International Agency for Research on Cancer (IARC)
... In epidemiological studies of exposure to ethylene oxide, the most frequently reported association has been with lymphatic and haematopoietic cancer. The populations studied fall into two groups - people using ethylene oxide as a sterilant and chemical workers manufacturing or using the compound. In ...
... In epidemiological studies of exposure to ethylene oxide, the most frequently reported association has been with lymphatic and haematopoietic cancer. The populations studied fall into two groups - people using ethylene oxide as a sterilant and chemical workers manufacturing or using the compound. In ...
Protein A gene expression is regulated by DNA supercoiling which
... (Dorman, 1991; Hsieh et al., 1991). In Escherichia coli, it has been estimated that roughly 50 % of the supercoiling is constrained by proteins bound to DNA. The remaining supercoils are maintained actively at the cost of ATP hydrolysis, via topoisomerase activities (Hatfield & Benham, 2002). Thus, ...
... (Dorman, 1991; Hsieh et al., 1991). In Escherichia coli, it has been estimated that roughly 50 % of the supercoiling is constrained by proteins bound to DNA. The remaining supercoils are maintained actively at the cost of ATP hydrolysis, via topoisomerase activities (Hatfield & Benham, 2002). Thus, ...
founders effect in québec - French
... excellent genes with them. But, as any founding population would have done, they also brought, by chance, some rare deleterious mutations, and when these mutations (many of which cause no problems when contributed by just one parent) met up with a like mutation, rare conditions surfaced. Not all of ...
... excellent genes with them. But, as any founding population would have done, they also brought, by chance, some rare deleterious mutations, and when these mutations (many of which cause no problems when contributed by just one parent) met up with a like mutation, rare conditions surfaced. Not all of ...
meiosis I - CARNES AP BIO
... During prophase I of meiosis, the duplicated chromosomes pair with their homologues, in a process called synapsis. During this process, a protein “zipper” called the synaptonemal complex holds the homologous chromosomes tightly together all along their lengths. When this complex disappears in late p ...
... During prophase I of meiosis, the duplicated chromosomes pair with their homologues, in a process called synapsis. During this process, a protein “zipper” called the synaptonemal complex holds the homologous chromosomes tightly together all along their lengths. When this complex disappears in late p ...
X chromosome inactivation failed to explain normal phenotype Clin
... We described a family with a girl with Rett syndrome in whom a novel missense mutation in the MECP2 gene was transmitted through the maternal germ line. The carrier mother was clinically asymptomatic and presented non-random XCI, resulting in the X chromosome harboring the mutant allele that was pre ...
... We described a family with a girl with Rett syndrome in whom a novel missense mutation in the MECP2 gene was transmitted through the maternal germ line. The carrier mother was clinically asymptomatic and presented non-random XCI, resulting in the X chromosome harboring the mutant allele that was pre ...
Magnusiomyces capitatus (de Hoog et al.) de Hoog et Smith
... ATCC Warranty The viability of ATCC® products is warranted for 30 days from the date of shipment, and is valid only if the product is stored and cultured according to the information included on this product information sheet. ATCC lists the media formulation that has been found to be effective for ...
... ATCC Warranty The viability of ATCC® products is warranted for 30 days from the date of shipment, and is valid only if the product is stored and cultured according to the information included on this product information sheet. ATCC lists the media formulation that has been found to be effective for ...
Hereditary Colorectal Cancer
... (CRC), based on the predominant anatomic location of the CRC: distal versus proximal. CRCs involving the distal colon are more likely to show aneuploid DNA content, harbor mutations in APC, p53, and K-ras genes, and behave more aggressively303,304; proximal CRCs are more likely to show diploid DNA, ...
... (CRC), based on the predominant anatomic location of the CRC: distal versus proximal. CRCs involving the distal colon are more likely to show aneuploid DNA content, harbor mutations in APC, p53, and K-ras genes, and behave more aggressively303,304; proximal CRCs are more likely to show diploid DNA, ...
Document
... • Human somatic cells (any cell other than a gamete) have 23 pairs of chromosomes • A karyotype is an ordered display of the pairs of chromosomes from a cell • The two chromosomes in each pair are called homologous chromosomes, or homologs • Chromosomes in a homologous pair are the same length and s ...
