anti-inflammatory activity of calcium channel blockers abstract
... Objective: To explore the anti-inflammatory activity of calcium channel blockers. Material and Methods: The anti-inflammatory activity was determined by producing inflammation in rats of either sex. Acute inflammation was produced by injecting carrageenan, formalin and histamine in hindpaw of rats. ...
... Objective: To explore the anti-inflammatory activity of calcium channel blockers. Material and Methods: The anti-inflammatory activity was determined by producing inflammation in rats of either sex. Acute inflammation was produced by injecting carrageenan, formalin and histamine in hindpaw of rats. ...
Plasma amino acid levels after single-dose aspartame
... pulation who carry the gene for PKU and thus have a r~uced capacity for phenylalanine metabolism. Studies in rAtsshow that elevations of plasma phenylalanine levels, as Supported in part by Grants NS 21231 and NS 05096 from the ational Institute of Neurological, Communicative Diseases, and Stroke, t ...
... pulation who carry the gene for PKU and thus have a r~uced capacity for phenylalanine metabolism. Studies in rAtsshow that elevations of plasma phenylalanine levels, as Supported in part by Grants NS 21231 and NS 05096 from the ational Institute of Neurological, Communicative Diseases, and Stroke, t ...
Identification of the date-rape drug GHB and its precursor GBL by
... as ‘liquid ecstasy’ or ‘liquid X’[1] is a Class C drug of abuse[2] that also occurs naturally in mammalian tissues in very small amounts (5 mg/L).[3] The drug has recently become associated with drug-facilitated sexual assaults or ‘date rape’.[4] In the 1960s, GHB, a central nervous system (CNS) dep ...
... as ‘liquid ecstasy’ or ‘liquid X’[1] is a Class C drug of abuse[2] that also occurs naturally in mammalian tissues in very small amounts (5 mg/L).[3] The drug has recently become associated with drug-facilitated sexual assaults or ‘date rape’.[4] In the 1960s, GHB, a central nervous system (CNS) dep ...
okf"kZd izfrosnu@Annual Report 2014-15
... students for all the success, in both professional and personal lives. The faculty members and students continued to be recognized with various honours and awards for their academic as well as research achievements. Close to 170 papers were published during this period. We were also successful in li ...
... students for all the success, in both professional and personal lives. The faculty members and students continued to be recognized with various honours and awards for their academic as well as research achievements. Close to 170 papers were published during this period. We were also successful in li ...
Product Monograph - AstraZeneca Canada
... potassium is recommended, especially when taken concomitantly with ACE inhibitors and potassium-sparing diuretics such as spironolactone. General Driving and Operating Machinery The effect of ATACAND on the ability to drive and use machines has not been studied, but based on its pharmacodynamic prop ...
... potassium is recommended, especially when taken concomitantly with ACE inhibitors and potassium-sparing diuretics such as spironolactone. General Driving and Operating Machinery The effect of ATACAND on the ability to drive and use machines has not been studied, but based on its pharmacodynamic prop ...
Memorandum
... Animal toxicology studies and studies evaluating the effect of Diosmin Complex on the digestive tract, reproductive function, and lactation demonstrated an excellent safety profile. In toxicity studies conducted by Heusser and Osswald on rats,, diosmin 200 mglkg per day orally for 50 days produced n ...
... Animal toxicology studies and studies evaluating the effect of Diosmin Complex on the digestive tract, reproductive function, and lactation demonstrated an excellent safety profile. In toxicity studies conducted by Heusser and Osswald on rats,, diosmin 200 mglkg per day orally for 50 days produced n ...
Prescribing Information
... No laboratory test interactions with FLOMAX capsules are known. Treatment with FLOMAX capsules for up to 12 months had no significant effect on prostate-specific antigen (PSA). 6.2 Postmarketing Experience The following adverse reactions have been identified during post-approval use of FLOMAX capsul ...
... No laboratory test interactions with FLOMAX capsules are known. Treatment with FLOMAX capsules for up to 12 months had no significant effect on prostate-specific antigen (PSA). 6.2 Postmarketing Experience The following adverse reactions have been identified during post-approval use of FLOMAX capsul ...
jwh-018 - Ministry of Health
... 33. As documented above, the JWH substances have an affinity for the CB1 receptor. Accordingly, the psychoactive effects of these substances are broadly similar to that of cannabis. However, subjective reports from users of these products indicate that there are subtle differences in physiological e ...
