction fragment length polymorphism analysis, as previously reported.20 In brief, genomic DNA was amplified using CYP3A5 6956Fm (5′-CTT TAA AGA GCT CTT TTG TCT CTC A-3′) as the forward primer and CYP3A5 7155R (5′-CCA GGA AGC CAG ACT TTG AT-3′) as the reverse primer. After a ...
AVT Figure template - International Medical Press
... presence of EFV was 20-fold and sixfold greater than wild-type IC50 and IC90, respectively [17]. Concomitant administration of TMC114 300 mg with RTV 100 mg twice daily and EFV 600 mg once daily resulted in a decreased exposure to TMC114. Exposure to EFV was increased when administered with TMC114/r ...
... presence of EFV was 20-fold and sixfold greater than wild-type IC50 and IC90, respectively [17]. Concomitant administration of TMC114 300 mg with RTV 100 mg twice daily and EFV 600 mg once daily resulted in a decreased exposure to TMC114. Exposure to EFV was increased when administered with TMC114/r ...
Clinical relevance of the small intestine as an organ of
... ***Note: Figures may be missing from this format of the document Abstract: Most drugs are taken orally. For those intended to act systemically, a significant fraction of the dose can be eliminated during its first passage through a sequence of organs before entry into the general circulation. For so ...
... ***Note: Figures may be missing from this format of the document Abstract: Most drugs are taken orally. For those intended to act systemically, a significant fraction of the dose can be eliminated during its first passage through a sequence of organs before entry into the general circulation. For so ...
A Descriptive Study of Adverse Events from
... from 2 regional poison centers for human exposures to clenbuterol. Data collected after individual chart review, including review of individual case notes fields, included demographics, substances involved including coingestatants if known, reason for exposure/use of clenbuterol, dose, clinical effe ...
... from 2 regional poison centers for human exposures to clenbuterol. Data collected after individual chart review, including review of individual case notes fields, included demographics, substances involved including coingestatants if known, reason for exposure/use of clenbuterol, dose, clinical effe ...
PRODUCT MONOGRAPH PrLUVOX
... The use of LUVOX® (fluvoxamine maleate) has been associated with the development of akathisia, characterized by a subjectively unpleasant or distressing restlessness and need to move, often accompanied by an inability to sit or stand still. This is most likely to occur within the first few weeks of ...
... The use of LUVOX® (fluvoxamine maleate) has been associated with the development of akathisia, characterized by a subjectively unpleasant or distressing restlessness and need to move, often accompanied by an inability to sit or stand still. This is most likely to occur within the first few weeks of ...
Neomycin - Australian Pesticides and Veterinary Medicines Authority
... provided to the APVMA and animal safety studies provided by holders. The most frequently reported AER was for injection site reactions in horses. The frequency of both Australian and global AERs was low and many appeared to be related to reactions to the procaine benzylpenicillin in one of the neomy ...
... provided to the APVMA and animal safety studies provided by holders. The most frequently reported AER was for injection site reactions in horses. The frequency of both Australian and global AERs was low and many appeared to be related to reactions to the procaine benzylpenicillin in one of the neomy ...
uniformity (a required drug dose). This led to the develop-
... four systems: (1) subdermal implants of nonbiodegradable polymers, such as Norplant (6 capsules of 36 mg levonorgestrel); (2) subdermal implant of biodegradable polymers; (3) steroid releasing intrauterine device (IUD); and (4) vaginal rings, which are silicone coated. Other applications have been m ...
... four systems: (1) subdermal implants of nonbiodegradable polymers, such as Norplant (6 capsules of 36 mg levonorgestrel); (2) subdermal implant of biodegradable polymers; (3) steroid releasing intrauterine device (IUD); and (4) vaginal rings, which are silicone coated. Other applications have been m ...
Increased risk of atherothrombotic events associated with
... The inhibition of platelet aggregation after clopidogrel treatment was significant at all points compared with baseline in both of the genotype groups (Fig. 3). When we compared the efficacy of clopidogrel in terms of the change in aggregation from baseline, there were no significant differences bet ...
... The inhibition of platelet aggregation after clopidogrel treatment was significant at all points compared with baseline in both of the genotype groups (Fig. 3). When we compared the efficacy of clopidogrel in terms of the change in aggregation from baseline, there were no significant differences bet ...
An investigation of the effects of fulvic and humic acids... the absorption of selected drugs, vitamins and minerals
... for each test compound was noted, the extent of the absorption increase or decrease was compound specific. The changes in absorption observed could be attributed to changes in compound solubility and mechanism of transport across the intestinal membrane once in complex. Drugs and vitamins were seen ...
... for each test compound was noted, the extent of the absorption increase or decrease was compound specific. The changes in absorption observed could be attributed to changes in compound solubility and mechanism of transport across the intestinal membrane once in complex. Drugs and vitamins were seen ...
Methadone treatment in Victoria User information booklet
... It is important to be as straightforward as you can about drugs you’ve been using, how often, how much and how you are feeling. Everybody is different, so your doctor needs to know about your situation and your body in order to better judge your particular needs. If you are not sure about going onto ...
... It is important to be as straightforward as you can about drugs you’ve been using, how often, how much and how you are feeling. Everybody is different, so your doctor needs to know about your situation and your body in order to better judge your particular needs. If you are not sure about going onto ...
Survey study of challenging experiences after ingesting psilocybin
... standard error of the mean) were used to characterize the responses to questions and the subscale scores of the questionnaires. Pearson correlations were used to analyze the associations among participant ratings of the degree of difficulty of the challenging experience, the duration of the challeng ...
... standard error of the mean) were used to characterize the responses to questions and the subscale scores of the questionnaires. Pearson correlations were used to analyze the associations among participant ratings of the degree of difficulty of the challenging experience, the duration of the challeng ...
PAXIL CR™ PRODUCT MONOGRAPH
... PAXIL CR™ is indicated for the symptomatic treatment of premenstrual dysphoric disorder (PMDD). The efficacy of PAXIL CR™ in the treatment of PMDD was established in 3 placebo-controlled trials (see CLINICAL TRIALS). The essential features of PMDD, according to DSM-IV, include markedly depressed moo ...
... PAXIL CR™ is indicated for the symptomatic treatment of premenstrual dysphoric disorder (PMDD). The efficacy of PAXIL CR™ in the treatment of PMDD was established in 3 placebo-controlled trials (see CLINICAL TRIALS). The essential features of PMDD, according to DSM-IV, include markedly depressed moo ...
Gamma-butyrolactone (GBL) - World Health Organization
... GBL is sold as a liquid, often presented in illicit sale as GHB. Prices of GBL vary between 9 cents to 2 euros for a recreational dose (1 ml). GBL is often used with other drugs, particularly cannabis, alcohol and ecstasy. Accurate estimates of the prevalence of the use of GBL for its intoxicating e ...
... GBL is sold as a liquid, often presented in illicit sale as GHB. Prices of GBL vary between 9 cents to 2 euros for a recreational dose (1 ml). GBL is often used with other drugs, particularly cannabis, alcohol and ecstasy. Accurate estimates of the prevalence of the use of GBL for its intoxicating e ...
HIGHLIGHTS OF PRESCRIBING INFORMATION
... Sudden death has been reported in association with CNS stimulant treatment at usual doses in children and adolescents with structural cardiac abnormalities or other serious heart problems. Although some serious heart problems alone carry an increased risk of sudden death, stimulant products generall ...
... Sudden death has been reported in association with CNS stimulant treatment at usual doses in children and adolescents with structural cardiac abnormalities or other serious heart problems. Although some serious heart problems alone carry an increased risk of sudden death, stimulant products generall ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.