• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Donwload Nomination Form - Protein Society of Thailand
Donwload Nomination Form - Protein Society of Thailand

... Institutional Affiliation and Current Position: ...
03a_plasma membrane
03a_plasma membrane

... the membrane. Ex: insulin, glucagon, & other hormones •Secrete (=squeeze out) substances that are synthesized inside the cell. •Compartmentalize and organize the interior of the cell. Ex: mitochondria, E.R., various vesicles ...
PROTEOME:
PROTEOME:

... • Label protein samples with heavy and light reagent • Reagent contains affinity tag and heavy or light isotopes Chemically reactive group: forms a covalent bond to the protein or peptide Isotope-labeled linker: heavy or light, depending on which isotope is used Affinity tag: enables the protein or ...
No Slide Title
No Slide Title

... •MAVS (mitochondrial antiviral signaling) protein on MOM is key •dsRNA receptors bind MAVS & trigger interferon & cytokine Synthesis •Viruses also interact with mt in countless specific ways ...
02_Classification and functions of simple and complex proteins
02_Classification and functions of simple and complex proteins

... shape. Such proteins are made up of long rod-shaped or stringlike molecules that can intertwine with one another and form strong fibers. They are water-insoluble and generally have structural functions within the human body. • А globular protein is а protein whose overall shape is roughly spherical ...
Phosphorylase Kinase
Phosphorylase Kinase

...  muscle contraction is stimulated by a transient increase in [Ca2+]cyt from 0.1 µM to 1 – 10 µM  the rate of glycogen breakdown (and thus the provision of ATP by anaerobic glycolysis) is linked to muscle contraction  for phosphorylase kinase to be fully activated the subunits must also be ...
TRUE or FALSE - GEOCITIES.ws
TRUE or FALSE - GEOCITIES.ws

... Ca++ is a second messenger for some hormones and neurotransmitters The cytosolic free Ca++ concentration is higher than the extracellular concentration Ca++ increase in a nerve terminal stimulates the release of acetylcholine The cytosolic free Ca++ concentration is lower than the extracellular conc ...
Argumentation activity: Gene expression regulation in bacteria You
Argumentation activity: Gene expression regulation in bacteria You

... A molecule in the environment (in the media, in the case of a single celled organism or in the extracellular matrix, in the case of a multicelled organism) finds its way to the surface of the cell’s plasma membrane. There are several different ways it can then interact with the inside of the cell. ...
Exporter la page en pdf
Exporter la page en pdf

... Langerhans cells. In the steady state, Langerin is predominantly found in the endosomal recycling compartment and in Birbeck granules. Langerin internalizes by classical receptormediated endocytosis and the first Birbeck granules accessible to endocytosed Langerin are those connected to recycling end ...
Quaternary structures
Quaternary structures

... G for folding is small (-20 to -60 kJ/mol) and primarily from hydrophobic interactions Why so low? ...
understanding bacterial iron transport
understanding bacterial iron transport

... membrane proteins. The crystal structures of three members of this class of porin-like proteins, FhuA, FecA and FepA from E. coli, have recently been determined, [1] and the related structure of the Vitamin B12 transporter BtuB is about to emerge. These bacterial transporters formed from a 22strande ...
Constitutive cycling: a general mechanism to regulate cell surface
Constitutive cycling: a general mechanism to regulate cell surface

... mediated by a non-canonical tyrosine-based sorting motif of the form YXXGL.(22) In the case of the water channel AQP2, no motif has yet been demonstrated for endocytosis. By contrast, ENaC has a short sequence in its C terminus (PPXYXXL) that is necessary for endocytosis.(23,24) It has been proposed ...
Death or Damage of Dopamine neurons
Death or Damage of Dopamine neurons

... that disrupt normal cell processes. Recently researchers have discovered other mechanisms by which this protein damages or kills dopamine-producing neurons, as well as other genes that may also play a role in driving the disease. ...
Slide 1
Slide 1

... protein will be imported into the matrix space. • It will be necessary to do this with the dozen other mitochondrial genes to know if Allotopic Replacement is a viable option. • It will have to be proved that the various proteins can assemble and function in the complexes. ...
Phosphoinositide regulation of clathrin
Phosphoinositide regulation of clathrin

