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Lecture 7 Host Defense Against Infection
Lecture 7 Host Defense Against Infection

... Flushing action of tears which drain through the lacrimal duct and deposit bacteria in nasopharynx  Tears contain a high concentration of lysozyme (effective against gram positive microorganisms ...
35-2 Reading Guide
35-2 Reading Guide

... specific immune response works in several ways, including: recognizing “self,” including cells and proteins that belong to the body. recognizing “nonself”, or antigens, molecules found on foreign substances. Antigens stimulate the immune system to produce cells called lymohocytes that recognize, att ...
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... ‘Fine-tuning’ by somatic hypermutation (error-prone DNA repair process) ...
Lymphatic system
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Immunological Memory And Role Of T Lymphocytes During Viral
Immunological Memory And Role Of T Lymphocytes During Viral

... T lymphocytes are part of the adaptive immune response, a sophisticated defense system present only at higher levels of evolution. The hallmark of adaptive immune responses is the capacity to “remember” the first encounter with a pathogen and to respond more rapidly and effectively following re-infe ...
Document
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... - Requires stimulation. - Response time is in days. Major features: • Diversity - many different pathogens recognized • Specificity - distinguishes particular molecules • Memory - responds faster with subsequent exposure ...
19 Physiology of leukocytes
19 Physiology of leukocytes

... divides repeatedly to produce identical daughter cells, which make and release the specific antibody for that antigen. In the blood or lymph these antigens bind with the antigen to form an antigen/antibody complex. This acts as a signal for phagocytic white blood cells to engulf and destroy the whol ...
Immunity - AState.edu
Immunity - AState.edu

... antigen and IL-4, the B cell produces plasma cells and memory cells Tc Cells come in contact with the antigen on the surface of infected cells in combination with the MHC 1 complex. When also have binding with IL-2, cells produce activated Tc Cells and memory cells. ...
Sex and Behaviour * Immune Response to Parasites
Sex and Behaviour * Immune Response to Parasites

... Many studies have concluded that the MMR vaccine is safe and only a few studies claim that it isn’t. However, this was not reflected by the media coverage. .The majority of coverage centred on the possibility of a link between the MMR vaccine and autism, while the government insisted that the vaccin ...
Mitosis Worksheet
Mitosis Worksheet

... The diagram below shows six cells in various phases of the cell cycle. Note the cells are not arranged in the order in which mitosis occurs and one of the phases of mitosis occurs twice. Use the diagram to answer questions 1-7. ...
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lec #1 done by Leen AbdelFattah / Slides #1
lec #1 done by Leen AbdelFattah / Slides #1

... -slide23: thymus cells will educate the new T lymphocytes coming from the BM (tell them what is self component and what is not) If the produced T cell reacts with a self component it must die ( to prevent autoimmunity), that is why we end with a smaller number of cells . ...
Fleisher WAC immune lab testing
Fleisher WAC immune lab testing

... Lymphocyte Function Testing • Response to mitogens, recall antigens, allogeneic cells – Proliferation assessed by 3 H-thymidine incorporation – Cytokine release into culture supernatant – Activation antigen upregulation (e.g. CD69 by flow) – Cell division(e.g. CFSE) or cell cycle (e.g. BrDU) • Cyto ...
CD8 T cells
CD8 T cells

... are generated in the thymus and express the Tcell receptor. However, rather than the CD4 molecule, cytotoxic T cells express a dimeric coreceptor, CD8, usually composed of one CD8α and one CD8β chain. CD8+ T cells recognise peptides presented by MHC Class I molecules, found on all nucleated cells. T ...
open lecture in Powerpoint
open lecture in Powerpoint

... Class 2 Objectives • Upon completion of this lesson, the student will be able to – differentiate the immune function across the lifespan. – determine the different effects of inflammation. – describe the four mechanisms of hypersensitivity. – contrast the concepts of autoimmunity, infection, and im ...
CD8+ T Cells
CD8+ T Cells

... are generated in the thymus and express the Tcell receptor. However, rather than the CD4 molecule, cytotoxic T cells express a dimeric coreceptor, CD8, usually composed of one CD8α and one CD8β chain. CD8+ T cells recognise peptides presented by MHC Class I molecules, found on all nucleated cells. T ...
Immunity - Seattle Central College
Immunity - Seattle Central College

... bacterial cells or antibodies Leads to chain rxn activation of neighboring compliments & inflammation, phagocytosis, and lysis ...
Innate vs. Adaptive Immunity - Welcome to people.pharmacy.purdue
Innate vs. Adaptive Immunity - Welcome to people.pharmacy.purdue

... The central questions • How does the immune system respond to different infections? – Microbes are recognized by two mechanisms, evolved broad recognition mechanisms (innate immunity), and by highly specific lymphocyte antibodies and T cell receptors (adaptive immunity) – Different types of microb ...
Cell Week6
Cell Week6

... 2. Where would you find the linear proteins Myosin and Actin? 3. We know that muscle cells produce large amounts of ATP, even at rest. The energy in ATP is then stored in the phosphate bond of another compound. What is this compound? Explain energy transfer ...
No T cells
No T cells

... an identical MHC gene locus T-cells recognize products of MHC genes as self or non-self If any cell of an individual starts to produce foreign (viral or bacterial) or abnormal (tumor associated) proteins, the T-cells recognize these antigen presenting cells as altered self cells and respond against ...
Immunoglobulins and the Complement System
Immunoglobulins and the Complement System

... as antibodies ...
Z333 Lecture
Z333 Lecture

... Helper T cells: stimulate B & cytotoxic T cell division Some T cells develop into memory cells ...
immune system - Doral Academy Preparatory
immune system - Doral Academy Preparatory

... 1. It creates a barrier that prevents bacteria and viruses from entering your body. (eg – skin) 2. If a bacteria or virus does get into the body, the immune system tries to detect and eliminate it before it can make itself at home and reproduce. (eg – phagocytic white blood cells) 3. If the virus o ...
The Development and Evaluation of Highly Specific
The Development and Evaluation of Highly Specific

... responsible for cancer initiation, development and metastasis. The identification of cancer stem cells is considered as one of the most important objectives for clinical diagnostic and therapeutic purposes. Research evidences indicated that Leucine-rich repeat containing G-protein-coupled receptor 5 ...
10_Blood/Lymph/Immune
10_Blood/Lymph/Immune

... Thymus  lymphatic ...
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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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