![[PDF]](http://s1.studyres.com/store/data/018857871_1-c19293b53f88a0846af4a57cc11880cc-300x300.png)
[PDF]
... Biophysically based models could also inform rational design of pharmacotherapies, given that current medications for schizophrenia are predominantly designed to act at the synaptic and cellular levels (although there is evidence that targeted transcranial magnetic stimulation, TMS, could possibly a ...
... Biophysically based models could also inform rational design of pharmacotherapies, given that current medications for schizophrenia are predominantly designed to act at the synaptic and cellular levels (although there is evidence that targeted transcranial magnetic stimulation, TMS, could possibly a ...
Priming and formal thought disorder in schizophrenia
... description of the disorder. Researchers studying language abnormalities in schizophrenia come from diverse backgrounds, such as neurolinguistics, psycholinguistics, psychiatry, and mainstream psychology (Titone, 2010). While schizophrenia is traditionally seen as a topic of research for psychiatry ...
... description of the disorder. Researchers studying language abnormalities in schizophrenia come from diverse backgrounds, such as neurolinguistics, psycholinguistics, psychiatry, and mainstream psychology (Titone, 2010). While schizophrenia is traditionally seen as a topic of research for psychiatry ...
Remission in Schizophrenia: Proposed Criteria and Rationale for
... nonpharmacological interventions with proven effectiveness, but with variable effect on specific disease features; pharmacological treatments are also characterized by substantial differences in the nature and severity of adverse effects (28–30). This variability highlights the need for and importan ...
... nonpharmacological interventions with proven effectiveness, but with variable effect on specific disease features; pharmacological treatments are also characterized by substantial differences in the nature and severity of adverse effects (28–30). This variability highlights the need for and importan ...
The emerging molecular architecture of schizophrenia - EU-GEI
... Susceptibility to schizophrenia incorporates genetic and environmental risk The scientific rationale for the genetic interrogation of a phenotype comes from the prior certainty of its genetic origin. Establishing that this is the case, by demonstrating the heritability of a trait, is the foundation ...
... Susceptibility to schizophrenia incorporates genetic and environmental risk The scientific rationale for the genetic interrogation of a phenotype comes from the prior certainty of its genetic origin. Establishing that this is the case, by demonstrating the heritability of a trait, is the foundation ...
chapter i - Sacramento - California State University
... social functioning (Meijer, Koeter, Sprangers, & Schene, 2009). A significant portion of people do not return to their pre-episodic level of functioning. One study found the full recovery rate to be 13.7% two years after initial contact with healthcare professionals (Robinson, Woerner, McMeniman, Me ...
... social functioning (Meijer, Koeter, Sprangers, & Schene, 2009). A significant portion of people do not return to their pre-episodic level of functioning. One study found the full recovery rate to be 13.7% two years after initial contact with healthcare professionals (Robinson, Woerner, McMeniman, Me ...
Guideline on clinical investigation of medicinal products,
... The effectiveness of the so-called first generation or typical antipsychotic agents, on symptoms in schizophrenia is mostly attributed to their anti-dopaminergic effect, particularly at the D2 receptors. The so-called second generation or atypical antipsychotic agents show in addition a varying deg ...
... The effectiveness of the so-called first generation or typical antipsychotic agents, on symptoms in schizophrenia is mostly attributed to their anti-dopaminergic effect, particularly at the D2 receptors. The so-called second generation or atypical antipsychotic agents show in addition a varying deg ...
Factors Involved in Outcome and Recovery in Schizophrenia
... Table 1 reports the data on the percent of patients with schizophrenia on medications at each of the 5 follow-ups over 15 years. As frequently found in the natural course of a large series of schizophrenia patients, there was no single, uniform treatment plan which applied to all patients. Rather, a ...
... Table 1 reports the data on the percent of patients with schizophrenia on medications at each of the 5 follow-ups over 15 years. As frequently found in the natural course of a large series of schizophrenia patients, there was no single, uniform treatment plan which applied to all patients. Rather, a ...
Chapter_12_-_Schizophrenia_and_Schizophrenia_Spect
... Psychotic symptoms are often more pronounced and obvious than symptoms of other disorders, making schizophrenia more apparent to others and increasing stigmatization. • Neurochemical, genetic, and neuroanatomical findings help explain the symptoms of schizophrenia; however, no one theory accounts ...
... Psychotic symptoms are often more pronounced and obvious than symptoms of other disorders, making schizophrenia more apparent to others and increasing stigmatization. • Neurochemical, genetic, and neuroanatomical findings help explain the symptoms of schizophrenia; however, no one theory accounts ...
Monitoring of physical health in a UHR service
... assessments were substantially lacking within case notes, and blood glucose assessments were found for only one individual. Although it was often reported whether a person used alcohol, substances or tobacco, more specific details relating to the extent of use were not recorded. Due to the limited d ...
