IMMUNOSELECT-R⢠IDENTIFY AND PRIORITIZE CANDIDATE
... — 95% sensitivity and 97% positive predictive value down to 10% mutant allele frequency at 150x coverage • Works on FFPE or frozen tissue • Matched patient normal (germline DNA) is required for optimal results • Accurate inference of HLA typing from whole-exome sequencing ...
... — 95% sensitivity and 97% positive predictive value down to 10% mutant allele frequency at 150x coverage • Works on FFPE or frozen tissue • Matched patient normal (germline DNA) is required for optimal results • Accurate inference of HLA typing from whole-exome sequencing ...
Immunity & Abnormal Responses
... – Those proteins made by the cell that are incorporated into the cell membrane & hold or present foreign antigenic material that has gotten into the cell – These are usually glycoproteins & everybody has different ones • Controlled by genes on chromosome 6 in region called MHC » MHC = major histocom ...
... – Those proteins made by the cell that are incorporated into the cell membrane & hold or present foreign antigenic material that has gotten into the cell – These are usually glycoproteins & everybody has different ones • Controlled by genes on chromosome 6 in region called MHC » MHC = major histocom ...
Extension of Mendelian Genetics
... • Allele i is recessive to both IA and IB • Alleles IA and IB are codominant – They are both expressed in a heterozygous individual ...
... • Allele i is recessive to both IA and IB • Alleles IA and IB are codominant – They are both expressed in a heterozygous individual ...
No T cells
... an identical MHC gene locus T-cells recognize products of MHC genes as self or non-self If any cell of an individual starts to produce foreign (viral or bacterial) or abnormal (tumor associated) proteins, the T-cells recognize these antigen presenting cells as altered self cells and respond against ...
... an identical MHC gene locus T-cells recognize products of MHC genes as self or non-self If any cell of an individual starts to produce foreign (viral or bacterial) or abnormal (tumor associated) proteins, the T-cells recognize these antigen presenting cells as altered self cells and respond against ...
... What is Genetics? C. Which allele of a 1. Each individual has two gene is expressed in factors, or alleles, for a diploid organism? each trait, which may or may not have the same information • Homozygous: the pair of alleles for a gene are identical (Example: GG or gg) • Heterozygous: the pair of al ...
Document
... Albinism • Phenotype results when pathway for melanin production is completely blocked • Genotype - Homozygous recessive at the gene locus that codes for tyrosinase, an enzyme in the melaninsynthesizing pathway ...
... Albinism • Phenotype results when pathway for melanin production is completely blocked • Genotype - Homozygous recessive at the gene locus that codes for tyrosinase, an enzyme in the melaninsynthesizing pathway ...
Genetics Test ____ 1. Two similar chromosomes that you inherit
... ____ 37. The arctic fox is blue-gray in the summer and white in the winter. What most likely influence(s) this change? a. genes and the environment c. the environment alone b. dominant alleles d. codominant alleles ____ 38. When Gregor Mendel crossed a tall plant with a short plant, the F1 plants in ...
... ____ 37. The arctic fox is blue-gray in the summer and white in the winter. What most likely influence(s) this change? a. genes and the environment c. the environment alone b. dominant alleles d. codominant alleles ____ 38. When Gregor Mendel crossed a tall plant with a short plant, the F1 plants in ...
IMMUNITY- humoral immunity, or antibody
... ii. Passive- antibodies come from serum of an immune individual (not always human) 1. immediate protection 2. short lived protection 3. mother/ fetus d. Antibodies- also known as "Ig"s (for immunoglobulins). Secreted by plasma cells or by activated B-cells i. Basic structure 1. "variable" region - a ...
... ii. Passive- antibodies come from serum of an immune individual (not always human) 1. immediate protection 2. short lived protection 3. mother/ fetus d. Antibodies- also known as "Ig"s (for immunoglobulins). Secreted by plasma cells or by activated B-cells i. Basic structure 1. "variable" region - a ...
all in the genes - The Wild Trout Trust
... The complete wild trout gene pool represents the ultimate “master library” of every single version of every single trout gene that could possibly be present in any lineages (whether domestic or wild). Both domestication and local adaptation in the wild involves selecting only a subset of the total g ...
