... that the paradoxical response was caused by the additives rather than the active drug. This is further supported by showing that terbutaline, when administered as pure drug through Turbuhaler® in the absence of any additives, had no significant bronchoconstrictor effect, and although just failing to ...
Pharmaceutical Applications of Ispaghula Husk
... improve its procesability and performance for specific application in the broad field of pharmacy. Exploitation of Isabgol husk mucilage as an “Excipient” and its innovative, non-conventional applications, chemical derivatization, use of its derivative in modern fashion of drug designing has become ...
... improve its procesability and performance for specific application in the broad field of pharmacy. Exploitation of Isabgol husk mucilage as an “Excipient” and its innovative, non-conventional applications, chemical derivatization, use of its derivative in modern fashion of drug designing has become ...
Evaluation of the effect of nitrous oxide and hydroxyzine in
... 7 reported on a controlled double blind study of pediatric patients with a meanage of 6 years, 4 months. In this study, 50 mg of hydroxyzine were administered to the patients of the test group I hr before the treatment. The results showed that "hydroxyzine reduced significantly the behavioral diffic ...
... 7 reported on a controlled double blind study of pediatric patients with a meanage of 6 years, 4 months. In this study, 50 mg of hydroxyzine were administered to the patients of the test group I hr before the treatment. The results showed that "hydroxyzine reduced significantly the behavioral diffic ...
FORMULATION DEVELOPMENT, OPTIMIZATION AND IN-VITRO RELEAS KINETIC STUDY ON
... Acetate, Isopropyl Alcohol (IPA) were procured from S.D Fine Chemicals, Alpha Galactosidase, and Galactomannase were procured from Deer Land Enzymes U.S. All ingredients used were of AR or GR grade and were used as such without further processing. Double distilled water was used where ever required. ...
... Acetate, Isopropyl Alcohol (IPA) were procured from S.D Fine Chemicals, Alpha Galactosidase, and Galactomannase were procured from Deer Land Enzymes U.S. All ingredients used were of AR or GR grade and were used as such without further processing. Double distilled water was used where ever required. ...
DRUG ABSORPTION, DISTRIBUTION AND ELIMINATION
... Many drugs will bind strongly to proteins in the blood or to food substances in the gut. Binding to plasma proteins will increase the rate of passive absorption by maintaining the concentration gradient of free drug. For many drugs, the gastrointestinal absorption rate, but not the extent of absorpt ...
... Many drugs will bind strongly to proteins in the blood or to food substances in the gut. Binding to plasma proteins will increase the rate of passive absorption by maintaining the concentration gradient of free drug. For many drugs, the gastrointestinal absorption rate, but not the extent of absorpt ...
Enhancement of dissolution rate of poorly water
... excipients were utilized (16, 17). In PG, the Φ value of Avicel PH 102 was found to be 0.16, while for Aerosil 200 the Φ-value used was equal to that of Cab-O-Sil M5, as they both possessed the same specific surface area and density and, according to Spireas et al. (17, 18), the Φ-value of a powder ...
... excipients were utilized (16, 17). In PG, the Φ value of Avicel PH 102 was found to be 0.16, while for Aerosil 200 the Φ-value used was equal to that of Cab-O-Sil M5, as they both possessed the same specific surface area and density and, according to Spireas et al. (17, 18), the Φ-value of a powder ...
pdf - Journal of Global Trends in Pharmaceutical Sciences
... screening carried out on ethanolic extract of Dalbergia latifolia revealed the presence of phytoconstituents such as alkaloids, tannins, flavonoids, carbohydrates, glycosides. The extract did not produce any toxic symptoms of mortality up to dose level of 5000 mg/kg body weight in mice and hence the ...
... screening carried out on ethanolic extract of Dalbergia latifolia revealed the presence of phytoconstituents such as alkaloids, tannins, flavonoids, carbohydrates, glycosides. The extract did not produce any toxic symptoms of mortality up to dose level of 5000 mg/kg body weight in mice and hence the ...