... 33. As documented above, the JWH substances have an affinity for the CB1 receptor. Accordingly, the psychoactive effects of these substances are broadly similar to that of cannabis. However, subjective reports from users of these products indicate that there are subtle differences in physiological e ...
Imovane (zopiclone)
... influenced by the alpha (distribution) (t½α) and beta (elimination) (t½β) half-lives of the administered drug and any active metabolites formed. When half-lives are long, the drug or metabolite may accumulate during periods of nightly administration and be associated with impairments of cognitive an ...
... influenced by the alpha (distribution) (t½α) and beta (elimination) (t½β) half-lives of the administered drug and any active metabolites formed. When half-lives are long, the drug or metabolite may accumulate during periods of nightly administration and be associated with impairments of cognitive an ...
Biomedical Interventional Protocol
... Design attributes such as single blind, double blind or open label; randomized, placebo or active placebo control; cross-over design, etc. Estimated duration for the main protocol (e.g., from start of screening to last subject processed and finishing the study) Single-center or multi-center; if mult ...
... Design attributes such as single blind, double blind or open label; randomized, placebo or active placebo control; cross-over design, etc. Estimated duration for the main protocol (e.g., from start of screening to last subject processed and finishing the study) Single-center or multi-center; if mult ...
Drugs Used In Peptic Ulcer and Eradication Therapy
... grow deep enough to reach the underlying blood flow. When that happens, the ulcer is said to have perforated the stomach wall, allowing stomach acid and pepsin can directly act on the tissue underneath. At this point the person with the perforation would be in considerable danger .If the acid reache ...
... grow deep enough to reach the underlying blood flow. When that happens, the ulcer is said to have perforated the stomach wall, allowing stomach acid and pepsin can directly act on the tissue underneath. At this point the person with the perforation would be in considerable danger .If the acid reache ...
Technical considerations for pen injectors
... Injectors may be subject to different regulatory provisions depending on their intended use, technological characteristics, proposed labeling, and packaging. For example, most injectors are intended for general use with a wide range of drugs/biological products and are marketed alone. Typically, gen ...
... Injectors may be subject to different regulatory provisions depending on their intended use, technological characteristics, proposed labeling, and packaging. For example, most injectors are intended for general use with a wide range of drugs/biological products and are marketed alone. Typically, gen ...
Design and physicochemical characterisation of novel
... We describe formulation and evaluation of novel dissolving polymeric microneedle (MN) arrays for the facilitated delivery of low molecular weight, high dose drugs. Ibuprofen sodium was used as the model here and was successfully formulated at approximately 50% w/w in the dry state using the copolyme ...
... We describe formulation and evaluation of novel dissolving polymeric microneedle (MN) arrays for the facilitated delivery of low molecular weight, high dose drugs. Ibuprofen sodium was used as the model here and was successfully formulated at approximately 50% w/w in the dry state using the copolyme ...
More efficient reversal of dabigatran inhibition of coagulation by activated prothrombin
... dabigatran. PCC improved haemostasis in a rabbit kidney injury model [19] and prevented excess intracerebral haematoma expansion in a murine intracerebral hemorrhage model [20]. PCC, APCC, rFVIIa all decreased the prolonged bleeding time in a rat tail bleeding model, but routine coagulation assays d ...
... dabigatran. PCC improved haemostasis in a rabbit kidney injury model [19] and prevented excess intracerebral haematoma expansion in a murine intracerebral hemorrhage model [20]. PCC, APCC, rFVIIa all decreased the prolonged bleeding time in a rat tail bleeding model, but routine coagulation assays d ...
paper of Dermatophyte Nail Infection-nowrozi_h-2013-01-07
... of treatment. Aims: This study aimed to find the effectiveness of 4 different antifungal agents in an in vitro model with some similarities to in vivo conditions. Materials and Methods: Strains of Trichophyton rubrum I-III, Trichophyton mentagrophytes (usual form), Trichophyton mentagrophytes 73, Ep ...
... of treatment. Aims: This study aimed to find the effectiveness of 4 different antifungal agents in an in vitro model with some similarities to in vivo conditions. Materials and Methods: Strains of Trichophyton rubrum I-III, Trichophyton mentagrophytes (usual form), Trichophyton mentagrophytes 73, Ep ...
Clofazimine (Lamprene, B663) in the Treatment of Lepromatous
... drug, all the others had previously received treatment with an antileprosy drug, usually with several, over a period of many years (Table 1). All 20 who were proven or suspected to be dapsone-resistant had taken dapsone for periods of between 6 and 25 years in doses now considered to be too low, oft ...
