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BASIC CONCEPTS IN IMMUNOLOGY (I)
BASIC CONCEPTS IN IMMUNOLOGY (I)

... It has a molecular mass of 154 kDa, based on two L chains of 22000 Da each and two H chains of 55000 each. The four subclasses of IgG differ in structure, relative concentration, and function. Production of IgG requires T-cell help. ...
Hyposplenism
Hyposplenism

... Romanovsky, A. A., et. al., The spleen: another mystery about its function [Editorial]. American Journal of Physiology v. 284 no. 6 (June 2003 pt2) p. R1378-9 Sunder-Plassmann, G., et. al., Functional asplenia and vasculitis associated with antineutrophil cytoplasmic antibodies. The New England Jour ...
AP Midterm Review 09-10
AP Midterm Review 09-10

... 45) A large proportion of archaeans are "extremophiles," so called because they inhabit extreme environments with high acidity and/or high temperature. Such environments are thought to have been much more common on the primitive Earth. Thus, modern extremophiles survive only in places that their anc ...
Document
Document

... no pro-inflammatory cytokines poor activation of Langerhans cells and stromal dendritic cells ...
Tag-it Violet™ Proliferation and Cell Tracking Dye
Tag-it Violet™ Proliferation and Cell Tracking Dye

Pathology of immune reactivity.Allergy
Pathology of immune reactivity.Allergy

Blood group change in acute myeloid leukemia
Blood group change in acute myeloid leukemia

... Corresponding author: Geetha Narayanan, MD, DM, Professor and Head, Department of Medical Oncology, Regional Cancer Centre, Trivandrum 695011, ...
notes
notes

... NO diffuses freely across cell membranes quickly consumed close to where it is synthesized acts in a paracrine or even autocrine fashion ...
Mechanisms of Danger-signal mediated Immune Modulation
Mechanisms of Danger-signal mediated Immune Modulation

Human Systems Review Science Department
Human Systems Review Science Department

Towards understanding the immune system
Towards understanding the immune system

... complex, intricate and interesting (Ahmed and Hashish, 2005). It is known to be multifunctional and multi-pathway i.e. most immune effectors do more than one job. Also each function of the immune system is typically done by more than one effector. This makes it more robust. The immune system has a s ...
Transplantation Immunology
Transplantation Immunology

... Alloantigens elicit both cell-mediated and humoral immune responses. ...
- Future Medicine
- Future Medicine

... biologically-compatible medical device. Encapsulation prevents direct exposure of the PEC-01 cells to cells of the immune system, thus preventing the provocation of an immune response. Moreover, the fact that the device is implanted under the skin means that it can easily be removed if serious adver ...
Plasma membrane Structure
Plasma membrane Structure

... (foreign) by cells involved with the immune response. The characteristics of the glycocalyx are genetically determined. For example the blood group (A ,B , AB & O ) of any individual is determined by the presence or absence of certain glycoproteins on the membrane of red blood cells. ...
Title here - British Society of Gastroenterology (BSG)
Title here - British Society of Gastroenterology (BSG)

... 1. Immune-manipulated mice do not develop colitis when germ-free 2. Certain strains induce colitis more than others 3. No single strain will induce colitis consistently in all models ...
PPoint - Dr. Stuart White
PPoint - Dr. Stuart White

... the mucosa-associated lymphoid tissues (MALT) that transport the antigens to the Peyer’s patches which are the doorway to the lymphatic system (immune responses to blood borne antigens are initiated in the spleen, while response to tissue antigens starts in the local lymph nodes)  Current immune co ...
Multiple Sclerosis - faculty at Chemeketa
Multiple Sclerosis - faculty at Chemeketa

... trigger a response. Body stores few cells for each antigen. T Cells: patrol for antigens, surface carries receptor molecules to detect. Regulatory T Cells (assist in making antibodies) Helper T Cells (activate the defense) Killer T Cells (attack disease or damaged cell by binding and inducing cytoki ...
Blood = formed elements + plasma
Blood = formed elements + plasma

Understanding Renal Cell Carcinoma and Immuno
Understanding Renal Cell Carcinoma and Immuno

... Normally the innate and adaptive immune systems recognize tumor cells and initiate anti-tumor responses to eliminate cancer. This is known as tumor immune surveillance.16,17,18 However, in some cases tumor cells can manage to evade the body’s immune response.16 Steps in the normal immune system resp ...
UNIVERSITY OF SCIENCES AND TECHNOLOGY HOUARI
UNIVERSITY OF SCIENCES AND TECHNOLOGY HOUARI

... mediated by cells and proteins. The most components of innate immunity are always present in healthy individuals and ready to prevent the entry of pathogens in host tissues. The innate immunity mechanisms rely on the ability …................. conserved microbial structures shared by large groups of ...
Keys (above) modified by the `Big Ideas`
Keys (above) modified by the `Big Ideas`

... between any of them. b. Disulfide bonds occur between two amino acids that have R groups with the element sulfur. Two cysteine amino acids can form disulfide bonds with one another. c. Hydrophobic interactions occur between nonpolar R groups in the tertiary structure of a protein. Cysteine and pheny ...
The importance of nutrition in immunity
The importance of nutrition in immunity

... - Vitamins as co-factors of enzymes, antioxidants, and for cell differentiation; - Minerals and trace elements as co-factors of enzymes. These nutrient requirements increase still further when the immune system is activated - in response to an infection, for example. Energy and protein are both need ...
CLONING THE FIRST DOG: HOW CLOSE ARE WE
CLONING THE FIRST DOG: HOW CLOSE ARE WE

... containing 0.1mM Mg2+, then transferred to an electrofusion chamber containing the same medium. Cell fusion was induced by applying 2, 3.0 kV/cm 25 usec DC pulses delivered by a BTX Electrocell Manipulator 200 (BTX, San Diego, CA). The couplets were then removed from the fusion chamber, washed and i ...
Intermediate 2 Biology Revision
Intermediate 2 Biology Revision

... 6. Describe the colour change that occurs. 7. Describe the conditions that must be present for haemoglobin and oxygen to become separated (dissociate). 8. How does the body compensate for the low oxygen levels found at higher altitudes? 11.6 Body defences 1. State the term for a disease causing orga ...
Mucosal Immunisation (Lung and Middle Ear)
Mucosal Immunisation (Lung and Middle Ear)

... Small Intestinal Lumen ...
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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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