... assessments were substantially lacking within case notes, and blood glucose assessments were found for only one individual. Although it was often reported whether a person used alcohol, substances or tobacco, more specific details relating to the extent of use were not recorded. Due to the limited d ...
Reasoning in schizophrenia. Review and analysis from the cognitive
... subjects perform worse, but delusional ones are even more sensitive than controls. Other studies seem to show that schizophrenic patients can be even better than healthy participants in conditional reasoning. Mellet et al. (2006) administered a demanding reasoning task to 26 schizophrenic patients a ...
... subjects perform worse, but delusional ones are even more sensitive than controls. Other studies seem to show that schizophrenic patients can be even better than healthy participants in conditional reasoning. Mellet et al. (2006) administered a demanding reasoning task to 26 schizophrenic patients a ...
Definitions of Abnormality
... Uses retrospective data (from childhood), this can be inaccurate because people might have forgotten and it can be distorted by schemas. It may take a long time; sometimes years so is not appropriate in cases when urgent intervention is required (i.e. suicidal patients). It is very expensive and rar ...
... Uses retrospective data (from childhood), this can be inaccurate because people might have forgotten and it can be distorted by schemas. It may take a long time; sometimes years so is not appropriate in cases when urgent intervention is required (i.e. suicidal patients). It is very expensive and rar ...
Prediction of Response to Antipsychotic Drugs in Schizophrenia
... Objective: Currently, schizophrenia guidelines recommend waiting for 3 to 6 weeks before considering a patient as non-responder. However, recent studies indicate that the response to antipsychotic medications starts within the first two weeks of treatment. The aim of this study is to determine the p ...
... Objective: Currently, schizophrenia guidelines recommend waiting for 3 to 6 weeks before considering a patient as non-responder. However, recent studies indicate that the response to antipsychotic medications starts within the first two weeks of treatment. The aim of this study is to determine the p ...
Steeper discounting of delayed rewards in
... 1996; Forchuk et al., 1997). Smoking impacts reward pathways (Barr et al., 2008), and is associated with increased discounting (Baker et al., 2003; Bickel et al., 1999; MacKillop et al., 2011; Reynolds, 2006). Therefore, differences in reward-related cognition in schizophrenia may be attributable to ...
... 1996; Forchuk et al., 1997). Smoking impacts reward pathways (Barr et al., 2008), and is associated with increased discounting (Baker et al., 2003; Bickel et al., 1999; MacKillop et al., 2011; Reynolds, 2006). Therefore, differences in reward-related cognition in schizophrenia may be attributable to ...
3 Gender Differences in Schizophrenia
... receptor sensitivity (Fink 1995). The effects of estrogen secretion on menstrual cycle-related and premenstrual cognitive functioning as well as in other mental disorders is not the topic of the present contribution. The applicability of the results of our animal experiments to human schizophrenia w ...
... receptor sensitivity (Fink 1995). The effects of estrogen secretion on menstrual cycle-related and premenstrual cognitive functioning as well as in other mental disorders is not the topic of the present contribution. The applicability of the results of our animal experiments to human schizophrenia w ...
Depression in schizophrenia and early psychosis: implications for
... Studies of depression in schizophrenia have used a variety of assessment tools, some of which have useful clinical applications and can help untangle depressive syndrome from negative symptoms or medication side-effects. For example, the Positive and Negative Syndrome Scale (PANSS) (Kay 1987) is a v ...
... Studies of depression in schizophrenia have used a variety of assessment tools, some of which have useful clinical applications and can help untangle depressive syndrome from negative symptoms or medication side-effects. For example, the Positive and Negative Syndrome Scale (PANSS) (Kay 1987) is a v ...
IPAP Schizophrenia Algorithm Node Notes
... cognition as the oral version of risperidone (Evidence Level C). A controlled study (Kane et al, 2003) evaluated 461 mildly ill (CGI average of 3), cooperative patients able to consent to participate in the 12 week study. 67% of the patients on long acting risperidone dropped out (15% during the ora ...
... cognition as the oral version of risperidone (Evidence Level C). A controlled study (Kane et al, 2003) evaluated 461 mildly ill (CGI average of 3), cooperative patients able to consent to participate in the 12 week study. 67% of the patients on long acting risperidone dropped out (15% during the ora ...
Genetics of schizophrenia and other psychotic disorders
... of many common genetic variants which each make a small contribution to risk. At the chromosomal level, studies of copy number variants (CNVs) are showing rarer variants which have a larger effect on risk. Both types of study are reinforcing the theme that schizophrenia shares some genetic influence ...
... of many common genetic variants which each make a small contribution to risk. At the chromosomal level, studies of copy number variants (CNVs) are showing rarer variants which have a larger effect on risk. Both types of study are reinforcing the theme that schizophrenia shares some genetic influence ...