... drug, all the others had previously received treatment with an antileprosy drug, usually with several, over a period of many years (Table 1). All 20 who were proven or suspected to be dapsone-resistant had taken dapsone for periods of between 6 and 25 years in doses now considered to be too low, oft ...
Minireviews Cracking the Egg: Potential of the Developing Chicken
... exposure to CO2. Eggs at ,1/2 of the total incubation period may be destroyed by cooling (,4°C for 4 hours), freezing, or prolonged exposure to CO2. The EU legislation on the protection of animals used for scientific purposes (2010/63/EU; EU, 2010) defines embryos or fetuses developed to .2/3 of the ...
... exposure to CO2. Eggs at ,1/2 of the total incubation period may be destroyed by cooling (,4°C for 4 hours), freezing, or prolonged exposure to CO2. The EU legislation on the protection of animals used for scientific purposes (2010/63/EU; EU, 2010) defines embryos or fetuses developed to .2/3 of the ...
Stevens Johnson Syndrome
... the patient, and the outcome is also included. in 1993 in France and in 1995 in the other countries. The study design and In addition to varying with the actual risk of specific adverse events in overall results for all drugs of 245 cases and 1147 controls ascertained association with a drug, the nu ...
... the patient, and the outcome is also included. in 1993 in France and in 1995 in the other countries. The study design and In addition to varying with the actual risk of specific adverse events in overall results for all drugs of 245 cases and 1147 controls ascertained association with a drug, the nu ...
EXTEMPORANEOUS PREPARATION OF PAEDIATRIC ORAL
... nifedipine amount was less than 80% of the theoretical value. Three quarters of the missing amount was located on the emptied powder papers. Oral powders were stable for up to one year. Nifedipine capsules, whose contents were simply emptied prior to use, were faster to prepare and when comparing th ...
... nifedipine amount was less than 80% of the theoretical value. Three quarters of the missing amount was located on the emptied powder papers. Oral powders were stable for up to one year. Nifedipine capsules, whose contents were simply emptied prior to use, were faster to prepare and when comparing th ...
Breakthrough Pain
... Risk factors include: low K+ or Mg+ (a side-effect of cisplatinum therapy), hx of CHF, bradycardia or baseline long QT, liver disease, concomitant disuse or use of medications, or a reduction in plasma protein levels which then increase methadone concentration QTc in females normal up to 460 mse ...
... Risk factors include: low K+ or Mg+ (a side-effect of cisplatinum therapy), hx of CHF, bradycardia or baseline long QT, liver disease, concomitant disuse or use of medications, or a reduction in plasma protein levels which then increase methadone concentration QTc in females normal up to 460 mse ...
Focus on Lisdexamfetamine: A Review of its use in Child and
... psychiatry. Method: A literature review was conducted using the PubMed search term: ‘lisdexamfetamine’ with limits: Human trials, English language, All Child (aged 0-18 years). Additional articles were identified from reference information and poster presentation data. Results: Lisdexamfetamine (Vyv ...
... psychiatry. Method: A literature review was conducted using the PubMed search term: ‘lisdexamfetamine’ with limits: Human trials, English language, All Child (aged 0-18 years). Additional articles were identified from reference information and poster presentation data. Results: Lisdexamfetamine (Vyv ...
IFU - Beckman Coulter
... provides only a preliminary analytical result; a positive result by this assay should be conrmed by another generally accepted non-immunological method such as thin layer chromatography (TLC), gas chromatography (GC), or gas chromatography/mass spectrometry (GC/MS). GC/MS is the preferred conrmato ...
... provides only a preliminary analytical result; a positive result by this assay should be conrmed by another generally accepted non-immunological method such as thin layer chromatography (TLC), gas chromatography (GC), or gas chromatography/mass spectrometry (GC/MS). GC/MS is the preferred conrmato ...
Product Monograph - AstraZeneca Canada
... 2-4 hours after dosing and are subject to a 4-fold variability. The plasma levels are proportional to dose over the range 50-400 mg and 6 to 16% of atenolol is bound to plasma proteins. The mean peak plasma concentrations of atenolol were approximately 300 and 700 nanogram/mL following 50 and 100 mg ...
... 2-4 hours after dosing and are subject to a 4-fold variability. The plasma levels are proportional to dose over the range 50-400 mg and 6 to 16% of atenolol is bound to plasma proteins. The mean peak plasma concentrations of atenolol were approximately 300 and 700 nanogram/mL following 50 and 100 mg ...
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon ""drug"" and kinetikos ""moving, putting in motion""; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.