bhsai.org - ACS Publications
... Tanimoto coefficient is a more stringent similarity measure than the cosine coefficient,8 the authors found that for most of the compounds, there were <15 near neighbors in the 1,309compound data set that met the 80% Tanimoto similarity criterion. In such situations, the cosine coefficient was used as the ...
... Tanimoto coefficient is a more stringent similarity measure than the cosine coefficient,8 the authors found that for most of the compounds, there were <15 near neighbors in the 1,309compound data set that met the 80% Tanimoto similarity criterion. In such situations, the cosine coefficient was used as the ...
Pharmacological and Medical Considerations in Hypnotic Use
... recognized that the activity of a drug may be modified by the presence of other drugs. Drug interactions can arise from an alteration of the absorption, distribution, metabolism, or elimination of one drug by another. For example, when two drugs compete for plasma protein binding sites, one is displ ...
... recognized that the activity of a drug may be modified by the presence of other drugs. Drug interactions can arise from an alteration of the absorption, distribution, metabolism, or elimination of one drug by another. For example, when two drugs compete for plasma protein binding sites, one is displ ...
epitan - Clinuvel Pharmaceuticals
... drug to be placed in the long acting implant. This trial is scheduled to take six months. The company is meeting with the US Food and Drug Administration (FDA) in early October 2003 for the purpose of obtaining approval to begin trials in the USA, via an Investigational New Drug (IND), with Melanota ...
... drug to be placed in the long acting implant. This trial is scheduled to take six months. The company is meeting with the US Food and Drug Administration (FDA) in early October 2003 for the purpose of obtaining approval to begin trials in the USA, via an Investigational New Drug (IND), with Melanota ...
here - Farmavita.Net
... pericarditis and spinal cord compression from Pott's Disease. Corticosteroids have been shown to be of benefit in preventing cardiac constriction from tuberculous pericarditis and in decreasing the neurologic sequelae of all stages of tuberculosis meningitis, especially when administered early in th ...
... pericarditis and spinal cord compression from Pott's Disease. Corticosteroids have been shown to be of benefit in preventing cardiac constriction from tuberculous pericarditis and in decreasing the neurologic sequelae of all stages of tuberculosis meningitis, especially when administered early in th ...
MELOXICAM Veterinary—Systemic
... For dogs weighing between 2.3 and 4.5 kg (5 and 10 pounds), the medication is also administered onto the food, rather than into the mouth. However, the dose can be measured by using either the dropper bottle or the syringe provided. Using the dropper, the dose is measured by the number of drops for ...
... For dogs weighing between 2.3 and 4.5 kg (5 and 10 pounds), the medication is also administered onto the food, rather than into the mouth. However, the dose can be measured by using either the dropper bottle or the syringe provided. Using the dropper, the dose is measured by the number of drops for ...
Determination of Carbamazepine in Pharmaceutical
... To develop a sensitive the first order- and second order- derivative spectrophotometric method, various solvent systems were tried, such as water, methanol and acetonitrile individually or in combinations of different proportions. The final decision of using methanol was based on sensitivity, interf ...
... To develop a sensitive the first order- and second order- derivative spectrophotometric method, various solvent systems were tried, such as water, methanol and acetonitrile individually or in combinations of different proportions. The final decision of using methanol was based on sensitivity, interf ...
ranitidine oral
... Administration of 800 mg of ranitidine bismuth citrate 30 minutes after a meal decreases the rate and extent of bismuth absorption by 50 and 25%, respectively, compared with administration 30 minutes prior to a meal. The absorption of bismuth from an 800-mg dose of ranitidine bismuth citrate was inc ...
... Administration of 800 mg of ranitidine bismuth citrate 30 minutes after a meal decreases the rate and extent of bismuth absorption by 50 and 25%, respectively, compared with administration 30 minutes prior to a meal. The absorption of bismuth from an 800-mg dose of ranitidine bismuth citrate was inc ...
pdf .
