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class set
class set

... In this activity, you will examine natural selection in a small population of wild rabbits. Evolution, on a genetic level, is a change in the frequency of alleles in a population over a period of time. Breeders of rabbits have long been familiar with a variety of genetic traits that affect the survi ...
D0794983_C11_L01_Lesson_Review_Workbook_A
D0794983_C11_L01_Lesson_Review_Workbook_A

... study how traits passed from one generation to the next. He created hybrids, which are crosses between true-breeding parents (the P generation) with different traits.  These hybrids were the F1 (first filial) generation.  They each showed the characteristic of only one parent. Mendel found that tr ...
11.1 Worksheet - Merrillville Community School
11.1 Worksheet - Merrillville Community School

... study how traits passed from one generation to the next. He created hybrids, which are crosses between true-breeding parents (the P generation) with different traits.  These hybrids were the F1 (first filial) generation.  They each showed the characteristic of only one parent. Mendel found that tr ...
HOMEWORK PACKET: (11.1) The Work of Gregor Mendel
HOMEWORK PACKET: (11.1) The Work of Gregor Mendel

... study how traits passed from one generation to the next. He created hybrids, which are crosses between true-breeding parents (the P generation) with different traits.  These hybrids were the F1 (first filial) generation.  They each showed the characteristic of only one parent. Mendel found that tr ...
Genetics - WalkerSci7and8
Genetics - WalkerSci7and8

... A trait that is covered over, or dominated, by another form of that trait and seems to disappear Hidden when the other copy of the gene contains the dominant allele. A recessive allele shows up only when there is no dominant allele present Shown with a lower-case letter ...
Study Guide - Mrs. Averett`s Classroom
Study Guide - Mrs. Averett`s Classroom

... of a particular set of genes. Phenotype refers to the physical characteristics resulting from those genes. An alternative form of a gene is an allele. The pea plants that Mendel worked with had two alleles for each gene. For example, there was an allele for round peas and an allele for wrinkled peas ...
Modified Mendelian Ratios I
Modified Mendelian Ratios I

... – If trait is dominant, it will not skip generations nor be passed on to offspring unless parents have it. – If trait is recessive, it will skip generations and will exist in carriers. • Form a hypothesis, e.g. autosomal recessive. • Deduce the genotypes. • Check that genotypes are consistent with p ...
Introduction to Genetics
Introduction to Genetics

...  The offspring from those parents are called the F1 generation (first filial) ...
Introduction to Genetics
Introduction to Genetics

...  The offspring from those parents are called the F1 generation (first filial) ...
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... 1 What do you know about dogs? 2. In your groups make a list of at least 10 different types of dogs 3. How do we get different types of dogs? ...
Chapter 5
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... represent dominant and recessive alleles.  letters representing two alleles from one parent are written along the top.  * Letters representing two alleles from the other parent are placed down the side.  Each square of the grid is filled in with one allele donated by each parent. ...
Selection, Gene Pools, Hardy
Selection, Gene Pools, Hardy

... Under Hardy-Weinberg equilibrium, the frequency of homozygotes for an allele is equal to the square of that allele's frequency. In other words, if p represents the frequency of W alelles, then p2 would give us the expected percentage of WW offspring. Likewise, if q is the fraction of w alleles, then ...
Evolutionary Concepts: Variation and Mutation
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... changes? • Accumulation of many small mutations, each with a small effect • Accumulation of several small mutations, each with a large effect • One large mutation with a large effect • Mutation in a regulatory sequence (affects regulation of development) ...
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... Positive role of IgE, autoimmunity and tolerance. Practically Film. Autoimmune disease. The rules of autoimmune diseases diagnostics - autoantibodies detection- IF method, ELISA, Western -blot and immune complexes detection. 8. Primary and secondary immunodeficiency Primary immunodeficiency: B-cell ...
Chapter 2 – Genotype Frequencies
Chapter 2 – Genotype Frequencies

... of simplifying assumptions about the structure of populations ² random mating* ² non-overlapping generations* ² migration (gene flow), mutation, and natural selection have negligible effects ²  large population size (= no genetic drift) ² sexual reproduction ² two alleles at a locus ² allele ...
Lecture#12 Page 1 BIOLOGY 207 - Dr.McDermid Lecture#12 Alleles
Lecture#12 Page 1 BIOLOGY 207 - Dr.McDermid Lecture#12 Alleles

