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IMMUNOLOGY
IMMUNOLOGY

CTL - Molecular Immunology
CTL - Molecular Immunology

Cell Biology Unit
Cell Biology Unit

... 1.2h - Many organic and inorganic substances dissolved in cells allow necessary chemical reactions to take place in order to maintain life. Large organic food molecules such as proteins and starches must initially be broken down (digested to amino acids and simple sugars respectively), in order to e ...
link to lecture - Welcome to brd4.braude.ac.il!
link to lecture - Welcome to brd4.braude.ac.il!

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chapter 20 immunodeficiency
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Immunoglobulln E Plus Antigen Challenge Induces
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... other members of this chemokine superfamily which are broadly expressed after a variety of stimuli. Even if it seems very unlikely that a cell line in the process of its establishment has gained a function in terms of a novel signal transduction pathway (induction of MARC via the Fc~KI in our case), ...
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... Read the information about the trialling of the first contraceptive pill. The Pill was developed by a team of scientists led by Gregory Pincus. The team needed to carry out large scale trials on humans. In the summer of 1955, Pincus visited the island of Puerto Rico. Puerto Rico is one of the most d ...
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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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