... been co-crystallized with the distal portion of the AP-2 µ-subunit (C-µ2) to which they bind in an extended conformation [16]. C-µ2 also harbours a structurally unresolved binding site for basic internalization motifs found in a variety of multimeric membrane proteins including postsynaptic AMPA (α- ...
Exam 2
Exam 2

... 19. [4 points] One reason why cellular signaling is so complex is that a single signaling pathway often splits to become several separate pathways. From the material presented in class and the assigned readings, indicate one specific example of where a signaling pathway splits to become two or more ...
Polyacrylamide gels
Polyacrylamide gels

... The copolymerization of acrylamide with methylenebisacrylamide produces a mesh-like network in three dimensions, consisting of acrylamide chains with interconnections formed from the methylenebisacrylamide ...
Protein regulation: The statistical theory of
Protein regulation: The statistical theory of

... chemical-shift based approaches. In a related study, Melacini and coworkers8 introduced a method in which coupled residues were identified through a covariance analysis of the chemical shift changes caused by a series of covalently modified analogs of the allosteric effectors. They illustrated this ...
Recombinant Ebola virus VP40 matrix protein
Recombinant Ebola virus VP40 matrix protein

... Novex® Sharp pre-stained protein markers. (B) Western blot detection of EBOV VP40 at 50 ng and 100 ng (lanes 1-2). EBOV VP40 was detected using IBT’s polyclonal antibody at 50 ng/mL (Cat. # 0301-010) and anti-rabbit IgG-HRP conjugate, followed by TMB membrane substrate. ELISA Data: EBOV VP40 ng/well ...
1.3 study guide - Peoria Public Schools
1.3 study guide - Peoria Public Schools

...  Cell membranes include phospholipids and proteins. These proteins may be classified as integral or peripheral proteins.  It is the hydrophobic and hydrophilic properties of phospholipids that maintain the structure of cell membranes.  Functions of membrane proteins include hormone binding sites, ...
File
File

... products of specific plant disease resistance (R) genes • An R protein recognizes a corresponding molecule made by the pathogen’s Avr gene • R proteins activate plant defenses by triggering signal transduction pathways • These defenses include the hypersensitive response and systemic acquired resist ...
Animal Form & Function Physiolog
Animal Form & Function Physiolog

...  Activates enzyme  Enzyme used to make cyclic AMP  Cyclic AMP targets cell responses ...
File - Serrano High School AP Biology
File - Serrano High School AP Biology

...  Activates enzyme  Enzyme used to make cyclic AMP  Cyclic AMP targets cell responses ...
1 Lecture 6: Protein Primary, Secondary and Tertiary Structure +
1 Lecture 6: Protein Primary, Secondary and Tertiary Structure +

... A few additional divisions in the above are also useful. For example, frequently found 2° structure patterns are termed “super secondary structures”; some proteins fold into one or more independent 3° structure “domains”; and the 4° structural association can occur between identical or dissimilar su ...
Biochemistry 2000 Sample Question Protein
Biochemistry 2000 Sample Question Protein

... (b) If a Trp residue has  = 60º ,  = ­120º, is it in an energetically favorable conformation? (c) If a Gly residue has  = 120º ,  = ­60º, is it in an energetically favorable conformation? (5) Pauling predicted the structures of both -helices and -sheets from modeling studies. What physiochemic ...
< 1 ... 265 266 267 268 269 270 271 272 273 ... 354 >

G protein–coupled receptor



G protein–coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.G protein–coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein–coupled receptors are involved in many diseases, and are also the target of approximately 40% of all modern medicinal drugs. Two of the United States's top five selling drugs (Hydrocodone and Lisinopril) act by targeting a G protein–coupled receptor. The 2012 Nobel Prize in Chemistry was awarded to Brian Kobilka and Robert Lefkowitz for their work that was ""crucial for understanding how G protein–coupled receptors function."". There have been at least seven other Nobel Prizes awarded for some aspect of G protein–mediated signaling.There are two principal signal transduction pathways involving the G protein–coupled receptors: the cAMP signal pathway and the phosphatidylinositol signal pathway. When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor (GEF). The GPCR can then activate an associated G protein by exchanging its bound GDP for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate from the β and γ subunits to further affect intracellular signaling proteins or target functional proteins directly depending on the α subunit type (Gαs, Gαi/o, Gαq/11, Gα12/13).
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report