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Chapter 17 Adaptive Immunity
Chapter 17 Adaptive Immunity

Institute for Microbiology, Medical Faculty of Masaryk
Institute for Microbiology, Medical Faculty of Masaryk

... Damage as a result of defence reactions b) Injuries caused by specific immune reaction (immunopathological consequences of hypersensitivity) ...
Marginal zone B cells – super potent, and super dangerous? Heike
Marginal zone B cells – super potent, and super dangerous? Heike

... The immune system is our best weapon in the fight against viruses and harmful bacteria. It possesses the amazing ability to distinguish between foreign substances and the body's own substances and cells. However, sometimes the immune system does not work properly and makes the serious mistake of att ...
Chapter 22 - Martini
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...  Presents a formidable physical barrier to most microorganisms  Is resistant to weak acids and bases, bacterial enzymes, and toxins ...
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... Inflammation. Inflammation is a local response designed to limit pathogen invasion and tissue damage. Phagocytes such as macrophages and neutrophils play a central role in the inflammatory response. They recognize foreign invaders through nonspecific receptors that identify common features of pathog ...
الرقم : بدون التاريخ : 08/ 11 / 1427
الرقم : بدون التاريخ : 08/ 11 / 1427

... a.antibodies that secreted from b-lymphocyte b.antigens that enter the body c.complement that secreted from monocyte/macrophage d.(a)&(c) 11.which of the following are types of immunity a.natural immunity that is non-specific , ready at once b.phagocytes and NK cell are important cells in innate imm ...
Disease and Immunity - Skinners` School Science
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... • Describe, with the aid of diagrams, the structure of antibodies. • Outline the mode of action of antibodies, with reference to the neutralisation and agglutination of pathogens. • Compare and contrast the primary and secondary immune responses. ...
Immune System Boosters for Increased Overall Health Our body`s
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... Our body’s immune system has to be functioning well in order to maintain health. It is like an army of soldiers fighting off foreign invaders such as bacteria, fungus, viruses etc. Our everyday lives can serve to strengthen this army and allow it to work smarter or drag it down and make us more susc ...
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... 1. What are some differences between innate immunity and adaptive immunity? 2. Where can pathogens inter the body? Provide examples of barriers to pathogen entry. 3. Draw a picture or series of pictures that demonstrates what happens in the inflammatory response when bacteria get in through a cut in ...
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... • T-cytotoxic (TC )cells recognize antigens on virus-infected host cells and tumor cells through antigen-specific TCRs. • Antigen-specific recognition triggers killing via perforin and granzymes. • Natural killer (NK) cells use the same effectors to kill virus-infected cells and tumors. However, NK ...
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What are cytokines and chemokines?

... • They bind to specific receptors on target cells to elicit a specific biological response. • Expression of cytokines and their receptors is usually tightly regulated. • Other more anachronistic terms include monokines and lymphokines. ...
Ch_31_Immune_system
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... Phagocytes Cells that may engulf, bind/remove, release toxins against antigens ...
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...  All body cells have MHC Class I proteins.  Our immune cells do not attack our own proteins  Our cells in another person’s body can trigger an immune response because they are foreign • Restricts donors for transplants ...
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... 14. Va Heijst et al (Science 325:1265; 2009) investigated whether the strength of the cell-mediated immune response is due to either the 1) number of different types of T-cells activated or 2) the amount of clonal expansion that occurs. To do so, they generated a large number of Tc cells with a TCR ...
Specific Resistance = Immunity
Specific Resistance = Immunity

... Cytotoxic T Cells: 1) They bind to infected target host cells (typically due to virus or intracellular bacterium) expressing the antigen-MHC via Tc cell receptor. They also bind to cells with non-self MHC (e.g. tranplants; tumor cells). 2) Binding stimulates secretion of extracellular enzymes (perf ...
Natural Killer (NK) cell “memory”
Natural Killer (NK) cell “memory”

... clearly suggest that epigenetic reprogramming might contribute to drive memory-like features in NK cells, but we still need to identify the genes responsible for such features and to understand when such properties are acquired. Based on these data, we would like to define the unique and/or T cell-l ...
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... • Immunoglobulin (IgG, IgA, IgM, IgE) levels • Specific antibody response • Protein antigens • CHO antigens ...
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Lecture 14: Evasion of the Immune System by Pathogens
Lecture 14: Evasion of the Immune System by Pathogens

... Contribute To Pathogenesis For many infections the disease is caused by the immune response. Other pathogens require immune system components to survive Two examples: Respiratory syncytial virus Mouse mammary tumor virus ...
Immunologic Concepts -Overview of Phagocytic, Cell Mediated
Immunologic Concepts -Overview of Phagocytic, Cell Mediated

... kills it, then itself dies. The M∅ assumes multiple functions including killing pathogens, but also including roles in tissue remodeling and repair, inflammation, clean up of debris, and regulation of immunity. The M∅ does not die after completing phagocytosis, but assumes a vital role which ties in ...
The Body`s Lines of Defense
The Body`s Lines of Defense

... (found in tears, saliva, mucous secretions, and perspiration), which keep it at a pH range of 3 to 5.  This is acidic enough to inhibit the growth of microbes. ...
Fever and Vomit
Fever and Vomit

... A fever occurs in response to infection, allergies or trauma. Fever inducing agents (Pyrogens) are released by body immune system (white blood cells) or infectious bacteria. A “fever” is the resetting of the thermostat and therefore a higher body temperature. Sometimes localized (cut). The chills ar ...
integumentary, immune and lymphatic systems
integumentary, immune and lymphatic systems

... **Penicillin and other antibiotics can also be used to help the immune system, but it is important to remember that antibiotics only kill bacteria! **Vaccines work by mimicking the body’s natural immune response. A small amount of the specially treated virus, bacterium or toxin (vaccine) is injected ...
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Immune system



The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.
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