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an-update-of-taste-m.. - Scholars Research Library
an-update-of-taste-m.. - Scholars Research Library

... pH 6.8 but readily, dissolves at gastric pH 1.2 could be a good candidate for taste masking. Choosing one of these polymers is not a simple selection. Before making a decision on coating material following factors must be considered. The particle size of drug, flow characteristics of drug, moisture ...
Patient Registries and Participating in Clinical Trials
Patient Registries and Participating in Clinical Trials

... Face to face presentation of each trial’s process/benefit and communicate to potential participants: Why do we have to discontinue our current meds? What are the measures of confidentiality required or available? Type of contact? In terms of ongoing trials: ...
A Review on Evidence Based Practice of Ginkgo biloba in Brain
A Review on Evidence Based Practice of Ginkgo biloba in Brain

... championing the role of diet in the care and treatment of people with mental health problems. Ginkgo biloba leaf extract has shown beneficial effect in treating impairments in memory, cognitive speed, activities of daily living (ADL), edema, inflammation and free-radical toxicity associated with tra ...
P otective  effects  of  inhaled  ipratropium ... on  bronchoconstriction  induced  by  adenosine
P otective effects of inhaled ipratropium ... on bronchoconstriction induced by adenosine

... Airway response was evaluated as forced expiratory volume in one second (FEV,). Inhaled lpratroplum bromide (40 Jlg), administered 20 mln prior to bronchoprovocation, Increased the provocation dose of Inhaled methacholine and adenosine required to reduce FEV, by 20% from baseline (PD,.) from 0.11 to ...
Cannabis Report of the Swiss Federal Commission For Drug Issues
Cannabis Report of the Swiss Federal Commission For Drug Issues

... In the course of its initial meetings, the Federal Commission for Drug Issues (EKDF) mandated by the Swiss Federal Council in early 1997 drew up an assessment of the situation regarding drugs in Switzerland and of the current need for action. Its predecessor (the Subcommission for Drug Issues attach ...
concerta - Janssen
concerta - Janssen

... hyperactive-impulsive criteria must be met. Special Diagnostic Considerations The specific etiology of ADHD is unknown, and there is no single diagnostic test. Adequate diagnosis requires the use not only of medical but of special psychological, educational, and social resources. Learning may or may ...
COMPARITIVE STUDIES OF GLUTATHIONE-S-TRANSFERASE KINETICS IN CONTROL,
COMPARITIVE STUDIES OF GLUTATHIONE-S-TRANSFERASE KINETICS IN CONTROL,

PRIAPISM INDUCED WITH SINGLE ORAL DOSE OF SILDENAFIL: A RARE CASE REPORT  Research Article 
PRIAPISM INDUCED WITH SINGLE ORAL DOSE OF SILDENAFIL: A RARE CASE REPORT  Research Article 

... the recommended dose is 50 mg taken, as needed, approximately 1  hour  before  sexual  activity.  Based  on  effectiveness  and  toleration,  the dose may be increased to a maximum recommended dose of 100  mg  or  decreased  to  25  mg.  The  onset  of  activity  of  sildenafil  is  14  min.  The  p ...
quality evidence - American Pain Society
quality evidence - American Pain Society

... ECG findings, methadone dose changes, and other risk factors for QTc interval prolongation (strong recommendation, lowquality evidence) Switch patients with QTc interval >=500 ms to an alternative opioid or immediately reduce the methadone dose; evaluate and correct causes of QTc interval prolongati ...
Effects of Caffeine in Operant Learning and Locomotor Activity
Effects of Caffeine in Operant Learning and Locomotor Activity

... Buffalo, Gillam, Allen and Paule, found that rhesus monkeys given caffeine showed behavioural alterations that caused them to improve at both learning and reinforcement tasks. According to the study conducted by Fernstrom and Fernstrom’s (1984) the mechanism, of caffeine altering reinforcement, may ...
Bipolar disorder: assessment and management
Bipolar disorder: assessment and management

... 1.3 Assessing suspected bipolar disorder in adults in secondary care ....................................................................... 20 1.4 Managing crisis, risk and behaviour that challenges in adults with bipolar disorder in secondary care 21 1.5 Managing mania or hypomania in adults in se ...
Medicines Management Programme Preferred Drugs Calcium
Medicines Management Programme Preferred Drugs Calcium