... possible types of interacting drugs: Clinical Drug (clnd), Pharmacological Substance (phsu), Antibiotic (antb), Biologically Active Substance (bacs), Chemical Viewed Structurally (chvs) and Amino Acid, Peptide, or Protein (aapp). The principal value of the DrugDDI corpus undoubtedly comes from its D ...
... possible types of interacting drugs: Clinical Drug (clnd), Pharmacological Substance (phsu), Antibiotic (antb), Biologically Active Substance (bacs), Chemical Viewed Structurally (chvs) and Amino Acid, Peptide, or Protein (aapp). The principal value of the DrugDDI corpus undoubtedly comes from its D ...
Syeda Bushra Yunus
... correlation coefficient and optical characteristics are summarized in Table No.2. Regression analysis of Beer’s law plot revealed a good correlation. The effects of various excipients generally present in the tablet dosage form of Clopidogrel bisulphate were investigated. The results indicated that ...
... correlation coefficient and optical characteristics are summarized in Table No.2. Regression analysis of Beer’s law plot revealed a good correlation. The effects of various excipients generally present in the tablet dosage form of Clopidogrel bisulphate were investigated. The results indicated that ...
Coactifed® Preparations - GlaxoSmithKline
... bleeding or other symptoms of ischemic colitis develop. Respiratory Codeine, including COACTIFIED®, is not recommended for use in any patient in whom respiratory function might be compromised including neuromuscular disorders, severe cardiac or respiratory conditions, lung infections, multiple traum ...
... bleeding or other symptoms of ischemic colitis develop. Respiratory Codeine, including COACTIFIED®, is not recommended for use in any patient in whom respiratory function might be compromised including neuromuscular disorders, severe cardiac or respiratory conditions, lung infections, multiple traum ...
Nanoparticles as `smart` pharmaceutical delivery
... nanoparticle delivery systems. In this review, we have also highlighted about the promising pharmaceutical deliveries like brain targeted delivery, ocular delivery, oral delivery, dermal and transdermal delivery, cancer chemotherapy, vaccine delivery, nucleic acids delivery and delivery system coupl ...
... nanoparticle delivery systems. In this review, we have also highlighted about the promising pharmaceutical deliveries like brain targeted delivery, ocular delivery, oral delivery, dermal and transdermal delivery, cancer chemotherapy, vaccine delivery, nucleic acids delivery and delivery system coupl ...
Establishment of selected baseline blood chemistry and hematological parameters in
... as a result of their exposure to diclofenac, it has become necessary to establish the mechanism of toxicity of this veterinary medicine to vultures. In doing so, it is hoped that other potential hazards may be identified and removed from their environment. At this stage little information is availab ...
... as a result of their exposure to diclofenac, it has become necessary to establish the mechanism of toxicity of this veterinary medicine to vultures. In doing so, it is hoped that other potential hazards may be identified and removed from their environment. At this stage little information is availab ...
Pharmaceutical Chemistry-IX - Keshav Group Of Institutions
... percolation (various types including processes for concentrated preparations, continuous hot percolation), maceration (various types including processes for organized and unorganized drugs and for concentrated preparations- double and triple maceration processes) and factors affecting choice of extr ...
... percolation (various types including processes for concentrated preparations, continuous hot percolation), maceration (various types including processes for organized and unorganized drugs and for concentrated preparations- double and triple maceration processes) and factors affecting choice of extr ...
The Usefulness of a Closed-system Device for the Mixing of
... discussion of measures to prevent exposure to anticancer drugs. As the number of cancer patients increases, the number of cases of anticancer drug preparation, as well as the number of cases of anti cancer drug combination therapy increases. Therefore it is expected that the risks of medical profes ...
... discussion of measures to prevent exposure to anticancer drugs. As the number of cancer patients increases, the number of cases of anticancer drug preparation, as well as the number of cases of anti cancer drug combination therapy increases. Therefore it is expected that the risks of medical profes ...