... • Human somatic cells (any cell other than a gamete) have 23 pairs of chromosomes • A karyotype is an ordered display of the pairs of chromosomes from a cell • The two chromosomes in each pair are called homologous chromosomes, or homologs • Chromosomes in a homologous pair are the same length and s ...
genotyping arabidopsis - STLCC.edu :: Users` Server
... For PCR, the only enzyme required is DNA polymerase. Magnesium chloride is added to the buffer because magnesium acts as a co-enzyme, fitting into the three dimensional structure of the protein to activate it. Too much magnesium can reduce the ability of the polymerase to stay attached to the templa ...
... For PCR, the only enzyme required is DNA polymerase. Magnesium chloride is added to the buffer because magnesium acts as a co-enzyme, fitting into the three dimensional structure of the protein to activate it. Too much magnesium can reduce the ability of the polymerase to stay attached to the templa ...
1903. - Sutton, Walter S. The chromosomes in heredity. Biological
... they represent. In other words, it is probable that specific differences and individual variations are alike traceable to a common source, which is a difference in the constitution of homologous chromatin entities. Slight differences in homologues would mean corresponding, slight variations in the c ...
... they represent. In other words, it is probable that specific differences and individual variations are alike traceable to a common source, which is a difference in the constitution of homologous chromatin entities. Slight differences in homologues would mean corresponding, slight variations in the c ...
Solid Tumour Section Inflammatory fibroid polyps Atlas of Genetics and Cytogenetics
... 16 out of 23 lesions showed mutations in PDGFRA (Schildhaus et al., 2008). This finding could be confirmed shortly after the first description by a second independent study (Lasota et al., 2009), and meanwhile four series and one case report with molecular analyses have been published covering a tot ...
... 16 out of 23 lesions showed mutations in PDGFRA (Schildhaus et al., 2008). This finding could be confirmed shortly after the first description by a second independent study (Lasota et al., 2009), and meanwhile four series and one case report with molecular analyses have been published covering a tot ...
Molecular genetics of Rett syndrome and clinical
... identi®ed in exons 3 and 4 of the gene, which contain a majority of the coding region (Fig. 1) [11 .,18 .,19,20 .± 22 .,23,24 .,25 .,26,27]. MECP2 mutations have been identi®ed in 75-90% of sporadic cases and approximately 50% of familial cases. Interestingly, C to T transitions at eight different C ...
... identi®ed in exons 3 and 4 of the gene, which contain a majority of the coding region (Fig. 1) [11 .,18 .,19,20 .± 22 .,23,24 .,25 .,26,27]. MECP2 mutations have been identi®ed in 75-90% of sporadic cases and approximately 50% of familial cases. Interestingly, C to T transitions at eight different C ...
Maternal uniparental disomyof chromosome 13
... Studies in the mouse15 have shown that UPD for some chromosomes is not associated with phenotypic abnormality and similar findings have been reported for human chromosomes 219 and 22.7 The mouse studies have also shown that UPD for other chromosomes is lethal for the developing conceptus. It has bee ...
... Studies in the mouse15 have shown that UPD for some chromosomes is not associated with phenotypic abnormality and similar findings have been reported for human chromosomes 219 and 22.7 The mouse studies have also shown that UPD for other chromosomes is lethal for the developing conceptus. It has bee ...
Developmental Validation of the Quantifiler Real-Time
... mathematical relationship between the starting copy number of target sequence molecules and the resulting CT , which is the basis for quantitative PCR. In practice, the user makes a dilution series containing known quantities of a human genomic DNA concentration standard, and runs the dilutions alon ...
... mathematical relationship between the starting copy number of target sequence molecules and the resulting CT , which is the basis for quantitative PCR. In practice, the user makes a dilution series containing known quantities of a human genomic DNA concentration standard, and runs the dilutions alon ...
one-step and stepwise magnification of a bobbed lethal
... regions (Figure lb). Similar observations have been made for other Y chromosomes stained with Hoechst 33258 or quinacrine (GATTI, PIMPINELLI and SANTINI1976; GATTI and PIMPINELLI1983). Three of the one-step y bb" chromosomes, 10, 35 and 48, appeared as acrocentric chromosomes with a uniformly staini ...
... regions (Figure lb). Similar observations have been made for other Y chromosomes stained with Hoechst 33258 or quinacrine (GATTI, PIMPINELLI and SANTINI1976; GATTI and PIMPINELLI1983). Three of the one-step y bb" chromosomes, 10, 35 and 48, appeared as acrocentric chromosomes with a uniformly staini ...
Article PDF
... nucleosomes.12 Post-translational modifications of these tails, which alter their electrostatics, are among the primary mechanisms regulating chromatin folding.12,13 It was recently suggested that a specific localized acidic patch on the histone core may play an important role in chromatin folding b ...
