Protein Sequence Analysis in SeqWEB
... redundancy mean that entries can take time before they are made available, but when they are, they are a complete and thorough resource. Annotation is updated with information from published review articles, and by external expert referees. The entries are similar in layout to EMBL entries, with sim ...
... redundancy mean that entries can take time before they are made available, but when they are, they are a complete and thorough resource. Annotation is updated with information from published review articles, and by external expert referees. The entries are similar in layout to EMBL entries, with sim ...
Chapter 1
... • All of the carbonyl O and amide H are involved in the H bonds with the chain nearly completely extended • Two possible orientations – Parallel if the N-termini are head-to-head – Antiparallel if the N-terminus of one chain is aligned with the C-terminus of the other ...
... • All of the carbonyl O and amide H are involved in the H bonds with the chain nearly completely extended • Two possible orientations – Parallel if the N-termini are head-to-head – Antiparallel if the N-terminus of one chain is aligned with the C-terminus of the other ...
Eukaryotic cell Plasma membrane
... 2- Regulate the passage of materials and exchange of • molecules between the cell and outside environment. 3- Participate in many chemical reactions. They contain • enzymes and other molecules that are necessary for chemical changes. 4- Transmit signals and information from out-side to inside the • ...
... 2- Regulate the passage of materials and exchange of • molecules between the cell and outside environment. 3- Participate in many chemical reactions. They contain • enzymes and other molecules that are necessary for chemical changes. 4- Transmit signals and information from out-side to inside the • ...
Protein Modeling Challenge Science Olympiad Trial Event
... Proteins spontaneously fold into a specific three dimensional “tertiary” structure that governs a protein’s function ...
... Proteins spontaneously fold into a specific three dimensional “tertiary” structure that governs a protein’s function ...
Iron and the Pathogenicity of Bacteria
... receptor protein in the OM, called FepA, and through a series of incompletely understood reactions, FepA internalizes ferric enterobactin (FeEnt) into the cell. This process requires energy and the action of another cell envelope protein, TonB. However, the biochemical mechanism of transport is not ...
... receptor protein in the OM, called FepA, and through a series of incompletely understood reactions, FepA internalizes ferric enterobactin (FeEnt) into the cell. This process requires energy and the action of another cell envelope protein, TonB. However, the biochemical mechanism of transport is not ...
View document as pdf
... produce a linear polypeptide chain, using the messenger RNA produced through transcription to determine the order of amino acids. With this collection, students can examine the interaction of the protein component and the ribosomal RNA component of the subunits. Students can also explore the differe ...
... produce a linear polypeptide chain, using the messenger RNA produced through transcription to determine the order of amino acids. With this collection, students can examine the interaction of the protein component and the ribosomal RNA component of the subunits. Students can also explore the differe ...
Detergent-resistant membranes and the protein
... they are derived have never been subjected to any detergents. This also means that non-detergent methods for preparing ‘lipid rafts’ are likely to generate a floating fraction containing membranes in general, from a number of subcellular sites, but not necessarily one enriched specifically in lipid ...
... they are derived have never been subjected to any detergents. This also means that non-detergent methods for preparing ‘lipid rafts’ are likely to generate a floating fraction containing membranes in general, from a number of subcellular sites, but not necessarily one enriched specifically in lipid ...
IOSR Journal of Applied Physics (IOSR-JAP)
... acids of a naturally occurring protein uniquely specifies its thermodynamically stable native structure”. How the native three-dimensional structure emanated from the sequence of amino acid is a pursue in which experimental methods like X-ray crystallography, Nuclear magnetic resonance (NMR), Protei ...
... acids of a naturally occurring protein uniquely specifies its thermodynamically stable native structure”. How the native three-dimensional structure emanated from the sequence of amino acid is a pursue in which experimental methods like X-ray crystallography, Nuclear magnetic resonance (NMR), Protei ...
MAP Kinase Pathways
... Activation of Raf Kinase This inactive conformation is stabilized by a dimer of the 143-3 protein, which binds phosphoserine residues in a number of important signaling proteins. Each 14-3-3 monomer binds to a phosphoserine residue in Raf, one to phosphoserine-259 in the N-terminal domain and the o ...
... Activation of Raf Kinase This inactive conformation is stabilized by a dimer of the 143-3 protein, which binds phosphoserine residues in a number of important signaling proteins. Each 14-3-3 monomer binds to a phosphoserine residue in Raf, one to phosphoserine-259 in the N-terminal domain and the o ...
