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Heart Anatomy (cont)
Heart Anatomy (cont)

... The fist size heart lies in the anterior thoracic cavity, slightly left of the midline, where it is surrounded by connective tissues of the mediastinum. The heart is posterior to the sternum within its own pericardial cavity and surrounded by the pericardium. The parietal pericardium is a dense, irr ...
Caring For Patients With Cardiomyopathy
Caring For Patients With Cardiomyopathy

... displacement of ventricular impulse - cardiomegaly  presystolic atrial impulse felt  harsh, mid systolic murmur at apex, LSB, possible radiation to axilla or base of heart  S, S may be present ...
diagnosis and prognosis of anomalous origin of the left coronary
diagnosis and prognosis of anomalous origin of the left coronary

... spect, this patient had echocardiographically visible regional hypokinesia of the antero-lateral left ventricular wall, which was not recognised before surgery. The coexistence of ALCAPA and VSD can be a dangerous combination. A large VSD may induce high pressure in the MPA, which preserves the left ...
Evaluation of Diastolic Dysfunction Using Cardiac MRI
Evaluation of Diastolic Dysfunction Using Cardiac MRI

... Phase contrast MR Flow patterns (Top two rows) and Doppler Echo images (Bottom two rows) through the mitral valves and pulmonary veins in patients with Grade 1 (left), Grade 2 (Middle) and Grade 3 ...
Echocardiographic Effects of Eplerenone and Aldosterone in
Echocardiographic Effects of Eplerenone and Aldosterone in

... gender has a different effect on hypertensive echocardiographic changes, these effects may not have been detected by a study that involved only male rats. The increase in cardiac mass (LVH) was expected in spontaneously hypertensive rats compared to controls. Recent epidemiological reports indicate ...
Involvement of mitogen-activated protein kinases in adriamycin
Involvement of mitogen-activated protein kinases in adriamycin

... phosphorylation of mitogen-activated protein kinases (MAPKs) as well as pro- and anti-apoptotic proteins in adriamycin (ADR)-induced cardiomyopathy (AIC) and heart failure in rats. Modulatory effects of antioxidant probucol on the activation of MAPKs were also examined. Male rats were administered w ...
Document
Document

... disease would most often have progressed extensively to involve other organs and the management is most often a palliative one. Overall, the symptomatologies in such patients are predominantly those related to other organ involvement rather than related to cardiac involvement. Diagnosis of intracard ...
Atrial Fibrillation Answers: A Patient Education
Atrial Fibrillation Answers: A Patient Education

... of breath ...
Frog Cardiovascular Physiology
Frog Cardiovascular Physiology

... normal. For example, if you applied a chemical that increased heart rate to a stable but higher-than-normal rate, you would see this message. The electrical stimulator is below the oscilloscope display. In the experiment, clicking Single Stimulus delivers a single electrical shock to the frog heart. ...
Simulation Study of the Electrophysiological Mechanisms for Heart
Simulation Study of the Electrophysiological Mechanisms for Heart

... repolarization (APD90) prolongation of 24% in HF versus normal conditions, as well as a 18% prolongation in APD50, so that triangulation (APD90-APD50) was increased in 43% under conditions of HF. Similar experimental observations taken from (2) are shown in Figure 1 panel B. Simulated and experiment ...
New Diagnostic and Therapeutic Possibilities For Diastolic Heart
New Diagnostic and Therapeutic Possibilities For Diastolic Heart

... mellitus. Of note, diastolic dysfunction is observed in about Echocardiographic speckle tracking 40% of patients with diabetes.5 These risk factors have conDeveloping methods for diagnosis of diastolic dysfunction siderable overlap with atherosclerosis, which suggested that include assessing left ve ...
Cardiomyopathy - The Heart Foundation
Cardiomyopathy - The Heart Foundation

... Most people are only mildly affected by cardiomyopathy and can lead relatively normal lives. However, people who have severe heart failure may need a heart transplant.† Cardiomyopathy is different to a heart attack. Heart attacks also damage part of your heart muscle, but may be caused by something ...
85 Study of Left Ventricular Diastolic Function in
85 Study of Left Ventricular Diastolic Function in

... are at increased risk of heart failure18-24. This increased risk is seen even in patients with normal LV systolic function. Similarly patients of myocardial infarction who are also diabetic are at higher risk of developing congestive heart failure than non diabetics22-25-27. Studies have attributed ...
Y-Adaptor Connection for LV Lead in Upgrading to Biventricular
Y-Adaptor Connection for LV Lead in Upgrading to Biventricular

... clinical deterioration in individuals with normal ventricular function.2-4 However, there are reports showing ventricularly based pacemakers per se might induce ventricular dysfunction and secondarily congestive heart failure. 5,6 Recent clinical studies have shown that either atrialbased or less RV ...
60% 1.00% 1.80% - Providence Health
60% 1.00% 1.80% - Providence Health

... Doppler ultrasound or angiography is undertaken. ...
Metabolic Cardiology
Metabolic Cardiology

... Congestive heart failure (CHF) and dilated cardiomyopathy are life-threatening conditions in which the heart muscle is so weak that effective pulsatile action is compromised. Pulmonary vascular congestion and swelling in the lower extremities as well as in the liver and lining of the gastrointestina ...
Mammalian Physiological Overview of the Heart
Mammalian Physiological Overview of the Heart

