10mb ppt - UCLA.edu
... Digalactose moiety not found in humans and Old World primates due to lack of a1--->3 galactosyl-transferase (a1--->3 GCT) Viruses grown in other mammalian cells can be neutralized by human or old-world primate sera (that have never seen the virus) due to high titer anti- Gal (a1-->3) Gal antibodies ...
... Digalactose moiety not found in humans and Old World primates due to lack of a1--->3 galactosyl-transferase (a1--->3 GCT) Viruses grown in other mammalian cells can be neutralized by human or old-world primate sera (that have never seen the virus) due to high titer anti- Gal (a1-->3) Gal antibodies ...
Slide 1
... – Relates to stem cell population in which driver mutations occured and the driver mutation(s) – e.g. Oncogene activation ...
... – Relates to stem cell population in which driver mutations occured and the driver mutation(s) – e.g. Oncogene activation ...
blood grouping
... Naturally occurring antibodies occur in the plasma of individuals who lack the corresponding antigen and who have not been pregnant or transfused. The most important are anti-A and anti-B. These are usually IgM antibodies. Immune antibodies develop in response to the introduction of red cells posses ...
... Naturally occurring antibodies occur in the plasma of individuals who lack the corresponding antigen and who have not been pregnant or transfused. The most important are anti-A and anti-B. These are usually IgM antibodies. Immune antibodies develop in response to the introduction of red cells posses ...
Diapositive 1 - Fondazione ARCO
... currently of major interest. Interestingly, previous studies have shown that chemotherapeutic agents alone (Figure 1) [1,2] and anti-EGFR therapies alone (Figure 2) [3] can induce more or less pronounced changes in the immunological cell profile. In particular, monoclonal antibodies (mAb) may direct ...
... currently of major interest. Interestingly, previous studies have shown that chemotherapeutic agents alone (Figure 1) [1,2] and anti-EGFR therapies alone (Figure 2) [3] can induce more or less pronounced changes in the immunological cell profile. In particular, monoclonal antibodies (mAb) may direct ...
Unit 3 - Nervous and Immune Systems Study Guide
... Phagocytes are also considered an innate defense. o What are macrophages? o What are monocytes o How do these WBCs play a role in the immune system? ...
... Phagocytes are also considered an innate defense. o What are macrophages? o What are monocytes o How do these WBCs play a role in the immune system? ...
Immunology 4
... The terms antigen, antigenic determinants and epitopes is often used loosely and interchangeably. Strictly speaking, however, an epitope refers to the particular area on a given antigen which the antibody can bind to. An epitope is the point where the antibody uses its antigen binding site and binds ...
... The terms antigen, antigenic determinants and epitopes is often used loosely and interchangeably. Strictly speaking, however, an epitope refers to the particular area on a given antigen which the antibody can bind to. An epitope is the point where the antibody uses its antigen binding site and binds ...
5c Acquired Immunity II
... Results of Antibody Binding to Antigen • Agglutination (coralling of the invader) • Precipitation (removal of soluble antigens from blood and lymph) • Neutralization (blocking antigen's activity and binding) ...
... Results of Antibody Binding to Antigen • Agglutination (coralling of the invader) • Precipitation (removal of soluble antigens from blood and lymph) • Neutralization (blocking antigen's activity and binding) ...
CL8
... are attached to needs to be destroyed. T cells – (white blood cells) attack and destroy infected cells that have antigens on their surface. DRUGS: 1. Antibiotics (e.g. Penicillin – a type of FUNGI!) – drugs used to TREAT a bacterial infection; they work by killing bacteria, stopping bacteria from ...
... are attached to needs to be destroyed. T cells – (white blood cells) attack and destroy infected cells that have antigens on their surface. DRUGS: 1. Antibiotics (e.g. Penicillin – a type of FUNGI!) – drugs used to TREAT a bacterial infection; they work by killing bacteria, stopping bacteria from ...
View Sample Pages - Plural Publishing
... until they bind antigen. Once they encounter an antigen, they upregulate specific surface receptors and become mature DCs. They then migrate into draining lymph nodes where they activate B and T cells by presenting the bound processed antigen. The APCs such as dendritic cells can take up antigens th ...
... until they bind antigen. Once they encounter an antigen, they upregulate specific surface receptors and become mature DCs. They then migrate into draining lymph nodes where they activate B and T cells by presenting the bound processed antigen. The APCs such as dendritic cells can take up antigens th ...
Adverse Immune Reactions and Immune Deficiencies
... cells and tissues. These Ab activate the complement cascade which in turn induces target cell death. ...
... cells and tissues. These Ab activate the complement cascade which in turn induces target cell death. ...
BIOL 256 SI, Molly 4/13/16 Exam 4 Review Distinguish among
... Natural killer cells – lyse and kill virus/cancer cells by releasing perforins and cytokines/ enhance inflammatory response ...
