Poster - IRMACS Centre - Simon Fraser University
... Fig. 3. Proposed configuration of iReceptor environment. Data migration services facilitate input of data into nodes of receptor databases (e.g., VDJServer data commons, BC Genome Sciences Centre, SFU, etc.). iReceptor database service authenticates access at 3 levels: public data “commons”; sharing ...
... Fig. 3. Proposed configuration of iReceptor environment. Data migration services facilitate input of data into nodes of receptor databases (e.g., VDJServer data commons, BC Genome Sciences Centre, SFU, etc.). iReceptor database service authenticates access at 3 levels: public data “commons”; sharing ...
See presentation #4
... • Grown from BM mononuclear cells by their adherence to plastic in tissue culture flasks ...
... • Grown from BM mononuclear cells by their adherence to plastic in tissue culture flasks ...
Postdoctoral Research Scientist in Immunology and Gene
... reactions but promoting deleterious immunosuppression in cancer. Thus, T cells play a pervasive role in health and disease but mechanisms that control the induction and maintenance of effector and regulatory cell characteristics are incompletely elucidated. Their discovery could enable development o ...
... reactions but promoting deleterious immunosuppression in cancer. Thus, T cells play a pervasive role in health and disease but mechanisms that control the induction and maintenance of effector and regulatory cell characteristics are incompletely elucidated. Their discovery could enable development o ...
Traffic across Membranes-2008
... from the originals by permission of the publisher. These illustrations may not be reproduced in any format for any purpose without express written permission from the publisher. BIOLOGY: CONCEPTS AND CONNECTIONS 4th Edition, by Campbell, Reece, Mitchell, and Taylor, ©2001. These images have been pro ...
... from the originals by permission of the publisher. These illustrations may not be reproduced in any format for any purpose without express written permission from the publisher. BIOLOGY: CONCEPTS AND CONNECTIONS 4th Edition, by Campbell, Reece, Mitchell, and Taylor, ©2001. These images have been pro ...
Pathophysiology
... Cytosol – aqueous gel-like medium Important metabolic processes occur here Organelles – membrane bound structures Membranes provide compartments for separation of chemical reactions ...
... Cytosol – aqueous gel-like medium Important metabolic processes occur here Organelles – membrane bound structures Membranes provide compartments for separation of chemical reactions ...
MCB 150: Molecular Immunology - Department of Molecular & Cell
... Antigen: material (from a pathogen) that induces an immune response Innate (natural) immunity: rapid, non specific immune response Adaptive (acquired) immunity: slower, specific immune response Leukocytes: blood cells Lymphocytes: specialized blood cells that mediate adaptive immunity (e.g. T and B ...
... Antigen: material (from a pathogen) that induces an immune response Innate (natural) immunity: rapid, non specific immune response Adaptive (acquired) immunity: slower, specific immune response Leukocytes: blood cells Lymphocytes: specialized blood cells that mediate adaptive immunity (e.g. T and B ...
Chemical reactions take place inside cells.
... and hydrogen. Inside cells, sugar molecules are broken down. This process provides usable energy for the cell. Simple sugar molecules can also be linked into long chains to form more complex carbohydrates, such as starch, cellulose, and glycogen. Starch and cellulose are complex carbohydrates made b ...
... and hydrogen. Inside cells, sugar molecules are broken down. This process provides usable energy for the cell. Simple sugar molecules can also be linked into long chains to form more complex carbohydrates, such as starch, cellulose, and glycogen. Starch and cellulose are complex carbohydrates made b ...
Phagocytosis, Innate Immunity, and Host–Pathogen Specificity
... over time, a mechanism that might help pathogens to evade the human immune response. What remains unanswered is how these proteins, which do not share overt homology, interact with the same receptor. General Paradigms in the Phagocytosis of Microbial Pathogens. The findings on CEACAM3 and Neisseria ...
... over time, a mechanism that might help pathogens to evade the human immune response. What remains unanswered is how these proteins, which do not share overt homology, interact with the same receptor. General Paradigms in the Phagocytosis of Microbial Pathogens. The findings on CEACAM3 and Neisseria ...
