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Coca leaf chewing as therapy for cocaine maintenance
Coca leaf chewing as therapy for cocaine maintenance

... parents and grandparents who were also coca consumers. And even though it was not an in-depth analysis, I had a very close general impression, from within the community, of the effects of coca chewing on the human body inside its social context. In my observations, I found that among the habitual co ...
Guidance for the use of substitute prescribing in the
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EVALUATION OF PHYSICAL PROPERTIES OF JIT-TRA-ROM FAST DISINTEGRATING TABLETS
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A novel bivalent morphine/heroin vaccine that prevents relapse to
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Project submission form for human involvement study
Project submission form for human involvement study

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... simply run out of phentermine. Typically, patients who discontinue phentermine then observe an increase or a return of hunger, cravings, or both. After a variable time lag, such patients find it increasingly difficult to maintain control of their food intake and most of them gain weight. Some patien ...
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Comment on: “Use of the Fluocinolone Acetonide Intravitreal Implant
Comment on: “Use of the Fluocinolone Acetonide Intravitreal Implant

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St.eroid Anesthetics: Old Compounds, New Drugs

... thereby maintaining a coupling between metabolism and blood flow. A number of open studies have defined ED,, induction doses in both benzodiazepine and opioid-premeditated patients as between 0.33 mg/kg and 0.46 mg/kg.4g-51 Induction resulted in minimal hemodynamic depression, the main side effects ...
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RADIATION THERAPY ONCOLOGY GROUP RTOG 97

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WARNING: DEATH RELATED TO ULTRA
WARNING: DEATH RELATED TO ULTRA

... because their mothers were ultra-rapid metabolizers of codeine [see Use in Specific Populations (8.3)]. Some individuals may be ultra-rapid metabolizers because of a specific CYP2D6 genotype (gene duplications denoted as *1/*1xN or *1/*2xN). The prevalence of this CYP2D6 phenotype varies widely and ...
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Polysubstance dependence



A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.
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