... The complete wild trout gene pool represents the ultimate “master library” of every single version of every single trout gene that could possibly be present in any lineages (whether domestic or wild). Both domestication and local adaptation in the wild involves selecting only a subset of the total g ...
link
... • Variety of B-cells produced by random recombination of genes for variable regions of antibody • During B-cell development, certain clonal lines are eliminated because their antibodies glom onto the bodys own antigens • B-cell production and clonal selection occurs in bone marrow during early years ...
... • Variety of B-cells produced by random recombination of genes for variable regions of antibody • During B-cell development, certain clonal lines are eliminated because their antibodies glom onto the bodys own antigens • B-cell production and clonal selection occurs in bone marrow during early years ...
Probability and Punnet Squares
... The X and the Y chromosomes are not ___________________. The X chromosome is much bigger than the Y, so there are some ________ on the X-chromosome that are not on the _______________________. The ____________ for sex-linked traits are written as ____________________ of the X-chromosome. _____ ...
... The X and the Y chromosomes are not ___________________. The X chromosome is much bigger than the Y, so there are some ________ on the X-chromosome that are not on the _______________________. The ____________ for sex-linked traits are written as ____________________ of the X-chromosome. _____ ...
Autoimmune disease I
... c) Single gene mutation (rare in AD): A few number of autoimmune diseases caused by single gene defect e.g.: ( AIRE= Defect in central tolerance and IL2 and its receptor D25) Diseases example: multiple sclerosis, & other OUTCOME> These cytokines may control the maintenance of regulatory T cells ...
... c) Single gene mutation (rare in AD): A few number of autoimmune diseases caused by single gene defect e.g.: ( AIRE= Defect in central tolerance and IL2 and its receptor D25) Diseases example: multiple sclerosis, & other OUTCOME> These cytokines may control the maintenance of regulatory T cells ...
Genetics - MWMS HW Wiki
... • Individual alleles control the inheritance of traits. Some are dominant and some are recessive. • Dominant Alleles: always show up and are expressed as a capital letter:Tt. • Recessive Alleles: gets masked when a dominant allele is present and is expressed as a lower case letter:Tt. ...
... • Individual alleles control the inheritance of traits. Some are dominant and some are recessive. • Dominant Alleles: always show up and are expressed as a capital letter:Tt. • Recessive Alleles: gets masked when a dominant allele is present and is expressed as a lower case letter:Tt. ...
DO NOT WRITE ON THIS PAPER
... placed in dish #3, the RIP graveyard. Continue his procedure until all alleles (beans) have been counted and sorted. ***Once in the RIP graveyard, these alleles are no longer able to be passes on the next generation. SO SAD!! 6. Count and record the ‘H’ and ‘h’ alleles obtained and place in the char ...
... placed in dish #3, the RIP graveyard. Continue his procedure until all alleles (beans) have been counted and sorted. ***Once in the RIP graveyard, these alleles are no longer able to be passes on the next generation. SO SAD!! 6. Count and record the ‘H’ and ‘h’ alleles obtained and place in the char ...
CH 14 Mendelian Genetics Gregor Mendel Mendel discovered the
... For example, the four phenotypes of the ABO blood group in humans are determined by three alleles for the enzyme (I) that attaches A or B carbohydrates to red blood cells: IA, IB, and i. The enzyme encoded by the IA allele adds the A carbohydrate, whereas the enzyme encoded by the IB allele adds th ...
... For example, the four phenotypes of the ABO blood group in humans are determined by three alleles for the enzyme (I) that attaches A or B carbohydrates to red blood cells: IA, IB, and i. The enzyme encoded by the IA allele adds the A carbohydrate, whereas the enzyme encoded by the IB allele adds th ...
Ch04 Extensions of Mendelian Genetics
... • Example: MN blood group in humans • Red blood cell glycoprotein surface antigen has two forms (M and N) • An individual may exhibit either or both ...
... • Example: MN blood group in humans • Red blood cell glycoprotein surface antigen has two forms (M and N) • An individual may exhibit either or both ...