Planet Earth and Its Environment A 5000-million
... This program proved to be very successful, and in 1979 WHO declared that it had eliminated the virus from the world population and eradicated the disease smallpox. The only samples of the virus in the world today are in a couple of research laboratories where scientists are studying its DNA. ...
... This program proved to be very successful, and in 1979 WHO declared that it had eliminated the virus from the world population and eradicated the disease smallpox. The only samples of the virus in the world today are in a couple of research laboratories where scientists are studying its DNA. ...
hybridoma technology for production of monoclonal antibodies
... myeloma tumor cells that can grow indefinitely in culture (myeloma is a B-cell cancer). This fusion is performed by making the cell membranes more permeable. The fused hybrid cells (called hybridomas), being cancer cells, will multiply rapidly and indefinitely and will produce large amounts of the d ...
... myeloma tumor cells that can grow indefinitely in culture (myeloma is a B-cell cancer). This fusion is performed by making the cell membranes more permeable. The fused hybrid cells (called hybridomas), being cancer cells, will multiply rapidly and indefinitely and will produce large amounts of the d ...
GRIM-19 interacts with HtrA2: To identify the cellular proteins that
... coding for the serine protease HtrA2. Fig.S1 shows a typical interaction between GRIM19 and HtrA2. While all yeast clones carrying individual plasmids grew normally a nutrient-rich growth medium, only the clone that coexpressed both GRIM-19 and HtrA2 thrived on selective medium. These cells turned b ...
... coding for the serine protease HtrA2. Fig.S1 shows a typical interaction between GRIM19 and HtrA2. While all yeast clones carrying individual plasmids grew normally a nutrient-rich growth medium, only the clone that coexpressed both GRIM-19 and HtrA2 thrived on selective medium. These cells turned b ...
Ig, Struction and Function
... • What is Immunoglobulin? Immunoglobulin are the critical ingredients of humoral acquired immune response. • The immunoglobulins are a group of glycoproteins present in the serum and tissue fluids of all mammals. ...
... • What is Immunoglobulin? Immunoglobulin are the critical ingredients of humoral acquired immune response. • The immunoglobulins are a group of glycoproteins present in the serum and tissue fluids of all mammals. ...
Lab: Modeling the Cell Membrane
... any energy to move things through the membrane. Active transport needs some energy to move things through the membrane. The cell membrane is made up of phospholipids where part is hydrophilic (water-loving) and part is hydrophobic (water-repelling). This causes the phospholipids to be arranged in a ...
... any energy to move things through the membrane. Active transport needs some energy to move things through the membrane. The cell membrane is made up of phospholipids where part is hydrophilic (water-loving) and part is hydrophobic (water-repelling). This causes the phospholipids to be arranged in a ...
CELLS structure and function
... In the body, diffusion causes molecules that are in a high concentration on one side of the cell membrane to move across the membrane until they are present in equal concentrations on both sides. It takes place because all molecules have an in-built vibration that causes them to move and collide unt ...
... In the body, diffusion causes molecules that are in a high concentration on one side of the cell membrane to move across the membrane until they are present in equal concentrations on both sides. It takes place because all molecules have an in-built vibration that causes them to move and collide unt ...
Mechanisms of Autoimmunity
... response not only through molecular mimicry, but also with polyclonal activation and release of isolated autoantigen. Lipopolysaccharide (LPS), a product of infectious microbes, bacterial DNA, and viruses serve as an adjuvant to immune response. They bind to Toll-like receptors (TLRs) on the surface ...
... response not only through molecular mimicry, but also with polyclonal activation and release of isolated autoantigen. Lipopolysaccharide (LPS), a product of infectious microbes, bacterial DNA, and viruses serve as an adjuvant to immune response. They bind to Toll-like receptors (TLRs) on the surface ...
T CELL DEFICIENCY
... •HYPER IgM SYNDROME (Autosomal) -Intrinsic B cell defect, activation induced deaiminase (AID) deficiency. Cytidine uridine conversion. -The enyme is involved in affinity maturation and Ig. class switch - Lack of opportunistic infections ...