Lipogenic effects of antipsychotic drugs in cultured cells and in rat
... drug-naïve schizophrenic patients and their first-degree unaffected relatives, indicating that they are not a result of the drug treatment or illness itself, but are rather associated with a vulnerability to develop the disorder [19, 20]. Thus, such abnormalities are not suitable as diagnostic crite ...
... drug-naïve schizophrenic patients and their first-degree unaffected relatives, indicating that they are not a result of the drug treatment or illness itself, but are rather associated with a vulnerability to develop the disorder [19, 20]. Thus, such abnormalities are not suitable as diagnostic crite ...
Effects of Exercise on Physical and Mental Health, and Cognitive
... improved their VO2 peak by 12%, while the control group showed no differences. In addition, changes in body composition of the performer were observed, as well as more efficient mechanical walking group. The improvement in peak VO2 is in line with the effects of eight ...
... improved their VO2 peak by 12%, while the control group showed no differences. In addition, changes in body composition of the performer were observed, as well as more efficient mechanical walking group. The improvement in peak VO2 is in line with the effects of eight ...
Psychological Disorders
... – Statistical infrequency: how does the frequency of the behavior compare to others in the culture? – Disability of dysfunction: Person is abnormal if their behavior interferes with their daily lives – Personal distress: Is the person unhappy about their behavior? – Violation of norms: A behavior is ...
... – Statistical infrequency: how does the frequency of the behavior compare to others in the culture? – Disability of dysfunction: Person is abnormal if their behavior interferes with their daily lives – Personal distress: Is the person unhappy about their behavior? – Violation of norms: A behavior is ...
Symptoms and signs of prodrome in psychosis
... identify and manage those patients who may be exhibiting early symptoms and signs of psychosis. Over the past fifteen years there has been an increased interest in the early detection of psychosis. More recently this interest has focused on the prodromal or prepsychotic stages. What is psychosis? Ps ...
... identify and manage those patients who may be exhibiting early symptoms and signs of psychosis. Over the past fifteen years there has been an increased interest in the early detection of psychosis. More recently this interest has focused on the prodromal or prepsychotic stages. What is psychosis? Ps ...
Combined Values-Focused and Exposure and Response
... psychosis, ultimately advocating for the use of a combination treatment of anti-obsessional and antipsychotic medications. However, they also report that ERP was attempted in three patients with mixed results: The introduction of ERP corresponded with an exacerbation of psychotic symptoms in one pat ...
... psychosis, ultimately advocating for the use of a combination treatment of anti-obsessional and antipsychotic medications. However, they also report that ERP was attempted in three patients with mixed results: The introduction of ERP corresponded with an exacerbation of psychotic symptoms in one pat ...
Psychosis – the basics
... an ever-evolving ‘formulation’ which outlines the development and maintenance of problems by examining the ‘triad’ of ‘thoughts, feelings and behaviours’. By focusing upon ‘core beliefs’ and the events which contradict them it is possible to plot the individual’s responses which create and then main ...
... an ever-evolving ‘formulation’ which outlines the development and maintenance of problems by examining the ‘triad’ of ‘thoughts, feelings and behaviours’. By focusing upon ‘core beliefs’ and the events which contradict them it is possible to plot the individual’s responses which create and then main ...
using antipsychotic medication for the treatment of
... As highlighted in Chapter H.5, the treatment of psychosis in young people requires a coordinated and integrated approach based on different components of care tailored to the individuals’ and their families’ needs. Optimal management of young people with psychosis requires a multimodal approach that ...
... As highlighted in Chapter H.5, the treatment of psychosis in young people requires a coordinated and integrated approach based on different components of care tailored to the individuals’ and their families’ needs. Optimal management of young people with psychosis requires a multimodal approach that ...
Schizophrenia and Public Health
... or persecution can often be observed. • Hallucinations: sensory perceptions in the absence of external stimuli. Auditory hallucinations (especially voices) and bizarre physical sensations are the most common. • Abnormal affect: reduction in emotional intensity or variation as well as affective respo ...
... or persecution can often be observed. • Hallucinations: sensory perceptions in the absence of external stimuli. Auditory hallucinations (especially voices) and bizarre physical sensations are the most common. • Abnormal affect: reduction in emotional intensity or variation as well as affective respo ...
Mechanisms of schizophrenia
![](https://commons.wikimedia.org/wiki/Special:FilePath/Artistic_view_of_how_the_world_feels_like_with_schizophrenia_-_journal.pmed.0020146.g001.jpg?width=300)
The underlying mechanisms of schizophrenia, a mental disorder characterized by a disintegration of the processes of thinking and of emotional responsiveness, are complex. A number of theories attempt to explain the link between altered brain function and schizophrenia, the most important of which are the dopamine hypothesis and the glutamate hypothesis. Note that these theories are separate from the causes of schizophrenia, which deal with actual starting points of the illness instead, e.g. genetic and environmental factors. The current theories attempt to explain how changes in brain functioning can contribute to symptoms of the disease.