parts nosology.
... 8. Arterial hyperemia: definition, causes, types (physiologic and pathologic), mechanisms (neurogenous, neuromyoparalytic and humoral) and consequences. Reactive hyperemia. Manifestations of arterial hyperemia and its mechanisms. 9. Venous hyperemia: definition, causes and consequences. Manifestatio ...
... 8. Arterial hyperemia: definition, causes, types (physiologic and pathologic), mechanisms (neurogenous, neuromyoparalytic and humoral) and consequences. Reactive hyperemia. Manifestations of arterial hyperemia and its mechanisms. 9. Venous hyperemia: definition, causes and consequences. Manifestatio ...
R.Giacomilli
... bone fail to reproduce the SC osteoblasts effects, suggesting that the factor(s) involved in this process is (are) not produced or produced in an ...
... bone fail to reproduce the SC osteoblasts effects, suggesting that the factor(s) involved in this process is (are) not produced or produced in an ...
Chapter 21 - Vaccines
... • Contain a mixture of different antigens and are more convenient to administer because fewer injections are ...
... • Contain a mixture of different antigens and are more convenient to administer because fewer injections are ...
Expression of CD1d in human scalp skin and hair follicles: hair cycle
... might bind lipid molecules and induce keratinocyte proliferation and differentiation, thus supporting anagen. This view is supported by the finding that CD1d deficient mice have severe skin disorders, manifested as hair loss and scab formation.19 Alternatively, as an antigen presenting molecule, CD1 ...
... might bind lipid molecules and induce keratinocyte proliferation and differentiation, thus supporting anagen. This view is supported by the finding that CD1d deficient mice have severe skin disorders, manifested as hair loss and scab formation.19 Alternatively, as an antigen presenting molecule, CD1 ...
Aloe Vera and the Human Immune System
... immuneslstemin a majorway. The mostobviousof theseis allergles.On the faceof it the last thing which the immunesystemmight appearto needin suchcasesis stimulatio4 becausethe trouble appearsto arisefrom an over-stimulatedconditionof the immune ...
... immuneslstemin a majorway. The mostobviousof theseis allergles.On the faceof it the last thing which the immunesystemmight appearto needin suchcasesis stimulatio4 becausethe trouble appearsto arisefrom an over-stimulatedconditionof the immune ...
External Seminar List - University of Birmingham Intranet
... 1. Molecular Pygmalion: a centenary celebration starring cyclin B1 2. What's the best way to inhibit the PPIase Pin1: structure based drug design or drinking green tea? Host: Dr Jo Morris ...
... 1. Molecular Pygmalion: a centenary celebration starring cyclin B1 2. What's the best way to inhibit the PPIase Pin1: structure based drug design or drinking green tea? Host: Dr Jo Morris ...
The Sphingosine-1-Phosphate Analogue FTY720 Reduces
... 4 of the 5 G protein– coupled sphingolipid receptors S1P1,-3,-4 and -53. These receptors mediate a multitude of physiological processes such as immunity, angiogenesis, cell migration, and inflammation.4,5 The immunosuppressive effect of FTY720 has been attributed to downregulation of lymphocyte S1P1 ...
... 4 of the 5 G protein– coupled sphingolipid receptors S1P1,-3,-4 and -53. These receptors mediate a multitude of physiological processes such as immunity, angiogenesis, cell migration, and inflammation.4,5 The immunosuppressive effect of FTY720 has been attributed to downregulation of lymphocyte S1P1 ...
How Mycobacterium tuberculosis Manipulates Innate and Adaptive Immunity: New Views of
... urine of TB-patients, illustrating the extensive distribution of this molecule in M. tuberculosis-infected hosts (Hamasur, Bruchfeld et al. 2001). Although the ability of LAM to inhibit phagosomal maturation is well established, the mechanism by which it causes this effect has not been addressed by ...
... urine of TB-patients, illustrating the extensive distribution of this molecule in M. tuberculosis-infected hosts (Hamasur, Bruchfeld et al. 2001). Although the ability of LAM to inhibit phagosomal maturation is well established, the mechanism by which it causes this effect has not been addressed by ...
Helicobacter pylori and cancer
... • intervals: – Dysplasia: 3-6 months – Moderate to severe atrophy: 2-3 years ...
... • intervals: – Dysplasia: 3-6 months – Moderate to severe atrophy: 2-3 years ...
How Does HIV Cause AIDS?
... tissues (2, 14). By incorporating noninfected cells into syncytia, a single gpl6Oexpressing cell can eliminate many uninfected CD4+ cells, the so-called bystander effect. HIV-expressing cells will also be killed by HIV-specific cytotoxic T cell responses, which are the normal mechanism for eliminati ...
... tissues (2, 14). By incorporating noninfected cells into syncytia, a single gpl6Oexpressing cell can eliminate many uninfected CD4+ cells, the so-called bystander effect. HIV-expressing cells will also be killed by HIV-specific cytotoxic T cell responses, which are the normal mechanism for eliminati ...
Type I interferons produced by hematopoietic cells protect
... NK cells play an essential role in the early response to many, but not all viral infections (25). These cells are particularly important components of host defense against members of the herpesvirus family, several of which have developed strategies to attenuate NK cell killing (26). Given this cent ...
... NK cells play an essential role in the early response to many, but not all viral infections (25). These cells are particularly important components of host defense against members of the herpesvirus family, several of which have developed strategies to attenuate NK cell killing (26). Given this cent ...