MICROEVOLUTION
... • Says that frequencies of alleles in a population remain constant over time. • This depends on the inheritance of ...
... • Says that frequencies of alleles in a population remain constant over time. • This depends on the inheritance of ...
Genes and Alleles
... According to what we learned in the past week, what would you predict the offspring to look like? This cross is an exception to Mendel’s principle. It is displaying Incomplete Dominance Incomplete Dominance – when some alleles are neither dominant or recessive. The heterozygous phenotype expresses ...
... According to what we learned in the past week, what would you predict the offspring to look like? This cross is an exception to Mendel’s principle. It is displaying Incomplete Dominance Incomplete Dominance – when some alleles are neither dominant or recessive. The heterozygous phenotype expresses ...
Document
... Human leukocyte antigens (HLA) HLA proteins are produced by major histocompatibility complex (MHC) class I and II genes. Link sugars to form branched glycoproteins on cell surface of white blood cells. HLA glycoproteins can recognize bacterial and viral proteins, marking them for immune system to ...
... Human leukocyte antigens (HLA) HLA proteins are produced by major histocompatibility complex (MHC) class I and II genes. Link sugars to form branched glycoproteins on cell surface of white blood cells. HLA glycoproteins can recognize bacterial and viral proteins, marking them for immune system to ...
Chapter 5 - SchoolRack
... What does that mean? Mendel decided that meant that one alleles was dominant and the other allele ...
... What does that mean? Mendel decided that meant that one alleles was dominant and the other allele ...
Marie Vranceanu, David de Lorenzo and Keith Grimaldi
... on weight loss of a gluten-free diet, and analyse the potential interactions between genetic factors affecting gluten sensitivity (located at the HLA-DQ gene) and gender. Dr. David de Lorenzo ...
... on weight loss of a gluten-free diet, and analyse the potential interactions between genetic factors affecting gluten sensitivity (located at the HLA-DQ gene) and gender. Dr. David de Lorenzo ...
Human leukocyte antigen
The human leukocyte antigen (HLA) system is the locus of genes that encode for proteins on the surface of cells that are responsible for regulation of the immune system in humans. This group of genes resides on chromosome 6 (exception: the gene for β2-microglobulin which is located on chromosome 15), and encodes cell-surface antigen-presenting proteins and has many other functions. The HLA genes are the human versions of the major histocompatibility complex (MHC) genes that are found in most vertebrates (and thus are the most studied of the MHC genes). The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants. The major HLAs are essential elements for immune function. Different classes have different functions:HLAs corresponding to MHC class I (A, B, and C) present peptides from inside the cell. For example, if the cell is infected by a virus, the HLA system brings fragments of the virus to the surface of the cell so that the cell can be destroyed by the immune system. These peptides are produced from digested proteins that are broken down in the proteasomes. In general, these particular peptides are small polymers, about 9 amino acids in length. Foreign antigens presented by MHC class I attract killer T-cells (also called CD8 positive- or cytotoxic T-cells) that destroy cells.HLAs corresponding to MHC class II (DP, DM, DOA, DOB, DQ, and DR) present antigens from outside of the cell to T-lymphocytes. These particular antigens stimulate the multiplication of T-helper cells, which in turn stimulate antibody-producing B-cells to produce antibodies to that specific antigen. Self-antigens are suppressed by regulatory T cells.HLAs corresponding to MHC class III encode components of the complement system.HLAs have other roles. They are important in disease defense. They are the major cause of organ transplant rejections. They may protect against or fail to protect (if down-regulated by an infection) against cancers. Mutations in HLA may be linked to autoimmune disease (examples: type I diabetes, coeliac disease). HLA may also be related to people's perception of the odor of other people, and may be involved in mate selection, as at least one study found a lower-than-expected rate of HLA similarity between spouses in an isolated community.Aside from the genes encoding the 6 major antigen-presenting proteins, there are a large number of other genes, many involved in immune function, located on the HLA complex. Diversity of HLAs in the human population is one aspect of disease defense, and, as a result, the chance of two unrelated individuals with identical HLA molecules on all loci is very low. HLA genes have historically been identified as a result of the ability to successfully transplant organs between HLA-similar individuals.