... •HYPER IgM SYNDROME (Autosomal) -Intrinsic B cell defect, activation induced deaiminase (AID) deficiency. Cytidine uridine conversion. -The enyme is involved in affinity maturation and Ig. class switch - Lack of opportunistic infections ...
The Body Defenses
... and differentiate into plasma cells or memory cells. • Most are transformed into plasma cells. They produce and secrete IgG antibodies. Each antibody combines with an antigen, marking it for destruction. • During initial contact with a microbial antigen, the antibody response is delayed. Plasma cell ...
... and differentiate into plasma cells or memory cells. • Most are transformed into plasma cells. They produce and secrete IgG antibodies. Each antibody combines with an antigen, marking it for destruction. • During initial contact with a microbial antigen, the antibody response is delayed. Plasma cell ...
Chapter One and Two:
... Passive Immunity: the temporary immunity that an infant acquires from its mother a bacteria is a single-celled microorganism. Some bacteria produce poisons that are harmful to human cells. If there are enough “bad cells and the person is not immune, disease results. Virus’s are not living cells, t ...
... Passive Immunity: the temporary immunity that an infant acquires from its mother a bacteria is a single-celled microorganism. Some bacteria produce poisons that are harmful to human cells. If there are enough “bad cells and the person is not immune, disease results. Virus’s are not living cells, t ...
Supplemental Information
... crystals belong to space group C2221 with the following unit cell parameters: a = 46.07 Å, b = 76.47 Å and c = 86.87 Å. There is one protein molecule in the asymmetric unit. All data were processed with HKL3000 (2), and the statistics are provided in Table 1. Structural determination and refinement. ...
... crystals belong to space group C2221 with the following unit cell parameters: a = 46.07 Å, b = 76.47 Å and c = 86.87 Å. There is one protein molecule in the asymmetric unit. All data were processed with HKL3000 (2), and the statistics are provided in Table 1. Structural determination and refinement. ...
Building Materials of Life
... (More H can be added to the carbons). • If there are more than one double bond in the fatty acids it is polyunsaturated. ...
... (More H can be added to the carbons). • If there are more than one double bond in the fatty acids it is polyunsaturated. ...
WK11-RhoJared
... CNF1 and DNT are both taken up by host cells via their aminoterminal domains into vesicles. Their translocation domains are used in acidic pHs to eject the toxins out of their vesicles into the cytoplasm. After this, these toxins convert Rho proteins into their active forms by stopping their GTPase ...
... CNF1 and DNT are both taken up by host cells via their aminoterminal domains into vesicles. Their translocation domains are used in acidic pHs to eject the toxins out of their vesicles into the cytoplasm. After this, these toxins convert Rho proteins into their active forms by stopping their GTPase ...
Pathophysiology of Lymphomas - Ipswich-Year2-Med-PBL-Gp-2
... Aetiology: Germinal centre B cells, t(14:18) [BCL2] Pathophysiolology: BCL2 antagonises apoptosis and promotes survival. Calls in reactive cells. Marrow, spleen and liver involvement common. Goes where B cells go (white pulp) ...
... Aetiology: Germinal centre B cells, t(14:18) [BCL2] Pathophysiolology: BCL2 antagonises apoptosis and promotes survival. Calls in reactive cells. Marrow, spleen and liver involvement common. Goes where B cells go (white pulp) ...
Supporting Information
... We constructed four plasmids encoding U6 promoter-driven shRNAs against different target sites within the MPHOSPH1 transcript, and transfected these vectors into HEK293 cells. As shown in Fig. S1, we chose the pBS/U6-M21 plasmid vector, which exhibits the strongest interfering effect, to construct ...
... We constructed four plasmids encoding U6 promoter-driven shRNAs against different target sites within the MPHOSPH1 transcript, and transfected these vectors into HEK293 cells. As shown in Fig. S1, we chose the pBS/U6-M21 plasmid vector, which exhibits the strongest interfering effect, to construct ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.