Phosphorylation of two cytosolic proteins
... lymphokines, usually interleukin-2 (IL-2). Even though the interactions of ligands with T-cellsurface receptors and the end points of the activation process have been fairly well characterized, little is known about the cascade of intracellular steps linking these two extreme events. By analogy with ...
... lymphokines, usually interleukin-2 (IL-2). Even though the interactions of ligands with T-cellsurface receptors and the end points of the activation process have been fairly well characterized, little is known about the cascade of intracellular steps linking these two extreme events. By analogy with ...
Probing proteinâmembrane interactions using optical traps
... 7. Probing protein–membrane interactions using optical traps One of the proteins involved in the process of synaptic vesicle fusion in the brain are the Doc2 (double C2 domain) proteins [170]. There are three Doc2 family proteins: Doc2a,-b, and -c, of which a,b are expressed in the brain [171]. Doc ...
... 7. Probing protein–membrane interactions using optical traps One of the proteins involved in the process of synaptic vesicle fusion in the brain are the Doc2 (double C2 domain) proteins [170]. There are three Doc2 family proteins: Doc2a,-b, and -c, of which a,b are expressed in the brain [171]. Doc ...
Expanded protein information at SGD: new pages and proteome browser.
... contains a smaller library of HMM domains found in signaling, extracellular and chromatin-associated proteins. TIGRFAM is a collection of manually-curated protein families based on multiple sequence alignments, HMMs and additional annotations. Panther contains a large collection of protein families, ...
... contains a smaller library of HMM domains found in signaling, extracellular and chromatin-associated proteins. TIGRFAM is a collection of manually-curated protein families based on multiple sequence alignments, HMMs and additional annotations. Panther contains a large collection of protein families, ...
Document
... Protein structure: Some computational tasks • Building a protein structure model from X-ray data • Building a protein structure model from NMR data • Computing the energy for a given protein structure (conformation) • Energy minimization: Finding the structure with the minimal energy according to ...
... Protein structure: Some computational tasks • Building a protein structure model from X-ray data • Building a protein structure model from NMR data • Computing the energy for a given protein structure (conformation) • Energy minimization: Finding the structure with the minimal energy according to ...
Two Structural Domains Mediate Two Sequential y-Zein
... those two domains. These mutants and the wild-type y-zein were expressed in Arabidopsis, and their subcellular distribution inside the cells was studied. A PvulXbal DNA fragment of a y-zein genomic clone (Boronat et ai., 1986) containing the y-zein coding sequence (669 bp), which is flanked by a sho ...
... those two domains. These mutants and the wild-type y-zein were expressed in Arabidopsis, and their subcellular distribution inside the cells was studied. A PvulXbal DNA fragment of a y-zein genomic clone (Boronat et ai., 1986) containing the y-zein coding sequence (669 bp), which is flanked by a sho ...
WRI116-Research_Review
... The yeast surface display is effective for “finer, residue-level resolution of antibodyantigen binding interactions”(1). In spite of Silverman et al research using yeast surface display, Lipovsek et al used a different approach on using the yeast surface display. Lipovsek et al investigated Fn3 vari ...
... The yeast surface display is effective for “finer, residue-level resolution of antibodyantigen binding interactions”(1). In spite of Silverman et al research using yeast surface display, Lipovsek et al used a different approach on using the yeast surface display. Lipovsek et al investigated Fn3 vari ...
PALI—a database of Phylogeny and ALIgnment of homologous
... with no similarity in their amino acid sequences, but with a common fold may or may not have similar function. However, 3-D structures of homologous proteins with clear sequence similarity have highly similar structures and often have similar biological roles in the living systems (for examples see ...
... with no similarity in their amino acid sequences, but with a common fold may or may not have similar function. However, 3-D structures of homologous proteins with clear sequence similarity have highly similar structures and often have similar biological roles in the living systems (for examples see ...
Histidine protonation and the activation of viral fusion proteins
... protein specifically play a critical role in fusion activation is that low pH also plays a role in the cleavage of the envelope protein precursor [7]. However, the structure of the uncleaved precursor and therefore its histidine environments are not ...
... protein specifically play a critical role in fusion activation is that low pH also plays a role in the cleavage of the envelope protein precursor [7]. However, the structure of the uncleaved precursor and therefore its histidine environments are not ...