SELEGILINE
... long as there is evidence that selegiline is favorably enhancing the actions of levodopa • Use of selegiline to slow functional loss in Parkinson’s disease or Alzheimer disease would be long-term if proven effective for this use ...
... long as there is evidence that selegiline is favorably enhancing the actions of levodopa • Use of selegiline to slow functional loss in Parkinson’s disease or Alzheimer disease would be long-term if proven effective for this use ...
Chapter 1 - Multidisciplinary Association for Psychedelic Studies
... Benjamin Paul Blood’s 1874 pamphlet, published his own paper about the subjective effects of nitrous oxide.37 James discussed his self-experiments with nitrous oxide and reported that these experiences had assisted him to better understand Hegel’s philosophy of the unification of opposites within a ...
... Benjamin Paul Blood’s 1874 pamphlet, published his own paper about the subjective effects of nitrous oxide.37 James discussed his self-experiments with nitrous oxide and reported that these experiences had assisted him to better understand Hegel’s philosophy of the unification of opposites within a ...
NCIC CTG Consent - BC Cancer Agency
... included to reassure participants that this type of genetic testing will not be done.] Hereditary genetic testing (to find out if cancer runs in your family) will not be done on these samples. The collection of theses samples is a necessary part of this study and will be used only for these purposes ...
... included to reassure participants that this type of genetic testing will not be done.] Hereditary genetic testing (to find out if cancer runs in your family) will not be done on these samples. The collection of theses samples is a necessary part of this study and will be used only for these purposes ...
A case of heroin overdose reversed by sublingually administered
... allows the clinical effects of buprenorphine to last significantly longer than would be expected based solely upon its elimination half-life. A combination pill, buprenorphine/naloxone, is available in the United States under the trade name Suboxone®. Because naloxone is absorbed poorly sublingually ...
... allows the clinical effects of buprenorphine to last significantly longer than would be expected based solely upon its elimination half-life. A combination pill, buprenorphine/naloxone, is available in the United States under the trade name Suboxone®. Because naloxone is absorbed poorly sublingually ...
Psychotropics in Psychiatric Patient – Bipolar disorders
... GI side effects, sedation are common All common allergic and idiosyncratic toxic effects also occur Augments effects of ADH; hyponatremia Blood dyscrasias; aplastic anemia, neutropenia, thrombocytopenia ...
... GI side effects, sedation are common All common allergic and idiosyncratic toxic effects also occur Augments effects of ADH; hyponatremia Blood dyscrasias; aplastic anemia, neutropenia, thrombocytopenia ...
Regulatory Considerations in the Post-Vioxx Era
... joint meeting of the Arthritis and Drug Safety and Risk Management Advisory Committees, FDA published a summary of the cardiovascular risk associated with the approved COX-2 inhibitor NSAIDs in April 2005: • The approved COX-2 selective drugs are associated with an increased risk of serious adverse ...
... joint meeting of the Arthritis and Drug Safety and Risk Management Advisory Committees, FDA published a summary of the cardiovascular risk associated with the approved COX-2 inhibitor NSAIDs in April 2005: • The approved COX-2 selective drugs are associated with an increased risk of serious adverse ...
Toxicological risk assessment of various emerging drugs Nathan Bijl
... physicians. Sometimes the drugs were used as medicine but the drugs were often taken for nonmedical reasons. When drugs are taken for nonmedical reasons it is called a drug of abuse. They include legal drugs/medicines as well as illicit drugs5. Until the 19th century, drugs originated from two sourc ...
... physicians. Sometimes the drugs were used as medicine but the drugs were often taken for nonmedical reasons. When drugs are taken for nonmedical reasons it is called a drug of abuse. They include legal drugs/medicines as well as illicit drugs5. Until the 19th century, drugs originated from two sourc ...
Enhancement of Dissolution Rate of Domperidone Using Melt
... Der Pharmacia Lettre, 2011, 3(2):25-33 ______________________________________________________________________________ Although, salt formation, solubilization and particle size reduction have commonly been use to increase dissolution rate of the drug, but there are particular limitations with these ...