... nucleosomes.12 Post-translational modifications of these tails, which alter their electrostatics, are among the primary mechanisms regulating chromatin folding.12,13 It was recently suggested that a specific localized acidic patch on the histone core may play an important role in chromatin folding b ...
meiosis I - HCC Learning Web
... homologs) and at the centromeres in anaphase II (separation of sister chromatids) • Meiosis I is called the reductional division because it reduces the number of chromosomes per cell © 2014 Pearson Education, Inc. ...
... homologs) and at the centromeres in anaphase II (separation of sister chromatids) • Meiosis I is called the reductional division because it reduces the number of chromosomes per cell © 2014 Pearson Education, Inc. ...
the PDF - Breastcancer.org
... This scoring system is named for the doctor who developed it. The system looks at what percentage of cells test positive for hormone receptors, along with how well the receptors show up after staining (this is called “intensity”). This information is then combined to score the sample on a scale from ...
... This scoring system is named for the doctor who developed it. The system looks at what percentage of cells test positive for hormone receptors, along with how well the receptors show up after staining (this is called “intensity”). This information is then combined to score the sample on a scale from ...
A novel DNA modification by sulphur
... 40027 (Li et al., 2003), all with DNA that is stable during electrophoresis and lacks DNA modification. Significantly, upon integration, DNA of all three species became highly unstable (Fig. 4, Li et al., 2003), like DNA of wild-type S. lividans 66. Furthermore, the dnd deletion mutant strain ZX1 re ...
... 40027 (Li et al., 2003), all with DNA that is stable during electrophoresis and lacks DNA modification. Significantly, upon integration, DNA of all three species became highly unstable (Fig. 4, Li et al., 2003), like DNA of wild-type S. lividans 66. Furthermore, the dnd deletion mutant strain ZX1 re ...
CTSC and PapillonLefvre syndrome: detection of recurrent
... In 1999, the first eight mutations of the CTSC gene were identified in consanguineous PLS families (Toomes et al. 1999). Since 1999, several reports have described mutations in the CTSC gene in different PLS cases from around the world (Table 1). CTSC mutations have also been reported in patients wi ...
... In 1999, the first eight mutations of the CTSC gene were identified in consanguineous PLS families (Toomes et al. 1999). Since 1999, several reports have described mutations in the CTSC gene in different PLS cases from around the world (Table 1). CTSC mutations have also been reported in patients wi ...
Agarose Gel Electrophoresis
... commonly incorporated into the gel and running buffer. The dye reduces the mobility of linear duplexes (Fig. 10.4.2D) and has a particularly pronounced effect on the mobility of closed circular DNA. Ethidium bromide changes the superhelical density of closed circular molecules by inducing positive s ...
... commonly incorporated into the gel and running buffer. The dye reduces the mobility of linear duplexes (Fig. 10.4.2D) and has a particularly pronounced effect on the mobility of closed circular DNA. Ethidium bromide changes the superhelical density of closed circular molecules by inducing positive s ...
CHAPTER 14 DNA applications in society
... produce sufficient growth hormone for use, very large numbers of pituitary glands from cadavers were required. Each batch of hGH was derived from a pool of pituitary glands from about 16 000 cadavers. During a year, patients received their hGH injections from two or three different batches. (A batc ...
... produce sufficient growth hormone for use, very large numbers of pituitary glands from cadavers were required. Each batch of hGH was derived from a pool of pituitary glands from about 16 000 cadavers. During a year, patients received their hGH injections from two or three different batches. (A batc ...
Agarose Gel Electrophoresis
... gradually removed, causing a concomitant decrease in the mobility of the DNA molecule. This occurs until a critical free-dye concentration is reached where no more superhelical turns remain (usually between 0.1 to 0.5 µg/ml). As still more ethidium bromide is bound, positive superhelical turns are g ...
... gradually removed, causing a concomitant decrease in the mobility of the DNA molecule. This occurs until a critical free-dye concentration is reached where no more superhelical turns remain (usually between 0.1 to 0.5 µg/ml). As still more ethidium bromide is bound, positive superhelical turns are g ...
Mutagen
In genetics, a mutagen is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level. As many mutations can cause cancer, mutagens are therefore also likely to be carcinogens. Not all mutations are caused by mutagens: so-called ""spontaneous mutations"" occur due to spontaneous hydrolysis, errors in DNA replication, repair and recombination.