... Natural killer cells – lyse and kill virus/cancer cells by releasing perforins and cytokines/ enhance inflammatory response ...
student notes
... Passive Immunity: when an individual __________________ antibodies. Example - those passed to the fetus across the placenta and to infants via milk Remember...___________________ on red blood cells determine if a person has type A, B, AB or O. Transfusion with incompatible blood leads to destruction ...
... Passive Immunity: when an individual __________________ antibodies. Example - those passed to the fetus across the placenta and to infants via milk Remember...___________________ on red blood cells determine if a person has type A, B, AB or O. Transfusion with incompatible blood leads to destruction ...
Factor VIII Inhibitor
... IRIS is a well recognized (but unknown MOA) condition seen in AIDS or other immunosuppressed conditions resulting in an overwhelming response to antigen as the immune system begins to recover Most commonly occurs with TB, M. avium, Cryptococcus, CMV, VZV, EBV, and viral hepatitis Up to 50% of patien ...
... IRIS is a well recognized (but unknown MOA) condition seen in AIDS or other immunosuppressed conditions resulting in an overwhelming response to antigen as the immune system begins to recover Most commonly occurs with TB, M. avium, Cryptococcus, CMV, VZV, EBV, and viral hepatitis Up to 50% of patien ...
AP.Blog Immunity
... nonspecific immune responses – Invertebrates lack pathogen-specific defense responses – Plant defenses include molecular recognition with systemic responses, infection triggers chemical responses that destroy infected and adjacent cells, localizing the effects. ...
... nonspecific immune responses – Invertebrates lack pathogen-specific defense responses – Plant defenses include molecular recognition with systemic responses, infection triggers chemical responses that destroy infected and adjacent cells, localizing the effects. ...
Chapter 15 Cellular Mediated immunity 1. Define immunity providing
... 13. Where do B cell mature in the human body? Where do T cells mature? (4 pts) 14. Where do B and T cell go after maturation? (2pts) 15. What are natural killer (NK) or cytotoxic killer (Tc) cells? a. What are their functions? (6 pts) ...
... 13. Where do B cell mature in the human body? Where do T cells mature? (4 pts) 14. Where do B and T cell go after maturation? (2pts) 15. What are natural killer (NK) or cytotoxic killer (Tc) cells? a. What are their functions? (6 pts) ...
T-cell development in thymus
... positive selection, in the cortex. DP cells interact with self-antigens in the context of major histocompatabilty complex (MHC) class I or class II molecules. Those cells that engage antigen/MHC with an appropriate affinity survive, whereas those cells that interact with a weaker affinity die by apo ...
... positive selection, in the cortex. DP cells interact with self-antigens in the context of major histocompatabilty complex (MHC) class I or class II molecules. Those cells that engage antigen/MHC with an appropriate affinity survive, whereas those cells that interact with a weaker affinity die by apo ...
Chapter One Introduction And Literature Review
... 2. Route: Generally the subcutaneous route is better than the intravenous or intragastric routes. The route of antigen administration can also alter the nature of the response. 3. Adjuvants: Substances that can enhance the immune response to an immunogen are called adjuvants. The use of adjuvants, h ...
... 2. Route: Generally the subcutaneous route is better than the intravenous or intragastric routes. The route of antigen administration can also alter the nature of the response. 3. Adjuvants: Substances that can enhance the immune response to an immunogen are called adjuvants. The use of adjuvants, h ...
Our perpetually vigilant internal guardian
... Royston ventured into active immunotherapy with CancerVax, a Carlsbad company that developed a vaccine against melanoma. The goal was to wake up the immune system to recognize the cancer. The vaccine, Canvaxin, used allogeneic irradiated cancer cells. Clinical testing of the vaccine failed, creating ...
... Royston ventured into active immunotherapy with CancerVax, a Carlsbad company that developed a vaccine against melanoma. The goal was to wake up the immune system to recognize the cancer. The vaccine, Canvaxin, used allogeneic irradiated cancer cells. Clinical testing of the vaccine failed, creating ...
The Immune System Second Edition
... Antibody responses against red blood cells. Autoimmune hemolytic anemia. Antibodies are raised against cell surface antigens on red blood cells, resulting in destruction of red cells and anemia. ...
... Antibody responses against red blood cells. Autoimmune hemolytic anemia. Antibodies are raised against cell surface antigens on red blood cells, resulting in destruction of red cells and anemia. ...
Specific Immunity. Antibodies
... IgM is the main immunoglobulin produced early in the primary response. It is present as a monomer on the surface of virtually all B cells, where it functions as an antigenbinding receptor. In serum, it is a pentamer composed of 5 H2L2 units plus one molecule of J (joining) chain. Because the pentame ...
... IgM is the main immunoglobulin produced early in the primary response. It is present as a monomer on the surface of virtually all B cells, where it functions as an antigenbinding receptor. In serum, it is a pentamer composed of 5 H2L2 units plus one molecule of J (joining) chain. Because the pentame ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.