To navigate effectively through a complex three dimensional
... vestibular neuritis, is likely the result of the reduced signal-to-noise ratio following the vestibular loss as postulated by Cousins et al. [Cousins et al., 2013]. Vestibular velocity storage mechanism – suprathreshold task The normal prolongation of vestibular-ocular and perceptual time constants ...
... vestibular neuritis, is likely the result of the reduced signal-to-noise ratio following the vestibular loss as postulated by Cousins et al. [Cousins et al., 2013]. Vestibular velocity storage mechanism – suprathreshold task The normal prolongation of vestibular-ocular and perceptual time constants ...
rp-hplc method for the estimation of tamsulosin in bulk and capsules
... RESULTS AND DISCUSSION HPLC Parameters fixation In order to ascertain and establish optimum conditions for good resolution, rapid, accurate quantitative separation and estimation of TSN, the experimental conditions such as detection wavelength, mobile phase composition, flow rate of mobile phase, pH ...
... RESULTS AND DISCUSSION HPLC Parameters fixation In order to ascertain and establish optimum conditions for good resolution, rapid, accurate quantitative separation and estimation of TSN, the experimental conditions such as detection wavelength, mobile phase composition, flow rate of mobile phase, pH ...
NIDA Research Report - MDMA
... banned the drug, placing it on approved the first small clinical its list of Schedule I drugs, corretrial for MDMA that will detersponding to those substances mine if the drug can be used with no proven therapeutic value. safely with 2 sessions of ongoing ...
... banned the drug, placing it on approved the first small clinical its list of Schedule I drugs, corretrial for MDMA that will detersponding to those substances mine if the drug can be used with no proven therapeutic value. safely with 2 sessions of ongoing ...
Geriatric Cardiology – You CAN treat Angina! Part 2
... and 4 hours (peak) after dosing was assessed after 2, 6 (trough only), and 12 weeks of treatment. Trough exercise duration increased by 115.6 seconds … vs 91.7 seconds in the placebo group (P = ...
... and 4 hours (peak) after dosing was assessed after 2, 6 (trough only), and 12 weeks of treatment. Trough exercise duration increased by 115.6 seconds … vs 91.7 seconds in the placebo group (P = ...
413 - The AIDS InfoNet
... when you are taking an ARV. When this happens, the drug will stop working. This is called “developing resistance” to the drug. See Fact Sheet 126 for more information on resistance. Sometimes, if your virus develops resistance to one drug, it will also have resistance to other ARVs of the same class ...
... when you are taking an ARV. When this happens, the drug will stop working. This is called “developing resistance” to the drug. See Fact Sheet 126 for more information on resistance. Sometimes, if your virus develops resistance to one drug, it will also have resistance to other ARVs of the same class ...
IQUIX - MedConnections
... Levofloxacin concentration in plasma was measured in 14 healthy adult volunteers during a 16-day course of treatment with IQUIX® solution. The dosing schedule was 1-2 drops per eye once in the morning on Days 1 and 16; 1-2 drops per eye every two hours Days 2 through 8; and 1-2 drops per eye every f ...
... Levofloxacin concentration in plasma was measured in 14 healthy adult volunteers during a 16-day course of treatment with IQUIX® solution. The dosing schedule was 1-2 drops per eye once in the morning on Days 1 and 16; 1-2 drops per eye every two hours Days 2 through 8; and 1-2 drops per eye every f ...
Body Temperature and Analgesic Effects of Selective Mu and Kappa
... from a digital thermometer (Model 49 TA, YSI). During the readings, the rat’s tail was held gently between two fingers, and the animal was otherwise free to move about. The first three measurements were taken at 30-min intervals. To allow for adaptation to the procedure, the first reading was discar ...
... from a digital thermometer (Model 49 TA, YSI). During the readings, the rat’s tail was held gently between two fingers, and the animal was otherwise free to move about. The first three measurements were taken at 30-min intervals. To allow for adaptation to the procedure, the first reading was discar ...
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon ""drug"" and kinetikos ""moving, putting in motion""; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.