... 1. From the wide variety of mutational possibilities for most genes, we can usually distinguish only functional and non-functional alleles. 2. The functional allele is usually dominant to the non-functional allele in individuals with both alleles (heterozygote). 3. Offspring from heterozygous parent ...
Lecture 4-POSTED-BISC441-2012
Lecture 4-POSTED-BISC441-2012

... Human genome: about 3 billion nucleotides, with about 3 million of them variable among any two random humans (99.9% identity); most variants probably have no phenotypic effects (are ‘neutral’) Human Genome Project has provided the sequence (all online) of one human, but the most interesting and impo ...
Codominance/Incomplete Dominance
Codominance/Incomplete Dominance

... The letters A and B refer to two carbohydrates on the surface of red blood cells. The i allele means that neither carbohydrate is present. The IA and IB alleles are both dominant over i, which is recessive. But neither IA or IB is dominant over the other. When IA and IB are both present in the genot ...
Introduction to Genetics
Introduction to Genetics

... Ex. Mice coat color is determined by one gene with four different alleles. Three different colors result from the combinations of these alleles. ...
Self tolerance
Self tolerance

... antigens are either killed (negative selection) or rendered harmless during their maturation in central (generative) lymphoid organs (i.e., in the thymus for T cells and in the bone marrow for B cells). ...
Genetic Evolution Note Review
Genetic Evolution Note Review

... ______________27. Evolution occurs when the frequency of alleles remains the same ______________28. All of the possible alleles in the population is the gene flow ______________29. Most mutations have no change on the individual ______________30. Lethal alleles are kept in the gene pool by homozygou ...
acquired immunity
acquired immunity

... 1. Diversity of the lymphocyte repertoire.(range of ...
Allele - West Ada
Allele - West Ada

... Phenotype - An organism’s physical appearance or visible traits. What can be seen. (ex: freckles, curly hair) Genotype - An organisms genetic makeup or allele combination. What can not be seen. (ex: AA, Aa, aa) Allele – 2 forms of a gene, 1 from each parent. (ex: AA, Aa, aa) Allele = Alphabet ...
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Human leukocyte antigen



The human leukocyte antigen (HLA) system is the locus of genes that encode for proteins on the surface of cells that are responsible for regulation of the immune system in humans. This group of genes resides on chromosome 6 (exception: the gene for β2-microglobulin which is located on chromosome 15), and encodes cell-surface antigen-presenting proteins and has many other functions. The HLA genes are the human versions of the major histocompatibility complex (MHC) genes that are found in most vertebrates (and thus are the most studied of the MHC genes). The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants. The major HLAs are essential elements for immune function. Different classes have different functions:HLAs corresponding to MHC class I (A, B, and C) present peptides from inside the cell. For example, if the cell is infected by a virus, the HLA system brings fragments of the virus to the surface of the cell so that the cell can be destroyed by the immune system. These peptides are produced from digested proteins that are broken down in the proteasomes. In general, these particular peptides are small polymers, about 9 amino acids in length. Foreign antigens presented by MHC class I attract killer T-cells (also called CD8 positive- or cytotoxic T-cells) that destroy cells.HLAs corresponding to MHC class II (DP, DM, DOA, DOB, DQ, and DR) present antigens from outside of the cell to T-lymphocytes. These particular antigens stimulate the multiplication of T-helper cells, which in turn stimulate antibody-producing B-cells to produce antibodies to that specific antigen. Self-antigens are suppressed by regulatory T cells.HLAs corresponding to MHC class III encode components of the complement system.HLAs have other roles. They are important in disease defense. They are the major cause of organ transplant rejections. They may protect against or fail to protect (if down-regulated by an infection) against cancers. Mutations in HLA may be linked to autoimmune disease (examples: type I diabetes, coeliac disease). HLA may also be related to people's perception of the odor of other people, and may be involved in mate selection, as at least one study found a lower-than-expected rate of HLA similarity between spouses in an isolated community.Aside from the genes encoding the 6 major antigen-presenting proteins, there are a large number of other genes, many involved in immune function, located on the HLA complex. Diversity of HLAs in the human population is one aspect of disease defense, and, as a result, the chance of two unrelated individuals with identical HLA molecules on all loci is very low. HLA genes have historically been identified as a result of the ability to successfully transplant organs between HLA-similar individuals.
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