Deletion mutant of FGFR4 induces onion
... Fibroblast growth factor receptors 1-4 (FGFR1-4) are high affinity receptors for the large family of fibroblast growth factors, which mediate a range of biological responses such as cell proliferation, differentiation and migration (Burgess and Maciag, 1989; Hughes, 1997; Ornitz and Itoh, 2001). The ...
... Fibroblast growth factor receptors 1-4 (FGFR1-4) are high affinity receptors for the large family of fibroblast growth factors, which mediate a range of biological responses such as cell proliferation, differentiation and migration (Burgess and Maciag, 1989; Hughes, 1997; Ornitz and Itoh, 2001). The ...
Lecture Title: INTRODUCTION TO MEDICAL MICROBIOLOGY ( 1
... Lymphocyte Circulation Recognition of antigen by lymphocytes subpopulation 2 mechanisms to maximize the efficiency of the specific arm ...
... Lymphocyte Circulation Recognition of antigen by lymphocytes subpopulation 2 mechanisms to maximize the efficiency of the specific arm ...
GAD AS AN IMMUNOMODULATOR IN TYPE 1 DIABETES Stina Axelsson
... months, a subgroup analysis showed that the treatment had an effect on preservation of residual insulin secretion, but the effect was not seen until after 30 months. Taken together, these results suggest that GAD-alum treatment might exert its effect through induction of an early Th2 skewed immune r ...
... months, a subgroup analysis showed that the treatment had an effect on preservation of residual insulin secretion, but the effect was not seen until after 30 months. Taken together, these results suggest that GAD-alum treatment might exert its effect through induction of an early Th2 skewed immune r ...
Full Meeting Booklet 15.10.15
... We recently identified two membrane proteins (TMEM16F and Xkr8) that are involved in scrambling of phospholipids in plasma membrane. TMEM16F carries 10 transmembrane regions, and requires Ca2+ to mediate phospholipid scrambling. It plays a role in the PtdSer-exposure in activated platelets for blood ...
... We recently identified two membrane proteins (TMEM16F and Xkr8) that are involved in scrambling of phospholipids in plasma membrane. TMEM16F carries 10 transmembrane regions, and requires Ca2+ to mediate phospholipid scrambling. It plays a role in the PtdSer-exposure in activated platelets for blood ...
Synaptonemal complex proteins - Journal of Cell Science
... cDNA expression library from hamster spermatocytes. This library was screened with sera from rabbits and mice inoculated with hamster SCs to identify clones producing SC antigens (Moens et al., 1992). Here we report characteristics ...
... cDNA expression library from hamster spermatocytes. This library was screened with sera from rabbits and mice inoculated with hamster SCs to identify clones producing SC antigens (Moens et al., 1992). Here we report characteristics ...
Immunology Coursebook 2016/17
... There are a number of social events throughout the year that provide an opportunity for students and staff to meet in an informal setting. These include poster day, when the Senior Sophister students present the results of their research projects; this is followed by an informal reception for studen ...
... There are a number of social events throughout the year that provide an opportunity for students and staff to meet in an informal setting. These include poster day, when the Senior Sophister students present the results of their research projects; this is followed by an informal reception for studen ...
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... recognize PAMPs expressed by microorganisms, but not by eukaryotes. TLRs can also be activated by endogenous signals such as uric acid activation of the NALP3/ASC/ Caspase 1 (NALP3/ASC: pyrin domain-containing protein 3/apoptosis-associated speck-like protein containing a caspase activation and recr ...
... recognize PAMPs expressed by microorganisms, but not by eukaryotes. TLRs can also be activated by endogenous signals such as uric acid activation of the NALP3/ASC/ Caspase 1 (NALP3/ASC: pyrin domain-containing protein 3/apoptosis-associated speck-like protein containing a caspase activation and recr ...
Ectopic lymphoid follicles - ORCA
... immune responses to invading pathogens.1 Here, the accumulation of foreign antigens within the highly organized cellular architecture of SLOs facilitates antigen presentation to T and B cells and the establishment of adaptive immunity. Encapsulated SLOs form at predetermined locations during embryon ...