... Table 8: Meta-analyses and reviews of CCBs in stable angina.......................................................................... 21 Table 9: Review of clinical guidelines for stable angina .................................................................................... 23 Table 10: Dosing r ...
Extract from the Clinical Evaluation Report for macitentan
Extract from the Clinical Evaluation Report for macitentan

... Pulmonary arterial hypertension (PAH) is characterised by vasculopathy and remodelling of the pulmonary circulation resulting in narrowing of the arterial lumen and impaired vasodilation. This leads to an increase in pulmonary arterial pressure and pulmonary vascular resistance, which limits the abi ...
Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients
Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients

... tests were carried out at least weekly as part of continued standard care including monitoring for hyperlactataemia and haematological abnormalities such as thrombocytopaenia and anaemia. All patients received epoetine-a (Eprex; Janssen-Cilag, Leiden, The Netherlands) pre-emptively in a dose of 2000 ...
AusPAR: Prednisone
AusPAR: Prednisone

... According to the Product Information document (PI), the initial daily dose is 10 mg and this may be titrated down in steps of 1 mg. In some cases short-term higher treatments of 12, 15 or 20 mg are required and thus the maximum daily dose is 20 mg. It follows from this and the tablets strengths bein ...
AusPAR: Trastuzumab
AusPAR: Trastuzumab

... The drug substance is manufactured by Chinese Hamster Ovary (CHO) cells into which the DNA coding for the humanised immunoglobulin light and heavy chains has been inserted. The drug substance manufacture consists of cell culture fermentation and purification. The master cell bank and the working cel ...
In vitro - In vivo Correlation: From Theory to
In vitro - In vivo Correlation: From Theory to

... biopharmaceutic drug classification and the work of Corrigan relating to extended release product, characterizing the permeability properties of a drug substance is a key element both in establishing the initial feasibility of any formulation program and in the subsequent interpretation of the obser ...
Buprenorphine: Everything You Need to Know
Buprenorphine: Everything You Need to Know

... to cut doses down. For addiction, we may do early refills and dose increases if craving and symptoms are not controlled. Likewise, we don’t cut people off buprenorphine when they use marijuana or other drugs — we shouldn’t stop an effective treatment because the patient has more than one problem.” — ...
Prodrugs for Amines
Prodrugs for Amines

... The use of (acyloxy)methyl esters as bridging groups (Scheme 2, R2=H) is generally a topic of controversy due to the generation of formaldehyde during breakdown. For this reason, (acyloxy)ethyl esters (Scheme 2, R2=CH3) are usually preferred. On the other hand, (acyloxy)ethyl derivatives introduce a ...
TRAMADOL – A Drug to be used cautiously
TRAMADOL – A Drug to be used cautiously

... of the racemate. As one of the least potent opioid painkillers many people believe tramadol is not addictive. This false sense of security can lead some people to develop an addiction without even realizing it. Tramadol was originally considered to have a much better safety profile than other opioid ...


Product Monograph
Product Monograph

... Amphetamines have a potential for abuse, misuse, dependence, or diversion for non-therapeutic uses that physicians should consider when prescribing this product (see Precautions, Dependence Liability.) The misuse of amphetamines may cause serious cardiovascular adverse events and sudden death. Pre-e ...
Dextromethorphan abuse: Clinical effects
Dextromethorphan abuse: Clinical effects

... inexpensive and easily accessible over-the-counter (OTC) medication intended for use as an antitussant— has in recent years been increasingly used for illicit purposes, particularly by adolescents. Because DM is a common ingredient in many OTC cough and cold medications, many abusers consider DM mis ...
Examination of the Evidence for Off
Examination of the Evidence for Off

... OBJECTIVES: (1) Describe the relevance of off-label use of gabapentin to managed care pharmacy; (2) summarize recent FDA warnings and media reports related to off-label gabapentin use; (3) review medical information pertaining to the off-label use of gabapentin; (4) outline alternatives to off-label ...
VA Medicaid PDL Criteria (effective 01/01/2010)
VA Medicaid PDL Criteria (effective 01/01/2010)

... Pentazocine combinations Propoxyphene combinations ...
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Polysubstance dependence



A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.
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