Ângela França and Nuno Cerca* Plasma is the main regulator of S
... Biofilms present a significant challenge to current clinical practice due to their increased tolerance to antibiotics and host immune response being, consequently, commonly associated with the development of chronic and recalcitrant infections (Costerton 1999). S. epidermidis, a skin- and mucosae-co ...
... Biofilms present a significant challenge to current clinical practice due to their increased tolerance to antibiotics and host immune response being, consequently, commonly associated with the development of chronic and recalcitrant infections (Costerton 1999). S. epidermidis, a skin- and mucosae-co ...
Ibrutinib inhibition of Bruton protein
... 1. The role of Bruton protein-tyrosine kinase in B cell antigen receptor signaling The Bruton kinase was originally identified in 1993 as a nonreceptor protein-tyrosine kinase that is defective in X-linked agammaglobulinemia [1–4]. B lymphocytes and immunoglobulins are almost completely nonexistent i ...
... 1. The role of Bruton protein-tyrosine kinase in B cell antigen receptor signaling The Bruton kinase was originally identified in 1993 as a nonreceptor protein-tyrosine kinase that is defective in X-linked agammaglobulinemia [1–4]. B lymphocytes and immunoglobulins are almost completely nonexistent i ...
Lecture 2- Immune and Lymphatic System
... make them more easily destroyed by phagocytes or complement proteins. Cell-mediated immunity on the other hand directly destroys pathogens by either killing them or releasing chemicals which active inflammation and other host defense mechanisms. These 2 forms of adaptive immunity are achieved throug ...
... make them more easily destroyed by phagocytes or complement proteins. Cell-mediated immunity on the other hand directly destroys pathogens by either killing them or releasing chemicals which active inflammation and other host defense mechanisms. These 2 forms of adaptive immunity are achieved throug ...
Lectins, Mitogens and Agglutinins
... Lectins can modulate IgE responses to other antigens [hG3 also does this, and there is some evidence that CD23 (the low-affinity IgE receptor) is in itself a C-type lectin.] Dietary lectins can induce the release of IL-4 and IL-13 from human basophils. Dietary lectins are known to prime TH2 helper l ...
... Lectins can modulate IgE responses to other antigens [hG3 also does this, and there is some evidence that CD23 (the low-affinity IgE receptor) is in itself a C-type lectin.] Dietary lectins can induce the release of IL-4 and IL-13 from human basophils. Dietary lectins are known to prime TH2 helper l ...
Immune Response by Chikungunya Virus Triggers an Innate Active
... CHIKF patients Fourteen patients with clinical acute disease were recruited during the second and third CHIKF outbreaks in Singapore (12). Clinical examinations and laboratory evaluations of these patients were carried out according to standardized protocol. All patients had high fever, rash, and ar ...
... CHIKF patients Fourteen patients with clinical acute disease were recruited during the second and third CHIKF outbreaks in Singapore (12). Clinical examinations and laboratory evaluations of these patients were carried out according to standardized protocol. All patients had high fever, rash, and ar ...
T-bet: a bridge between innate and adaptive immunity
... binds to large domains that have clusters of enhanc‑ ers associated with important T cell genes — known as ‘super enhancers’ — which are characteristics of master regulatory genes that define cell identity 10. However, in most cases, it remains to be formally proven that these specific interactions ...
... binds to large domains that have clusters of enhanc‑ ers associated with important T cell genes — known as ‘super enhancers’ — which are characteristics of master regulatory genes that define cell identity 10. However, in most cases, it remains to be formally proven that these specific interactions ...
Thesis - KI Open Archive
... consistent immunosuppressive capacity in vitro comparable to that of bone marrow-derived mesenchymal stromal cells (MSCs). This immune suppression was partly contact-dependent. Factors of importance in this process were found to include interferon-γ (IFN-γ), prostaglandin E2, indoleamine-2,3-dioxyge ...
... consistent immunosuppressive capacity in vitro comparable to that of bone marrow-derived mesenchymal stromal cells (MSCs). This immune suppression was partly contact-dependent. Factors of importance in this process were found to include interferon-γ (IFN-γ), prostaglandin E2, indoleamine-2,3-dioxyge ...
Immune mechanisms in Borrelia burgdorferi sensu lato
... eradication of the B. burgdorferi s.l. bacteria and a good clinical outcome. The inflammatory response must be down-regulated by an anti-inflammatory response in order to avoid excessive immune responses that will end in tissue injury. The proper down-regulation will also protect against development ...
... eradication of the B. burgdorferi s.l. bacteria and a good clinical outcome. The inflammatory response must be down-regulated by an anti-inflammatory response in order to avoid excessive immune responses that will end in tissue injury. The proper down-regulation will also protect against development ...
The 2016 Faculty Scholars
... Mitochondria, cells’ tiny power plants, are essential for many cellular activities, and their dysfunction is associated with aging, metabolic disorders, Parkinson’s disease, bacterial infections, and cancer. Cole Haynes is investigating the mechanisms cells use to monitor their mitochondria and, whe ...
... Mitochondria, cells’ tiny power plants, are essential for many cellular activities, and their dysfunction is associated with aging, metabolic disorders, Parkinson’s disease, bacterial infections, and cancer. Cole Haynes is investigating the mechanisms cells use to monitor their mitochondria and, whe ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.