... Sinoatrial node – greatest frequency Thus it is the primary pacemaker (atrial pacemaker complex) -8X2 mm -small round cells* and slender elongated cells Cells of the AV junction can also act as a pacemaker under aberrant conditions ...
Neural Networks in ECG classification
Neural Networks in ECG classification

... complex data sets. Correct classification of heart beats is fundamental to ECG monitoring systems such as an intensive care etc. Computers are used to automate signal processing. ANNs can detect patterns and make distinctions between different patterns that may not be apparent to human analysis. ...
Ventricular Precontracting Area in the Wolff- Parkinson
Ventricular Precontracting Area in the Wolff- Parkinson

... trast, the c point of the lower ventricular sections occurred about .03 second after the onset of QRS, as occurs in normal beats. In other words, it is clear that the lower sections of the ventricles are not late in starting to contract. Contrariwise, the higher seetions beginl contracting much earl ...
Chapter review questions
Chapter review questions

... © 2013 Pearson Education, Inc. ...
Cor Pulmonale
Cor Pulmonale

...  right ventricular and right atrial enlargement  pulmonic and tricuspid insufficiency  right ventricular pressure overload  pulmonary artery systolic pressure increase  Pulmonary function  Arterial blood gas analysis  Right heart cardic catherization TREATMENT  Cardiopulmonary support for pa ...
Gene Therapy in Large Animal Models of Human Cardiovascular
Gene Therapy in Large Animal Models of Human Cardiovascular

... Gene therapy is one molecular-based option for heart disease patients. It has traditionally been used to transfer a gene that encodes a functional protein into a diseased patient, to produce long-term expression of the deficient protein (Lyon et al. 2008; Vinge et al. 2008). This strategy, often ref ...
Basic Cardiovascular System and Pathological Abnormalities
Basic Cardiovascular System and Pathological Abnormalities

... • Palpate liver • +/- rales and CXR to evaluate for CHF • Reverse dehydration  Reverse acidosis ...
119 - Coastal West Sussex Formulary
119 - Coastal West Sussex Formulary

... NICE recommendations Sacubitril valsartan is a combined neprilysin inhibitor +angiotensin II receptor inhibitor. It is recommended as an option for treating symptomatic chronic heart failure with reduced ejection fraction, only in people: ...
Outcome Analysis of Cardiac Resynchronisation of Moderate to
Outcome Analysis of Cardiac Resynchronisation of Moderate to

... Abstract: In approximately 30% of patients with chronic heart failure the disease process not only depresses cardiac contractility but also affects the conduction pathways, causing delay in the onset of right/left ventricular systole. This dyssynchrony is apparent on the electrocardiogram (ECG) as a ...
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Heart failure



Heart failure (HF), often referred to as congestive heart failure (CHF), occurs when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs. The terms chronic heart failure (CHF) or congestive cardiac failure (CCF) are often used interchangeably with congestive heart failure. Signs and symptoms commonly include shortness of breath, excessive tiredness, and leg swelling. The shortness of breath is usually worse with exercise, while lying down, and may wake the person at night. A limited ability to exercise is also a common feature.Common causes of heart failure include coronary artery disease including a previous myocardial infarction (heart attack), high blood pressure, atrial fibrillation, valvular heart disease, excess alcohol use, infection, and cardiomyopathy of an unknown cause. These cause heart failure by changing either the structure or the functioning of the heart. There are two main types of heart failure: heart failure due to left ventricular dysfunction and heart failure with normal ejection fraction depending on if the ability of the left ventricle to contract is affected, or the heart's ability to relax. The severity of disease is usually graded by the degree of problems with exercise. Heart failure is not the same as myocardial infarction (in which part of the heart muscle dies) or cardiac arrest (in which blood flow stops altogether). Other diseases that may have symptoms similar to heart failure include obesity, kidney failure, liver problems, anemia and thyroid disease.The condition is diagnosed based on the history of the symptoms and a physical examination with confirmation by echocardiography. Blood tests, electrocardiography, and chest radiography may be useful to determine the underlying cause. Treatment depends on the severity and cause of the disease. In people with chronic stable mild heart failure, treatment commonly consists of lifestyle modifications such as stopping smoking, physical exercise, and dietary changes, as well as medications. In those with heart failure due to left ventricular dysfunction, angiotensin converting enzyme inhibitors or angiotensin receptor blockers along with beta blockers are recommended. For those with severe disease, aldosterone antagonists, or hydralazine plus a nitrate may be used. Diuretics are useful for preventing fluid retention. Sometimes, depending on the cause, an implanted device such as a pacemaker or an implantable cardiac defibrillator may be recommended. In some moderate or severe cases cardiac resynchronization therapy (CRT) may be suggested or cardiac contractility modulation may be of benefit. A ventricular assist device or occasionally a heart transplant may be recommended in those with severe disease despite all other measures.Heart failure is a common, costly, and potentially fatal condition. In developed countries, around 2% of adults have heart failure and in those over the age of 65, this increases to 6–10%. In the year after diagnosis the risk of death is about 35% after which it decreases to below 10% each year. This is similar to the risks with a number of types of cancer. In the United Kingdom the disease is the reason for 5% of emergency hospital admissions. Heart failure has been known since ancient times with the Ebers papyrus commenting on it around 1550 BCE.
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