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Slide 1 - pharmaHUB
Slide 1 - pharmaHUB

... molecules are absorbed through the small openings between epithelial cells that are filled with aqueous solution Comprises the 0.01% of the total surface area of the epithelium Intercellular spaces vary according to their location in the GI tract – Duodenum – 0.8 nm – Colon – 0.3 nm ...
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... invader in a very short time becomes 2, and then they divide producing 4, and then again to 8. This will go on until either your immune system adapts to the invader, producing antibodies to alert the macrophages to eat the bacteria, or until the number of bacteria overwhelms the body, leading to the ...
PowerPoint 演示文稿 - Shandong University
PowerPoint 演示文稿 - Shandong University

... Important functions of innate immunity: • Innate immunity is the initial response to microbes • The effector mechanisms of innate immunity are often used to eliminate microbes even in adaptive immune responses • Innate immunity to microbes stimulates adaptive immune responses and can influence the ...
Microbiology: A Systems Approach, 2nd ed.
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... • Discharged by bone marrow into bloodstream, live as phagocytes for a few days, then differentiate into macrophages • Responsible for – Many specific and nonspecific phagocytic and killing functions – Processing foreign molecules and presenting them to lymphocytes – Secreting biologically active co ...
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Lecture Notes: Immune System (Part I)
Lecture Notes: Immune System (Part I)

... the antigen which activated them. They kill by inserting perforins (see above) and by initiating apoptosis. Cellular immunity constitutes a major defense against infections due to viruses, fungi, and a few bacteria such as the tubercle bacillus. It also helps defend against tumors. Development of th ...
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Topics Tested: Physics – Nine questions each on the topics below:
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70 COPYRIGHT 2005 SCIENTIFIC AMERICAN, INC.
70 COPYRIGHT 2005 SCIENTIFIC AMERICAN, INC.

... lupus, especially the chromosomal fragments, is often abnormal. In healthy cells, certain short sequences of DNA carry methyl groups that serve as tags controlling gene activity. The DNA in circulating immune complexes from lupus patients is undermethylated. Scientists have several reasons to suspec ...
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CO2 would move across a plasma membrane more quickly than
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... 1. The oxygen required for cellular respiration is _inhaled_____ into the_lungs___, _diffuses _ into the _blood____, and is delivered to the _mitochondria________ of the body cells by _red blood cells_______. We exhale the waste products from cellular respiration, _ CO2_____ and _ H2O _____. 2. The ...
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antibodies for cancer immunology immunotherapy research

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Lecture notes
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... The main function of secondary lymphoid tissues is to provide an optimal environmental for the antigen-specific clonal selection and activation of T and B lymphocytes: this could not happen as efficiently within the infected tissues themselves. This is why antigens are carried from sites of infectio ...
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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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