Bioinformatics Analysis of Phenylacetaldehyde Synthase (PAAS), a
... or primary structure of a protein is the most important indication for its function. However, it is approved that prediction of protein characteristics from the primary amino acid sequence is not possible directly. Therefore, methods to predict protein characteristics have converged on tertiary and ...
... or primary structure of a protein is the most important indication for its function. However, it is approved that prediction of protein characteristics from the primary amino acid sequence is not possible directly. Therefore, methods to predict protein characteristics have converged on tertiary and ...
CV_Siemens (PDF / 534 KB)
... that respond to a remarkable variety of chemical and physical stimuli. While physiological roles for many TRP channels remain unknown, several family members have now been proposed to function as molecular sensors of environmental stimuli in organisms ranging from yeast to humans. A subset of these ...
... that respond to a remarkable variety of chemical and physical stimuli. While physiological roles for many TRP channels remain unknown, several family members have now been proposed to function as molecular sensors of environmental stimuli in organisms ranging from yeast to humans. A subset of these ...
+ BMP-4
... Morphogenic Protein-4 (BMP-4), made by neuroectodermal cells. 4. BMP-4 inhibits neuralization and promotes the epidermal fate in neighboring cells. 5. Mesodermal cells secrete proteins (Chordin, Noggin, Follistatin) which directly bind and antagonizes BMP-4 activity. 6. Neuroectodermal cells become ...
... Morphogenic Protein-4 (BMP-4), made by neuroectodermal cells. 4. BMP-4 inhibits neuralization and promotes the epidermal fate in neighboring cells. 5. Mesodermal cells secrete proteins (Chordin, Noggin, Follistatin) which directly bind and antagonizes BMP-4 activity. 6. Neuroectodermal cells become ...
VIRTUAL SCREENING OF POTENTIAL DRUG-LIKE INHIBITORS FROM MEDICINAL PLANTS
... consumed worldwide as a spice and flavoring agent and is attributed to have many medicinal properties. It possess antioxidant properties ...
... consumed worldwide as a spice and flavoring agent and is attributed to have many medicinal properties. It possess antioxidant properties ...
The Dock and Lock Method: A Novel
... human carcinoembryonic antigen (CEACAM5). The first A, C-DDD1-Fab-hMN-14, was generated by linking the DDD1 peptide sequence, which is composed of amino acids 1 to 44 of human RIIa, to the COOH-terminal end of the Fd chain via a 14-residue flexible peptide linker (Fig. 2B). This construct was modifi ...
... human carcinoembryonic antigen (CEACAM5). The first A, C-DDD1-Fab-hMN-14, was generated by linking the DDD1 peptide sequence, which is composed of amino acids 1 to 44 of human RIIa, to the COOH-terminal end of the Fd chain via a 14-residue flexible peptide linker (Fig. 2B). This construct was modifi ...
How do neurons communicate?
... saving energy (neurons have to synthesize or produce their own NT) ...
... saving energy (neurons have to synthesize or produce their own NT) ...
Disparate proteins use similar architectures to damage membranes
... lytic peptides can lyse phosphatidylcholine containing (zwitterionic) membranes [14], they are often more active on those containing negatively charged lipids (e.g. phosphatidylglycerol or phosphatidylserine). Phosphatidylethanolamine, which normally forms a hexagonal phase, can be induced to form b ...
... lytic peptides can lyse phosphatidylcholine containing (zwitterionic) membranes [14], they are often more active on those containing negatively charged lipids (e.g. phosphatidylglycerol or phosphatidylserine). Phosphatidylethanolamine, which normally forms a hexagonal phase, can be induced to form b ...
G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.G protein–coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein–coupled receptors are involved in many diseases, and are also the target of approximately 40% of all modern medicinal drugs. Two of the United States's top five selling drugs (Hydrocodone and Lisinopril) act by targeting a G protein–coupled receptor. The 2012 Nobel Prize in Chemistry was awarded to Brian Kobilka and Robert Lefkowitz for their work that was ""crucial for understanding how G protein–coupled receptors function."". There have been at least seven other Nobel Prizes awarded for some aspect of G protein–mediated signaling.There are two principal signal transduction pathways involving the G protein–coupled receptors: the cAMP signal pathway and the phosphatidylinositol signal pathway. When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor (GEF). The GPCR can then activate an associated G protein by exchanging its bound GDP for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate from the β and γ subunits to further affect intracellular signaling proteins or target functional proteins directly depending on the α subunit type (Gαs, Gαi/o, Gαq/11, Gα12/13).