... immune responses to invading pathogens.1 Here, the accumulation of foreign antigens within the highly organized cellular architecture of SLOs facilitates antigen presentation to T and B cells and the establishment of adaptive immunity. Encapsulated SLOs form at predetermined locations during embryon ...
to TCR Ligand Potency Within MHC Molecule or Antigenic Peptide
... then tested for its response to two sets [differing in their N terminus: one being Ac and the other nonacetylated (non-Ac)] of sizing mixtures ranging from tripeptides to decapeptides (X3-X10). As shown in Fig. 1B, TCC TL5F6 showed no response to Ac X3-X7, a weak response to Ac X8, and a strong resp ...
... then tested for its response to two sets [differing in their N terminus: one being Ac and the other nonacetylated (non-Ac)] of sizing mixtures ranging from tripeptides to decapeptides (X3-X10). As shown in Fig. 1B, TCC TL5F6 showed no response to Ac X3-X7, a weak response to Ac X8, and a strong resp ...
Selection of rules
... [11] and Hofmeyr [12]. The adaptive part of the immune system consists of a class of white blood cells called lymphocytes, which circulate the body via the blood and lymph systems. Their primary function is to detect pathogens and assist in their elimination. There are millions of lymphocytes circul ...
... [11] and Hofmeyr [12]. The adaptive part of the immune system consists of a class of white blood cells called lymphocytes, which circulate the body via the blood and lymph systems. Their primary function is to detect pathogens and assist in their elimination. There are millions of lymphocytes circul ...
Biochem Chapter 44 [4-20
... The RBC cytoplasm has Hgb, and enzymes needed to prevent and repair damage done by ROS and make energy RBCs can only make ATP by glycolysis The ATP is used for ion transport across the cell membrane, phosphorylation of membrane proteins, and priming rxns of glycolysis RBC glycolysis uses the Rapopor ...
... The RBC cytoplasm has Hgb, and enzymes needed to prevent and repair damage done by ROS and make energy RBCs can only make ATP by glycolysis The ATP is used for ion transport across the cell membrane, phosphorylation of membrane proteins, and priming rxns of glycolysis RBC glycolysis uses the Rapopor ...
Islet inflammation in human type 1 diabetes
... human disease is not recapitulated fully in any of the available animal models. β-cell loss in type 1 diabetes Early studies of the pancreatic gland recovered from patients with T1D identified the presence of small, nucleated, cells around the periphery (and sometimes within) the islets of Langerhan ...
... human disease is not recapitulated fully in any of the available animal models. β-cell loss in type 1 diabetes Early studies of the pancreatic gland recovered from patients with T1D identified the presence of small, nucleated, cells around the periphery (and sometimes within) the islets of Langerhan ...
NIH Public Access
... inflammasome — a large multiprotein complex formed by an NLR, the adaptor protein ASC (apoptosis- associated speck-like protein containing a caspase recruitment domain) and procaspase 1 (REF. 11). The assembly of the inflammasome leads to the activation of caspase 1, which cleaves pro-interleukin-1β ...
... inflammasome — a large multiprotein complex formed by an NLR, the adaptor protein ASC (apoptosis- associated speck-like protein containing a caspase recruitment domain) and procaspase 1 (REF. 11). The assembly of the inflammasome leads to the activation of caspase 1, which cleaves pro-interleukin-1β ...
Regulated MIP-3/CCL20 production by human intestinal epithelium
... amino-terminal cysteines. In CC chemokines, two aminoterminal cysteines are adjacent, whereas in CXC chemokines, the two amino-terminal cysteines are separated by an intervening amino acid (2, 30). Macrophage inflammatory protein (MIP)-3␣/CCL20 (31), also known as liver and activation-regulated chem ...
... amino-terminal cysteines. In CC chemokines, two aminoterminal cysteines are adjacent, whereas in CXC chemokines, the two amino-terminal cysteines are separated by an intervening amino acid (2, 30). Macrophage inflammatory protein (MIP)-3␣/CCL20 (31), also known as liver and activation-regulated chem ...
