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Mark scheme - Edexcel
Mark scheme - Edexcel

... The name of the study is for convenience in marking, it is not an element of the evaluation so if the name does not match the evaluation it is of no concern if the evaluation can be identified as from a study in the list. Mark the evaluation only. Yuille and Cutshall (A case study of eyewitness memo ...
Comparison of the efficacy and safety of mometasone furoate dry
Comparison of the efficacy and safety of mometasone furoate dry

... due to treatment and centre and treatment-by-centre interaction. Since all pairwise comparisons were of independent interest, each ANOVA was followed by Duncan's multiple range test to compare all treatment groups. The results of these tests are considered significant at the 0.05 level. The assessme ...
TECHtalk CE - Teva Pharmacy Solutions
TECHtalk CE - Teva Pharmacy Solutions

... Program (http://www.cphir.ca); identifying possible contributing factors or causes of common medication incidents that occur in seniors; and offering suggestions on how pharmacy technicians can play an important role in preventing these incidents from happening again in the future. Background Why ar ...
Primer on estimating withdrawal times after extralabel drug
Primer on estimating withdrawal times after extralabel drug

... long should the half-life be extended?In this scenario, our starting dosewould now be 200 g, and thus after only 1 more half-life, we would be back to a 100-g dose. The WDT would only be extended by a single half-life (2 hours) to 22 hours and would remain 1 day Extralabel WDT adjustment-When a vete ...


... molecule by formulating a dosage form being convenient for the administration. To improve quality of life and fastening of treatment, orally disintegrating tablets (ODT) dosage form is a better alternative for oral medication. These dosage forms dissolve or disintegrate within matter of seconds. Oro ...
A New Approach to Drug Discovery and Development
A New Approach to Drug Discovery and Development

... substitution can in principle improve the safety, efficacy, and/or tolerability of a therapeutic agent. Selective deu- ...
DETERMINATION OF LEVOCETIRIZINE CONFIGURATIONAL STABILITY IN TABLETS USING  CHIRAL HPLC METHOD  Research Article 
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... (racemates).  In  many  cases  the  two  enantiomers  differ  in  their  pharmacokinetic  and  pharmacodynamic  properties.  Replacing  existing  racemates  with  single  isomers  has  resulted  in  improved  safety and/or efficacy profile of various racemates1,2.  Many optically active enantiomers  ...
Opiates Drug Information
Opiates Drug Information

... were ingested. The presence of morphine alone would generally indicate either clinical morphine use or illicit morphine or heroin use. A specific metabolite of heroin, 6monoacetylmorphine, is also at times detected and would definitely confirm illicit drug (heroin) use. Poppy seeds, which have not b ...
oral controlled release drug delivery system
oral controlled release drug delivery system

... site of absorption. The distribution of drugs in tissues can be important factor in the overall drug elimination kinetics. Since it not only lowers the concentration of circulating drug but it also can be rate limiting in its equilibrium with blood and extra vascular tissue, consequently apparent vo ...
The incentive sensitization theory of addiction
The incentive sensitization theory of addiction

... At some time in their life, most people try a potentially addictive drug (e.g. alcohol). However, few become addicts. Addiction implies a pathological and compulsive pattern of drug-seeking and drug-taking behaviours, which occupies an inordinate amount of an individual’s time and thoughts, and pers ...
Syddansk Universitet The Monoamine Oxidase Inhibitor
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... TCAs in the serotonergic end of the TCA spectrum, like clomipramine [2]. Though also later studies used amitriptyline in combination with MAOIs [17,18], for more than 30 years the active main metabolite of amitriptyline, nortriptyline was preferred with isocarboxazid in Denmark [1]. Isocarboxazid mu ...
Ballantyne Plenary Panel 2014
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... clinical settings. This will decrease the time it takes for research to be incorporated into treatment settings and will thereby to improve the quality of drug abuse treatment throughout the country. Focus on Buprenorphine In 2002, tablet formulations of buprenorphine were approved by the Food and D ...
Physician Education Forum - Florida
Physician Education Forum - Florida

... higher dose to produce the same effect Opioids desensitize the brain’s own natural opioid system, making it less responsive over time [3] ...
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... Doxy 100, Doryx ...
Uppers, Downers, All Arounders, 7th Edition
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... (HPPD). A number of users experience mental flashbacks of sensations, or of a bad trip they had while under the influence of LSD. Most flashbacks are provoked by some sensory stimulus: sight, sound, odor, or touch. The other type of HPPD is the intermittent or continuous experience of LSD-like visua ...
ASHP Guidelines on Surgery and Anesthesi
ASHP Guidelines on Surgery and Anesthesi

... continuation of maintenance medications and discontinuation of unnecessary medications postoperatively. Medication-Use Evaluation. The pharmacist should take a leadership role in the performance of medication-use evaluations by establishing criteria, collecting data, analyzing the data, making recom ...
(PSD) March 2016 PBAC Meeting
(PSD) March 2016 PBAC Meeting

... The resubmission stated that rates of withdrawal from modafinil therapy indicates that there is a clinical need for more than one medication in the therapeutic area, with armodafinil having been shown in long-term studies to provide an effective and tolerable option for some patients. For more detai ...
Comparison  between  a  new once-daily,
Comparison between a new once-daily,

... 0 =no symptoms; I =slight; 2 =slight to moderate; 3 =moderate; 4 =moderately severe; 5 =severe symptoms. At the end of the study, the patients were asked in which of the two periods they experienced the fewest asthmatic symptoms and the fewest side effects and which of the two periods they preferred ...
xtram plus
xtram plus

... provide prior medical records or contact information for other treating physician(s). “Doctor shopping” to obtain additional prescriptions is common among drug abusers and people suffering from untreated addiction. Abuse and addiction are separate and distinct from physical dependence and tolerance. ...
PPT
PPT

... alternative route. There are less uncomfortable side affects; lesser risk of tolerance, abuse or withdrawal symptoms and thus this may provide greater reasons for patient compliance and overall satisfaction with the drug treatment. Modafinil achieves the same promising effects for treatment as other ...
training workshop on pharmaceutical quality, good manufacturing
training workshop on pharmaceutical quality, good manufacturing

... administration in the same molar dose are similar to such a degree that their effects can be expected to be essentially the same ...
ARCI-025-020 Medications and Prohibited Substances
ARCI-025-020 Medications and Prohibited Substances

... prominent CNS effects, but which do have prominent cardiovascular or respiratory system effects (bronchodilators. Bronchodilators are included in this class); (b) A local anesthetic which that has nerve blocking potential but also has a high potential for producing urine residue levels from a method ...
here - Resist-TB
here - Resist-TB

... [07-26-2016] The U.S. Food and Drug Administration (FDA) approved changes to the labels of fluoroquinolone antibacterial drugs for systemic use (i.e., taken by mouth or by injection). These medicines are associated with disabling and potentially permanent side effects of the tendons, muscles, joints ...
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Polysubstance dependence



A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.
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