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PRESS RELEASE 2011-10-03 The 2011 Nobel Prize in Physiology or Medicine
PRESS RELEASE 2011-10-03 The 2011 Nobel Prize in Physiology or Medicine

... can recognize such microorganisms and activate innate immunity, the first step in the body´s immune response. Ralph Steinman discovered the dendritic cells of the immune system and their unique capacity to activate and regulate adaptive immunity, the later stage of the immune response during which m ...
What`s in a Cell?
What`s in a Cell?

... Imagine that you crumpled up a piece of giant piece of newspaper and could get it inside of a beach ball. That’s kind of what the ER is. Instead of newspaper…it’s a network of membranes. Substances like nutrients and wastes move along the surface to get from one place to another within a cell. There ...
Topic 5 - cloudfront.net
Topic 5 - cloudfront.net

... a. at higher pressures of CO2 haemoglobin releases its oxygen more readily b. at higher pressures of CO2 haemoglobin is more efficient at taking up oxygen c. at low oxygen concentration the % saturation of haemoglobin is directly proportional to the pressure of CO2 d. at high oxygen concentration th ...
Physical Characteristics of Blood
Physical Characteristics of Blood

... – Recognize small organisms such as bacteria by producing antibodies – antibodies = small proteins that bind foreign antigens and target the foreign cell for destruction by the host’s immune system – can respond to viruses if “helped” by T cells ...
7.4mb ppt - UCLA.edu
7.4mb ppt - UCLA.edu

... For Class II the polymorphisms are also concentrated in the binding pocket with the -chain showing more variability than the -chain ...
Protozoan Diseases
Protozoan Diseases

... • ½ the eggs can remain: invade intestinal wall, liver, or bladder → hemorrhage • Unexcreted eggs induce cell-mediated delayed type hypersensitvity. Large granulomas are formed and walled off by fibrous tissue • Granulomas often obstruct venous blood flow to the liver or bladder. ...
Lecture 12 - Immunology
Lecture 12 - Immunology

... which bind to foreign substances like toxins & bacteria to “tag” or mark them for destruction. Driven by T cells & B cells. Cellular Immunity: Cell-mediated immunity which includes the actions of lymphocytes that attack foreign cells or cells infected with cancer, viruses, or parasites. Driven by T ...
foreign antigen
foreign antigen

... if they react to “self” antigens, they are destroyed during maturation ...
Lecture 18
Lecture 18

... The Concept of Immunity- Recognition • Host Toll-like receptors (TLRs) - a class of proteins that play a key role in the innate immune system • Membrane-spanning receptors that recognize structurally conserved molecules derived from microbes – Localized on cell surface Monocytes/macrophages B lymph ...
Immune System lecture
Immune System lecture

...  antibodies against many molecules released by normal breakdown of cells ...
Disease Immune System
Disease Immune System

... Immune Response System Two Coordinated White Blood Cellular Systems 1) Humoral or Antibody Immunity (Using B Cells) 2) Cell-Mediated Immunity (Using T Cells) Both Cellular Systems Work by Identifying Antigens Non-Self Debris, Cells or Molecules Auto-Immune Disease – When Immune Cells No Longer Reco ...
- National Press Foundation
- National Press Foundation

... In monkey studies, removing killer cells led to dramatic increases in viral load and restoring Killer T cells in those same monkey studies led to suppression of viral load Individuals with high levels of Killer T cells have been shown to have low viral loads Two interesting groups of individuals — H ...
Chapter 3: Cell
Chapter 3: Cell

... • a barrier allows some substances to pass through it while excluding others. • Thus, it allows nutrients to enter the cell but keeps many undesirable substances out. At the same time, valuable cell proteins and other substances are kept within the cell, and wastes are allowed to pass out of it. • M ...
Gene Delivery Course - University of Pittsburgh
Gene Delivery Course - University of Pittsburgh

review for the biology regents exam
review for the biology regents exam

... • Specialization or differentiation is the process that changes a stem cell into a specialized cell • Stem cells are cells that have not yet been specialized • Almost all cells have a complete set of genes, but only those genes needed for the cells’ particular job are “turned on”. ...
IMMUNITY
IMMUNITY

... Pathophysiology and Etiology, continued • Type III (Immune complex-mediated) hypersensitivity – Results from formation of IgG or IgM antibody-antigen immune complexes in circulatory system ...
2-Infectious diseases
2-Infectious diseases

... secreted by goblet cells and are then transported by ciliary action to the back of the throat, where they are swallowed and cleared. 3- Organisms smaller than 5 µm travel directly to the alveoli, where they are phagocytosed by alveolar macrophages or by neutrophils recruited to the lung by cytokines ...
Chapter 3
Chapter 3

... What do mitochondria do and what do they look like? • A highly folded organelle in eukaryotic cells • Produces energy in the form of ATP • They are thought to be derived from an engulfed prokaryotic cell ...
T cells - De Anza College
T cells - De Anza College

... • M (microfold) cells in Peyer's patches which contains • Dendritic cells which are antigen-presenting cells and • T cells ...
book light - Journées de l`ecole Doctorale 85 de Nice
book light - Journées de l`ecole Doctorale 85 de Nice

... Mice exposed to higher levels of sensory, motor, social and cognitive stimuli show altered survival to viral challenge or endotoxin shock associated to increase type I interferon production. ...
autumn 11 newsletter
autumn 11 newsletter

... Treatments are $70.00 (normally $95) through the end of December This is a busy season and the added stress can take a toll on the immune system. Acupuncture switches body chemistry from the “flight and flight” response to the “rest and rebuild” mode. Consequently, blood flow is directed toward the ...
Document
Document

... Generally, proteins are the macromolecules composed by amino acids that carry out virtually all of a cell’s activities; they are the molecular tools and machines that make things happen. It is estimated that a typical mammalian cell may have as many as 10,000 different proteins having a diverse arra ...
Primary and Secondary Immune Response: Lectuer-9
Primary and Secondary Immune Response: Lectuer-9

... 4. Size and Number of doses 5. Multiple antigens 6. Adjuvant 7. Immunosuppressive agent Cellular Immune Response: The term cell rnediated immunity refers to the specific immune responses that do not involve antibodies, induction of cell mediated immune response (CMI) consists of specifically sensiti ...


... Anaphylaxis is an acute systemic (multi-system) and severe Type I Hypersensitivity allergic reaction in humans and other mammals. The term comes from the Greek words ανα ana (against) and φύλαξις phylaxis (protection). ...
PowerPoint - Scranton Prep Biology
PowerPoint - Scranton Prep Biology

... against specific antigens  When an antigen enters the body it activates only a small subset of lymphocytes that have complementary receptors.  In clonal selection, the selected lymphocyte cells – multiply into clones of short-lived effector cells, specialized for defending against the antigen that ...
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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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