Poster
... Mycobacterium tuberculosis (Mtb) due to its effects on the immune system. Interest has risen for vit. D’s ability to modulate immune responses by signaling through the vitamin D receptor (VDR). Vit. D is obtained through dietary sources, like seafood, or exposure to sun’s UVB rays. Vit. D in its act ...
... Mycobacterium tuberculosis (Mtb) due to its effects on the immune system. Interest has risen for vit. D’s ability to modulate immune responses by signaling through the vitamin D receptor (VDR). Vit. D is obtained through dietary sources, like seafood, or exposure to sun’s UVB rays. Vit. D in its act ...
Dendritic cell vaccination for glioblastoma multiforme: review with focus on predictive
... Phase III trial.8 A significant improvement of median overall survival (OS) from 12.1 to 14.6 months, and of median progression-free survival (PFS) from 5.0 to 6.9 months was the result of adding temozolomide chemotherapy to surgery and radiotherapy. Strikingly, there was an important increase of lo ...
... Phase III trial.8 A significant improvement of median overall survival (OS) from 12.1 to 14.6 months, and of median progression-free survival (PFS) from 5.0 to 6.9 months was the result of adding temozolomide chemotherapy to surgery and radiotherapy. Strikingly, there was an important increase of lo ...
Alternative Activation Is an Innate Response to Injury That Requires CD4
... statistically indistinguishable in the first 3 days, with the one exception that parasite implant led to an immediate increase in eosinophils at 24 h (6.7 * 3.0 & 105) that was less pronounced in the surgery-only mice (0.7 * 0.3 & 105). The presence of the parasite, however, led to a further increas ...
... statistically indistinguishable in the first 3 days, with the one exception that parasite implant led to an immediate increase in eosinophils at 24 h (6.7 * 3.0 & 105) that was less pronounced in the surgery-only mice (0.7 * 0.3 & 105). The presence of the parasite, however, led to a further increas ...
Comparative analysis of the acute response of the trout, O. mykiss
... in vivo. This technology will provide a deeper understanding of overall cellular and tissue processes during immune activation. A number of recent reports concerning PAMP recognition [9], activated macrophage transcriptomics [8] and immunomics [10-16] and genome-wide surveys [17] show that fish and ...
... in vivo. This technology will provide a deeper understanding of overall cellular and tissue processes during immune activation. A number of recent reports concerning PAMP recognition [9], activated macrophage transcriptomics [8] and immunomics [10-16] and genome-wide surveys [17] show that fish and ...
Shen-Diabetes 2014 - Stanford Medicine
... To examine the effects of diet-induced obesity on B cells, we fed C57BL/6J mice the NCD (15 kcal% fat) or the HFD (60 kcal% fat) for 9 weeks, which reliably results in obesity-associated IR and glucose intolerance (16). We subsequently compared the frequencies of CD19+ B-cell subpopulations in the P ...
... To examine the effects of diet-induced obesity on B cells, we fed C57BL/6J mice the NCD (15 kcal% fat) or the HFD (60 kcal% fat) for 9 weeks, which reliably results in obesity-associated IR and glucose intolerance (16). We subsequently compared the frequencies of CD19+ B-cell subpopulations in the P ...
Protective immunity against Toxoplasma gondii induced by DNA
... (TgCDPK3) and evaluated its protective efficacy against T. gondii infection in Kunming mice. The gene sequence encoding TgCDPK3 was inserted into the eukaryotic expression vector pVAX I, and mice were immunized with pVAX-CDPK3 intramuscularly. Results: The results showed that mice immunized with pVA ...
... (TgCDPK3) and evaluated its protective efficacy against T. gondii infection in Kunming mice. The gene sequence encoding TgCDPK3 was inserted into the eukaryotic expression vector pVAX I, and mice were immunized with pVAX-CDPK3 intramuscularly. Results: The results showed that mice immunized with pVA ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.