... Der Pharmacia Lettre, 2011, 3(2):25-33 ______________________________________________________________________________ Although, salt formation, solubilization and particle size reduction have commonly been use to increase dissolution rate of the drug, but there are particular limitations with these ...
www.ijpbs.com Rishikesh S Deshmukh*et al Int J Pharm Bio Sci
... Impurities present in excess of 0.1% should be identified and quantified by selective methods. The suggested structures of the impurities can be synthesized and will provide the final evidence for their structures, previously determined by spectroscopic methods. Therefore it is essential to know the ...
... Impurities present in excess of 0.1% should be identified and quantified by selective methods. The suggested structures of the impurities can be synthesized and will provide the final evidence for their structures, previously determined by spectroscopic methods. Therefore it is essential to know the ...
Opioid Antagonists, Partial Agonists, and Agonists
... ♦ Training/experience as determined by State licensing board ♦ Other criteria established by Health and Human Services Qualified physicians must submit notification to Center for Substance Abuse Treatment (CSAT) and a unique identification is then issued from the DEA in the form of an “X” number, ...
... ♦ Training/experience as determined by State licensing board ♦ Other criteria established by Health and Human Services Qualified physicians must submit notification to Center for Substance Abuse Treatment (CSAT) and a unique identification is then issued from the DEA in the form of an “X” number, ...
A Review: Stereochemical consideration and eudismic ratio in chiral
... extensions of the life cycle of drugs have been impetus for developing single enantiomers [1]. The biological activity (both pharmacological and toxicological) of the enantiomers is considered as the tool of advance research because of the different activities shown by R-enantiomer and S- ...
... extensions of the life cycle of drugs have been impetus for developing single enantiomers [1]. The biological activity (both pharmacological and toxicological) of the enantiomers is considered as the tool of advance research because of the different activities shown by R-enantiomer and S- ...
Cannabinoids in the Treatment of Epilepsy
... Downloaded from nejm.org at NYU WASHINGTON SQUARE CAMPUS on September 10, 2015. For personal use only. No other uses without permission. Copyright © 2015 Massachusetts Medical Society. All rights reserved. ...
... Downloaded from nejm.org at NYU WASHINGTON SQUARE CAMPUS on September 10, 2015. For personal use only. No other uses without permission. Copyright © 2015 Massachusetts Medical Society. All rights reserved. ...
TREATMENT bulletin . 4 - HIV i-Base
... In the Lancet (6 April 2002), investigators from the Petra trial of the prevention of transmission of HIV from mother to child report that short-term prophylaxis with a two-drug antiretroviral combination significantly reduces vertical transmission rates more than two-fold in early infancy. At 6 wee ...
... In the Lancet (6 April 2002), investigators from the Petra trial of the prevention of transmission of HIV from mother to child report that short-term prophylaxis with a two-drug antiretroviral combination significantly reduces vertical transmission rates more than two-fold in early infancy. At 6 wee ...
FORMULATION AND EVALUATION OF ORODISPERSIBLE FILM OF SILDENAFILCITRATE Research Article
... persistent nausea, sudden episodes of allergic attacks, or coughing for those who have an active life style[8].In disease conditions such as motion sickness, sudden episodes of attacks of coughing and repeated emesis and swallowing[9], conventional tablets become difficult. Orally disintegrating dos ...
... persistent nausea, sudden episodes of allergic attacks, or coughing for those who have an active life style[8].In disease conditions such as motion sickness, sudden episodes of attacks of coughing and repeated emesis and swallowing[9], conventional tablets become difficult. Orally disintegrating dos ...
Evidence-based guideline: Antiepileptic drug selection
... have been developed,9 yet none currently exists for AED-ARV therapy. AED-ARV interactions that raise blood levels of drugs in either class may increase toxicity risk. Use of ARVs that reduce AED levels could lead to loss of therapeutic AED effects, including seizure control. Use of AEDs that decreas ...
... have been developed,9 yet none currently exists for AED-ARV therapy. AED-ARV interactions that raise blood levels of drugs in either class may increase toxicity risk. Use of ARVs that reduce AED levels could lead to loss of therapeutic AED effects, including seizure control. Use of AEDs that decreas ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.